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| 1 | 14-3-3 Binding to Cyclin Y contributes to cyclin Y/CDK14 association显示文摘Cyclin Y 是在 eumetazoans 之中的高度保存的 cyclin,然而,它的功能和规定糟糕被理解。到 searchfor Cyclin 交往 Y 蛋白质,我们屏蔽了酵母把人的 Cyclin Y (CCNY ) 用作一个诱饵和 identifiedthe 追随者 interactors 的二混血儿的图书馆:CDK14 和 14-3-3 家庭的四个成员(,,,) 。在 CCNY 和 14-3-3proteins 之间的相互作用在 vitro 并且在 vivo 被证实。结果证明在 CCNY 的 Ser-100 和 Ser-326 残余为 14-3-3 绑定是关键的。有趣地,到 14-3-3 的有约束力的 ofCCNY 显著地提高了在 CCNY 和 CDK14 之间的协会。我们的调查结果可以增加对它的 kinase 搭挡有约束力的 regulationof CCNY 的新层。 | Shan Li Mei Jiang Wenjuan Wang Jiangye Chen | 2014 | Acta Biochimica et Biophysica Sinica2014，46，4： | 3 |
| 2 | 紊乱的肺部菌群通过分泌外膜囊泡调控白介素-17B的产生促进肺纤维化显示文摘文章简介粘膜微生态一直是当前免疫学领域的研究热点,它已经被证明广泛参与多种粘膜组织免疫稳态的维持以及相关疾病的发生。该团队多年来围绕粘膜微生态与白介素-17家族细胞因子做了一系列研究工作,一方面肠癌发生过程中紊乱的微生态菌群可以通过调控IL-17C的产生促进肠癌的发生,另一方面肠道中微生态菌群也可以通过调控IL-17A的分泌促进肠道损伤修复。尽管如此,目前我们对肺组织中微生态的功能尚知之甚少。 | 杨大平 Xi Chen Jingjing Wang Qi Lou Yunwei Lou Li Li Honglin Wang Jiangye Chen Meng Wu Xinyang Song 钱友存 | 2020 | 科学新闻2020，，2： | 3 |
| 3 | A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins显示文摘hPFTAIRE1 (PFTK1 ) , Cdc2 相关的蛋白质 kinase,高度在人的大脑被表示。它在 Hela 房间展出细胞质的分发,尽管它在它的 N 终点包含二个原子本地化信号(NLS ) 。到为它的底层和规章的部件的搜索,我们由把全身的 hPFTAIRE1 用作一个诱饵屏蔽了一个二混血儿的图书馆。四 14-3-3 isoforms (贝它, epsilon,希腊语字母的第七字,字形物) 被识别与 hPFTAIRE1 交往。我们在 hPFTAIRE1 发现了一个通常认为的 14-3-3 绑定一致主题(RHSSPSS ) ,它与它的第二 NLS 重叠了。RHSSPSS 主题的删除或有在保存有约束力的主题的翼的 Ser119 的替换废除了在 hPFTAIRE1 和 14-3-3 蛋白质之间的特定的相互作用。变异的 S120A hPFTAIRE1 也显示出一个弱相互作用到 14-3-3 蛋白质。结果建议 Ser119 为在 hPFTAIRE1 和 14-3-3 蛋白质之间的相互作用是关键的。当熔化了到绿荧光灯的蛋白质( GFP )的C终点时,所有 hPFTAIRE1 异种在 Hela 房间和人的 neuroblastoma 房间( SH-SY5Y )的细胞质散布了,显示有 14-3-3 蛋白质的那绑定不贡献潜水艇 hPFTAIRE1 的细胞的本地化,尽管绑定可以涉及它的发信号的规定。 | Yankun Gao Mei Jiang Tao Yang Jian Ni Jiangye Chen | 2006 | Cell Research2006，16，6： | 3 |
| 4 | Rim101-upregulated Fets contribute to dark pigment formation in gray cells of Candida albicans显示文摘Candida albicans has long been known to switch between white and opaque phases;however,a third cell type,referred to as the‘gray’phenotype,was recently characterized.The three phenotypes have different colonial morphologies,with white cells forming white-colored colonies and opaque and gray cells forming dark-colored colonies.We previously showed that Wor1-upregulated ferroxidases(Fets)function as pigment multicopper oxidases that regulate the production of dark-pigmented melanin in opaque cells.In this study,we demonstrated that Fets also contributed to dark pigment formation in gray colonies but in a Wor1-independent manner.Deletion of both WOR1 and EFG1 locked cells in the gray phenotype in some rich media.However,the efg1/efg1 wor1/wor1 mutant could switch between white&gray in minimal media depending on the ambient pH.Specifically,mutant cells exhibited the white phenotype at pH 4.5 but switched to gray at pH 7.5.Consistent with phenotype switching,Fets expressions&melanin production were also regulated by ambient pH.Ectopic expression of the Rim101-405 allele in the mutant enabled the pH restriction to be bypassed&promoted gray cell formation in acidic media.Our data suggest that Rim101-upregulated Fets contribute to dark pigment formation in the gray cells. | Baodi Dai Yinxing Xu Hongyu Wu Jiangye Chen | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 1 |
| 5 | Efficient design ofcontinuously adjustable reactors for distributionnetworks显示文摘 | Liu H P JiangY Ye Y L | 2005 | Electric Power Component and System2005，，33： | 1 |
| 6 | Determination on the contents of chlorogenic acid in Chrysanthemum indicum L from different commercial regions 显示文摘 | FUL PANCX JIANGY etal | 2010 | 中国实验方剂学杂志2010，16，5： | 1 |
| 7 | A modified particle swarm optimizer with dynamic adaptation 显示文摘 | Yang Xueming Yuan Jinsha Yuan Jiangye | 2007 | Applied Mathematics and Computation2007，189，： | 1 |
| 8 | Liquid desiccant air conditioning system and its applications显示文摘 | JIANGY LI Z CHEN XL LIU XH | 2004 | Heat Ventil Air Condition2004，34，： | 1 |
| 9 | Thecomprehensiveeffectsofhy-perlipidemiaandhyperhomocysteinemiaonpathogenesisofathero-sclerosisandDNAhypomethylationinApoE-/- mice显示文摘 | JiangY ZhangH SunT etal | 2012 | ActaBiochimBiophysSin2012，44，10： | 1 |
| 10 | IdentificationofKPC-2-producingPseudomonasaeruginosaisolatesinChina显示文摘 | GeC WeiZ JiangY etal | 2011 | JAntimicrobChemother2011，66，5： | 1 |
| 11 | A modified particle swarm optimizer with dynamic adaptation显示文摘 | Xueming Yang Jinsha Yuan Jiangye Yuan Huina Mao | 2006 | Applied Mathematics and Computation2006，，2： | 1 |
| 12 | Chinese medicine enterprise development strategy research[J]显示文摘 | JIANGY | 2011 | 中国高新技术企业2011，，9： | 1 |
| 13 | Vaspin attenuates the apoptosis of human osteoblasts through ERK signaling pathway显示文摘 | ZhuX JiangY ShanPF | 2013 | Amino Acids2013，44，3： | 1 |
| 14 | Antiviralactivityofrecombinantmouseβ-defensin3againstinfluenzaAvirusin vitro and in vivo显示文摘 | JiangY YangD LiW etal | 2012 | AntivirChemChemother2012，22，6： | 1 |
| 15 | Ananalysisonthediagnosticvaluesof transcranialDopplerandangiographyintransientischemicattack显示文摘 | JiangY HuJ GaoQ | | 0，，02： | 1 |
| 16 | Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis显示文摘 | XuJ JiangY WangJ | 2014 | Cell Death Differ2014，21，8： | 1 |
| 17 | A modified particle swarm optimizer with dynamic adaptation显示文摘 | Yang Xueming Yuan Jinsha Yuan Jiangye | 2007 | Applied Mathematics and Computation2007，189，： | 1 |
| 18 | Stable-isotope probing of bacterial community for dissolved inorganic carbon utilization in Microcystis aeruginosa-dominated eutrophic water显示文摘Dissolved inorganic carbon(DIC) is an important source of carbon in aquatic ecosystems,especially under conditions of increased frequency of cyanobacterial bloom. However, the importance of bacteria in direct or indirect utilization of DIC has been widely overlooked in eutrophic freshwater. To identify the functional bacteria that can actively utilize DIC in eutrophic freshwater during cyanobacterial bloom, stable-isotope probing(SIP) experiments were conducted on eutrophic river water with or without inoculation with cyanobacteria(Microcystis aeruginosa). Our 16 S rRNA sequencing results revealed the significance of Betaproteobacteria, with similar relative abundance as Alphaproteobacteria, in the active assimilation of H^(13)CO^(3-) into their DNA directly or indirectly, which include autotrophic genera Betaproteobacterial ammonia-oxidizing bacteria. Other bacterial groups containing autotrophic members, e.g. Planctomycetes and Nitrospira, also presented higher abundance among free-living bacteria in water without cyanobacteria. Microcystis aggregates showed a preference for some specific bacterial members that may utilize H^(13)CO^(3-) metabolized by Microcystis as organic matter, e.g. Bacteroidetes(Cytophagales, Sphingobacteriales), and microcystindegrading bacteria Betaproteobacteria(Paucibacter/Burkholderiaceae). This study provides some valuable information regarding the functional bacteria that can actively utilize DIC in eutrophic freshwater. | Weiguo Zhang Jiangye Li Chengcheng Wang Xue Zhou Yan Gao Zhongjun Jia | 2019 | Journal of Environmental Sciences2019，31，5： | 1 |
| 19 | Facileaerosolsynthesisandcharacterizationofternarycrumpledgra-phene-TiO2-magnetitenanocompositesforadvancedwa-tertreatment 显示文摘 | JiangY Wang W N BiswasP etal | 2014 | ACS Applied Materials & Inter-faces2014，6，11： | 1 |
| 20 | GeneraltranscriptionfactorIIA-gammaincreasesosteoblast-specificosteocalcingeneexpressionviaactivatingtranscriptionfactor4andrunt-relatedtranscriptionfactor2显示文摘 | YuS JiangY GalsonDL etal | 2008 | JBiolChem2008，283，9： | 1 |
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