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| 1 | Ultrafast epitaxial growth of metre-sized single-crystal graphene on industrial Cu foil显示文摘A foundation of the modern technology that uses single-crystal silicon has been the growth of highquality single-crystal Si ingots with diameters up to 12 inches or larger. For many applications of graphene, large-area high-quality(ideally of single-crystal) material will be enabling. Since the first growth on copper foil a decade ago, inch-sized single-crystal graphene has been achieved. We present here the growth, in 20 min, of a graphene film of(5 ×50) cm^2 dimension with >99% ultra-highly oriented grains.This growth was achieved by:(1) synthesis of metre-sized single-crystal Cu(1 1 1) foil as substrate;(2)epitaxial growth of graphene islands on the Cu(1 1 1) surface;(3) seamless merging of such graphene islands into a graphene film with high single crystallinity and(4) the ultrafast growth of graphene film.These achievements were realized by a temperature-gradient-driven annealing technique to produce single-crystal Cu(1 1 1) from industrial polycrystalline Cu foil and the marvellous effects of a continuous oxygen supply from an adjacent oxide. The as-synthesized graphene film, with very few misoriented grains(if any), has a mobility up to ~23,000 cm^2 V^(-1)s^(-1)at 4 K and room temperature sheet resistance of ~230 Ω/□. It is very likely that this approach can be scaled up to achieve exceptionally large and high-quality graphene films with single crystallinity, and thus realize various industrial-level applications at a low cost. | Xiaozhi Xu Zhihong Zhang Jichen Dong Ding Yi Jingjing Niu Muhong Wu Li Lin Rongkang Yin Mingqiang Li Jingyuan Zhou Shaoxin Wang Junliang Sun Xiaojie Duan Peng Gao Ying Jiang Xiaosong Wu Hailin Peng Rodney S. Ruoff Zhongfan Liu Dapeng Yu Enge Wang Feng Ding Kaihui Liu | 2017 | Science Bulletin2017，62，15： | 40 |
| 2 | Identification of a Stable Quantitative Trait Locus for Percentage Grains with White Chalkiness in Rice (Oryza sativa)显示文摘High chalkiness is a major problem in many rice-producing areas of the world, especially in hybrid rice (Oryza sativa L.) in China. We previously showed a major quantitative trait locus for the percentage of grains with white chalkiness (QTLqPGWC-8) in the interval G1149-R727 on chromosome 8 using a chromosome segment substitution line (CSSL). Here, we selected the line-CSSL50 harboring the QTLqPGWC-8 allele from the CSSLs derived from a cross between Asominori (as a recurrent parent) and IR24 (as a donor parent), which had higher percentage chalkiness, markedly different from that of Asominori. There were also significant differences in starch granules, appearance of amylose content (AAC) and milling qualities between Asominori and CSSL50, but not in grain size or thousand grain weight (TGW). The BC4F2 and BC4F3 populations from a cross between CSSL50 and Asominori were used for fine mapping of qPGWC-8. We narrowed down the location of this QTL to a 142 kb region between Indel markers 8G-7 and 8G-9. QTLqPGWC-8 accounted for 50.9% of the difference in PGWC between the parents. The markers tightly linked to qPGWC-8 should facilitate cloning of the gene underlying this QTL and will be of value for marker-assisted selection in breeding rice varieties with better grain quality. | Tao Guo Xiaolu Liu Xiangyuan Wan Jianfeng Weng Shijia Liu Xi Liu Mingjiang Chen Jingjing Li Ning Su Fuqing Wu Zhijun Cheng Xiuping Guo Cailin Lei Jiulin Wang Ling jiang Jianmin Wan | 2011 | Journal of Integrative Plant Biology2011，53，8： | 25 |
| 3 | The Hardy Rubber Tree Genome Provides Insights into the Evolution of Polyisoprene Biosynthesis显示文摘Eucommia ulmoides,也叫的强壮的橡胶树,是一棵经济地重要的树;然而,它的染色体顺序的缺乏 ?限制基本生物研究和这植物种的应用研究。这里,我们在场它的 1.2-Gb 染色体的一个高质量的集会(支架 N50 ?=? 1.88 Mb ) 与至少 26 ? 为 E 的 723 预言的基因。ulmoides,顺序 Garryales 的首先定序的染色体,它用联合定序的 Illumina 的综合策略被获得,定序的 PacBio,和印射的 BioNano。作为到 lamiids 和 campanulids 的姐妹 taxon, E。ulmoides 经历了三倍由核心 eudicots 而是没有进一步整个染色体的复制分享了的一个古老的染色体 ? 在最后 1.25 亿年里。E。ulmoides 为涉及压力回答和第二等的代谢物的生合成的多重基因展出高表达式层次或基因数字扩大,它可以说明它的可观的环境适应性。与橡胶树(Hevea brasiliensis ) 相对照,它生产 cis 聚异式戊二我烯, E。ulmoides 演变综合经由 farnesyl diphosphate synthases (FPS ) 的长链的 trans 聚异式戊二我烯。而且, FPS 和橡胶延伸 factor/small 橡胶粒子蛋白质基因家庭从 H 独立地被扩展。brasiliensis 系。这些结果提供新卓见进 E. 的生物学 ? ulmoides 和聚异式戊二我烯生合成的起源。 | Ta-na Wuyun Lin Wang Huimin Liu Xuewen Wang Liangsheng Zhang Jeffrey L. Bennetzen Tiezhu Li Lirong Yang Panfeng Liu Lanying Du Lu Wang Mengzhen Huang Jun Qing Iili Zhu Wenquan Bao Hongguo Li Qingxin Du Jingle Zhu Hong Yang Shuguang Yang Hui Liu Hui Yue Jiang Hu Suoliang Yu Yu Tian Fan Liang Jingjing Hu Depeng Wang Ruiwen Gao Dejun Li Hongyan Du | 2018 | Molecular Plant2018，11，3： | 24 |
| 4 | Size distribution of chemical elements and their source apportionment in ambient coarse, fine, and ultrafine particles in Shanghai urban summer atmosphere显示文摘Ambient coarse particles (diameter 1.8-10 μm), fine particles (diameter 0.1-1.8 μm), and ultrafine particles (diameter < 0.1 μm) in the atmosphere of the city of Shanghai were sampled during the summer of 2008 (from Aug 27 to Sep 08). Microscopic characterization of the particles was investigated by scanning electron microscopy coupled with energy dispersive X-ray spectroscopy (SEM/EDX). Mass concentrations of Si, P, S, Cl, K, Ca, Ti, V, Cr, Mn, Fe, Ni, Cu, Zn, As, Se, Br, Rb, Sr, and Pb in the size-resolved particles were quantified by using synchrotron radiation X-ray fluorescence (SRXRF). Source apportionment of the chemical elements was analyzed by means of an enrichment factor method. Our results showed that the average mass concentrations of coarse particles, fine particles and ultrafine particles in the summer air were 9.38 ± 2.18, 8.82 ± 3.52, and 2.02 ± 0.41 μg/m3, respectively. The mass percentage of the fine particles accounted for 51.47% in the total mass of PM10, indicating that fine particles are the major component in the Shanghai ambient particles. SEM/EDX results showed that the coarse particles were dominated by minerals, fine particles by soot aggregates and fly ashes, and ultrafine particles by soot particles and unidentified particles. SRXRF results demonstrated that crustal elements were mainly distributed in the coarse particles, while heavy metals were in higher proportions in the fine particles. Source apportionment revealed that Si, K, Ca, Fe, Mn, Rb, and Sr were from crustal sources, and S, Cl, Cu, Zn, As, Se, Br, and Pb from anthropogenic sources. Levels of P, V, Cr, and Ni in particles might be contributed from multi-sources, and need further investigation. | Senlin Lu Rui Zhang Zhenkun Yao Fei Yi Jingjing Ren Minghong Wu Man Feng Qingyue Wang | 2012 | Journal of Environmental Sciences2012，24，5： | 22 |
| 5 | Abscisic Acid Signaling Inhibits Bmssinosteroid Signaling through Dampening the Dephosphorylation of BIN2 by ABI1 and ABI2显示文摘 | Haijiao Wang Jie Tang Jing Liu Jin Hu Jingjing Liu Yuxiao Chen Zhenying Cai Xuelu Wang | 2018 | Molecular Plant2018，11，2： | 17 |
| 6 | Effect of activation agents on the surface chemical properties and desulphurization performance of activated carbon显示文摘Flue gas pollution is a serious environmental problem that needs to be solved for the sustainable development of China.The surface chemical properties of carbon have great influence on its desulphurization performance.A series of activated carbons (ACs) were prepared using HNO3,H2O2,NH3·H2O and steam as activation agents with the aim to introduce functional groups to carbon surface in the ACs preparation process.The ACs were physically and chemically characterized by iodine and SO2 adsorption,ultimate analysis,Boehm titration,and temperature-programmed reduction (TPR).Results showed that the iodine number and desulphurization capacity of NH3·H2O activated carbon (AC-NH3) increase with both activation time,and its desulphurization capacity also increases with the concentration of activation agent.However,HNO3 activated carbon (AC-HNO3) and H2O2 activated carbon (AC-H2O2) exhibit more complex behavior.Only their iodine numbers increase monotonously with activation time.Compared with steam activated AC (AC-H2O),the nitrogen content increases 0.232% in AC-NH3 and 0.077% in AC-HNO3.The amount of total basic site on AC-HNO3 is 0.19 mmol·g-1 higher than that on AC-H2O.H2O2 activation introduces an additional 0.08 mmol·g-1 carboxyl groups to AC surface than that introduced by steam activation.The desulphurization capacity of ACs in simulate flue gas desulphurization decreases as follows: AC-NH3 > AC-HNO3 > AC-H2O2 > AC-H2O.This sequence is in accord with the SO2 catalytic oxidation/oxidation ratio in the absence of oxygen and the oxidation property reflected by TPR.In the presence of oxygen,all adsorbed SO2 on ACs can be oxidized into SO3.The desulphurization capacity increases differently according to the activation agents;the desulphurization capacity of AC-NH3 and AC-HNO3 improves by 4.8 times,yet AC-H2O increases only by 2.62 as compared with the desulphurization of corresponding ACs in absence of oxygen. | ZHANG XiangLan,ZHANG Yan,WANG ShuangSheng,ZHANG JingJing & ZHOU Wei School of Chemical and Environmental Engineering,China University of Mining and Technology (Beijing),Beijing 100083,China | 2010 | Science China(Technological Sciences)2010，53，9： | 14 |
| 7 | Nutritional assessment with different tools in leukemia patients after hematopoietic stem cell transplantation显示文摘Objective:Correct nutritional assessment is essential for leukemia patients after hematopoietic stem cell transplantation(HSCT).This study aimed to investigate the best nutritional assessment method for leukemia patients after HSCT,and find the possible nutritional risk of the patients during the transplantation process in order to intervene in the patients with nutritional risks and undernourished patients timely,so that the entire transplantation process could be successfully completed.Methods:A prospective study was performed in 108 leukemia patients after HSCT,and different nutritional assessment methods,including nutritional risk screening 2002(NRS2002),mini nutritional assessment(MNA),subjective globe assessment(SGA)and malnutritional universal screening tools(MUST),were used.The associations between nutritional status of these patients and nutritional assessment methods were analyzed.Results:A total of 108 patients completed SGA,and 99 patients completed NRS2002,MNA and MUST.During the treatment process,85.2%of the patients lost weight,wherein,50%lost weight greater than5%,and 42.6%had significantly reduced food intake.For nutritional risk assessment,the positive rates of NRS2002,MNA and MUST were 100%,74.7%and 63.6%,respectively.There was a significant difference(P<0.05)among the positive rates of NRS2002,MNA and MUST.In undernutrition assessment,the positive rate of SGA(83.3%)was significantly higher than that of MNA(17.2%)(P<0.05),and the incidence rate of nutritional risk among leukemia patients≤30 years old was greater than that of patients>30 years old(P<0.05).Conclusions:Patients with leukemia were in poor nutritional status during and after HSCT.The leukemia patients≤30 years old had a greater incidence rate of nutritional risk.As nutritional risk screening tool,the specificity of NRS2002 is not high,but it can be used for evaluating nutritional deficiencies.MNA is a good nutritional risk screening tool,but not an adequate tool for nutritional assessment.If assessment of undernutrition is necessary,the combination of all these screening tools and clinical laboratory indicators should be applied to improve accuracy. | Boshi Wang Xia Yan Jingjing Cai Yu Wang Peng Liu | 2013 | Chinese Journal of Cancer Research2013，25，6： | 14 |
| 8 | Weldability, microstructure and mechanical properties of laser-welded selective laser melted 304 stainless steel joints显示文摘Laser welding is a promising process for joining small components produced by selective laser melting (SLM) to fabricate the large-scale and complex-shaped parts. In the work, the morphology, microstructure, microhardness, tensile properties and corrosion resistance of the laser welded stress-relieved SLMed 304 stainless steel joints are investigated, as the different sections of stress-relieved SLMed 304 stainless steel are joined. Results show that the SLMed 304 stainless steel plates have a good laser weldability. The microstructure of laser-welded joints consists of the cellular dendrites in austenite matrix within columnar grains, exhibiting a coarser dendrite structure, lower microhardness (~220HV) and tensile properties (tensile strength of ~750 MPa, and area reduction of ~27.6%), but superior corrosion resistance to those of SLMed plates. The dendrite arm spacing of the joints varies from ~3.7μm in center zone, to ~5.0 (xm in fusion zone, to ~2.5 in epitaxial zone. The SLMed anisotropy shows a negligible effect on the microstructure and performance of the laser-welded joints. The laser welding along the building directions of the SLMed base plates can induce a slightly finer dendritic structure and higher tensile properties. | Jingjing Yang Yun Wang Fangzhi Li Wenpu Huang Guanyi Jing Zemin Wang Xiaoyan Zeng | 2019 | Journal of Materials Science & Technology2019，35，9： | 14 |
| 9 | Time-domain analysis methodology for large-scale RLC circuits and its applications显示文摘With soaring work frequency and decreasing feature sizes, VLSI circuits with RLC parasitic components are more like analog circuits and should be carefully analyzed in physical design. However, the number of extracted RLC components is typically too large to be analyzed efficiently by using present analog circuit simulators like SPICE. In order to speedup the simulations without error penalty, this paper proposes a novel methodology to compress the time-descritized circuits resulted from numerical integration approximation at every time step. The main contribution of the methodology is the efficient structure-level compression of DC circuits containing many current sources, which is an important complement to present circuit analysis theory. The methodology consists of the following parts: 1) An approach is proposed to delete all intermediate nodes of RL branches. 2) An efficient approach is proposed to compress and back-solve parallel and serial branches so that it is error-free and of linear complexity to analyze circuits of tree topology. 3) The Y toπtransformation method is used to error-free reduce and back-solve the intermediate nodes of ladder circuits with the linear complexity. Thus, the whole simulation method is very accurate and of linear complexity to analyze circuits of chain topology. Based on the methodology, we propose several novel algorithms for efficiently solving RLC-model transient power/ground (P/G) networks. Among them, EQU-ADI algorithm of linear-complexity is proposed to solve RLC P/G networks with mesh-tree or mesh-chain topologies. Experimental results show that the proposed method is at least two orders of magnitude faster than SPICE while it can scale linearly in both time- and memory-complexity to solve very large P/G networks. | LUO Zuying CAI Yici Sheldon X.-D Tan HONG Xianlong WANG Xiaoyi PAN Zhu FU Jingjing | 2006 | Science in China(Series F)2006，49，5： | 13 |
| 10 | Comparison of dynamic adsorption/desorption characteristics of toluene on different porous materials显示文摘Four different types of adsorbents, SBA-15, MCM-41, NaY and SiO2, were used to study the dynamic adsorption/desorption of toluene. To further investigate the influence of pore structure on its adsorption performance, two SBA-15 samples with different microspores were also selected. It is shown that microporous material NaY has the largest adsorption capacity of 0.2873 mL/g, and the amorphous SiO2 exhibits the least capacity of 0.1003 mL/g. MCM-41 also shows a lower break through capacity in spite of the relatively small pore diameter, because it can not provide the necessary small geometric confinement for the tiny adsorbates. However, the mesoporous SBA-15 silica with certain micropore volume shows relatively higher adsorption capacity than that of MCM-41 silica. The presence of micropores directly leads to an increase in the dynamic adsorption capacity of toluene. Although NaY has the highest adsorption capacity for toluene, its complete desorption temperature for toluene is high (> 350°C), which limits its wide application. On the contrary, mesoporous silica materials exhibits a good desorption performance for volatile organic compounds at lower temperatures. Among these materials mesoporous SBA-15 samples, with a larger amount micropores and a lower desorption temperature, are a potentially interesting adsorbent for the removal of volatile organic compounds. This behavior should been related with the best synergetic effect of mesopores and micropores. | Weiwei Zhang Zhenping Qu Xinyong Li Yi Wang Ding Ma Jingjing Wu | 2012 | Journal of Environmental Sciences2012，24，3： | 13 |
| 11 | The determination of 52 elements in marine geological samples by an inductively coupled plasma optical emission spectrometry and an inductively coupled plasma mass spectrometry with a high-pressure closed digestion method显示文摘An improved analytical method to determine the content of 52 major, minor and trace elements in marine geological samples, using a HF-HCl-HNO_3 acid system with a high-pressure closed digestion method(HPCD), is studied by an inductively coupled plasma optical emission spectrometry(ICP-OES) and an inductively coupled plasma mass spectrometry(ICP-MS). The operating parameters of the instruments are optimized, and the optimal analytical parameters are determined. The influences of optical spectrum and mass spectrum interferences, digestion methods and acid systems on the analytical results are investigated. The optimal spectral lines and isotopes are chosen, and internal standard element of rhodium is selected to compensate for matrix effects and analytical signals drifting. Compared with the methods of an electric heating plate digestion and a microwave digestion, a high-pressure closed digestion method is optimized with less acid, complete digestion,less damage for digestion process. The marine geological samples are dissolved completely by a HF-HCl-HNO_3 system, the relative error(RE) for the analytical results are all less than 6.0%. The method detection limits are 2–40μg/g by the ICP-OES, and 6–80 ng/g by ICP-MS. The methods are used to determine the marine sediment reference materials(GBW07309, GBW07311, GBW07313), rock reference materials(GBW07103, GBW07104,GBW07105), and cobalt-rich crust reference materials(GBW07337, GBW07338, GBW07339), the obtained analytical results are in agreement with the certified values, and both of the relative standard deviation(RSD) and the relative error(RE) are less than 6.0%. The analytical method meets the requirements for determining 52 elements contents of bulk marine geological samples. | GAO Jingjing LIU Jihua LI Xianguo YAN Quanshu WANG Xiaojing WANG Hongmin | 2017 | Acta Oceanologica Sinica2017，36，1： | 13 |
| 12 | Kinetics of the accumulation of group 2 innate lymphoid cells in IL-33-induced and IL-25-induced murine models of asthma:a potential role for the chemokine CXCL16显示文摘ILC2s are implicated in asthma pathogenesis, but little is known about the mechanisms underlying their accumulation in airways.We investigated the time course of ILC2 accumulation in different tissues in murine models of asthma induced by a serial per-nasalchallenge with ovalbumin (OVA), house dust mice (HDM), IL-25 and IL-33 and explored the potential roles of ILC2-attractingchemokines in this phenomenon. Flow cytometry was used to enumerate ILC2s at various time points. The effects of cytokines andchemokines on ILC2 migration were measured in vitro using a chemotaxis assay and in vivo using small animal imaging. Comparedwith saline and OVA challenge, both IL-25 and IL-33 challenge alone induced significant accumulation of ILC2s in the mediastinallymph nodes, lung tissue and bronchoalveolar lavage fluid of challenged animals, but with a distinct potency and kinetics. In vitro,IL-33 and CXCL16, but not IL-25 or CCL25, directly induced ILC2 migration. Small animal in vivo imaging further confirmed that asingle intranasal provocation with IL-33 or CXCL16 was sufficient to induce the accumulation of ILC2s in the lungs followinginjection via the tail vein. Moreover, IL-33-induced ILC2 migration involved the activation of ERK1/2, p38, Akt, JNK and NF-κB, whileCXCL16-induced ILC2 migration involved the activation of ERK1/2, p38 and Akt. These data support the hypothesis that epitheliumderived IL-25 and IL-33 induce lung accumulation of ILC2s, while IL-33 exerts a direct chemotactic effect in this process. AlthoughILC2s express the chemokine receptors CXCR6 and CCR9, only CXCL16, the ligand of CXCR6, exhibits a direct chemoattractanteffect. | Yan Li Shihao Chen Yafei Chi Yiran Yang Xiwen Chen Huating Wang Zhe Lv Jingjing Wang Linjie Yuan Ping Huang Kewu Huang Chris JCorrigan Wei Wang Sun Ying | 2019 | Cellular & Molecular Immunology2019，16，1： | 13 |
| 13 | Downregulation of serum mi R-17 and mi R-106b levels in gastric cancer and benign gastric diseases显示文摘Altered micro RNA(mi RNA) associated with gastric cancer(GC) development and mi R-17 and mi R-106 b were differentially expressed in GC tissues. This study detected serum levels of mi R-17 and mi R-106 b expression in GC, benign gastric disease(BGD) and healthy controls to assess them as tumor markers for GC. Serum samples from 40 GC, 32 BGD(10 gastric ulcer, 14 gastric polyps, and 8 gastric ulcer with polyps) and 36 healthy individuals were subjected to quantitative reverse transcription polymerase chain reaction(q RT-PCR) analysis of mi R-17 and mi R-106 b expression. The data showed that the serum levels of mi R-17 and mi R-106 b were significantly reduced in healthy individuals and BGD patients compared to GC patients. There was a significant association of mi R-17 and mi R-106 b expression with age, but not with other clinicopathological features, such as gender, tumor differentiation, stage and lymphatic metastasis. Further analysis showed that, in discriminating GC patients from healthy controls, mi R-17 could yield a receiver-operating characteristic(ROC) area under the curve(AUC) of 0.879 with 80.6% sensitivity and 87.5% specificity and mi R-106 b could yield an AUC of 0.856 with 75.0% sensitivity and 92.5% specificity. The combined AUC of mi R-17 and mi R-106 b was 0.913 with 83.3% sensitivity and 87.5% specificity. Collectively, these data suggest that detection of serum mi R-17 and mi R-106 b levels should be further evaluated as novel non-invasive biomarkers in early GC detection and surveillance of disease progression. | Qinghai Zeng Cuihong Jin Wenhang Chen Fang Xia Qi Wang Fan Fan Juan Du Yihang Guo Changwei Lin Kaiyan Yang Jingjing Li Xiaowei Peng Xiaorong Li Ke Cao | 2014 | Chinese Journal of Cancer Research2014，26，6： | 12 |
| 14 | Geochronology and Geochemistry of Li(Be)-Bearing Granitic Pegmatites from the Jiajika Superlarge Li-Polymetallic Deposit in Western Sichuan, China显示文摘Strategic emerging minerals such as lithium,beryllium,niobium and tantalum are the most important rare metals currently,especially with the increasing demand of emerging industries on rare metals in China.The Jiajika deposit with a complete Li-Be-Nb-Ta metallogenic series is the largest pegmatite type rare metal deposit in China at present.In this paper,systematic researches of geochronology and petrogeochemistry were carried out to understand the genetic relationships between mineralization and magma evolution in the Jiajika deposit,which might be helpful to further rare-element prospecting in Songpan-Garze area.Zircon LA-ICP-MS U-Pb dating yields a concordia age of 217±1.1 Ma and a weighted mean 206 Pb/238 U age of 217±0.84 Ma for the aplite from the No.308 pegmatite.Cassiterite LA-MC-ICPMS dating yields concordant ages of 211±4.6 Ma for the No.308 pegmatite vein and198±4.4 Ma for the No.133 pegmatite vein,indicating that the rare metal mineralization mainly occurred in the Late Indosinian Period,further suggesting that the granites,aplites and pegmatites in Jiajika formed during a relatively stable stage after the intense orogeny of the Indosinian cycle.The rare metal-bearing granitic rocks and pegmatites show a clear linear relationship between A/CNK and A/NK and are enriched in total alkalis and depleted in CaO,FeO,MnO,MgO,Ba and Sr.All barren rocks and mineralized rocks feature similar rare earth element and trace element geochemical patterns.Thus,these characteristics indicate that the aplites and pegmatites represent the highly differentiated products of the two-mica granite(MaG)in this area,which is the most likely parent magma.During the evolution of magma,strong alkali metasomatism occurred between the melt phase and the volatile-rich fluid phase;as a result,large-scale rare metal mineralization occurred in certain structural zones of the pegmatite veins in the Jiajika deposit. | Hongzhang Dai Denghong Wang Lijun Liu Yang Yu Jingjing Dai | 2019 | Journal of Earth Science2019，30，4： | 12 |
| 15 | Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer显示文摘胃的癌症是世界范围的最普通的恶意之一;然而,在 tumorigenesis 的分子的机制仍然需要探索。BCL2L11 属于 BCL-2 家庭,并且充当内在的 apoptotic 串联的一个中央管理者并且调停房间 apoptosis。尽管 miRNAs 被报导了涉及癌症开发的每个阶段,在 GC 的 miR-24 的角色还没被报导。在现在的学习,当 BCL2L11 的表示在 GC 的肿瘤纸巾被禁止时, miR-24 被发现起来调整。研究从在 vitro 并且在显示出的 vivo,那 miR-24 调整 BCL2L11 表示由与 mRNA 的 3UTR 直接有约束力,因此支持房间生长,移植当禁止房间 apoptosis 时。因此, miR-24 是能是为未来的潜在的药目标的新奇 onco-miRNA 临床的使用。 | Haiyang Zhang Jingjing Duan Yanjun Qu Ting Deng Rui Liu Le Zhang Ming Bai Jialu Li Tao Ning Shaohua Ge Xia Wang ZhenzhenWang~ Qian Fan Hongli Li Guoguang Ying Dingzhi Huang Yi Ba | 2016 | Protein & Cell2016，7，2： | 11 |
| 16 | Overcoming HBV immune tolerance to eliminate HBsAg-positive hepatocytes via pre-administration of GM-CSF as a novel adjuvant for a hepatitis B vaccine in HBV transgenic mice显示文摘尽管有矛盾的结果, Granulocyte 巨噬细胞刺激殖民地的因素(GM-CSF ) 从动物和人的研究被知道是一个潜在的疫苗的助手。差异可能由于被使用的 GM-CSF 的不同剂量和政体,给那成熟或不成熟的树枝状的房间(DC ) 能在不同条件下面被导致。为了测试假设,那 GM-CSF 能为一个肝炎 B 病毒(HBV ) 被用作一个新奇助手治疗学的疫苗,我们与 recombinant HBV 疫苗(rHBVvac ) 在种痘以前每天管理了 GM-CSF 一次三天在老鼠。我们在作为与白天 1 每日的 GM-CSF 管理或白天 2 相比的白天 3 点在这些预先对待的动物观察了更大的 DC 成熟。这策略进一步为它打破在肝炎 B 表面建立的有免疫力的忍耐的能力被调查抗原转基因(HBsAg-Tg ) 动物。我们发现导致的 anti-HBsAg 抗体的层次在在第三免疫以后在 rHBV 种痘前跟随三天 GM-CSF 预告的处理的动物是显著地更高的。除了 anti-HBsAg 抗体层次的增加,调停房间的 anti-HBsAg 回答包括延期类型超敏性, T 房间增长, interferon-γ生产,和细胞毒素的 T 淋巴细胞,戏剧性地在三天的 GM-CSF 被提高预先对待的组。在从使免疫的动物的 CD8 + T 房间的采纳转移以后,抗原特定的 CD8 + T 房间在接受者 HBsAg-Tg 动物的肝被观察。而且,有在 rHBVvac 种痘以前的 GM-CSF 的三天的预告的处理能显著地消除 HBsAg 积极的 hepatocytes,建议有益的治疗学的效果。因此,与 rHBVvac 疫苗在联合作为一个助手利用 GM-CSF 的这个协议有潜力为长期的肝炎 B 病人成为新奇免疫疗法。 | Xianzheng Wang Aihua Dong Jingjing Xiao Xingjun Zhou Haili Mi Hanqian Xu Jiming Zhang Bin Wang | 2016 | Cellular & Molecular Immunology2016，13，6： | 11 |
| 17 | Associations between individual and environmental factors and habitual physical activity among older Chinese adults:A social–ecological perspective显示文摘Purpose: To examine, within a social–ecological framework, associations between multifaceted individual and environmental factors and habitual physical activity(HPA) among older Chinese adults.Methods: Through a mix of qualitative and quantitative methods, a survey instrument assessing various factors underlying 3 social–ecological dimensions of intrapersonal, interpersonal, and community and environmental resources was developed. Using a cross-sectional design, older adults(n = 1580, aged 67 ± 7 years) recruited from 10 communities in Shandong province completed the social–ecological survey of HPA. Data were analyzed using Partial Least Squares Path Modeling.Results: Factors related to intrapersonal(medical knowledge, motivation, physical function, sport skills, socioeconomic status, and education),interpersonal(social support, social activity, and social norms), and community and physical environmental resources(safety, capacity, availability of and access to physical activity facilities) were found to be significantly associated with older adults' participation in HPA.Conclusion: The findings provide an initial validation of a social–ecological approach to the study of HPA in China, suggesting that strategies aimed at promoting physical activity in older adults should address multiple levels of factors that may contribute to the likelihood of older Chinese adults being physically active. | Xiangren Yi Zachary Pope Zan Gao Shumei Wang Fang Pan Jingpeng Yan Meng Liu Peipei Wu Jingjing Xu Rui Wang | 2016 | Journal of Sport and Health Science2016，5，3： | 11 |
| 18 | Hypoxia-induced factor-1 alpha upregulates vascular endothelial growth factor C to promote lymphangiogenesis and angiogenesis in breast cancer patients显示文摘Hypoxia-induced factor-1 alpha(HIF-1α)affects many effector molecules and regulates tumor lymphangiogenesis and angiogenesis during hypoxia.The aim of this study was to investigate the role of HIF-1αin the regulation of vascular endothelial growth factor C(VEGF-C)expression and its effect on lymphangiogenesis and angiogenesis in breast cancer.Lymphatic vessel density(LVD),microvessel density(MVD)and the expressions of HIF-1αand VEGF-C proteins were evaluated by immunohistochemistry in 75 breast cancer samples.There was a significant correlation between HIF-1αand VEGF-C(P=0.014,r=0.273,Spearman's coefficient of correlation).HIF-1αand VEGF-C overexpression was significantly correlated with higher LVD(P=0.003 and P=0.017,respectively),regional lymph nodal involvement(P=0.002 and P=0.004,respectively)and advanced tumor,node,metastasis(TNM)classification(P=0.001 and P=0.01,respectively).Higher MVD was observed in the group expressing higher levels of HIF-1αand VEGF-C(P=0.033 and P=0.037,respectively).Univariate analysis showed shorter survival time in patients expressing higher levels of HIF-1αand VEGF-C.HIF-1αwas also found to be an independent prognostic factor of overall survival in multivariate analysis.The results suggest that HIF-1αmay affect VEGF-C expression,thus acting as a crucial regulator of lymphangiogenesis and angiogenesis in breast cancer.This study highlights promising potential of HIF-1αas a therapeutic target against tumor lymph node metastasis. | Xiaojian Ni Yingchun Zhao Jingjing Ma Tiansong Xia Xiaoan Liu Qiang Ding Xiaoming Zha Shui Wang | 2013 | The Journal of Biomedical Research2013，27，6： | 10 |
| 19 | Counteraction of ABA-Mediated Inhibition of Seed Germination and Seedling Establishment by ABA Signaling Terminator in Arabidopsis显示文摘Seed germination and seedling establishment are important for the reproductive success of plants,but seeds and seedlings typically encounter constantly changing environmental conditions.By inhibiting seed germination and post-germinative growth through the PYR1/PYL/RCAR ABA receptors and PP2C co-receptors,the phytohormone abscisic acid(ABA)prevents premature germination and seedling growth under unfavorable conditions.However,little is known about how the ABA-mediated inhibition of seed germination and seedling establishment is thwarted.Here,we report that ABA Signaling Terminator(ABT),a WD40 protein,efficiently switches off ABA signaling and is critical for seed germination and seedling establishment.ABT is induced by ABA in a PYR1/PYL/RCAR-PP2C-dependent manner.Overexpression of ABT promotes seed germination and seedling greening in the presence of ABA,whereas knockout of ABT has the opposite effect.We found that ABT interacts with the PYR1/PYL/RCAR and PP2C proteins,interferes with the interaction between PYR1/PYL4 and ABI1/ABI2,and hampers the inhibition of ABI1/ABI2 by ABA-bound PYR1/PYL4,thereby terminating ABA signaling.Taken together,our results reveal a core mechanism of ABA signaling termination that is critical for seed germination and seedling establishment in Arabidopsis. | Zhijuan Wang Ziyin Ren Chunhong Cheng Tao Wang Hongtao Ji Yang Zhao Zhiping Deng Liya Zhi Jingjing Lu Xinying Wu Shimin Xu Mengmeng Cao Hongtao Zhao Liu Liu Jiankang Zhu Xia Li | 2020 | Molecular Plant2020，13，9： | 10 |
| 20 | Isolation and characterization of Sporobolomyces sp. LF1 capable of degrading chlorimuron-ethyl显示文摘A yeast strain which was capable of degrading sulfonylurea herbicide chlorimuron-ethyl named as LF1 was isolated from a chlorimuron-ethyl contaminated soil near the warehouse of the factory producing chlorimuron-ethyl in Shenyang City,Northeast China. The strain was identified as Sporobolomyces sp.,based on its morphological and physiological characteristics and the phylogenetic analysis of 18S rRNA gene sequence.So far,this is the only yeast strain of Sporobolomyces sp.which is able to degrade chlorimuron-ethyl.Incubation tests showed that when the initial concentration of chlorimuron-ethyl in culture was 5 mg/L,LF1 could degrade more than 77%of the herbicide after incubation for 4 d at 30°C.The possible mechanism of chlorimuron-ethyl degradation by LF1 could be the acidic hydrolysis caused by the acids from the metabolism of the yeast strain.Further study should be conducted to examine the pathways of chlorimuron-ethyl degradation by LF1 and to approach the feasibility of using LF1 to degrade the chlorimuron-ethyl in soil system. | ZHANG Xiaoli ZHANG Huiwen LI Xu SU Zhencheng WANG Jingjing ZHANG Chenggang | 2009 | Journal of Environmental Sciences2009，21，9： | 10 |
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