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| 1 | Up-regulation of Bcl-2 is required for the progression of prostate cancer cells from an androgen-dependent to an androgen-independent growth stage显示文摘Bcl-2 是 anti-apoptotic oncoprotein,它的蛋白质层次相反地在许多癌症与预后被相关。然而,在前列腺癌症的前进的 Bcl-2 的角色不是清楚的。这里,我们报导 Bcl-2 从一个雄激素依赖者为 LNCaP 前列腺癌症细胞的前进被要求到一个雄激素无关的生长阶段。Bcl-2 的信使 rna 和蛋白质层次显著地在雄激素无关的前列腺癌症被增加在雄激素无关的前列腺癌症房间的 Bcl-2 的调停 cells.shRNA 的基因 silencing 导致 promotesUV 的 apoptosis 并且压制前列腺肿瘤的生长体内。在在形成的雄激素剥夺条件结果下面的 Growingandrogen 依赖的房间 ofandrogen 独立的殖民地;并且到 androgen-independentgrowth 的从雄激素依赖者的转变被 Bcl-2 对手 Bax 或 Bcl-2 shRNA 的宫外的表示堵住。因此,我们的结果证明 Bcl-2 为 androgen-independentprostate 癌症细胞的幸存是批评的不仅,但是也为前列腺癌症细胞的前进被要求从对一个雄激素无关的生长阶段 anandrogen 依赖。 | Yuting Lin Junichi Fukuchi Richard A Hiipakka John M Kokontis Jialing Xiang | 2007 | Cell Research2007，17，6： | 5 |
| 2 | Extraction of lithium from the simulated pyrometallurgical slag of spent lithium-ion batteries by binary eutectic molten carbonates显示文摘The effective and low-temperature extraction of lithium from the pyrometallurgical slag of spent lithium-ion batteries(LIBs)remains a great challenge.Herein,potassium carbonate/sodium carbonate(K_(2)CO_(3)/Na_(2)CO_(3)),which could form a eutectic molten salt system at 720℃,was used as a roasting agent to extract lithium from pyrometallurgical slag.Lithium was successfully extracted from the slag by K_(2)CO_(3)/Na_(2)CO_(3) roasting followed by water leaching.Theoretical calculation results indicate that the lengths of Li-O bonds increase after K^(+)/Na^(+)adsorption,resulting in the easy release of Li^(+)from the LiAlSi_(2)O_(6) lattice after roasting with K_(2)CO_(3)/Na_(2)CO_(3).Thermogravimetry-differential scanning calorimetry results indicate that the eutectic phenomenon of K_(2)CO_(3) and Na_(2)CO_(3) could be observed at 720℃ and that the reaction of the slag and eutectic molten salts occurs at temperatures above 720℃.X-ray diffraction results suggest that Li^(+)in the slag is exchanged by K^(+)in K_(2)CO_(3) with the concurrent formation of KAlSiO_(4),while Na_(2)CO_(3) mainly functions as a fluxing agent.The lithium extraction efficiency can reach 93.87%under the optimal conditions of a roasting temperature of 740℃,roasting time of 30 min,leaching temperature of 50℃,leaching time of 40 min,and water/roasted sample mass ratio of 10:1.This work provides a new system for extracting lithium from the pyrometallurgical slag of spent LIBs. | Hui Dang Zhidong Chang Hualei Zhou Sihang Ma Min Li Jialing Xiang | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，9： | 2 |
| 3 | Enhanced tumor homing of pathogen-mimicking liposomes driven by R848 stimulation: A new platform for synergistic oncology therapy显示文摘Although multifarious tumor-targeting modifications of nanoparticulate systems have been attempted in joint efforts by our predecessors,it remains challenging for nanomedicine to traverse physiological barriers involving blood vessels,tissues,and cell barriers to thereafter demonstrate excellent antitumor effects.To further overcome these inherent obstacles,we designed and prepared mycoplasma membrane(MM)-fused liposomes(LPs)with the goal of employing circulating neutrophils with the advantage of inflammatory cytokine-guided autonomous tumor localization to transport nanoparticles.We also utilized in vivo neutrophil activation induced by the liposomal form of the immune activator resiquimod(LPsR848).Fused LPs preparations retained mycoplasma pathogen characteristics and achieved rapid recognition and endocytosis by activated neutrophils stimulated by LPs-R848.The enhanced neutrophil infiltration in homing of the inflammatory tumor microenvironment allowed more nanoparticles to be delivered into solid tumors.Facilitated by the formation of neutrophil extracellular traps(NETs),podophyllotoxin(POD)-loaded MM-fused LPs(MM-LPs-POD)were concomitantly released from neutrophils and subsequently engulfed by tumor cells during inflammation.MM-LPs-POD displayed superior suppression efficacy of tumor growth and lung metastasis in a 4T1 breast tumor model.Overall,such a strategy of pathogen-mimicking nanoparticles hijacking neutrophils in situ combined with enhanced neutrophil infiltration indeed elevates the potential of chemotherapeutics for tumor targeting therapy. | Xiaobei Cheng Pei Yu Xiang Zhou Jiale Zhu Yubao Han Chao Zhang Lingyi Kong | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 4 | The BH3-only protein BAD mediates TNFα cytotoxicity despite concurrent activation of IKK and NF-κB in septic shock显示文摘煽动性的 cytokine TNF 在许多煽动性、传染的疾病的病理起一个关键作用。然而,在这些疾病位于 TNF cytotoxicity 下面的机制不完全地被理解。这里,我们报导 pro-apoptotic BCL-2 家庭成员坏调停尽管有在由由得到多重机关的织物损坏并且贡献死亡在在有教养的房间并且在 vivo 导致 apoptosis 的 vitro 的 IKK 和 NF-B 的并发的激活的 TNF cytotoxicity 腐败吃惊。在高剂量, TNF 显著地通过 Src-p190GAP 小径的激活使 RhoA 失去活性,导致巨大的肌动朊压力纤维 destabilization,从细胞骨架由实质的坏版本列在后面到 cytosol。在这个条件下面,激活 IKK 没有通过所有 cytosolic 到 phosphorylate 坏,允许对线粒体不适宜的 non-phosphorylated 的 translocation 触发 apoptosis。Polymicrobial 感染利用象高剂量的 TNF 的一样的机制得到多重机关的联系 apoptosis 的织物损坏。因而,损失坏或坏 pro-apoptotic 活动的消除保护老鼠免受多重机关和还原剂死亡率的织物损坏的伤害。我们的结果支持在的一个模型坏调停尽管有在有教养的哺乳动物的房间并且在的 IKK-NF-B 小径的并发的激活的 TNF cytotoxicity 腐败吃惊。 | Jie Yan Hao Zhang Jialing Xiang Yu Zhao Xiang Yuan Beicheng Sun Anning Lin | 2018 | Cell Research2018，28，7： | 2 |
| 5 | JNK Suppresses Apoptosis via Phosphorylation of the Proapoptotic Bcl-2 Family Protein BAD显示文摘 | Chenfei Yu Yuzuru Minemoto Jiyan Zhang Jing Liu Fangming Tang Truc N. Bui Jialing Xiang Anning Lin | 2004 | Molecular Cell2004，，3： | 1 |
| 6 | Fabrication, characterization, exchange coupling and magnetic behavior of CoFe2 O4/CoFe2 O4 nanocomposite nanofibers 显示文摘 | XIANG Jun ZHANG Xionghui LI Jiale | 2013 | Chem Phys Lett2013，576，： | 1 |
| 7 | Heat Transfer Performance and Structural Optimization of a Novel Micro-channel Heat Sink显示文摘With the advent of the 5G era,the design of electronic equipment is developing towards thinness,intelligence and multi-function,which requires higher cooling performance of the equipment.Micro-channel heat sink is promising for the heat dissipation of super-thin electronic equipment.In this study,thermal resistance theoretical model of the micro-channel heat sink was first established.Then,fabrication process of the micro-channel heat sink was introduced.Subsequently,heat transfer performance of the fabricated micro-channel heat sink was tested through the developed testing platform.Results show that the developed micro-channel heat sink has more superior heat dissipation performance over conventional metal solid heat sink and it is well suited for high power LEDs application.Moreover,the micro-channel structures in the heat sink were optimized by orthogonal test.Based on the orthogonal optimization,heat dissipation performance of the micro-channel radiator was further improved. | Jianhua Xiang Liangming Deng Chao Zhou Hongliang Zhao Jiale Huang Sulian Tao | 2022 | Chinese Journal of Mechanical Engineering2022，35，2： | 0 |
| 8 | Identifying Hidden Li–Si–O Phases for Lithium-Ion Batteries via First-Principle Thermodynamic Calculations显示文摘SiO–based materials are promising alloys and conversion-type anode materials for lithium-ion batteries and are recently found to be excellent dendrite-proof layers for lithium-metal batteries.However,only a small fraction of the Li–Si–O compositional space has been reported,significantly impeding the understanding of the phase transition mechanisms and the rational design of these materials both as anodes and as protection layers for lithium-metal anodes.Herein,we identify three new thermodynamically stable phases within the Li–Si–O ternary system(Li_(2)SiO_(5),Li_(4)SiO_(6),and Li_(4)SiO_(8))in addition to the existing records via first-principle calculations.The electronic structure simulation shows that Li_(2)SiO_(5)and Li_(4)SiO_(8)phases are metallic in nature,ensuring high electronic conductivity required as electrodes.Moduli calculations demonstrate that the mechanical strength of Li–Si–O phases is much higher than that of lithium metal.The diffusion barriers of interstitial Li range from 0.1 to 0.6 eV and the interstitial Li hopping serves as the dominating diffusion mechanism in the Li–Si–O ternary systems compared with vacancy diffusion.These findings provide a new strategy for future discovery of improved alloying anodes for lithium-ion batteries and offer important insight towards the understanding of the phase transformation mechanism of alloy-type protection layers on lithium-metal anodes. | Jiale Qu Chao Ning Xiang Feng Bonan Yao Bo Liu Ziheng Lu Tianshuai Wang Zhi Wei Seh Siqi Shi Qianfan Zhang | 2022 | Energy & Environmental Materials2022，5，3： | 0 |
| 9 | Effects of Radix Puerariae, Radix Rehmanniae and Their Compatibility on Blood Glucose and Blood Lipids in Mice显示文摘[Objectives]To explore the effects of the compatibility of Radix Puerariae and Radix Rehmanniae on blood glucose and blood lipids in diabetic mouses.[Methods]Diabetic mouse model was established.The body weight and fasting blood glucose of mice were measured after 7 and 14 d of administration,and the biochemical indicators of blood lipids(TC,HDL-C,and LDL-C)were detected after 14 d of administration.[Results]Compared with the Radix Puerariae group and Radix Rehmanniae group,the compatibility group(1:2)had the best hypoglycemic effect(P<0.05),and TC and LDL-C in the compatibility group(2:1)significantly decreased(P<0.05),while HDL-C in the compatibility group(1:1)significantly increased(P<0.05).[Conclusions]Radix Puerariae,Radix Rehmanniae and their combination can reduce the blood glucose of diabetic mice.The compatibility group(1:2)had a significant hypoglycemic effect(P<0.05),and LDL-C in the compatibility group(2:1)significantly declined,while HDL-C in the compatibility group(1:1)rose significantly. | Yumei ZHANG Yulin ZHAO Yanmei QIN Jialing WEI Xiang QIN Suoyi HUANG | 2024 | Medicinal Plant2024，15，1： | 0 |
| 10 | Non-fused medium bandgap electron acceptors for efficient organic photovoltaics显示文摘The cost-effective organic semiconductors are strongly needed in organic photovoltaics(OPVs). Herein,two medium bandgap(MBG) electron acceptors, TPT4F and TPT4Cl are developed via the new design of multi-noncovalent interaction assisted unfused core, flanked with two electron withdrawing end groups. These fullly non-fused MBG acceptors adapt the planar and rigid conformation in solid, therefore exhibiting the ordered face-on stacking and strong photoluminescence in films. As results, TPT4Cl^(-)based OPVs, upon blending with the PBDB-TF polymer donor, have achieved a power conversion efficiency of 10.16% with a low non-radiative loss of 0.27 e V, representing one of the best fullly non-fused medium bandgap acceptors with desirable cost-efficiency balance. | Tian-Jiao Wen Jiale Xiang Nakul Jain Zhi-Xi Liu Zeng Chen Xinxin Xia Xinhui Lu Haiming Zhu Feng Gao Chang-Zhi Li | 2022 | Journal of Energy Chemistry2022，31，7： | 0 |
| 11 | Proteasomal degradation unleashes the pro-death activity of androgen receptor显示文摘雄激素受体(AR ) 能在雄激素无关的前列腺癌症房间独立于它的抄写活动支持导致压力的房间死亡。然而,内在的机制不完全地被理解。这里,我们报导 AR 的那导致压力的 proteasomal 降级贡献它的支持死亡的活动。在到紫外光和 staurosporine 的暴露之上, AR 经历了 proteasomal 降级。AR 降级的封锁显著地在雄激素无关的前列腺癌症房间压制了导致压力的 apoptosis。没有任何另外的死亡刺激, AR N 终端(AR-N ) 域的宫外的表示,缺乏 DNA 有约束力、 ligand 有约束力的能力,导致了房间死亡。截断分析表明那个 AR-N 领域包含调整 AR 的支持死亡的活动的几子域,明确地开始的 105 氨基酸,哪个是的功能 caspases 在上游的代理的一个最小的支持死亡的领域。AR N 终端碎片的 pro-apoptotic 活动被 Bcl-2 的宫外的表示压制或选择了 caspase 禁止者。因此,我们的结果揭示 AR 在雄激素无关的前列腺癌症房间由支持导致压力的房间死亡的新奇机制。 | Bradley Godfrey Yuting Lin Jeffery Larson Bonnie Haferkamp Jialing Xiang | 2010 | Cell Research2010，20，10： | 0 |
| 12 | Coupling of piezocatalysis and photocatalysis for efficient degradation of methylene blue by Bi_(0.9)Gd_(0.07)La_(0.03)FeO_(3) nanotubes显示文摘Photocatalytic degradation of organic pollutants is of great significance for wastewater remediation but is still hindered by the poor catalytic efficiency of the catalysts.Herein,we report a strategy to simultaneously introduce piezocatalysis and to enhance the intrinsic photocatalysis in a single catalyst,which improved the performance for catalytic degradation of methylene blue(MB)significantly.Specifically,piezoelectric BiFeO_(3)(BFO)nanotube doped with different contents of Gd and La(Bi_(0.9)(GdxLa_(1−x))0.1FeO_(3))were produced by electrospinning.The doping led to a higher concentration of surface oxygen vacancy(OV)in Bi_(0.9)Gd_(0.07)La_(0.03)FeO_(3),which effectively increased the piezoelectric field due to the deformation of BFO,and suppressed the recombination of photon-generated electron–hole pairs.The Bi_(0.9)Gd_(0.07)La_(0.03)FeO_(3)nanotube showed excellent catalytic performance under simultaneous light irradiation and ultrasonic excitation,giving an extraordinary 95%degradation of MB within 90 min.These findings suggest that the piezoelectric effect combined with defect engineering can enhance the catalytic performance of Bi_(0.9)Gd_(0.07)La_(0.03)FeO_(3)nanotube.This could potentially be extended to other catalytic systems for high-performance pollutant treatment. | Angom Devadatta MANI Jie LI Ziquan WANG Jiale ZHOU Huaicheng XIANG Jinlai ZHAO Libo DENG Haitao YANG Lei YAO | 2022 | Journal of Advanced Ceramics2022，11，7： | 0 |
| 13 | Regulating adsorption ability toward polysulfides in a porous carbon/Cu_(3)P hybrid for an ultrastable high-temperature lithium-sulfur battery显示文摘Lithium-sulfur batteries(LSBs)can work at high temperatures,but they suffer from poor cycle life stability due to the“shuttle effect”of polysulfides.In this study,pollen-derived porous carbon/cuprous phosphide(PC/Cu_(3)P)hybrids were rationally synthesized using a one-step carbonization method using pollen as the source material,acting as the sulfur host for LSBs.In the hybrid,polar Cu_(3)P can markedly inhibit the“shuttle effect”by regulating the adsorption ability toward polysulfides,as confirmed by theoretical calculations and experimental tests.As an example,the camellia pollen porous carbon(CPC)/Cu_(3)P/S electrode shows a high capacity of 1205.6 mAh g^(−1) at 0.1 C,an ultralow capacity decay rate of 0.038%per cycle after 1000 cycles at 1 C,and a rather high initial Coulombic efficiency of 98.5%.The CPC/Cu_(3)P LSBs can work well at high temperatures,having a high capacity of 545.9 mAh g^(−1) at 1 C even at 150℃.The strategy of the PC/Cu_(3)P hybrid proposed in this study is expected to be an ideal cathode for ultrastable high-temperature LSBs.We believe that this strategy is universal and worthy of in-depth development for the next generation energy storage devices. | Yichuan Guo Rabia Khatoon Jianguo Lu Qinggang He Xiang Gao Xiaopeng Yang Xun Hu Yang Wu Jiale Lian Zhoupeng Li Zhizhen Ye | 2021 | Carbon Energy2021，3，6： | 0 |
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