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| 1 | Profiling and bioinformatics analysis of differentially expressed circular RNAs in human intervertebral disc degeneration显示文摘The functional changes of nucleus pulposus (NP) cells are considered to be the initiating factors of intervertebral disc degeneration (IDD), and the differentially expressed circRNAs in NP cells may play an important role in the process of IDD. To identify circular RNAs (circRNAs) associated with human IDD, we isolated the NP cells from human degenerated and non-degenerated intervertebral disc and identified NP cells by microscopy and cell proliferation. CircRNA microarray expression profiles were obtained from NP cells of degenerated and non-degenerated intervertebral disc and further validated by quantitative reverse transcription PCR (qRTPCR). The expression data were analyzed by bioinformatics. Microarray analysis identified 7294 circRNAs differentially expressed in degenerated human IDD NP cells. Among them, 3724 circRNAs were up-regulated and 3570 circRNAs were down-regulated by more than 2 folds. After validating by qRT-PCR, we predicted the possible miRNAs of the top dysregulated circRNAs using TargetScan, and miRanda. Furthermore, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that the most modulated circRNAs regulate the viability, degradation, apoptosis and oxidative stress in NP cells, and the possible mechanism underlying IDD was discussed. These results revealed that circRNAs may play a role in IDD and might be a promisi ng can didate molecular target for gene therapy. | Shunmin Wang Jingchuan Sun Haisong Yang Weiguo Zou Bing Zheng Yu Chen Yongfei Guo Jiangang Shi | 2019 | Acta Biochimica et Biophysica Sinica2019，51，6： | 4 |
| 2 | The joint long-term distribution of design environmental factors for offshore structures Multivariate probabilities and simulating method显示文摘With the development of ocean engineering, it is one of the most important factors which determine the structural safety, cost and suitable forms of engineerings to select the ocean environmental design criteria. Owing to the complexity , variation and randomness of ocean environmental conditions, the commonly used methods for determining design criteria cannot consider the joint occurring probabilities of several environmental factors ,therefore, lead to overestimate design criteria of them and result in an unnecessary overspend invest in engineering. On the basis of the measured and hindcasting data and the multi-demension joint probability theory, this paper presented the study of the joint loads of wind , wave and current on the offshore structures and its responsible joint probability level with the application of random simulation techniques, and presented the joint design criteria of environmental loads for the realistic design of engineerings. | Shi Jiangang, Liu Defu and Wang Zheng Department of Ocean Engineering and Naval Architecture, Tianjin University, Tianjin 300072, China | 1993 | Acta Oceanologica Sinica1993，12，3： | 3 |
| 3 | Changes in compressed neurons from dogs with acute and severe cauda equina constrictions following intrathecal injection of brain-derived neurotrophic factor-conjugated polymer nanoparticles显示文摘This study established a dog model of acute multiple cauda equina constriction by experimental constriction injury (48 hours) of the lumbosacral central processes in dorsal root ganglia neurons. The repair effect of intrathecal injection of brain-derived neurotrophic factor with 15 mg encapsulated biodegradable poly(lactide-co-glycolide) nanoparticles on this injury was then analyzed. Dorsal root ganglion cells (L7) of all experimental dogs were analyzed using hematoxylin-eosin staining and immunohistochemistry at 1, 2 and 4 weeks following model induction. Intrathecal injection of brain-derived neurotrophic factor can relieve degeneration and inflammation, and elevate the expression of brain-derived neurotrophic factor in sensory neurons of compressed dorsal root ganglion. Simultaneously, intrathecal injection of brain-derived neurotrophic factor obviously improved neurological function in the dog model of acute multiple cauda equina constriction. Results verified that sustained intraspinal delivery of brain-derived neurotrophic factor encapsulated in biodegradable nanoparticles promoted the repair of histomorphology and function of neurons within the dorsal root ganglia in dogs with acute and severe cauda equina syndrome. | Junming Tan Jiangang Shi Guodong Shi Yanling Liu Xiaohong Liu Chaoyang Wang Dechun Chen Shunming Xing Lianbing Shen Lianshun Jia Xiaojian Ye Hailong He Jiashun Li | 2013 | Neural Regeneration Research2013，8，3： | 2 |
| 4 | Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle显示文摘Whether glucose is predomi nantly metabolized via oxidative phosphorylati on or glycolysis differs between quiesce nt versus proliferating cells,iincluding tumor cells.However,how glucose metabolism is coordinated with cell cycle in mammalian cells remains elusive.Here,we report that mammalian cells predominantly utilize the tricarboxylic acid(TCA)cycle in G1 phase,but prefer glycolysis in S phase.Mechanistically,coupling cell cycle with metabolism is largely achieved by timely destruction of IDH1/2,key TCA cycle enzymes,in a Skp2-dependent manner.As such,depleting SKP2 abolishes cell cycle-dependent fluctuation of IDH1 protein abundance,leading to reduced glycolysis in S phase.Furthermore,elevated Skp2 abundance in prostate cancer cells destabilizes IDH1 to favor glycolysis and subsequent tumorigenesis.Therefore,our study reveals a mechanistic link between two cancer hallmarks,aberrant cell cycle and addiction to glycolysis,and provides the underlying mechanism for the coupling of metabolic fluctuation with periodic cell cycle in mammalian cells. | Jing Liu Yunhua Peng Le Shi Lixin Wan Hiroyuki Inuzuka Jiangang Long Jianping Guo Jinfang Zhang Min Yuan Shuangxi Zhang Xun Wang Jing Gao Xiangpeng Dai Shozo Furumoto Lijun Jia Pier Paolo Pandolfic John M.Asara William G.Kaelin Jr. Jjankang Liu Wenyi Wei | 2021 | Cell Research2021，31，1： | 2 |
| 5 | Analysis of Abnormal Characteristics of Regional Crustal Deformation before the Menyuan MS6.4 Earthquake by GPS Continuous Data显示文摘In order to study the characteristics of crustal deformation around the epicenter before the 2016 M_S6. 4 Menyuan earthquake,the GPS continuous stations of the period from 2010 to 2016 were selected according to the observation data of the tectonic environment monitoring network in Chinese Mainland. The deformation characteristics of the crust before the earthquake were discussed through inter-station baseline time series analysis and the strain time series analysis in the epicentral region. The results show that a trend turn of the baseline movement state around the epicenter region occurred after 2014,and the movement after 2014 reflects an obvious decreasing trend of compressional deformation.During this period,the stress field energy was in a certain accumulation state. Since the beginning of 2014,the EW-component linear strain and surface strain rate weakened gradually before the earthquake. It shows that there was an obvious deformation deficit at the epicentral area in the past two years,which indicates that the region accumulated a high degree of strain energy before the earthquake. Therefore,there was a significant background change in the area before the earthquake. The results of the study can provide basic research data for understanding the seismogenic process and mechanism of this earthquake. | Ma Haiping Feng Jiangang Guo Peng Shi Xuelu | 2017 | Earthquake Research in China2017，31，2： | 2 |
| 6 | Application of Monte-Carlo statistical experiments in design of ocean engineering - Estimating the parameters, models and probabilities显示文摘Recently, some results have been acquired with the Monte- Carlo statistical experiments in the design of ocean en gineering. The results show that Monte-Carlo statistical experiments can be widely used in estimating the parameters of wave statistical distributions, checking the probability model of the long- term wave extreme value distribution under a typhoon condition and calculating the failure probability of the ocean platforms. | Liu Defu, Shi Jiangang and Zhou Zhigang Department of Ocean Engineering and Naval Architecture, Tianjin University. Tianjin, China Business & Project Division China Offshore Industrial Corporation (COIC).No. 10 Beixiaojie,Yuetan,BeijingsChina | 1990 | Acta Oceanologica Sinica1990，9，4： | 2 |
| 7 | Clinical classification of canda equina syndrome for proper treatment:A retrospective analysis of 39 patients显示文摘 | Jiangang Shi Lanshun Jia Wen Yuan | 2010 | Acta Orthopaedica2010，81，3： | 1 |
| 8 | Syringomyelia after operation:diagnosis and its formational mechanism显示文摘描述 MRI 调查结果并且在脊骨以后在病人讨论 syringomyelia 的致病形成机制的目的外科的操作。完全, 13 个病人在学习被注册的方法。在手术前,任何一个都没与针的绳索 syringomyelia 我们的病人介绍。吝啬的后续持续时间由 MRI 是 6 年(范围 210 月) 。在针的绳索肿瘤以后的 13 个病人中的四个移开操作,在针的损伤操作以后的 3 个病人, 2 个盒子以前有脊柱侧凸, 2 个盒子是颈的 spondylotic myelopathy, 2 个盒子以前拴住绳索症候群操作。操作前的先生特征并且在所有病人上操作以后与外科的结果和临床的症状在对比被学习。辐射学诊断被 3 个不同放射线学者分别地做。长度,宽度,信号,洞的形状以及 subarachnoid 形状的特征上被集中。结果所有病人以前没在 MRI 上有 syringomyelia 手术。7 个病人的针的绳索出现了坚持压缩和 2 个病人以前拴住绳索操作。在在我们的情况中的操作以后的 syringomyelia 的 MRI 特征证明有鸣管液体的纵的洞有脑髓的液体(CSF ) 的 T1 和 T2 关系特征。吝啬的长度是 5.5 针的片断, 13 个病人的 4 绳索介绍了从前面的材料压缩的绳索, 4 发生了对腰部的针的运河和 1 格的针的绳索的背的手术后的粘附依附颈的针的运河的前面墙。在在针的外科的干预以后的病人的 syringomyelia 的机制可以是在操作前的时期的针的绳索的坚持的压缩或意愿的结论或操作以后。浮肿,包囊,针的绳索的 malacia 是最重要的损害,风险因素导致 syringomyelia。 | Shi Jiangang Jia Lianshun Yuan Wen Shi Guodong Wu Jianfeng Ye XiaoJian Ni Bin Xiao Jianru Tan Junming Xu Guohua | 2008 | Journal of Medical Colleges of PLA(China)2008，23，2： | 1 |
| 9 | LC–MS/MS determination of naringin, hesperidin and neohesperidin in rat serum after orally administrating the decoction of Bulpleurum falcatum L. and Fractus aurantii显示文摘 | Xiuling Li Hongbin Xiao Xinmiao Liang Dazhuo Shi Jiangang Liu | 2003 | Journal of Pharmaceutical and Biomedical Analysis2003，，1： | 1 |
| 10 | Empirical Study on the Incentive Model of Knowledge Sharing Within Project - oriented Organization Based on Knowledge Potential Theory 显示文摘 | SHI JIANGANG L/N LINNA | 2014 | Journal of applied sci- ences2014，14，3： | 1 |
| 11 | Reductase activity of human thioredoxin-like protein and its effects on cell apoptosis显示文摘Thioredoxin is a ubiquitous dithiol oxidoreductase found in many organisms and involved in numerous biochemical processes. Human thioredoxin-like protein (hTRXL) is differentially expressed at different development stages of human fetal cerebrum and belongs to an expanding family of thioredoxins. Recombinant hTRXL and truncated hTRXLs corresponding to the N-terminal (hTRXL-N) and C-terminal (hTRXL-C) domains are expressed and purified. In insulin disulfide reduction assay, both full-length hTRXL and hTRXL-N show reducing activity for the insulin disulfide bonds. As expected, the hTRXL-C failed to reduce insulin. MCF-7 cell stably transfected with hTRXL cDNA exhibits increased sensitivity to apoptosis induced by phorbol myristic acetate (PMA) and ionomysin. | JIN Jian, ZHOU Yan, HU Xiaoyan, SHI Ning, HAN Chunyu, XU Caimin, QIANG Boqin,YUAN Jiangang and PENG Xiaozhong(National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College & Chinese Academy of Medical Sciences, National Human Genome Center, Beijing 100005, China) | 2002 | Progress in Natural Science:Materials International2002，12，9： | 0 |
| 12 | Utilization of 3D printing technology in hepatopancreatobiliary surgery显示文摘The technology of three-dimensional(3D)printing emerged in the late 1970s and has since undergone considerable development to find numerous applications in mechanical engineering,industrial design,and biomedicine.In biomedical science,several studies have initially found that 3D printing technology can play an important role in the treatment of diseases in hepatopancreatobiliary surgery.For example,3D printing technology has been applied to create detailed anatomical models of disease organs for preoperative personalized surgical strategies,surgical simulation,intraoperative navigation,medical training,and patient education.Moreover,cancer models have been created using 3D printing technology for the research and selection of chemotherapy drugs.With the aim to clarify the development and application of 3D printing technology in hepatopancreatobiliary surgery,we introduce seven common types of 3D printing technology and review the status of research and application of 3D printing technology in the field of hepatopancreatobiliary surgery. | Wujiang SHI Jiangang WANG Jianjun GAO Xinlei ZOU Qingfu DONG Ziyue HUANG Jialin SHENG Canghai GUAN Yi XU Yunfu CUI Xiangyu ZHONG | 2024 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2024，25，2： | 0 |
| 13 | Author Correction:Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle显示文摘The author affiliations were mixed up in the previous published version.In addition,the author contribution section missed a statement of The idea was conceived by J.K.L.,W.W.and This correction does not affect the description of the results or the conclusion of this work.We apologize for any inconvenience this may have caused. | Jing Liuc Yunhua Peng Le Shi Lixin Wanc Hiroyuki Inuzuka Jiangang Long Jianping Guo Jinfang Zhang Min Yuan Shuangxi Zhang Xun Wangc Jing Gao Xiangpeng Dai Shozo Furumoto Lijun Jia Pier Paolo Pandolfi John M.Asara William G.Kaelin Jr. Jiankang Liu Wenyi Wei | 2021 | Cell Research2021，31，1： | 0 |
| 14 | Influence of inherent iron and oxygen concentrations on selenite sorption process using bentonite显示文摘The oxygen concentration and inherent Fe in bentonite have a significant influence on the Se(IV) sorption process.In this study,the sorption of selenite on natural bentonite was investigated using a batch experiment method,and the distribution coefficient(K_d)values were obtained in the pH range from 2.0 to 10.0 under oxic/anoxic conditions.The K_d values always reached a maximum value at a pH of 4 under oxic conditions and at a pH of 8 under anoxic conditions;meanwhile,the K_d value under anoxic conditions was larger than the value under oxic conditions,especially in regard to the maximum K_d values.The oxygen conditions have a significant influence on the ratio of redox-sensitive Fe^(2+)/Fe^(3+),which was closely related to the difference in the K_d values under both oxic/anoxic conditions.Ferric selenite and green rust could be responsible for the maximum K_d values under oxic/anoxic conditions.In the leaching experiments,we found that the Fe^(2+) in bentonite could replace Mg^(2+) and Al^(3+) in the octahedral sheet.Spectroscopy methods,such as Fourier transform infrared spectroscopy(FTIR),X-ray diffraction(XRD) and X-ray absorption spectroscopy(XAS) were used to characterize the surface properties of the samples after reaction.Overall,this study shows that the addition of Fe^(2+)-containing materials into backfill/buffer materials under anoxic condition could enhance the sorption of ^(79)Se(IV). | Jiangang He Xueling Qiao Yanlin Shi Yao Li Xiaoyu Yang Wanqiang Zhou Chunli Liu | 2017 | Science China Chemistry2017，60，9： | 0 |
| 15 | Stability of selenium and its speciation analysis in water using automatic system separation and HR-ICP-MS measurement显示文摘A simple and convenient method has been developed for the pre-concentration and separation of inorganic selenium species from environmental water samples using anion exchange chromatographic column combined with high resolution inductively coupled plasma mass spectrometry(HR-ICP-MS)measurement.^(75)Se(Ⅳ) and ^(75)Se(Ⅵ)were prepared and used as tracers during the experiments.The volatility of selenium during solution evaporation was investigated to establish a reliable water samples pretreatment procedure.The parameters which affect the uptake of Se(Ⅳ)and Se(Ⅵ)on Dowex1×8 resin was optimized and the procedure for Se(Ⅳ)and Se(Ⅵ)separation was proposed.Both Se(Ⅳ)and Se(Ⅵ)are retained on the column in natural or alkaline solution with high distribution coefficient.The successive gradient elution of pre-concentrated species of selenium with HNO_(3)solution allows to differentiate between them.Se(Ⅳ)and Se(Ⅵ)finally were eluted with 0.05 mol/L HNO_(3) and 5.0 mol/L HNO_(3),respectively.The proposed method has been successfully verified using the certified reference materials(CRMs)of real water samples,and spiked recoveries for real samples were 98%-104%with 5%relative standard deviations(RSDs).The developed procedure is proved to be reliable and can be used for the rapid determination of selenium species in environmental water samples. | Junqiang Yang Yawen Chen Keliang Shi Kesheng Hu Run Li Xiaoqing Gao Qian Wang Weibo Zhang Yun Zhou Yanyun Wang Jiangang He Tonghuan Liu Xiaolin Hou | 2022 | Chinese Chemical Letters2022，33，7： | 0 |
| 16 | Tannic acid coated single-wall carbon nanotube membranes for the recovery of Au from trace-level solutions显示文摘The efficient recovery of gold from industrial sewage is important for saving precious metals and remains a big challenge.We report the extraction of gold ions from a trace-level aqueous solution using a tannic acid(TA)coated single-wall carbon nanotube(SWCNT)film.The TA has many redox ligands that efficiently adsorb Au(III)from the solution and reduce them to Au particles.The interwoven SWCNTs not only act as a framework to improve the mechanical stability of the hybrid membrane,but also provide abundant paths for H_(2)O transport,and facilitate the full exposure of the TA.As a result,the hybrid membrane has an excellent ability to capture gold ions from solution with a high flux of 157 L/(m^(2)·h·bar),and an ultra-high adsorption capacity of 2095 mg/g from solutions with an extremely low gold concentration of 20 ppm.The adsorbed gold ions are reduced to Au particles,which can be easily collected by oxidation.The recovered Au nanoparticles on the TA–SWCNT hybrid film had a remarkable surface-enhanced Raman scattering effect that enabled the sensitive detection of rhodamine 6G. | Chunmei Wang Peng-Xiang Hou Yiming Zhao Chao Shi Jiangang Zhang An-Ping Wu Chang Liu Hui-Ming Cheng | 2023 | Nano Research2023，16，8： | 0 |
| 17 | Erratum to: Tannic acid coated single-wall carbon nanotube membranes for the recovery of Au from trace-level solutions显示文摘Erratum to Nano Research,2023,16(8):11350–11357 http://gffzzd3cc09b8251d45dfsx60popf9w50c69f6.ffgz.tsg.suse.edu.cn/10.1007/s12274-023-5803-y The article'Tannic acid coated single-wall carbon nanotube membranes for the recovery of Au from trace-level solutions',written by Chunmei Wang et al.,was erroneously originally published electronically on the publisher’s internet portal(currently SpringerLink)on 27 June 2023 with Fig.3(a).In Fig.3(a),the rejection of MWCNT is 38.9%instead of 98.3%. | Chunmei Wang Peng-Xiang Hou Yiming Zhao Chao Shi Jiangang Zhang An-Ping Wu Chang Liu Hui-Ming Cheng | 2024 | Nano Research2024，17，4： | 0 |
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