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| 1 | IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma显示文摘 | Jiankun Liu Yuzhong Duan Xiaoming Cheng Xi Chen Wei Xie Haixia Long Zhihua Lin Bo Zhu | 2011 | Biochemical and Biophysical Research Communications2011，，2： | 2 |
| 2 | IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma显示文摘 | Jiankun Liu Yuzhong Duan Xiaoming Cheng Xi Chen Wei Xie Haixia Long Zhihua Lin Bo Zhu | 2011 | Biochemical and Biophysical Research Communications2011，，2： | 1 |
| 3 | Deformation Mechanism in Fe_(61)Mn_(18)Si_(11)Cr_(10) Medium Entropy Alloy Under Different Strain Rates显示文摘We introduce a non-equiatomic Fe_(61)Mn_(18)Si_(11)Cr_(10) medium entropy alloy designed by subjecting it to transformation-induced plasticity upon deformation at room temperature. Microstructure characterization carried out using scanning electron microscopy(SEM), electron backscatter diffraction(EBSD), transmission electron microscopy(TEM) and X-ray diffraction(XRD) shows a homogeneous solid solution FCC + BCC structured dual phase. Investigations on the deformation substructures at specific strain levels via EBSD reveal the deformation-induced transformations of γ→α′ and γ→ ε. The strengths, particularly yield strength, of the designed alloy are found to be higher than these of the well-studied five component FeMnNiCoCr system for the introduction of the hard phase( α′-martensite). When tensile tests are performed at different strain rates of 10^(–4)s^(-1), 10^(–3)s^(-1), 10^(–2)s^(-1), the tested material exhibits a slightly negative strain rate sensitivity and work hardening rate sensitivity. | Shaoheng Sun Yun Zhang Zhiyong Xue Jiankun Lin Xiaohua Chen | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，8： | 0 |
| 4 | Simultaneous manipulations of thermal expansion and conductivity in symbiotic ScTaO_(4)/SmTaO_(4) composites via multiscale effects显示文摘Effective manipulations of thermal expansion and conductivity are significant for improving operational performances of protective coatings,thermoelectric,and radiators.This work uncovers determinant mechanisms of the thermal expansion and conductivity of symbiotic ScTaO_(4)/SmTaO_(4) composites as thermal/environmental barrier coatings(T/EBCs),and we consider the effects of interface stress and thermal resistance.The weak bonding and interface stress among composite grains manipulate coefficient of thermal expansion(CTE)stretching from 6.4×10^(−6) to 10.7×10^(−6) K^(−1) at 1300℃,which gets close to that of substrates in T/EBC systems.The multiscale effects,including phonon scattering at the interface,mitigation of the phonon speed(vp),and lattice point defects,synergistically depress phonon thermal transports,and we estimate the proportions of different parts.The interface thermal resistance(R)reduces the thermal conductivity(k)by depressing phonon speed and scattering phonons because of different acoustic properties and weak bonding between symbiotic ScTaO_(4) and SmTaO_(4) ceramics in the composites.This study proves that CTE of tantalates can be artificially regulated to match those of different substrates to expand their applications,and the uncovered multiscale effects can be used to manipulate thermal transports of various materials. | Lin Chen Jiankun Wang Baihui Li Keren Luo Jing Feng | 2023 | Journal of Advanced Ceramics2023，12，8： | 0 |
| 5 | Two-dimensional finite element modeling on the crustal shortening and the surface erosion-sedimentation process across northern piedmont of the Tianshan Mountains显示文摘The Tianshan Mountains,located in the northwestern China,are bounded by the Tarim Basin to south and the Junggar Basin to north.In the north piedmont of this mountain range,ongoing thrusting and folding forms a set of roughly parallel anticlines.Geological observations predicted that averaged over last^1 Ma time scale,the shortening rates of these anticlines are about2.1–5.5 mm/a;However by averaged over about 10±2 kyr,their shortening rates reduce to merely about 1.25±0.5 mm/a.The slow shortening of the anticlines in the last^10±2 kyr is coarsely concurrent in time with the last global deglaciation.Here,we use a two-dimensional finite element model to explore crustal deformation across north piedmont of the Tianshan Mountains under various erosion-sedimentation conditions that are assumed to represent the climate-controlled surface process.Numerical experiments show that with a relatively weak erosion-sedimentation strength,the crustal shortening is accommodated mainly by north piedmont of the Tianshan Mountains,similar to the high shortening rate of anticlines averaged over the last^1Ma.By increasing erosion-sedimentation strength,the resultant crustal shortening is transformed gradually toward the Tianshan Mountains,resulting in the shortening rate in its north piedmont being decelerated to what is observed as averaged over the last^10±2 kyr.This result suggests that erosion and sedimentation could play an important role mechanically on strain localization across an intra-continent active tectonic belt.Hence,if the climate change around the last global deglaciation could be simply representative to the enhancement of surface erosion and sedimentation across the pre-existed Tianshan Mountains and its foreland,our models indicate that the observed shortening-rate variations averaged over^1 Ma and^10±2kyr time scales around north piedmont of the Tianshan Mountains should be resulted from climate changes. | XIAO Jie XIONG Lin HE JianKun | 2015 | Science China Earth Sciences2015，58，10： | 0 |
| 6 | Nicotinamide N-methyltransferase and liver diseases显示文摘Cellular metabolism-induced epigenetic regulation is essential for the maintenance of cellular homeostasis.Nicotinamide N-methyltransferase(NNMT)is emerging as a key point of intersection between cellular metabolism and epigenetic regulation and has a central role in various physiological and pathological processes.NNMT catalyzes the methylation of nicotinamide(NAM)using the universal methyl donor S-adenosyl methionine(SAM)to yield S-adeno-syl-L-homocysteine(SAH)and N1-methylnicotinamide(MNAM),directly linking methylation balance with nicotinamide adenosine dinucleotide(NAD+)contents.NNMT acts on either the SAM-methylation balance or both NAD+metabolism,depending on the tissue involved or pathological settings where metabolic demand is increased.Under physiological conditions,the liver act as an essential metabolic organ with abundant NNMT expression,while NNMT hepatic function is not mediated by its methyltransferase activity due to other major methyltransferases such as glycine N-methyltransferase(GNMT)in the liver.However,hepatic NNMT,as well as its metabolite is improperly regulated and linked to the worse pathological states in liver diseases,including alcoholic liver disease,non-alcoholic fatty liver disease(NAFLD),liver cirrhosis,and hepatocellular carcinoma(HCC),suggesting a potential role in the process of liver diseases.In this review,we summarize how NNMT regulates cell methylation balance and NAD metabolism,and extensively outline the current knowledge concerning the functions of NNMT in hepatic metabolism including glucose,lipid and energy,with a specific focus on the contribution of NNMT to the pathophysiology of liver-related diseases.NNMT is involved in the development and progression of liver diseases.Understanding the complex NNMT regulatory network and its effects on pathogenesis could provide new therapeutic strategies in the context of liver diseases. | Guangyu Liang Ying Li Yan Lin Xiao Yang Jiankun Yang Shaobo Hu Anding Liu | 2023 | Genes & Diseases2023，10，5： | 0 |
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