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| 1 | Microstructure and electrical properties of Y_2O_3-doped ZnO-based varistor ceramics prepared by high-energy ball milling显示文摘Y2O3-doped ZnO-based varistor ceramics were prepared using high-energy ball milling (HEBM) and low-temperature sin- tering technique, with voltage-gradient of 1934-2197 V/mm, non-linear coefficients of 20.8-21.8, leakage currents of 0.59-1.04 μA, and densities of 5.46-5.57 g/cm3. With increasing Y2O3 content, the voltage-gradient increases because of the decrease of ZnO grain size; the non-linear coefficient and the leakage current improve but the density decreases because of more porosity; the donor con- centration and density of interface states decrease, whereas the barrier height and width increase because of the acceptor effect of Y2O3 in varistor ceramics. | Hongyu Liu Xueming Ma Dongmei Jiang Wangzhou Shi | 2007 | Journal of University of Science and Technology Beijing2007，14，3： | 13 |
| 2 | Reversible and irreversible heat generation of NCA/Si–C pouch cell during electrochemical energy-storage process显示文摘To meet the requirements of electronic vehicles(EVs) and hybrid electric vehicles(HEVs),the high energy density Li Ni_(0.8) Co_(0.15) Al_(0.05) O_2(NCA) cathode and Si–C anode have attracted more attention.Here we report the thermal behaviors of NCA/Si–C pouch cell during the charge/discharge processes at different current densities.The total heat generations are derived from the surface temperature change during electrochemical Li+insertion/extraction in adiabatic surrounding.The reversible heat is determined by the entropic coefficients,which are related with open-circuit voltage at different temperatures; while the irreversible heat is determined by the internal resistance,which can be obtained via V–I characteristic,electrochemical impedance spectroscopy and hybrid pulse power characterization(HPPC).During the electrochemical process,the reversible heat contributes less than 10% to total heat generation; and the heat generated in charge process is less than that in discharge process.The results of thermal behaviors analyses are conducive to understanding the safety management and paving the way for building a reliable thermal model of high energy density lithium ion battery. | Ying Bai Limin Li Yu Li Guanghai Chen Huichun Zhao Zhaohua Wang Chuan Wu Hongyun Ma Xinquan Wang Hongyue Cui Jiang Zhou | 2019 | Journal of Energy Chemistry2019，28，2： | 7 |
| 3 | Low serum albumin levels predict poor outcome in patients with acute ischaemic stroke or transient ischaemic attack显示文摘Background To examine the relationship of serum albumin with poor functional outcome and mortality in patients with acute ischaemic stroke(AIS)or transient ischaemic attack(TIA),and perform a meta-analysis to summarise the association.Methods We analysed data from the Third China National Stroke Registry(CNSR-Ⅲ).Patients were divided into four groups based on serum albumin levels at admission.The outcomes included poor functional outcome(modified Rankin Scale(mRS)score of 3 to 6)and mortality at 3 months and 1 year.Multiple logistic regression models and Cox regression models were used to evaluate the association,respectively.We used a fixed-effect model to calculate the risk ratio for poor functional outcome and a random-effect model for mortality in the meta-analysis.Results A total of 13618 patients were enrolled.During the 3-month follow-up period,compared with 40 to 44.9 g/L group,patients in<35 g/L group had an increased risk of poor functional outcome and mortality(adjusted OR 1.37(95%CI 1.12 to 1.67);adjusted HR 2.13(95%CI 1.41 to 3.23)).The relationship in per 10 g/L decreased serum albumin with prognosis was consistently inversed(adjusted OR 1.17(95%CI 1.01 to 1.35);adjusted HR 1.86(95%CI 1.30 to 2.64)).Also,low serum albumin levels were independently correlated with clinical outcomes at 1 year.In the meta-analysis,the OR for poor functional outcome pooled 3 studies per 1 g/L decrease was 1.03(95%CI 1.02 to 1.05),and the HR for mortality pooled 5 studies was 1.07(95%CI 1.03 to 1.11).Conclusions Low serum albumin levels predict poor functional outcome and mortality in patients with AIS or TIA. | Hongyu Zhou Anxin Wang Xia Meng Jinxi Lin Yong Jiang Jing Jing Yingting Zuo Yilong Wang Xingquan Zhao Hao Li Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，3： | 7 |
| 4 | Jixuecao(Herba Centellae Asiaticae) alleviates mesangial cell proliferation in IgA nephropathy by inducing mitofusin 2 expression显示文摘OBJECTIVE:To investigate the effect of mitofusin 2 (Mfn2) and its downstream signaling pathway on glomerular mesangial cells (GMCs) proliferation in IgA nephropathy (IgAN),as well as the mechanism of action of Jixuecao (Herba Centellae Asiaticae,HCA) in the treatment of IgAN.METHODS:Adenovirus-mediated Mfn2 gene transfection and Mfn2 expression were analyzed by real-time polymerase chain reaction (PCR) and Western blotting.IgA1 induced the proliferation of GMCs,which were then treated with HCA.Cell proliferation was detected with cell counting kit-8 (CCK-8),and Mfn2 expression was analyzed by real-time PCR and western blotting.An IgAN animal model was also established and treated with HCA.GMCs proliferation was detected by hematoxylin-eosin staining,mitochondrial structure was analyzed by electron microscopy,mitochondrial function was determined by the Clark oxygen electrode method,and the expression of Mfn2,Phospho-extracellular regulated protein kinases1/2 (P-ERK1/2),Cyclin-dependent kinase 2 (CDK2),Phospho-p27 (p-p27),and cyclin A was analyzed by Western blotting.RESULTS:In vitro,HCA inhibited GMCs in a concentration-dependent manner in association with the upregulation of Mfn2 expression.The overexpression of Mfn2 inhibited IgA1-induced GMCs proliferation and elevated the effect of HCA.In vivo,treatment with HCA could alleviate albuminuria and creatinine and GMCs proliferation.These effects were related to the upregulation of Mfn2,p-p27 and inhibition of p-ERK1/2,CDK2,and cyclinA.Mitochondrial swelling,vacuolar degeneration,and reduction of respiratory control rate were identified in IgAN,but HCA could improve the mitochondrial structure and function.CONCLUSION:HCA inhibited GMCs proliferation via the upregulation Mfn2 and the inhibition of Ras-Raf-ERK/MAPK.We revealed that changes of mitochondrial structure and function are associated with IgAN,but that HCA can improve these mitochondrial features. | Chen Hongyu Du Yuanyuan Li Yayu Zeng Jiali Miao Jianxia Jiang Xue | 2019 | Journal of Traditional Chinese Medicine2019，39，3： | 6 |
| 5 | Fe3C-N-doped carbon modified separator for high performance lithium-sulfur batteries显示文摘A new Fe3C-N-doped reduced graphene oxide(Fe3C-N-rGO)prepared by a facile method is used as a separator for high performance lithium-sulfur(Li-S)batteries.The Fe3C-N-rGO is coated on the surface of commercial polypropylene separator(Celgard 2400)close to the sulfur cathode.The special nanotubes are in-situ catalyzed by Fe3C nanoparticles.They could entrap lithium polysulfides(Li PSs)to restrain the shuttle effect and reduce the loss of active material.The battery with the modified separator and sulfur cathode shows an excellent cycle performance.It has a high rate performance,580.5 mAh/g at the high current rate of 4 C relative to 1075 mAh/g at 0.1 C.It also has an initial discharge capacity of 774.8 m Ah/g measured at 0.5 C and remains 721.8 mAh/g after 100 cycles with a high capacity retention of 93.2%.The outstanding performances are notable in recently reports with modified separator. | Hongyu Pan Zhong Tan Haihui Zhou Lanlan Jiang Zhongyuan Huang Qjaoxia Feng Qiang Zhou Shuai Ma Yafei Kuang | 2019 | Journal of Energy Chemistry2019，28，12： | 5 |
| 6 | A new method of micro-motion parameters estimation based on cyclic autocorrelation function显示文摘Signals with sinusoidal frequency modulation(FM)are the general form of micro-Doppler signals in radar echoes from targets with micro-motions.This paper derives the cyclic autocorrelation function of a sinusoidal FM signal using its cyclostationary characteristics,and estimates the parameters of amplitude,modulation index,micro-motion period and noise power based on cyclic autocorrelation function.The estimation method is robust in noise environment when compared with conventional time-frequency analysis methods.Finally,the performances of estimation by utilizing the simulation data and darkroom measurement are shown in tables.The Monte-Carlo simulation results show that the estimator is asymptotically optimal at SNR above6 dB. | NIU Jie LI KangLe JIANG WeiDong LI Xiang KUANG GangYao ZHU HongYu | 2013 | Science China(Information Sciences)2013，56，10： | 4 |
| 7 | Effects of cooling rate on the microstructure and electrical properties of Dy_2O_3-doped ZnO-based varistor ceramics显示文摘The microstructure, electrical properties, and density of Dy2O3-doped ZnO-based varistor ceramics, prepared us-ing high-energy ball milling (HEBM) and sintered at 800°C, were investigated by increasing the cooling rate in the order of H (slow cooling in furnace) → L (cooling in furnace) → K (cooling in air). With the increase in cooling rate, the grain size and density decreased, the breakdown voltage (V1 mA / mm) increased, and the nonlinear coefficient (α) and leakage current (IL) exhibited extremum. The sample with the cooling type L showed the best properties with the breakdown voltage of 2650 V/mm, α of 20.3, IL of 5.2 μA, and density of 5.42 g/cm3. The barrier height (φB), donor concentration (Nd), density of the interface states (Ns), and barrier width (ω) all exhibited extremum during the alteration in cooling rate. The different relative amount of Bi-rich phase and its distribution as well as the characteristic parameters of grain boundary, resulting from the alteration of cooling rate, led to the changes in the properties of varistor ceramics. | LIU Hongyu KONG Hui JIANG Dongmei SHI Wangzhou MA Xueming ZHANG Huining | 2007 | Rare Metals2007，26，1： | 4 |
| 8 | The POM-DOM piezophilic microorganism continuum(PDPMC)—The role of piezophilic microorganisms in the global ocean carbon cycle显示文摘The deep ocean piezosphere accounts for a significant part of the global ocean,hosts active and diverse microbial communities which probably play a more important role than hitherto recognized in the global ocean carbon cycle.The conventional biological pump concept and the recently proposed microbial carbon pump mechanism provide a foundation for our understanding of the role of microorganisms in cycling of carbon in the ocean.However,there are significant gaps in our knowledge and a lack of mechanistic understanding of the processes of microbially-mediated production,transformation,degradation,and export of marine dissolved and particulate organic matter(DOM and POM)in the deep ocean and the ecological consequence.Here we propose the POM-DOM piezophilic microorganism continuum(PDPMC)conceptual model,to address these important biogeochemical processes in the deep ocean.We propose that piezophilic microorganisms(bacteria and archaea)play a pivotal role in deep ocean carbon cycle where microbial production of exoenzymes,enzymatic breakdown of DOM and transformation of POM fuels the rapid cycling of marine organic matter,and serve as the primary driver for carbon cycle in the deep ocean. | FANG JiaSong ZHANG Li LI Jiang Tao Chiaki KATO Christian TAMBURINI ZHANG YuZhong DANG HongYue WANG GuangYi WANG FengPing | 2015 | Science China Earth Sciences2015，58，1： | 4 |
| 9 | Microstructural evolution and defect formation in a powder metallurgy nickel-based superalloy processed by selective laser melting显示文摘In this study,the selective laser melting(SLM)technology has been employed to manufacture a nickelbased superalloy which was conventionally prepared through powder metallurgy(PM)route.The microstructural features and defects were systematically investigated both prior to and after heat treatment and compared with the PM counterpart.Both solidification cracking and liquation cracking were observed in the SLM specimen in which the grain misorientation and low melting point(γ+γ')eutectic played a vital role in their formation mechanism.Columnar grains oriented along building direction were ubiquitous,corresponding to strong<001>fiber texture.Solidification cell structures and melt pools are pervasive and noγ'precipitates were detected at about 10 nm scale before heat treatment.After supersolvus solution and two-step aging treatments,high volume fractionγ'precipitates emerged and their sizes and morphologies were comparable to those in PM alloy.<001>texture is relieved and columnar grains tend to become more equiaxed due to static recrystallization process and grain boundary migration events.Significant annealing twins formed in SLM alloy and are clarified as a consequence of recrystallization.Our results provide fundamental understandings for the SLM PM nickel-based superalloy both before and after heat treatment and demonstrate the potential to fabricate this group of alloys using SLM technology. | Hongyu Wu Dong Zhang Biaobiao Yang Chao Chen Yunping Li Kechao Zhou Liang Jiang Ruiping Liu | 2020 | Journal of Materials Science & Technology2020，36，1： | 4 |
| 10 | Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function显示文摘Innate immunity mediated by Toll-like receptors(TLRs),which can recognize pathogen molecular patterns,plays a critical role in type 1 diabetes development.TLR7 is a pattern recognition receptor that senses single-stranded RNAs from viruses and host tissue cells;however,its role in type 1 diabetes development remains unclear.In our study,we discovered that Tlr7-deficient(Tlr7^(−/−))nonobese diabetic(NOD)mice,a model of human type 1 diabetes,exhibited a significantly delayed onset and reduced incidence of type 1 diabetes compared with Tlr7-sufficient(Tlr7^(+/+))NOD mice.Mechanistic investigations showed that Tlr7 deficiency significantly altered B-cell differentiation and immunoglobulin production.Moreover,Tlr7^(−/−)NOD B cells were found to suppress diabetogenic CD4^(+)T-cell responses and protect immunodeficient NOD mice from developing diabetes induced by diabetogenic T cells.In addition,we found that Tlr7 deficiency suppressed the antigen-presenting functions of B cells and inhibited cytotoxic CD8^(+)T-cell activation by downregulating the expression of both nonclassical and classical MHC class I(MHC-I)molecules on B cells.Our data suggest that TLR7 contributes to type 1 diabetes development by regulating B-cell functions and subsequent interactions with T cells.Therefore,therapeutically targeting TLR7 may prove beneficial for disease protection. | Juan Huang Jian Peng James Alexander Pearson Georgios Efthimiou Youjia Hu Ningwen Tai Yanpeng Xing Luyao Zhang Jianlei Gu Jianping Jiang Hongyu Zhao Zhiguang Zhou F.Susan Wong Li Wen | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 11 | Role of helicity of a-helical antimicrobia peptides to improve specificity显示文摘 | Yibing Huang Liyan He Guirong Li Naicui Zhai Hongyu Jiang Yuxin Chen | 2014 | Protein & Cell2014，5，8： | 3 |
| 12 | Construction and characterization of a hrpG mutant rendering constitutive expression of hrp genes in Xanthomonas campestris pv.campestris显示文摘在 Xanthomonas 的 hrp 基因的表示被 hrpG, OmpR 类型 transcriptional 使活跃之物,和罐头调整被导致由人工模仿中等 XVM2,但是在富有的中等 NYG 镇压了。在这研究,在 Xanthomonas campestris pv 的 hrpG 的一个地点特定的变化。campestris (Xcc ) 被指导 PCR 的点傻瓜发育不全产生并且被它的显型和 transcriptional 表示分析描绘。结果显示 E45K 变异 hrpG 显示了在抑制媒介 NYG 组成地表示的所有 hrp 基因。植物测试证明那变异的 hrpG 提高了预定和过分敏感的反应(HR ) 的紧张在上上非招待植物辣椒,但是没在文化媒介和植物影响 Xcc 的生长。E45K 变化没引起 exopolysaccharide 绗维素酶和淀粉酶的生产的重要变化,但是在里面禁止了细胞外的朊酶的分泌物。这异种 8004 比对在学习 transcriptional 规定的 vitroand 识别 hrp 家属受动器的野类型更合适染色体宽。 | JIANG Bole XU Rongqi LI Xianzhen WEI Hongyu BAI Faan HU Xi HE Yongqiang TANG Jiliang | 2006 | Progress in Natural Science:Materials International2006，16，5： | 3 |
| 13 | TatD DNases of African trypanosomes confer resistance to host neutrophil extracellular traps显示文摘African trypanosomatid parasites escape host acquired immune responses through periodic antigenic variation of their surface coat.In this study,we describe a mechanism by which the parasites counteract innate immune responses.Two Tat D DNases were identified in each of Trypanosoma evansi and Trypanosoma brucei.These DNases are bivalent metal-dependent endonucleases localized in the cytoplasm and flagella of the parasites that can also be secreted by the parasites.These enzymes possess conserved functional domains and have efficient DNA hydrolysis activity.Host neutrophil extracellular traps(NETs)induced by the parasites could be hydrolyzed by native and recombinant Tat D DNases.NET disruption was prevented,and the survival rate of parasites was decreased,in the presence of the DNase inhibitor aurintricarboxylic acid.These data suggest that trypanosomes can counteract host innate immune responses by active secretion of Tat D DNases to degrade NETs. | Kai Zhang Ning Jiang Hongyu Chen Naiwen Zhang Xiaoyu Sang Ying Feng Ran Chen Qijun Chen | 2021 | Science China(Life Sciences)2021，64，4： | 3 |
| 14 | CW interference mitigation in GNSS receiver based on frequency-locked loop显示文摘Global navigation satellite system(GNSS) receivers are highly susceptible to continuous wave(CW)interference because the received signals are extremely weak. Current interference mitigation techniques mainly use a notch filter or transform domain. This paper proposes a computationally effective algorithm based on a frequency-locked loop(FLL) to mitigate interference in GNSS receivers. The performance of the algorithm is validated through an analysis of the characteristics of the interference reduction filter and interference estimation precision. A Monte Carlo simulation is used to compare the proposed algorithm with various previous algorithms:the adaptive IIR notch filter, adaptive linear-phase FIR filter, and N-sigma DFT algorithm. The simulation results show that the proposed algorithm exhibits excellent interference estimation precision and superior antijamming performance compared with the conventional algorithms. | Hongyu REN Yongqing WANG Lei JIANG Siliang WU | 2016 | Science China(Information Sciences)2016，59，8： | 2 |
| 15 | Effect of glucose concentrations on wear resistance of Al/APC composites prepared by hydrothermal carbonized deposition on chips显示文摘In this study,a novel method termed hydrothermal carbonized deposition on chips(HTCDC)is proposed to prepare aluminum alloy-amorphous carbon(Al/APC)composites.The influences of glucose concentration in hydrothermally reaction on the microstructure and wear resistance of the Al/APC composites were thoroughly studied.Amorphous carbon was deposited by HTCDC onto Al–20Si chips as a supporter.The Al/APC composites were prepared by hot extrusion from the chips.The results indicated that a uniform carbon film was successfully synthesized on the surface of the chips,improving the wear resistance of the Al/APC composites.With increasing concentration of glucose solution,the size and the number of delamination on the wear surface and the coefficient of friction decreased,and the wear rate decreased at first and then increased.In addition,the dehydration and carbonization processes in the hydrothermal reaction of glucose were analyzed.A schematic model of the wear surface of the Al/APC composites was established and the wear mechanisms were discussed. | Yingjie He Hongyu Xu Maoliang Hu Bo Jiang Zeshengji | 2020 | Journal of Materials Science & Technology2020，52，18： | 2 |
| 16 | Regulation of eight avr genes by hrpG and hrpX in Xanthomonas campestris pv. campestris and their role in pathogenicity显示文摘Eight putative avirulence genes in Xanthomonas campestris pv. campestris (Xcc) strain 8004 were characterized by Tn5gusA5 mutagenesis and gene expression analysis. The virulence test of mutants on Chinese radish showed that all mutants in individual avr genes except avrBs2 mutant were not significantly different from the wild type in virulence. The avrBs2 mutant showed reduced virulence and bacterial growth in planta. Gene expression analysis using β-glucuronidase as reporter indicated that avrBs1.1,avrBs1,avrXccB,avrXccC,avrXccE1 were regulated by hrpG, whereas avrXccA1, avrXccA2 and avrBs2 were not. RT-PCR analysis showed that all hrpG-regulated genes except avrBs1 were also regulated by hrpX. In addition, it was demonstrated that avrBs1 was responsible for elicitation of a type III dependent hypersensitive reaction (HR) on nonhost plant pepper ECW-10R, and wild type Xcc 8004 was unable to cause HR on pepper ECW-20R. | XU Rongqi LI Xianzhen WEI Hongyu JIANG Bole LI Kai HE Yongqiang FENG Jiaxun TANG jiliang | 2006 | Progress in Natural Science:Materials International2006，16，12： | 2 |
| 17 | A critical review of mineral–microbe interaction and co-evolution:mechanisms and applications显示文摘Mineral–microbe interactions play important roles in environmental change,biogeochemical cycling of elements and formation of ore deposits.Minerals provide both beneficial(physical and chemical protection,nutrients,and energy)and detrimental(toxic substances and oxidative pressure)effects to microbes,resulting in mineral-specific microbial colonization.Microbes impact dissolution,transformation and precipitation of minerals through their activity,resulting in either genetically controlled or metabolism-induced biomineralization.Through these interactions,minerals and microbes co-evolve through Earth history.Mineral–microbe interactions typically occur at microscopic scale but the effect is often manifested at global scale.Despite advances achieved through decades of research,major questions remain.Four areas are identified for future research:integrating mineral and microbial ecology,establishing mineral biosignatures,linking laboratory mechanistic investigation to field observation,and manipulating mineral–microbe interactions for the benefit of humankind. | Hailiang Dong Liuqin Huang Linduo Zhao Qiang Zeng Xiaolei Liu Yizhi Sheng Liang Shi Geng Wu Hongchen Jiang Fangru Li Li Zhang Dongyi Guo Gaoyuan Li Weiguo Hou Hongyu Chen | 2022 | National Science Review2022，9，10： | 2 |
| 18 | Rare Metal Materials andEngineering显示文摘 | Yan Hui Jiang Hongyuan Zhao Hongyu | 2011 | 40(12): 20922011，40，12： | 1 |
| 19 | SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling显示文摘Dysfunction of the Hippo pathway enables cells to evade contact inhibition and provides advantages for cancerous overgrowth.However,for a significant portion of human cancer,how Hippo signaling is perturbed remains unknown.To answer this question,we performed a genome-wide screening for genes that affect the Hippo pathway in Drosophila and cross-referenced the hit genes with human cancer genome.In our screen,Prosap was identified as a novel regulator of the Hippo pathway that potently affects tissue growth.Interestingly,a mammalian homolog of Prosap,SHANK2,is the most frequently amplified gene on 11 q13,a major tumor amplicon in human cancer.Gene amplification profile in this 11q13 amplicon clearly indicates selective pressure for SHANK2 amplification.More importantly,across the human cancer genome,SHANK2 is the most frequently amplified gene that is not located within the Myc amplicon.Further studies in multiple human cell lines confirmed that SHANK2 overexpression causes deregulation of Hippo signaling through competitive binding for a LATS1 activator,and as a potential oncogene,SHANK2 promotes cellular transformation and tumor formation in vivo.In cancer cell lines with deregulated Hippo pathway,depletion of SHANK2 restores Hippo signaling and ceases cellular proliferation.Taken together,these results suggest that SHANK2 is an evolutionarily conserved Hippo pathway regulator,commonly amplified in human cancer and potently promotes cancer.Our study for the first time illustrated oncogenic function of SHANK2,one of the most frequently amplified gene in human cancer.Furthermore,given that in normal adult tissues,SHANK2 s expression is largely restricted to the nervous system,SHANK2 may represent an interesting target for anticancer therapy. | Liang Xu Peixue Li Xue Hao Yi Lu Mingxian Liu Wenqian Song Lin Shan Jiao Yu Hongyu Ding Shishuang Chen Ailing Yang Yi Arial Zeng Lei Zhang Hai Jiang | 2021 | Protein & Cell2021，12，3： | 1 |
| 20 | Highly efficient sulfur-containing polymeric photoinitiators bearing side-chain benzophenone and coinitiator amine for photopolymerization 显示文摘 | Hongyu Wang Jun Wei Xuesong Jiang | 2007 | Journal of Photochemistry and Photobiology A: Chemistry2007，186，： | 1 |
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