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| 1 | WRKY transcription factors in plant responses to stresses显示文摘The WRKY gene family is among the largest families of transcription factors(TFs) in higher plants.By regulating the plant hormone signal transduction pathway,these TFs play critical roles in some plant processes in response to biotic and abiotic stress.Various bodies of research have demonstrated the important biological functions of WRKY TFs in plant response to different kinds of biotic and abiotic stresses and working mechanisms.However,very little summarization has been done to review their research progress.Not just important TFs function in plant response to biotic and abiotic stresses,WRKY also participates in carbohydrate synthesis,senescence,development,and secondary metabolites synthesis.WRKY proteins can bind to W-box(TGACC(A/T)) in the promoter of its target genes and activate or repress the expression of downstream genes to regulate their stress response.Moreover,WRKY proteins can interact with other TFs to regulate plant defensive responses.In the present review,we focus on the structural characteristics of WRKY TFs and the research progress on their functions in plant responses to a variety of stresses. | Jingjing Jiang Shenghui Ma Nenghui Ye Ming Jiang Jiashu Cao Jianhua Zhang | 2017 | Journal of Integrative Plant Biology2017，59，2： | 75 |
| 2 | Water-Saving and High-Yielding Irrigation for Lowland Rice by Controlling Limiting Values of Soil Water Potential显示文摘现在的学习调查了一个灌溉系统是否能被建立节省水和增加谷物产量在灌溉低地大米(Oryza sativa L.) 在领域水平由合适的用水管理提高水生产率。用二地成年的米饭栽培变种,二个灌溉系统;常规灌溉和节省水的灌溉,被进行。在节省水的灌溉系统,限制与特定的生长阶段有关的土壤水潜力的价值作为灌溉索引被建议。与排水在在哪儿的常规灌溉相比在另外的时间,增加的谷物在 7.4% ~ 11.3% 产出的节省水的灌溉,在 24.5% ~ 29.2% 的减少的灌溉用水,和增加的水生产率中间季节、充满(谷物每灌溉用水的立方的米让步) 在 43.1% ~ 50.3% 。节省水的灌溉显著地增加了产量指数,改进 milling 和外观质量,在根流血提高了玉米素 + 玉米素核糖甙集中并且提高了在谷物的蔗糖 synthase,腺苷 diphosphateglucose pyrophosphorylase,淀粉 synthase 和淀粉分叉酶的活动。我们的结果由控制限制根和谷物,还原剂水输入,和增加谷物的生理的活动产出的与阶段能提高的特定的生长有关的土壤水潜力的价值显示那节省水的灌溉。 | Jianchang Yang Kai Liu Zhiqin Wang Yong Du Jianhua Zhang | 2007 | Journal of Integrative Plant Biology2007，49，10： | 46 |
| 3 | Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third-or further-line treatment显示文摘Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and c-MET;therefore,it exhibits both antitumor and anti-angiogenetic activities.A phase III trial has shown that anlotinib improved progression-free survival(PFS)and overall survival(OS)in patients with advanced non-small cell lung cancer(NSCLC),who presented with progressive disease or intolerance after standard chemotherapy.This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment.Methods:Data were collected from March 2015 to January 2017 from a randomized,double-blind,placebo-controlled,multicenter,phase III trial of anlotinib(ALTER0303).A total of 437 patients were enrolled and randomly allocated(2:1)to the anlotinib and placebo groups.Kaplan–Meier analysis and log-rank test were performed to compare PFS and OS.Cox proportional hazards model was adopted for multivariate prognostic analysis.Results:Multivariate analysis indicated that high post-therapeutic peripheral blood granulocyte/lymphocyte ratio and elevated alkaline phosphatase levels were independent risk factors for PFS.Meanwhile,elevated thyroid-stimulating hormone,blood glucose,and triglyceride levels;hypertension;and hand–foot syndrome were independent protective factors of PFS.High posttherapeutic peripheral blood granulocyte/lymphocyte ratio,an Eastern Cooperative Oncology Group(ECOG)score≥2,and the sum of the maximal target lesion length at baseline were independent risk factors of OS,and hypertriglyceridemia was an independent protective factor of OS.Conclusions:This study preliminarily explored the possible factors that affected PFS and OS after anlotinib treatment in patients with advanced refractory NSCLC,and the baseline characteristics of the therapeutically dominant populations were then identified. | Jing Wang Yizhuo Zhao Qiming Wang Li Zhang Jianhua Shi Zhehai Wang Ying Cheng Jianxing He Yuankai Shi Hao Yu Yang Zhao Weiqiang Chen Yi Luo Xiuwen Wang Kejun Nan Faguang Jin Jian Dong Baolan Li Zhujun Liu Baohui Han Kai Li | 2018 | Cancer Biology & Medicine2018，15，4： | 46 |
| 4 | Genome-Wide Analysis of WOX Gene Family in Rice,Sorghum,Maize,Arabidopsis and Poplar显示文摘WUSCHEL-related homeobox (WOX) genes form a large gene family specifically expressed in plants.They are known to play important roles in regulating the development of plant tissues and organs by determining cell fate.Recent available whole genome sequences allow us to do more comprehensive phylogenetic analysis of the WOX genes in plants.In the present study,we identified 11 and 21 WOXs from sorghum (Sorghum bicolor) and maize (Zea mays),respectively.The 72 WOX genes from rice (Oryza sativa),sorghum,maize,Arabidopsis (Arabidopsis thaliana) and poplar (Populus trichocarpa) were grouped into three well supported clades with nine subgroups according to the amino acid sequences of their homodomains.Their phylogenetic relationship was also supported by the observation of the motifs outside the homodomain.We observed the variation of duplication events among the nine sub-groups between monocots and eudicots,for instance,more gene duplication events of WOXs within subgroup A for monocots,while,less for dicots in this subgroup.Furthermore,we observed the conserved intron/exon structural patterns of WOX genes in rice,sorghum and Arabidopsis.In addition,WUS (Wuschel)-box and EAR (the ERF-associated amphiphilic repression)-like motif were observed to be conserved among several WOX subgroups in these five plants.Comparative analysis of expression patterns of WOX genes in rice and Arabidopsis suggest that the WOX genes play conserved and various roles in plants.This work provides insights into the evolution of the WOX gene family and is useful for future research. | Xin Zhang Jie Zong Jianhua Liu Jinyuan Yin Dabing Zhang | 2010 | Journal of Integrative Plant Biology2010，52，11： | 38 |
| 5 | Efficacy and safety of Xinfeng capsule in patients with rheumatoid arthritis:a multi-center parallel-group double-blind randomized controlled trial显示文摘OBJECTIVE:To evaluate the efficacy and safety of Xinfeng capsule in patients suffering rheumatoid arthritis(RA).METHODS:A multi-center parallel-group designed,double-blind,randomized,controlled trial was conducted.Totally 304 RA patients were assigned to two groups:one group was administered Xinfeng capsule(XFC) plus the placebo of leflunomide and the other given leflunomide(LEF) plus the placebo of XFC for twelve weeks.The clinical and laboratory parameters were compared at baseline and fourth,eighth,and twelfth weeks.RESULTS:After twelve-week treatment,patients in two groups all showed some trend of effectiveness when compared in terms of American Rheumatism Association(ACR) recommended 20%,50%,70%improvement criteria,but it was insignificant.The validity in ameliorate modified disease activity score(DAS28) and laboratory indexes as erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),rheumatoid factor(RF) were also found no difference.The score of health assessment questionnaire(HAQ),self-rating anxiety scale(SAS),self-rating depression scale(SDS) and quality of life questionnaire with rheumatoid arthritis(RAQOL)both lower than the first week and the changes showed no difference.However,the score of SDS dropped more in XFC group than in the other.A total of 147 adverse reaction cases were reported,which shows no difference between the two groups.The most common adverse reactions were hepatic impairment,anemia,leukocytopenia,epigastric discomfort and phalacrosis.CONCLUSION:XFC demonstrated better improvement in the scores of SDS and compared with those of LEF group. | Liu Jian Wang Yuan Huang Chuanbing Xu Jianhua Li Zhijun Xu Liang He Liyun Sun Yue Wang Yali Xu Shengqian Zhao Ping Mao Tongjun Tan Bin Zhu Fubing Zhang Pingheng Fang Li | 2015 | Journal of Traditional Chinese Medicine2015，35，5： | 27 |
| 6 | Using aripiprazole to reduce antipsychotic-induced hyperprolactinemia: meta-analysis of currently available randomized controlled trials显示文摘 | Meiling MENG Wei LI Shaowei ZHANG Hongyan WANG Jianhua SHENG Jijun WANG Chunbo LI | 2015 | 上海精神医学2015，27，1： | 22 |
| 7 | Trends in cancer mortality in China from 2004 to 2018:A nationwide longitudinal study显示文摘Background:The long-term trend in cancer death in a rapidly developing country provides information for cancer prophylaxis.Here,we aimed to identify the trends in cancer mortality in China during the 2004-2018 period.Methods:Using raw data from the national mortality surveillance system of China,we assessed the mortalities of all cancer and site-specific cancers during the 2004-2018 period.The participants were divided into three age groups:≥65 years,40-64 years,and≤39 years.Changing trends in cancer death by gender,residency,and tumor location were estimated using fitting joinpoint models to log-transformed crude mortality rates(CMRs)and age-standardizedmortality rates(ASMRs).Results:Cancer death accounted for 24% of all-cause of death in China during 2014-2018.The CMR of all cancer was 150.0 per 100,000 persons.Cancer was the leading cause of death in the population<65 years.The six major cancer types(lung/bronchus cancer,liver cancer,stomach cancer,esophagus cancer,colorectal cancer,and pancreas cancer)accounted for 75.85% of all cancer deaths.The CMR of all cancer increased while the ASMR decreased during 2014-2018(P<0.001).Lung/bronchus cancer and liver cancer were the leading causes of cancer death in the population<65 years,accounting for 45.31%(CMR)and 44.35%(ASMR)of all cancer death,respectively.The ASMR of liver cancer was higher in the 40-64 years population than in the≥65 years population,in contrast to the other five major cancers.The ASMRs of liver cancer,stomach cancer,and esophagus cancer decreased although they were higher in rural residents than in urban residents;the ASMRs of lung/bronchus cancer,colorectal cancer,and pancreas cancer increased in rural residents although they were higher in urban residents than in rural residents during 2014-2018.Conclusion:Although the ASMR of all cancer decreased in China during 2004-2018,lung/bronchus cancer and liver cancer remained the leading causes of cancer-related premature death.Lung/bronchus cancer,colorectal cancer,and pancreas cancer increased in rural residents. | Dongming Jiang Lijuan Zhang Wenbin Liu Yibo Ding Jianhua Yin Rongbing Ren Qi Li Yifan Chen Jiaying Shen Xiaojie Tan Hongwei Zhang Guangwen Cao | 2021 | Cancer Communications2021，41，10： | 23 |
| 8 | The Yanshan orogeny and late Mesozoic multi-plate convergence in East Asia—Commemorating 90th years of the “Yanshan Orogeny”显示文摘The Yanshan movement/orogeny has been proposed for 90 years, which is of special significance in the history of geological research in China. This study conducted a review by synthesizing major achievements regarding episodic deformation features, sedimentary and magmatic records of the Yanshan orogeny in China, and clarified the episodic tectono-magmatism and its geodynamic origins. The tectonic implications of the Yanshan orogeny are discussed in the context of global plate tectonics and supercontinent reconstruction. Lines of evidence from structural, sedimentary and magmatic data suggest that the Yanshan orogeny represents a regional-scale tectonic event that affected the entire China continent in late Mesozoic period. Numerous age and structural constraints consistently indicate that the Yanshan orogeny was initiated in the Jurassic(at ~170±5 Ma). and was characterized by alternating stages of crustal shortening at ~170–136 Ma, crustal extension at ~135–90 Ma, and weak shortening at ~80 Ma. The 170–136 Ma crustal shortening was reflected in the generation of two regional stratigraphic unconformities(the Tiaojishan and Zhangjiakou unconformities), which were initially named the A and B episodes of 'the Yanshan Orogeny' by Mr.Wong Wenhao in 1928. Geodynamically, the Yanshan orogeny in East Asia was associated with nearly coeval oceanic subduction and continental convergence in the Paleo-Pacific, Neo-Tethys, and Mongol-Okhotsk tectonic domains. As a consequence, three giant accretionary-collisional tectonic systems were formed along the continental margins of East Asia, i.e., the Mongol-Okhotsk, Bangonghu-Nujiang, and SE China subduction-and collision-related accretionary systems. The Yanshan orogeny induced widespread crustal-scale folding and thrusting, tectonic reactivation of long-lived zones of crustal weakness,and extensive magmatism and mineralization in intraplate regions. Based on the time principle of supercontinent assembly and break-up, we propose that the mid-Late Jurassic multi-plate convergence in East Asia might represent the initiation of the assembly of the Amasia supercontinent, and the Yanshan orogeny might be the first 'stirrings' that is a prerequisite for the birth of the Amasia supercontinent. | Shuwen DONG Yueqiao ZHANG Hailong LI Wei SHI Huaimin XUE Jianhua LI Shiqi HUANG Yongchao WANG | 2018 | Science China Earth Sciences2018，61，12： | 21 |
| 9 | Response of runoff in the headwater region of the Yellow River to climate change and its sensitivity analysis显示文摘在到气候变化和它的敏感的黄河的 headwater 区域的流量的反应在时期期间在四个水文学车站和十个气象站基于测量数据被分析 19592008。结果显示在这个区域的温度的那个变化与全球温暖和在在这个区域的每个分区的温度一直在介绍的年度一般水准的变化有一种明显的相应关系过去的 50 年里的一个变动、升起的状态。因为不同地理位置和环境的影响,然而,降水的变化在总体上生产流量的区域一直在介绍的年度降水的各种各样的区域,和变化是比在这个区域的温度的变化更复杂的过去的 50 年里的一个变动、减少的状态。并且在这个区域在流量和降水和温度之间有一种显著非线性的相互关系。因为,自从 1990,在这个区域的流量连续地一直在减少降水总体上生产流量的区域显然减少,年度平均温度连续地升起。总体上,当在在 Jimai 上面的分区的流量相应地在在这个区域的其它比那对温度变化更敏感时,在黄河的 headwater 区域的每个分区的流量对降水变化相当敏感。 | LAN Yongchao ZHAO Guohui ZHANG Yaonan WEN Jun HU Xinglin LIU Jinqi GU Minglin CHANG Junjie MA Jianhua | 2010 | Journal of Geographical Sciences2010，20，6： | 20 |
| 10 | Impacts of Diurnal Variation of Mountain-plain Solenoid Circulations on Precipitation and Vortices East of the Tibetan Plateau during the Mei-yu Season显示文摘Diurnal variations of two mountain-plain solenoid(MPS) circulations associated with 'first-step' terrain [Tibetan Plateau(TP)] and 'second-step' terrain(high mountains between the TP and 'east plains') in China and their influence on the southwest vortex(SWV) and the mei-yu front vortex(MYFV) were investigated via a semi-idealized mesoscale numerical model [Weather Research and Forecasting(WRF)] simulation integrated with ten-day average fields(mei-yu period of 1–10 July 2007). The simulations successfully reproduced two MPS circulations related to first- and second-step terrain, diurnal variations from the eastern edge of the TP to the Yangtze River–Huaihe River valleys(YHRV), and two precipitation maximum centers related to the SWV, MYFV. Analyses of the averaged final seven-day simulation showed the different diurnal peaks of precipitation at different regions: from the afternoon to early evening at the eastern edge of the TP; in the early evening to the next early morning in the Sichuan Basin(SCB); and in the late evening to the next early morning over the mei-yu front(MYF). Analyses of individual two-day cases confirmed that the upward branches of the nighttime MPS circulations enhanced the precipitation over the SWV and the MYFV and revealed that the eastward extension of the SWV and its convection were conducive to triggering the MYFVs. The eastward propagation of a rainfall streak from the eastern edge of the TP to the eastern coastal region was primarily due to a series of convective activities of several systems from west to east, including the MPS between the TP and SCB, the SWV, the MPS between second-step terrain and the east plains, and the MYFV. | ZHANG Yuanchun SUN Jianhua FU Shenming | 2014 | Advances in Atmospheric Sciences2014，31，1： | 20 |
| 11 | Development of Mining Technology and Equipment for Seafloor Massive Sulfide Deposits显示文摘Seafloor massive sulfide(SMS) deposits which consist of Au, Ag, Cu, and other metal elements, have been a target of commercial mining in recent decades. The demand for established and reliable commercial mining system for SMS deposits is increasing within the marine mining industry. The current status and progress of mining technology and equipment for SMS deposits are introduced. First, the mining technology and other recent developments of SMS deposits are comprehensively explained and analyzed.The seafloor production tools manufactured by Nautilus Minerals and similar mining tools from Japan for SMS deposits are compared and discussed in turn. Second, SMS deposit mining technology research being conducted in China is described, and a new SMS deposits mining tool is designed according to the environmental requirement. Finally, some new trends of mining technology of SMS deposits are summarized and analyzed. All of these conclusions and results have reference value and guiding significance for the research of SMS deposit mining in China. | LIU Shaojun HU Jianhua ZHANG Ruiqiang DAI Yu YANG Hengling | 2016 | Chinese Journal of Mechanical Engineering2016，29，5： | 19 |
| 12 | The Interdisciplinary Research of Big Data and Wireless Channel: A Cluster-Nuclei Based Channel Model显示文摘Recently,internet stimulates the explosive progress of knowledge discovery in big volume data resource,to dig the valuable and hidden rules by computing.Simultaneously,the wireless channel measurement data reveals big volume feature,considering the massive antennas,huge bandwidth and versatile application scenarios.This article firstly presents a comprehensive survey of channel measurement and modeling research for mobile communication,especially for 5th Generation(5G) and beyond.Considering the big data research progress,then a cluster-nuclei based model is proposed,which takes advantages of both the stochastical model and deterministic model.The novel model has low complexity with the limited number of cluster-nuclei while the cluster-nuclei has the physical mapping to real propagation objects.Combining the channel properties variation principles with antenna size,frequency,mobility and scenario dug from the channel data,the proposed model can be expanded in versatile application to support future mobile research. | Jianhua Zhang | 2016 | China Communications2016，13，S2： | 19 |
| 13 | Effects of high pressure on the microstructure and hardness of a Cu-Zn alloy显示文摘The microstructure of a Cu-Zn alloy treated under different high pressures was investigated by means of metallographic, scanning electron microscope (SEM), energy dispersive spectrometer (EDS), and X-ray diffraction (XRD), and the hardness of the Cu-Zn alloy was also measured. The results show that the α phase with a smaller grain size, different shapes, and random distribution appears in the Cu-Zn alloy during the solid-state phase transformation generation in the temperature range of 25-750°C and the pressure range of 0-6 GPa. The amount of residual α phase in the microstructure decreases and then increases with increasing pressure. Under a high pressure of 3 GPa, the least volume fraction of residual α phase was obtained, and under a high pressure of 6 GPa, the changes of the microstructure of the Cu-Zn alloy were not obvious. In addition, high pressure can increase the hardness of the Cu-Zn alloy, but it cannot generate any new phase. | ZHAO Juna LIU Lin YANG Jingru PENG Guirong LIU Jianhua ZHANG Ruijuna XING Guangzhong | 2008 | Rare Metals2008，27，5： | 18 |
| 14 | Effect of manganese oxide-modified biochar addition on methane production and heavy metal speciation during the anaerobic digestion of sewage sludge显示文摘Low organic matter content and high heavy metal levels severely inhibit the anaerobic digestion(AD) of sewage sludge. In this study, the effect of added manganese oxidemodified biochar composite(MBC) on methane production and heavy metal fractionation during sewage sludge AD was examined. The MBC could increase the buffering capacity,enhance the methane production and degradation of intermediate acids, buffer the pH of the culture, and stabilize the sewage sludge AD process. The application of MBC positively impacted methane production and the cumulative methane yield increased up to 121.97%,as compared with the control. The MBC addition can improve metal stabilization in the digestate. An optimum MBC dose of 2.36 g was recommended, which would produce up to 121.1 L/kg volatile solids of methane. After the AD process, even though most of the metals accumulated in the residual solids, they could be transformation from the bio-available fractions to a more stable fraction. The total organic-and sulfide-bound and residual fraction content at a 3 g dose of MBC that is 0.12 g/g dry matter were 51.06% and 35.11% higher than the control, respectively. The results indicated that the application of MBC could improve the performance of AD and promote stabilization of heavy metals in sewage sludge post the AD process. | Jianhua Li Min Zhang Zhiyin Ye Changming Yang | 2019 | Journal of Environmental Sciences2019，31，2： | 17 |
| 15 | Multifunctional core/satellite polydopamine@Nd^3+- sensitized upconversion nanocomposite: A single 808 nm near-infrared light-triggered theranostic platform for in vivo imaging-guided photothermal therapy显示文摘重要变细并且过热,在水里由刺激乐队(980 nm ) 的吸收引起了,是主要障碍在在里面做 lanthanide 的 upconversion nanoparticles (UCNP ) 的 vivo 申请。因此,有 808 nm 刺激的适当地组织的 Nd 3+-doped UCNP 能是一种有希望的选择。此处,我们开发了 core-shell-shell 作为成像代理人组织了 Nd 3+-sensitized UCNP,并且装饰了他们到 polydopamine (PDA ) 的表面上构造新奇多功能的核心 / 卫星 nanotheranostic (PDA@UCNPs ) 为在 vivo 成像指导 photothermal 治疗使用单身者 808 nm 激光照耀。core-shell-shell 组织了设计启用的突出的 upconversion 光性质和强壮的 X 光检查变细,从而为优秀 upconversion luminescence/computed 断层摄影术使 nanocomposites 成为潜在的候选人双形式的成像。另外, PDA 核心不仅提供高 photothermal 变换效率和突出的 antitumor 效果,而且由于它的自然特征赋予站台以柔韧的 biocompatibility。因此,这多功能的 nanocomposite 能是在未来 oncotherapy 的有希望的 theranostic,与高治疗学的有效性但是低副作用。这研究将刺激在设计 bio-application-compatible 使多功能的 nanocomposites 感兴趣,特别为在 vivo 的癌症诊断和治疗。 | Xing Ding Jianhua Liu Dapeng Liu Junqi Li Fan Wang Leijiao Li Yinghui Wang Shuyan Song Hongjie Zhang | 2017 | Nano Research2017，10，10： | 16 |
| 16 | Joint TDOA, FDOA and differential Doppler rate estimation: Method and its performance analysis显示文摘Considering the estimation accuracy reduction of Frequency Difference of Arrival(FDOA) caused by relative Doppler companding, a joint Time Difference of Arrival(TDOA),FDOA and differential Doppler rate estimation method is proposed and its Cramer-Rao low bound is derived in this paper.Firstly, second-order ambiguity function is utilized to reduce the dimensionality and estimate initial TDOA and differential Doppler rate.Secondly, the TDOA estimation is updated and FDOA is obtained using cross ambiguity function, in which relative Doppler companding is compensated by the existing differential Doppler rate.Thirdly, differential Doppler rate estimation is updated using cross estimator.Theoretical analysis on estimation variance and Cramer-Rao low bound shows that the final estimation of TDOA, FDOA and differential Doppler rate performs well at both low and high signal–noise ratio, although the initial estimation accuracy of TDOA and differential Doppler rate is relatively poor under low signal–noise ratio conditions.Simulation results finally verify the theoretical analysis and show that the proposed method can overcome relative Doppler companding problem and performs well for all TDOA, FDOA and differential Doppler rate estimation. | Dexiu HU Zhen HUANG Shangyu ZHANG Jianhua LU | 2018 | Chinese Journal of Aeronautics2018，31，1： | 16 |
| 17 | MECHANICS ANALYSIS ON PRECISE FORMING PROCESS OF EXTERNAL SPLINE COLD ROLLING显示文摘According to the suitable assumption, the deformation process of external spline cold rolling is analyzed. By the graphing method, the slip-line field of plastically deforming area in process of external spline cold rolling is set up. Different friction-conditions are used in different contact areas in order to realistically reflect the actual situation. The unit average pressure on contact surface of the rolling process is solved according to the stress filed theory of slip-line. And the formulae of the rolling-force and rolling-moment are established. The theoretical result is well consistent with the finite element analysis. A theoretical basis is provided for the precise forming process of spline cold rolling and the production of external splined shafts. | ZHANG Dawei LI Yongtang FU Jianhua ZHENG Quangang | 2007 | Chinese Journal of Mechanical Engineering2007，20，3： | 16 |
| 18 | Colorectal cancer burden and trends:Comparison between China and major burden countries in the world显示文摘Objective:To summarize the colorectal cancer(CRC)burden and trend in the world,and compare the difference of CRC burden between other countries and China.Methods:Incidence and mortality data were extracted from the GLOBOCAN2018 and Cancer Incidence in Five Continents.Age-specific incidence trend was conducted by Joinpoint analysis and average annual percent changes were calculated.Results:About 1.85 million new cases and 0.88 million deaths were expected in 2018 worldwide,including 0.52 million(28.20%)new cases and 0.25 million(28.11%)deaths in China.Hungary had the highest age-standardized incidence and mortality rates in the world,while for China,the incidence and mortality rates were only half of that.CRC incidence and mortality were highly correlated with human development index(HDI).Unlike the rapid increase in Republic of Korea and the downward trend in Canada and Australia,the age-standardized incidence rates by world standard population in China and Norway were rising gradually.The age-specific incidence rate in the age group of 50-59 years in China was increasing rapidly,while in Republic of Korea and Canada,the fastest growing age group was 30-39 years.Conclusions:The variations of CRC burden reflect the difference of risk factors,as well as levels of HDI and screening(early detection activities).The burden of CRC in China is high,and the incidence of CRC continues to increase,which may lead to a sustained increase in the burden of CRC in China in the future.Screening should be expanded to control CRC,and focused on young people in China. | Jiachen Zhou Rongshou Zheng Siwei Zhang Hongmei Zeng Shaoming Wang Ru Chen Kexin Sun Minjuan Li Jianhua Gu Guihua Zhuang Wenqiang Wei | 2021 | Chinese Journal of Cancer Research2021，33，1： | 16 |
| 19 | Functions and mechanisms of the CBL-CIPK signaling system in plant response to abiotic stress显示文摘To cope with environmental stimuli, plants have evolved precise regulatory mechanisms to perceive, transduce and respond to abiotic stresses that can negatively affect growth and development. The CBL-CIPK signaling system is a newly emerging plant-specific and Ca2+-dependent network mediating abiotic stress tolerance. CBLs may sense a Ca2+ signature triggered by abiotic stresses, and have specific interactions with novel CIPK-type kinases after binding Ca2+. The CBL/CIPK complexes may post-translationally phosphory-late downstream target proteins to regulate abiotic stress tolerance in a cell or tissue-specific manner. In some cases transcription factors are induced to activate stress-responsive genes that control adaptation reactions. The CBL-CIPK signaling system exhibits specificity, diversity and complexity. Meanwhile, cross talk also exists in the CBL-CIPK signaling. To date, significant progress has been made in the role of the CBL-CIPK signaling system in responding to salt, low K+ and to high pH, which will provide a fast and efficient method of molecular design breeding combined with the CBL/CIPK engineering of crop plants, for enhanced tolerance to abiotic stresses. However, more CBL/CIPK components remain to be identified, particularly from specific plants that grow in conditions with abiotic stress, and the specificity of their abiotic stress signaling will need to be dissected. | Ruifen Li Junwen Zhang Jianhua Wei Hongzhi Wang Yanzhen Wang Rongcai Ma | 2009 | Progress in Natural Science:Materials International2009，19，6： | 15 |
| 20 | Moderate wetting and drying increases rice yield and reduces water use, grain arsenic level, and methane emission显示文摘To meet the major challenge of increasing rice production to feed a growing population under increasing water scarcity,many water-saving regimes have been introduced in irrigated rice,such as an aerobic rice system,non-flooded mulching cultivation,and alternate wetting and drying(AWD).These regimes could substantially enhance water use efficiency(WUE) by reducing irrigation water.However,such enhancements greatly compromise grain yield.Recent work has shown that moderate AWD,in which photosynthesis is not severely inhibited and plants can rehydrate overnight during the soil drying period,or plants are rewatered at a soil water potential of-10 to-15 k Pa,or midday leaf potential is approximately-0.60 to-0.80 MPa,or the water table is maintained at 10 to 15 cm below the soil surface,could increase not only WUE but also grain yield.Increases in grain yield WUE under moderate AWD are due mainly to reduced redundant vegetative growth;improved canopy structure and root growth;elevated hormonal levels,in particular increases in abscisic acid levels during soil drying and cytokinin levels during rewatering;and enhanced carbon remobilization from vegetative tissues to grain.Moderate AWD could also improve rice quality,including reductions in grain arsenic accumulation,and reduce methane emissions from paddies.Adoption of moderate AWD with an appropriate nitrogen application rate may exert a synergistic effect on grain yield and result in higher WUE and nitrogen use efficiency.Further research is needed to understand root–soil interaction and evaluate the long-term effects of moderate AWD on sustainable agriculture. | Jianchang Yang Qun Zhou jianhua Zhang | 2017 | The Crop Journal2017，5，2： | 15 |
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