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| 1 | Genome-wide identification and co-expression network analysis of the Os NF-Y gene family in rice显示文摘Nuclear factor Y(NF-Y) is a ubiquitous transcription factor that regulates important physiological and developmental processes. In this study, we identified 34 Os NF-Y genes in rice, including 6 newly identified genes. Expression profile analysis covering the whole life cycle revealed that transcripts of Os NF-Y differentially accumulated in a tissue-specific,preferential or constitutive manner. In addition, gene duplication studies and expression analyses were performed to determine the evolutionary origins of the Os NF-Y gene family.Nine Os NF-Y genes were differentially expressed after treatment of seedlings with one or more abiotic stresses such as drought, salt and cold. Analysis of expression correlation and Gene Ontology annotation suggested that Os NF-Y genes were co-expressed with genes that participated in stress, accumulation of seed storage reserves, and plant development.Co-expression analysis also revealed that Os NF-Y genes might interact with each other,suggesting that NF-Y subunits formed complexes that take part in transcriptional regulation. These results provide useful information for further elucidating the function of the NF-Y family and their regulatory pathways. | Wenjie Yang Zhanhua Lu Yufei Xiong Jialing Yao | 2017 | The Crop Journal2017，5，1： | 7 |
| 2 | Design of bionic locust mouthparts stubble cutting device显示文摘Given the technical problems of low maize stubble breaking efficiency,large cutting torque and high power consumption faced during springtime no-till planting in Northeast China,we designed a high-performance coupling bionic stubble cutting device capable by integrating the structure(multi-segment and serrate)and cutting mode(isokinetic and symmetrical)of locust mouthparts.Methods of bionic construction,mechanism design,theoretical analysis,parameter optimization,Arduino systems and intelligent control were combined to design a planetary gear mechanism and an intelligent speed control system.In particular,the bionic cutting blade could reconstruct the multi-segment and serrate structure of locust mouthparts,while the planetary gear mechanism and the intelligent speed control system jointly comprised the bionic drive system,which could simulate the isokinetic and symmetrical cutting mode,thereby bionically coupling morphological structures and movement patterns.Analysis of comparative tests showed the coupling bionic cutting device could reduce the cutting torque by 26.6%-31.6%and the power consumption by 21.9%-26.1%.This work confirmed that coupling bionic method can significantly improve the stubble cutting efficiency,which was a valuable contribution to the design of stubble cutting device for no-till planter. | Jiale Zhao Mingzhuo Guo Yun Lu Dongyan Huang Jian Zhuang | 2020 | International Journal of Agricultural and Biological Engineering2020，13，1： | 4 |
| 3 | In-situ construction of a Mg-modified interface to guide uniform lithium deposition for stable all-solid-state batteries显示文摘Uniform lithium(Li)deposition in all-solid-state Li metal batteries is greatly influenced by the anode/electrolyte interface.Herein,a Mg-modified interface was constructed via the simple in-situ electrochemical reduction of Mg^(2+)from Mg(TFSI)_(2) in polyethylene oxide(PEO)and a Li bis(trifluoromethane)sulfoni mide(Li TFSI)formulae.As confirmed by cryogenic transmission electron microscopy,the anode/electrolyte interface exhibited hybrids consisting of crystalline Mg,Li_(2)O,and Li dots embedded in an amorphous polymer electrolyte.The crystalline Mg dots guided the uniform Li nucleation and growth,inducing a smoother anode/electrolyte interface compared with the pristine electrolyte.With 1 wt%Mg(TFSI)_(2) in the PEO-Li TFSI electrolyte,the Mg-modified electrolyte enabled the Li/Li symmetric cells with cycling performance of over 1700 and 1400 h at current densities of 0.1 and 0.2 m A cm^(-2),respectively.Moreover,the full LFP/Li cells using the novel Mg-modified electrolyte delivered a cycling lifespan of over 450 cycles with negligible capacity loss. | Tiefeng Liu Jiale Zheng Hualiang Hu Ouwei Sheng Zhijin Ju Gongxun Lu Yujing Liu Jianwei Nai Yao Wang Wenkui Zhang Xinyong Tao | 2021 | Journal of Energy Chemistry2021，30，4： | 3 |
| 4 | Photocrosslinking silver nanoparticles–aloe vera–silk fibroin composite hydrogel for treatment of full-thickness cutaneous wounds显示文摘Damage to the skin causes physiological and functional issues.The most effective treatment approach is the use of wound dressings.Silk fibroin(SF)is a promising candidate biomaterial for regulating wound healing;however,its antibacterial properties and biological activity must be further improved.In this study,a photocrosslinking hydrogel was developed to treat full-thickness cutaneous wounds.The composite hydrogel(Ag-AV-SF hydrogel)was prepared by introducing the silver nanoparticles(AgNPs)and aloe vera(AV)as the modifiers.In vitro study exhibited great antibacterial ability,biocompatibility and cell-proliferation and-migration-promoting capacities.It also showed the pH-response releasing properties which release more AgNPs in a simulated chronic infection environment.The healing effect evaluation in vivo showed the healing-promoting ability of the Ag-AV-SF hydrogel was stronger than the single-modifiers groups,and the healing rate of it reached 97.02%on Day 21,higher than the commercial wound dressing,silver sulfadiazine(SS)cream on sale.Additionally,the histological and protein expression results showed that the Ag-AV-SF hydrogel has a greater effect on the pro-healing regenerative phenotype with M2 macrophages at the early stage,reconstructing the blood vessels networks and inhibiting the formation of scars.In summary,the Ag-AV-SF hydrogel developed in this study had good physical properties,overwhelming antibacterial properties,satisfactory biocompatibility and significantly promoting effect on cell proliferation,migration and wound healing.Overall,our results suggest that the Ag-AV-SF hydrogel we developed has great potential for improving the wound healing in clinical treatment. | Yangkun Liu JinChuan Fan MingQi Lv Kepeng She Jiale Sun Qingqing Lu Changhao Han SongTao Ding Shuang Zhao GuiXue Wang YuChan Zhang GuangChao Zang | 2021 | Regenerative Biomaterials2021，8，6： | 2 |
| 5 | Variable elliptical vibrating screen: Particles kinematics and industrial application显示文摘Traditional vibrating screen usually adopts the linear centralized excitation mode,which causes the difficulty in particles loosening and low screening efficiency.The variable elliptical vibrating screen(VEVS)trajectory is regulated to adapt the material mass along the direction of the screen length,improving the particles distribution as well as the screening efficiency.In this work,a theoretical model was developed for analyzing the screen surface motion law during VEVS-based screening process.An equation was obtained to show the relationship between the horizontal amplitude and the vertical amplitude.The materials kinetic characteristics were studied by using high-speed camera during screening process.Compared with equal-amplitude screen(EAS),the material moving velocity was increased by 13.03%on the first half but decreased by 3.52% on the second half,and the total screening time was reduced by 9.42% by using VEVS.In addition,-6 mm screening test was carried out.At the length of VEVS equaled to 1.2 m,the screening efficiency and the total misplaced material content were 92.50% and 2.90%,respectively.However,the screening efficiency was 89.91% and the total misplaced material content was 3.76% during EAS-based screening process.Furthermore,when external moisture is 5.96%,the screening efficiency of VEVS could reach 86.95%.The 2 TKB50113 type VEVS with double-layered screen surface used in Huoshizui Coal Mine was 5.0 m in width and 11.3 m in length.The areas of single layer and double layer were 56.5 and 113 m~2,respectively.In industrial production,the processing capacity was 2500-3000 t/h and the screening efficiency was larger than 90%. | Chenlong Duan Jiale Yuan Miao Pan Tao Huang Haishen Jiang Yuemin Zhao Jinpeng Qiao Weinan Wang Shijie Yu Jiawang Lu | 2021 | International Journal of Mining Science and Technology2021，31，6： | 2 |
| 6 | Plant-Me- diated synthesis of Ag-Pd alloy nanoparticles and their applica- tion as catalyst toward selective hydrogenation显示文摘 | FENFEN LU DAOHUA SUN JIALE HUANG | 2014 | ACS Sustain- able Chemistry Engineering2014，2，： | 1 |
| 7 | Quantified assessment of deep brain stimulation on Parkinson’s patients with task fNIRS measurements and functional connectivity analysis:a pilot study显示文摘Background:Deep brain stimulation(DBS)has proved effective for Parkinson’s disease(PD),but the identification of stimulation parameters relies on doctors’subjective judgment on patient behavior.Methods:Five PD patients performed 10-meter walking tasks under different brain stimulation frequencies.During walking tests,a wearable functional near-infrared spectroscopy(fNIRS)system was used to measure the concentration change of oxygenated hemoglobin(ΔHbO_(2))in prefrontal cortex,parietal lobe and occipital lobe.Brain functional connectivity and global efficiency were calculated to quantify the brain activities.Results:We discovered that both the global and regional brain efficiency of all patients varied with stimulation parameters,and the DBS pattern enabling the highest brain efficiency was optimal for each patient,in accordance with the clinical assessments and DBS treatment decision made by the doctors.Conclusions:Task fNIRS assessments and brain functional connectivity analysis promise a quantified and objective solution for patient-specific optimization of DBS treatment.Trial registration:Name:Accurate treatment under the multidisciplinary cooperative diagnosis and treatment model of Parkinson’s disease.Registration number is ChiCTR1900022715.Date of registration is April 23,2019. | Ningbo Yu Siquan Liang Jiewei Lu Zhilin Shu Haitao Li Yang Yu Jialing Wu Jianda Han | 2021 | Chinese Neurosurgical Journal2021，7，3： | 1 |
| 8 | Identification of quantitative trait loci associated with resistance to Xanthomonas oryzae pv. oryzae pathotypes prevalent in South China显示文摘Bacterial blight(BB), which is caused by Xanthomonas oryzae pv. oryzae(Xoo), is an important rice disease responsible for significant yield losses. In the rice-growing regions of South China where BB outbreaks are common, the resistance of cultivars with BB resistance genes Xa4 and Xa21 has been lost because of rapid changes in the Xoo population structure and virulence. In this study, 421 diverse rice accessions were evaluated regarding their resistance to two Xoo strains, namely GD1358(C5) and IV, which are prevalent pathotypes in South China and overcame the resistance of Xa4 and Xa21, respectively. Using the 4.8 mio filtered SNP dataset, we conducted a genome-wide association study, which identified 13 loci associated with BB resistance, including eight new quantitative trait loci(QTL) and five QTL harboring known BB resistance genes: Xa3/Xa26, xa5, Xa35(t), Xa36(t), Xa40, Xa43(t), and xa44(t). Intriguingly, a steep peak was detected on chromosomes 5 and 11. Six QTL including three new ones, were distributed on chromosome 11, whereas a new QTL q BB5.1 and a known QTL were detected on chromosome 5. Haplotype analyses indicated that the LOC;s05 g01610(Os PRAF2) gene within the q BB5.1 region, which encodes a PRAF protein, is associated with BB resistance. Furthermore, Os PRAF2 knockout lines generated using the CRISPR-Cpf1 system were significantly more resistant to Xoo strains than the wild-type plants. Our results provide researchers and breeders with useful information regarding QTL and gene resources,which may be relevant for developing new BB-resistant rice cultivars. | Jialing Lu Quanlin Li Chunchao Wang Mingming Wang Dan Zeng Fan Zhang Wenxue Zhai Yongli Zhou | 2022 | The Crop Journal2022，10，2： | 1 |
| 9 | Protective effects of Ginkgo biloba extract on 6-hydroxydopamine-induced apoptosis in PC12 cells显示文摘The present study analyzed the protective effects of Ginkgo biloba extract against 6-hydroxydopamine-induced PC12 cell apoptosis in a model of Parkinson's disease. The results showed that Ginkgo biloba extract had a potent cytoprotective action and inhibited apoptosis of PC12 cells induced by 6-hydroxydopamine. Ginkgo biloba extract decreased the ratio of Bax to Bcl-2 and markedly inhibited the activation of p53 and caspase-3. These experimental findings indicate that Ginkgo biloba extract may significantly reduce the effects of oxidative stress induced by 6-hydroxydopamine in PC12 cells and suppress cell apoptosis. The potential effects of Ginkgo biloba extract might be greater than those of levodopa in the treatment of Parkinson's disease. | Jie Wang Yanbo Cheng Jiale Yin Qian LU Xingshun Xu Xiaoxing Yin | 2011 | Neural Regeneration Research2011，6，33： | 1 |
| 10 | Tailoring Cationic Helical Polypeptides for Efficient Cytosolic Protein Delivery显示文摘Protein delivery is of central importance for both diagnostic and therapeutic applications.However,protein delivery faces challenges including poor endosomal escape and thus limited efficiency.Here,we report the facile construction and screening of a small library of cationic helical polypeptides for cytosolic protein delivery.The library is based on a random copolymer poly(γ-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}esteryl-L-glutamate)-randompoly(γ-6-chlorohexyl-L-glutamate)[P(EG3-r-ClC6)Glu],which is then modified with various pyridine derivatives and alkyl thiols.Flow Cytometry,confocal laser scanning microscopy,and viability assay collaboratively identify two leading polymers,showing efficient delivery of enhanced green fluorescent protein(eGFP)and low cytoto-xicity.This finding is further validated by the cytosolic delivery of RNase A and cytochrome C(Cyt C)to HeLa cells in the viability assay.Together,this work demonstrates that high-throughput screening is an effective and viable approach to the selection of cationic helical polypeptides for the cytosolic delivery of functional proteins. | WANG Ruijue SHENG Kai HOU Yingqin SUN Jialing LU Hua | 2020 | Chemical Research in Chinese Universities2020，36，1： | 1 |
| 11 | Rif1 interacts with non-canonical polycomb repressive complex PRC1.6 to regulate mouse embryonic stem cells fate potential显示文摘Mouse embryonic stem cells(mESCs)cycle in and out of a transient 2-cell(2C)-like totipotent state,driven by a com-plex genetic circuit involves both the coding and repetitive sections of the genome.While a vast array of regulators,including the multi-functional protein Rif1,has been reported to influence the switch of fate potential,how they act in concert to achieve this cellular plasticity remains elusive.Here,by modularizing the known totipotency regulatory factors,we identify an unprecedented functional connection between Rif1 and the non-canonical polycomb repres-sive complex PRC1.6.Downregulation of the expression of either Rif1 or PRC1.6 subunits imposes similar impacts on the transcriptome of mESCs.The LacO-LacI induced ectopic colocalization assay detects a specific interaction between Rif1 and Pcgf6,bolstering the intactness of the PRC1.6 complex.Chromatin immunoprecipitation followed by sequencing(ChIP-seq)analysis further reveals that Rif1 is required for the accurate targeting of Pcgf6 to a group of genomic loci encompassing many genes involved in the regulation of the 2C-like state.Depletion of Rif1 or Pcgf6 not only activates 2C genes such as Zscan4 and Zfp352,but also derepresses a group of the endogenous retroviral element MERVL,a key marker for totipotency.Collectively,our findings discover that Rif1 can serve as a novel auxiliary component in the PRC1.6 complex to restrain the genetic circuit underlying totipotent fate potential,shedding new mechanistic insights into its function in regulating the cellular plasticity of embryonic stem cells. | Lu Li Pishun Li Jiale Chen Li Li Yunfan Shen Yangzixuan Zhu Jiayi Liu Lu Lv Song Mao Fang Chen Guang Hu Kai Yuan | 2022 | Cell Regeneration2022，11，1： | 1 |
| 12 | Role of endovascular embolisation for curative treatment of intracranial non- Galenic pial arteriovenous fistula显示文摘Background and purpose The safety and effectiveness of endovascular treatment for non-Galenic pial arteriovenous fistula(NGPAVF)is inadequately known.The aim of this study is to explore the role of endovascular embolisation for curative treatment of NGPAVF.Materials and methods Patients with NGPAVF underwent endovascular treatment from January 2011 to November 2019 in our institution were retrospectively reviewed.Demographics,clinical information,treatment details and clinical outcomes were collected.Factors associated with clinical outcomes were statistically analysed.Results Twenty patients were included,with a total of 22(2 patients have 2 fistulas)lesions.A total of 25 procedures were performed and 5 patients underwent 2 procedures.Follow-up ranged from 3 to 84 months(mean=34.5 months).Thirteen(59.1%)lesions in 12(60.0%)patients acquired immediate occlusion after initial treatment(immediately occluded group)and follow-up confirmed the complete obliteration.A total of 17(77.3%)lesions in 15(75.0%)patients were cured at last follow-up.The maximal diameter of feeding arteries(p=0.04)and the maximal diameter of the varix(p=0.01)in immediately occluded group was smaller than non-immediately occluded group.The number of feeding artery(p=0.004)and the maximal diameter of the varix(p<0.001)were much smaller in curative group than non-curative group.Seven patients suffered procedure-related complications.No patients had an increased Modified Rankin Scale(mRS)and all patients had favourable clinical outcome(mRS≥2)at last follow-up.Conclusions Endovascular therapy plays an important role in curative treatment of NGPAVF.Patients with less feeding arteries and small varix may be easier to be cured by endovascular embolisation. | Hengwei Jin Xiangyu Meng Jiale Quan Yi Lu Youxiang Li | 2021 | Stroke & Vascular Neurology2021，6，2： | 1 |
| 13 | Design and experiment of bionic stubble breaking-deep loosening combined tillage machine显示文摘Under the conditions of straw returning operation,there are three major technical bottlenecks in the Phaeozem region of northeast China,namely low stubble breaking rate,poor tillage depth consistency,and high fuel consumption.In this research,a bionic stubble-deep loosening combined tillage machine(BSD)was designed through bionic prototype analysis,coupled bionic analysis,coupled bionic design,theoretical analysis and application of intelligent control techniques.It consists of a bionic stubble breaking device and a bionic self-excited vibratory deep loosening device.Based on the unique biting pattern of locust mouthparts on maize rootstocks,the bionic stubble breaking device adopted a new multi-segment serrated bionic structure and a symmetrical rotational motion,which could significantly increase the stubble breaking rate(p<0.05)and reduce the resistance to stubble breaking operations(p<0.05).Based on the unique biology of the hare’s paws,toes and nails,the bionic self-excited vibration deep loosening device adopted a new series-parallel composite bionic elastic system and an intelligent tilling depth control system with a fuzzy algorithm,which significantly improved the tilling depth consistency(p<0.05).The operational performance of the BSD was verified at different operating speeds through comparative experiments and reveals the mechanism of its excellent performance through theoretical analysis.The final experiment results showed that,at the same operating speed,the BSD improved the stubble breaking rate by 9.62%and 10.67%,reduced the stubble breaking torque by 28 N·m and 33 N·m,reduced the tillage depth coefficient of variation by 12.73%and 13.48%,and reduced the specific fuel consumption by 36 g/km·h and 40 g/km·h compared to the two most common models.The operating performance of the three kinds of machines will decrease with the increase of operating speed,and the BSD has the least decrease. | Jiale Zhao Yun Lu Mingzhuo Guo Jun Fu Yijia Wang | 2021 | International Journal of Agricultural and Biological Engineering2021，14，4： | 1 |
| 14 | A long noncoding RNA regulates photopefiod-sensi- rive male sterility, an essential component of hybrid rice 显示文摘 | Jihua Ding Qing Lu Yidan Ouyang Hailiang Mao Pingbo Zhang Jialing Yao Caiguo Xu Xianghua Li Jinghua Xiao Qifa Zhang | 2012 | Proceedings of the National Academy of Sciences2012，109，7： | 1 |
| 15 | On residents' satisfaction with community health services after health care system reform in Shanghai,China,2011显示文摘 | Zhijian Li Jiale Hou Lin Lu | | 0，，01： | 1 |
| 16 | On residentsj sat- isfaction with community health ser- vices after health care system reform in Shanghai, China 显示文摘 | Li Zhijian Hou Jiale Lu Lin Tang Shenglan Ma Jin | 2012 | BMC Public Health2012，，12： | 1 |
| 17 | Quantitative in vivo and in vitro characterization of co-infection by two genetically distant grass carp reoviruses 显示文摘 | Wang Tu Li Jiale Lu Liqun | 2013 | J Gen Virol2013，94，： | 1 |
| 18 | Biomimetic earthworm dynamic soil looser for improving soybean emergence rate in cold and arid regions显示文摘In cold and arid regions,soil moisture content and accumulated temperature were seriously insufficient during spring sowing,which made it difficult for soybean seedling to emerge.Based on the principle of earthworm optimization and improvement of soil structure,this study innovatively designed a biomimetic earthworm dynamic soil looser through bionic design and theoretical calculation.By highly reducing the movement path and mode of earthworm in the soil,the mechanism could improve the soil temperature(ST)and soil moisture content(SMC),and thus greatly improve the soybean emergence rate(SER).In this study,the effects of biomimetic earthworm dynamic soil looser and its design parameters on soil temperature(ST),soil moisture content(SMC)and soybean emergence rate(SER)were investigated by two-factor test,analysis of variance(ANOVA)and Least significant Difference(LSD).Regression analysis was used to establish the mathematical model between design parameters and soybean emergence rate.MATLAB software was used to optimize the model,and the optimal design parameter combination was obtained.The contrast experiments showed that the biomimetic earthworm dynamic soil looser could construct the soil structure more suitable for the cold and arid regions.Compared with rotary blade(RB)and notched disc harrow(DH),biomimetic earthworm dynamic soil looser could increase soil moisture content by 41.30%and 27.50%,respectively.Compared with the notched disc harrow,the soil temperature could be increased by 7.97%.There was no significant difference between the effect of rotary blade on soil temperature(p>0.05).The soybean emergence rate was increased by 25.40%and 20.70%,respectively,compared with that of notched disc harrow and rotary blade. | Jiale Zhao Xiaogeng Wang Yun Lu Yanpeng Wei Mingzhuo Guo Jun Fu | 2021 | International Journal of Agricultural and Biological Engineering2021，14，3： | 1 |
| 19 | Rapid Preparation Process of Silver Nanoparticles by Bioreduction and Their Characterizations 1 1 Supported by the National Natural Science Foundation of China (No.20376076).显示文摘 | Mouxing FU Qingbiao LI Daohua SUN Yinghua LU Ning HE Xu DENG Huixuan WANG Jiale HUANG | 2006 | Chinese Journal of Chemical Engineering2006，，1： | 1 |
| 20 | Machine learning of materials design and state prediction for lithium ion batteries显示文摘With the widespread use of lithium ion batteries in portable electronics and electric vehicles,further improvements in the performance of lithium ion battery materials and accurate prediction of battery state are of increasing interest to battery researchers.Machine learning,one of the core technologies of artificial intelligence,is rapidly changing many fields with its ability to learn from historical data and solve complex tasks,and it has emerged as a new technique for solving current research problems in the field of lithium ion batteries.This review begins with the introduction of the conceptual framework of machine learning and the general process of its application,then reviews some of the progress made by machine learning in both improving battery materials design and accurate prediction of battery state,and finally points out the current application problems of machine learning and future research directions.It is believed that the use of machine learning will further promote the large-scale application and improvement of lithium-ion batteries. | Jiale Mao Jiazhi Miao Yingying Lu Zheming Tong | 2021 | Chinese Journal of Chemical Engineering2021，34，9： | 0 |
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