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| 1 | Radical induced quartet photosensitizers with high ^(1)O_(2) production for in vivo cancer photodynamic therapy显示文摘Singlet oxygen(^(1)O_(2)) is a strong oxidant which plays important roles in photodynamic therapy(PDT). The exploitation of photosensitizers with high ^(1)O_(2) production is crucial to improve PDT efficiency. In this study, a radical labeled quartet photosensitizer Cy-DENT is reported with high singlet oxygen quantum yield(Φ_(Δ)=32.3%) due to a radical enhanced inter-system crossing(ISC) process. After the introduction of 2,2,6,6-tetramethylpiperidinyloxy(TEMPO) radical, quartet state ^(4)[R,T] of CyDENT could be formed to give an over 20-fold enhancement of singlet oxygen quantum yield compared to Cy-DEN(without TEMPO radical) under irradiation of near infrared(NIR) light. In addition, the ^(1)O_(2 )production is well controlled by varying the electron-donating ability of the terminal substituent group. Cy-DENT possesses good cell permeability and is localized in mitochondria. Under the irradiation of 700 nm light, Cy-DENT can produce high levels of ROS to destroy the mitochondria membrane potential and induce cell apoptosis. Through the encapsulation of PEG-SS-PCL micelle, Cy-DENT can be effectively delivered to tumors and suppresses the tumor growth after PDT treatment. | Feng Xu Haoying Ge Ning Xu Cheng Yang Qichao Yao Saran Long Wen Sun Jiangli Fan Xinsheng Xu Xiaojun Peng | 2021 | Science China Chemistry2021，64，3： | 2 |
| 2 | Does airway pressure release ventilation offer new hope for treating acute respiratory distress syndrome?显示文摘Mechanical ventilation(MV)is an essential life support method for patients with acute respiratory distress syn-drome(ARDS),which is one of the most common critical illnesses with high mortality in the intensive care unit(ICU).A lung-protective ventilation strategy based on low tidal volume(LTV)has been recommended since a few years;however,as this did not result in a significant decrease of ARDS-related mortality,a more optimal venti-lation mode was required.Airway pressure release ventilation(APRV)is an old method defined as a continuous positive airway pressure(CPAP)with a brief intermittent release phase based on the open lung concept;it also perfectly fits the ARDS treatment principle.Despite this,APRV has not been widely used in the past,rather only as a rescue measure for ARDS patients who are difficult to oxygenate.Over recent years,with an increased under-standing of the pathophysiology of ARDS,APRV has been reproposed to improve patient prognosis.Nevertheless,this mode is still not routinely used in ARDS patients given its vague definition and complexity.Consequently,in this paper,we summarize the studies that used APRV in ARDS,including adults,children,and animals,to illustrate the settings of parameters,effectiveness in the population,safety(especially in children),incidence,and mechanism of ventilator-induced lung injury(VILI)and effects on extrapulmonary organs.Finally,we found that APRV is likely associated with improvement in ARDS outcomes,and does not increase injury to the lungs and other organs,thereby indicating that personalized APRV settings may be the new hope for ARDS treatment. | Jiangli Cheng Aijia Ma Meiling Dong Yongfang Zhou Bo Wang Yang Xue Peng Wang Jing Yang Yan Kang | 2022 | Journal of Intensive Medicine2022，2，4： | 0 |
| 3 | Clinical efficacy and safety of linezolid in intensive care unit patients显示文摘Background:To characterize the population of critically ill patients and infections treated with linezolid in the intensive care unit(ICU),and to evaluate the clinical efficacy and safety of linezolid therapy.Methods::This multi-center,observational,real-world study was conducted across 52 hospitals between June 9,2018,and December 28,2019.Patients who met the following inclusion criteria were included:(1)admitted to the ICU,(2)of any age group,and(3)having a clinical or laboratory diagnosis of a Gram-positive bacterial infection.Clinical efficacy was categorized as success(cured or improved),failed,or non-evaluable.Adverse events and serious adverse events were recorded during treatment.Results::A total of 366 ICU patients who met the inclusion criteria were evaluated.Linezolid was used as second-and first-line treatment in 232(63.4%)and 134(36.6%)patients,respectively.The most common isolated strain was Staphylococcus aureus(methicillin-resistant Staphylococcus aureus:n=37/119,31.1%;methicillin-susceptible Staphylococcus aureus:n=15/119,12.6%);this was followed by Enterococci(vancomycin-resistant Enterococci:n=8/119,6.7%;vancomycin-susceptible Enterococci:n=11/119,9.2%)and Streptococcus pneumoniae(multidrug-resistant:n=4/119,3.4%;non-multidrug resistant:n=2/119,1.7%).The main infection sites where pathogens were detected included the lung(n=216/366,59.6%),skin and soft tissue(n=104/366,28.4%),and blood(n=50/366,13.7%).Clinical success was achieved in 301(82.2%)patients;34(9.3%)were cured and 267(73.0%)improved;treatment failure and non-evaluable outcomes were observed in 29(7.9%)in 36(9.8%)patients,respectively.Linezolid-related adverse events were reported in 8(2.2%)patients.No treatment-related serious adverse events were reported.Conclusions::Based on real-world results,linezolid was found to be effective and safe in the treatment of Gram-positive bacterial infections in critically ill patients. | Aijia Ma Meiling Dong Jiangli Cheng Xuelian Liao Wei Dong Chang Liu Chenggong Hu Jing Yang Yan Kang | 2023 | Journal of Intensive Medicine2023，3，1： | 0 |
| 4 | Modified Subgradient Extragradient Method for Variational Inequality Problems and Fixed Point Problems显示文摘Many approaches inquiring into variational inequality problems have been put forward,among which subgradient extragradient method is of great significance.A novel algorithm is presented in this article for resolving quasi-nonexpansive fixed point problem and pseudomonotone variational inequality problem in a real Hilbert interspace.In order to decrease the execution time and quicken the velocity of convergence,the proposed algorithm adopts an inertial technology.Moreover,the algorithm is by virtue of a non-monotonic step size rule to acquire strong convergence theorem without estimating the value of Lipschitz constant.Finally,numerical results on some problems authenticate that the algorithm has preferable efficiency than other algorithms. | Xiaoyin Li Hongwei Liu Jiangli Cheng Dongyao Zhang | 2022 | Journal of Harbin Institute of Technology(New Series)2022，29，5： | 0 |
| 5 | A general synthesis strategy for the multifunctional 3D polypyrrole foam of thin 2D nanosheets显示文摘 | Jiangli XUE Maosong MO Zhuming LIU Dapeng YE Zhihua CHENG Tong XU Liangti QU | 2018 | Frontiers of Materials Science2018，12，2： | 0 |
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