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1Time range of Mesozoic tectonic regime inversion in eastern North China Block显示文摘An important tectonic inversion took place in eastern North China Block(NCB) during Mesozoic, which caused a great lithosphere thinning, reconstruction of basin-range series, powerful interaction between mantle and crust, a vast granitic intrusion and volcanism, and large-scale metallogenic explosion. The time range of the Mesozoic tectonic regime inversion in the eastern North China Block is one of the key issues to understand mechanism of tectonic regime inversion. Our updated results for recognizing the time range are mainly obtained from the following aspects: structural analyses along northern and southern margins of the NCB and within the NCB for revealing tectonic inversion from compression to extension and structural striking from ~EW to NNE; geothermic analyses of the eastern sedimental basins for a great change of thermal history and regime; basin analysis for basin inversion from compression to extension and basin migration from ~EW to NNE; petrological and geochemical studies of volcanic rocks and lowermost crust xenoliths for recognizing peak period of mantle upwelling and intense interaction between mantle and crust, and main metallogenic epoch. All the studies of the above give the same time range from~150-140 Ma to ~110-100Ma, peaking at ~120 Ma.ZHAI Mingguo ZHU Rixiang LIU Jianming MENG Qingren HOU Quanlin HU Shengbiao LIU Wei LI Zhong ZHANG Hongfu ZHANG Huafeng 2004Science China Earth Sciences2004,47,2:89
2Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing,China显示文摘Previous studies have showed clinical characteristics of patients with the 2019 novel coronavirus disease(COVID-19)and the evidence of person-to-person transmission.Limited data are available for asymptomatic infections.This study aims to present the clinical characteristics of 24 cases with asymptomatic infection screened from close contacts and to show the transmission potential of asymptomatic COVID-19 virus carriers.Epidemiological investigations were conducted among all close contacts of COVID-19 patients(or suspected patients)in Nanjing,Jiangsu Province,China,from Jan 28 to Feb 9,2020,both in clinic and in community.Asymptomatic carriers were laboratory-confirmed positive for the COVID-19 virus by testing the nucleic acid of the pharyngeal swab samples.Their clinical records,laboratory assessments,and chest CT scans were reviewed.As a result,none of the 24 asymptomatic cases presented any obvious symptoms while nucleic acid screening.Five cases(20.8%)developed symptoms(fever,cough,fatigue,etc.)during hospitalization.Twelve(50.0%)cases showed typical CT images of ground-glass chest and 5(20.8%)presented stripe shadowing in the lungs.The remaining 7(29.2%)cases showed normal CT image and had no symptoms during hospitalization.These 7 cases were younger(median age:14.0 years;P=0.012)than the rest.None of the 24 cases developed severe COVID-19 pneumonia or died.The median communicable period,defined as the interval from the first day of positive nucleic acid tests to the first day of continuous negative tests,was 9.5 days(up to 21 days among the 24 asymptomatic cases).Through epidemiological investigation,we observed a typical asymptomatic transmission to the cohabiting family members,which even caused severe COVID-19 pneumonia.Overall,the asymptomatic carriers identified from close contacts were prone to be mildly ill during hospitalization.However,the communicable period could be up to three weeks and the communicated patients could develop severe illness.These results highlighted the importance of close contact tracing and longitudinally surveillance via virus nucleic acid tests.Further isolation recommendation and continuous nucleic acid tests may also be recommended to the patients discharged.Zhiliang Hu Ci Song Chuanjun Xu Guangfu Jin Yaling Chen Xin Xu Hongxia Ma Wei Chen Yuan Lin Yishan Zheng Jianming Wang Zhibin Hu Yongxiang Yi Hongbing Shen 2020Science China(Life Sciences)2020,63,5:77
3Clinical characteristics and response to tyrosine kinase inhibitors of patients with non-small cell lung cancer harboring uncommon epidermal growth factor receptor mutations显示文摘Objective: To investigate the clinical features of patients with non-small cell lung cancer(NSCLC) harboring uncommon epidermal growth factor receptor(EGFR) mutations, and the treatment outcomes of EGFR tyrosine kinase inhibitors(TKIs) in these patients.Methods: We retrospectively analyzed the data of 128 NSCLC patients pathologically diagnosed with uncommon EGFR mutation in the Department of Pathology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College and Beijing Hospital from January 2010 to December 2015, including 40 advanced patients who received EGFR-TKI.Results: Among the total 128 patients, 11 patients were non-adenocarcinoma, including squamous carcinoma(3.9%), adenosquamous carcinoma(2.3%), large cell carcinoma(0.8%), and composite neuroendocrine carcinoma(1.6%). Single mutations accounted for 75.0%(96/128), including G719X(29.7%), S768I(18.0%), 20 exon insertion(13.3%), L861Q(12.5%), De novo T790M(0.8%), and T725(0.8%). Thirty-two patients harbored complex mutations. Forty advanced patients received EGFR-TKI, the objective response rate(ORR) was 20.0%,the disease control rate(DCR) was 85.0%, and the progression-free survival(PFS) was 6.4 [95% confidence interval(95% CI), 4.8–7.9] months. The exploratory analysis of tumor response and PFS in 33 patients with G719X/S768I/L861 Q subtypes showed that ORR was 21.2%(7/33), the DCR was 93.9%(31/33), and PFS was 7.6(95% CI, 5.8–9.4) months. Patients with exon 20 insertion mutation and De novo T790 M experienced rapid disease progression with PFS no more than 2.7 months.Conclusions: Uncommon EGFR-mutant NSCLCs are heterogeneous, EGFR-TKIs can have different efficacy in this specific subtype, and thus further individual assessment is required for each case.Yan Zhang Zheng Wang Xuezhi Hao Xingsheng Hu Hongyu Wang Yan Wang Jianming Ying 2017Chinese Journal of Cancer Research2017,29,1:19
4Application of bioactive hydrogels combined with dental pulp stem cells for the repair of large gap peripheral nerve injuries显示文摘Due to the limitations in autogenous nerve grafting or Schwann cell transplantation,large gap peripheral nerve injuries require a bridging strategy supported by nerve conduit.Cell based therapies provide a novel treatment for peripheral nerve injuries.In this study,we first experimented an optimal scaffold material synthesis protocol,from where we selected the 10%GFD formula(10%GelMA hydrogel,recombinant human basic fibroblast growth factor and dental pulp stem cells(DPSCs))to fill a cellulose/soy protein isolate composite membrane(CSM)tube to construct a third generation of nerve regeneration conduit,CSM-GFD.Then this CSM-GFD conduit was applied to repair a 15-mm long defect of sciatic nerve in a rat model.After 12 week post implant surgery,at histologic level,we found CSM-GFD conduit could regenerate nerve tissue like neuron and Schwann like nerve cells and myelinated nerve fibers.At physical level,CSM-GFD achieved functional recovery assessed by a sciatic functional index study.In both levels,CSM-GFD performed like what gold standard,the nerve autograft,could do.Further,we unveiled that almost all newly formed nerve tissue at defect site was originated from the direct differentiation of exogeneous DPSCs in CSM-GFD.In conclusion,we claimed that this third-generation nerve regeneration conduit,CSM-GFD,could be a promising tissue engineering approach to replace the conventional nerve autograft to treat the large gap defect in peripheral nerve injuries.Lihua Luo Yan He Ling Jin Yanni Zhang Fernando P.Guastaldi Abdullkhaleg A.Albashari Fengting Hu Xiaoyan Wang Lei Wang Jian Xiao Lingli Li Jianming Wang Akon Higuchi Qingsong Ye 2021Bioactive Materials2021,6,3:11
5Research and application of wireless sensor network technology in power transmission and distribution system显示文摘Power is an important part of the energy industry,relating to national economy and people’s livelihood,and it is of great significance to ensure the security and stability in operation of power transmission and distribution system.Based on Wireless Sensor Network technology(WSN)and combined with the monitoring and operating requirements of power transmission and distribution system,this paper puts forward an application system for monitoring,inspection,security,and interactive service of layered power transmission and distribution system.Furthermore,this paper demonstrates the system verification projects in Wuxi,Jiangsu Province and Lianxiangyuan Community in Beijing,which have been widely used nationwide.Jianming Liu Ziyan Zhao Jerry Ji Miaolong Hu 2020Intelligent and Converged Networks2020,1,2:7
6Study on the sedimentation capability of bauxite flotation concentrate显示文摘The sedimentation behaviors of bauxite flotation concentrates were investigated at different pH values and flocculant dosages. The effects of three types of flocculants (cationic,anionic and non-ionic polyacrylamide flocculants) as well as the molecular weight of anionic flocculants on the sedimentation of concentrate were studied. It is shown from the experimental results that at the pH 7.0,best sedimentation capability is reached when anionic polyacrylamide flocculant (molecular weight 14 million) is added and the optimal dosage is 30 g/t.Chen Jianming Liu Sanjun Qin Wenqing Chen Zhiyou Hu Yuehua 2008Engineering Sciences2008,6,4:5
7Reliability Evaluation of IEEE 802.11p-Based Vehicle-to-Vehicle Communication in an Urban Expressway显示文摘IEEE 802.11p/DSRC(Dedicated Short Range Communication) is considered to be a promising wireless communication standard for enhancing transportation safety and efficiency. However, IEEE 802.11p-based Vehicleto-Vehicle(V2V) communication is still unreliable because of the complicating factors of high vehicle speed and complex radio environments. In this paper, we performed a data-based evaluation of V2 V communication reliability,using real-world measurements in a typical urban expressway in Beijing. With respect to the characteristics of the urban expressway and our experimental data, we found road slope and traffic density to be the major environmental factors having a significant impact on the V2 V communication's Line-Of-Sight(LOS) conditions. On the basis of these two factors, we propose a fuzzy classification method for the LOS conditions, and separate the realtime communication environments into different LOS cases. For each LOS case, we quantify the metrics as received signal strength indication, packet delivery rate, and communication latency. The results reveal that the communication reliability in urban expressways is very unstable because of the changing LOS conditions. This study provides a useful reference for the IEEE 802.11p-based cooperative systems in urban expressways.Yizhi Wang Jianming Hu Yi Zhang Chao Xu 2015Tsinghua Science and Technology2015,20,4:5
8Introduction of fluorin into PBO polymer chains:Toward higher thermal stability and lower dielectric constant显示文摘A series of novel fluorinated benzoxazole polymers (6FPBO's) with high thermal stability and low dielectric constant were synthesized by copolymerization of 1,3-diamino-4, 6-dihydroxybenzene dihy-drochloride (DAR), 1,4-benzenedicarboxylic acid (PTA) and various amount of 4'4- (hexafluoroisopro-pylidene) bis (benzoic acid) (BIS-B-AF) in the medium of polyphosphoric acid (PPA). 6FPBO fibers were then obtained via dry-jet wet-spinning technique and characterized by means of Fourier transform infrared (FTIR) spectra, thermogravimetric analysis (TGA), single fiber tensile testing machine and scanning electron microscopy (SEM). FTIR spectrum of 6FPBO fibers indicated that the fluorine groups had been incorporated into PBO molecular chains successfully. TGA curves revealed that 6FPBO fibers possessed high thermal stability just as pure PBO fibers. Moreover, dielectric constant spectrum of 6FPBO exhibited that the polymers had low dielectric constant, especially in the range of high- frequency.ZHANG Tao HU DaYong JIN JunHong YANG ShengLin LI Guang JIANG JianMing 2009Science China(Technological Sciences)2009,52,1:4
9Swarm Intelligence Algorithm Inspired by Route Choice Behavior显示文摘Daxin Tian Junjie Hu Zhengguo Sheng Yunpeng Wang Jianming Ma Jian Wang 2016Journal of Bionic Engineering2016,13,4:4
10PhaseⅠdose-escalation and expansion study of PARP inhibitor,fluzoparib(SHR3162),in patients with advanced solid tumors显示文摘Objective:Fluzoparib(SHR3162)is a novel,potent poly(ADP-ribose)polymerases(PARP)1,2 inhibitor that showed anti-tumor activity in xenograft models.We conducted a phaseⅠ,first-in-human,dose-escalation and expansion(D-Esc and D-Ex)trial in patients with advanced solid cancer.Methods:This was a 3+3 phaseⅠD-Esc trial with a 3-level D-Ex at 5 hospitals in China.Eligible patients for DEsc had advanced solid tumors refractory to standard therapies,and D-Ex enrolled patients with ovarian cancer(OC).Fluzoparib was administered orally once or twice daily(bid)at 11 dose levels from 10 to 400 mg/d.Endpoints included dose-finding,safety,pharmacokinetics,and antitumor activity.Results:Seventy-nine patients were enrolled from March,2015 to January,2018[OC(47,59.5%);breast cancer(BC)(16,20.3%);colorectal cancer(8,10.1%),other tumors(8,10.1%)];48 patients were treated in the D-Esc arm and 31 in the D-Ex arm.The maximum tolerated dose(MTD)was 150 mg bid,with a half-life of 9.14 h.Grade 3/4 adverse events included anemia(7.6%)and neutropenia(5.1%).The objective response rate(ORR)was 30%(3/10)in patients with platinum-sensitive OC and 7.7%(1/13)in patients with BC.Among patients treated with fluzoparib≥120 mg/d,median progression-free survival(m PFS)was 7.2[95%confidence interval(95%CI),1.8-9.3]months in OC,9.3(95%CI,7.2-9.3)months in platinum-sensitive OC,and 3.5(range,2.0-28.0)months in BC.In patients with germline BC susceptibility gene mutation(g BRCAMut)(11/43 OC;2/16 BC),m PFS was 8.9 months for OC(range,1.0-23.2;95%CI,1.0-16.8)and 14 and 28 months for BC(those two patients both also had somatic BRCAMut).Conclusions:The MTD of fluzoparib was 150 mg bid in advanced solid malignancies.Fluzoparib demonstrated single-agent antitumor activity in BC and OC,particularly in BRCAMut and platinum-sensitive OC.Huiping Li Rongrui Liu Bin Shao Ran Ran Guohong Song Ke Wang Yehui Shi Jihong Liu Wenjing Hu Fu Chen Xiaoran Liu Gairong Zhang Chuanhua Zhao Ru Jia Quanren Wang Hope S.Rugo Yifan Zhang Guangze Li Jianming Xu 2020Chinese Journal of Cancer Research2020,32,3:4
11Enzyme-electrolytic degradation of dichloromethane: Efficiency, kinetics and mechanism显示文摘Enzymatic electrolysis cell(EEC)has advantages over microbial electrolysis cell(MEC)due to the needless of microbe inoculation and high-efficiency of enzymatic reaction.In this study,an EEC was first applied to achieve the effective degradation of halogenated organic pollutants and dichloromethane(CH2Cl2)was utilized as a model pollutant.The results indicate that the degradation efficiency of CH2Cl2 after 2 hr reaction in the EEC was almost100%,which was significantly higher than that with enzyme(51.1%)or current(19.0%).The current induced the continuous regeneration of reduced glutathione(GSH),thus CH2Cl2 was degraded under the catalysis of GSH-dependent dehalogenase through stepwise dechlorination,and successively formed monochloromethane(CH3Cl)and methane(CH4).The kinetic result shows that with a current of 15 mA,the maximum specific degradation rate of CH2Cl2(3.77×10-3 hr-1)was increased by 5.7 times.The optimum condition for CH2Cl2 dechlorination was also obtained with pH,current and temperature of 7.0,15 mA and 35°C,respectively.Importantly,this study helps to understand the behavior of enzymes and the fate of halogenated organic pollutants with EEC,providing a possible treatment technology for halogenated organic pollutants.Jianming Yu Meng Wu Yuwei Tang Jiaqi Shi Jun Hu Zhiliang Yu Jianmeng Chen 2019Journal of Environmental Sciences2019,31,12:3
12Optimal Combinations and Variable Departure Intervals for Micro Bus System显示文摘It is becoming increasingly difficult for Chinese citizens to access traditional public transport because of overcrowded community structures. Therefore, novel ideas are required to improve the transport system. In this respect, this study considers the design of a public transport scheduling model for a micro system. The model aims to minimize passenger waiting time and maximize number of passengers one bus carries, by simultaneously optimizing departure intervals and use of traditional and rapid buses. The model is superior to traditional models, as it analyzes the phenomena of vehicle overtaking, vehicle capacity limit, and passenger determination uncertainty.In addition, the model is a sophisticated nonlinear multi-objective optimization problem and contains more than one type of decision variable, therefore two composite algorithms, HPSO and GAPSO, are proposed, which are improvements of the Genetic Algorithm(GA) and Particle Swarm Optimization(PSO). These two algorithms are compared to the classical GA with respect to stability and effect, and the results show them to be strong in both respects. In addition, the simultaneous optimization method has evident advantages compared to single-method optimizations.Jiaoyang Li Jianming Hu Yi Zhang 2017Tsinghua Science and Technology2017,22,3:3
13Biosynthesis of clinically used antibiotic fusidic acid and identification of two short-chain dehydrogenase/reductases with converse stereoselectivity显示文摘Fusidic acid is the only fusidane-type antibiotic that has been clinically used. However,biosynthesis of this important molecule in fungi is poorly understood. We have recently elucidated the biosynthesis of fusidane-type antibiotic helvolic acid, which provides us with clues to identify a possible gene cluster for fusidic acid(fus cluster). This gene cluster consists of eight genes, among which six are conserved in the helvolic acid gene cluster except fusC1 and fusB1. Introduction of the two genes into the Aspergillus oryzae NSAR1 expressing the conserved six genes led to the production of fusidic acid. A stepwise introduction of fusC1 and fusB1 revealed that the two genes worked independently without a strict reaction order. Notably, we identified two short-chain dehydrogenase/reductase genes fusC1 and fusC2 in the fus cluster, which showed converse stereoselectivity in 3-ketoreduction. This is the first report on the biosynthesis and heterologous expression of fusidic acid.Zhiqin Cao Shaoyang Li Jianming Lv Hao Gao Guodong Chen Takayoshi Awakawa Ikuro Abe Xinsheng Yao Dan Hu 2019Acta Pharmaceutica Sinica B2019,9,2:3
14Simulation of the Accumulation Process of Biogenic Gas Hydrates in the Shenhu Area of Northern South China Sea显示文摘Objective Previous work has largely discussed the relations between sediment structures and accumulation of gas hydrates in the Shenhu area of South China Sea,but has not documented why the gas hydrates occurred at the seafloor topographic highs.Many gas hydrate exploration examples abroad also indicate that the saturation ofLIAO Jing GONG Jianming Lü Wanjun WU Nengyou YUE Baojing LUAN Xiwu HU Gaowei 2016Acta Geologica Sinica(English Edition)2016,90,6:3
15Adaptive Iterative Learning Control for a Class of Nonlinear Time-varying Systems with Unknown Delays and Input Dead-zone显示文摘This paper presents an adaptive iterative learning control(AILC) scheme for a class of nonlinear systems with unknown time-varying delays and unknown input dead-zone.A novel nonlinear form of dead-zone nonlinearity is presented.The assumption of identical initial condition for iterative learning control(ILC) is removed by introducing boundary layer function.The uncertainties with time-varying delays are compensated for by using appropriate Lyapunov-Krasovskii functional and Young’s inequality.Radial basis function neural networks are used to model the time-varying uncertainties.The hyperbolic tangent function is employed to avoid the problem of singularity.According to the property of hyperbolic tangent function,the system output is proved to converge to a small neighborhood of the desired trajectory by constructing Lyapunov-like composite energy function(CEF) in two cases,while keeping all the closedloop signals bounded.Finally,a simulation example is presented to verify the effectiveness of the proposed approach.Jianming Wei Yunan Hu Meimei Sun 2014IEEE/CAA Journal of Automatica Sinica2014,1,3:3
16IMPROVED ALGORITHM FOR MINIMUM DATA AGGREGATION TIME PROBLEM IN WIRELESS SENSOR NETWORKS显示文摘Wireless sensor networks promise a new paradigm for gathering data via collaborationamong sensors spreading over a large geometrical region.Many applications impose delay requirementsfor data gathering and ask for time-efficient schedules for aggregating sensed data and sending tothe data sink.In this paper,the authors study the minimum data aggregation time problem undercollision-free transmission model.In each time round,data sent by a sensor reaches all sensors withinits transmission range,but a sensor can receive data only when it is the only data that reaches thesensor.The goal is to find the method that schedules data transmission and aggregation at sensorsso that the time for all requested data to be sent to the data sink is minimal.The authors propose anew approximation algorithm for this NP-hard problem with guaranteed performance ratio (7Δ)/(Iog_2|S|)+c,which significantly reduces the current best ratio of Δ-1,where S is the set of sensors containingsource data,Δ is the maximal number of sensors within the transmission range of any sensor,and c is aconstant.The authors also conduct extensive simulation,the obtained results justify the improvementof proposed algorithm over the existing one.Jianming ZHU Xiaodong HU 2008Journal of Systems Science & Complexity2008,21,4:2
17An Exploration on Adaptive Iterative Learning Control for a Class of Commensurate High-order Uncertain Nonlinear Fractional Order Systems显示文摘This paper explores the adaptive iterative learning control method in the control of fractional order systems for the first time. An adaptive iterative learning control(AILC) scheme is presented for a class of commensurate high-order uncertain nonlinear fractional order systems in the presence of disturbance.To facilitate the controller design, a sliding mode surface of tracking errors is designed by using sufficient conditions of linear fractional order systems. To relax the assumption of the identical initial condition in iterative learning control(ILC), a new boundary layer function is proposed by employing MittagLeffler function. The uncertainty in the system is compensated for by utilizing radial basis function neural network. Fractional order differential type updating laws and difference type learning law are designed to estimate unknown constant parameters and time-varying parameter, respectively. The hyperbolic tangent function and a convergent series sequence are used to design robust control term for neural network approximation error and bounded disturbance, simultaneously guaranteeing the learning convergence along iteration. The system output is proved to converge to a small neighborhood of the desired trajectory by constructing Lyapnov-like composite energy function(CEF)containing new integral type Lyapunov function, while keeping all the closed-loop signals bounded. Finally, a simulation example is presented to verify the effectiveness of the proposed approach.Jianming Wei Youan Zhang Hu Bao 2018IEEE/CAA Journal of Automatica Sinica2018,5,2:2
18Transcriptome and Regulatory Network Analyses of CD19-CAR-T Immunotherapy for B-ALL显示文摘Chimeric antigen receptor (CAR) T cell therapy has exhibited dramatic anti-tumor effi-cacy in clinical trials. In this study,we reported the transcriptome profiles of bone marrow cells in four B cell acute lymphoblastic leukemia (B-ALL) patients before and after CD19-specific CAR-T therapy. CD19-CAR-T therapy remarkably reduced the number of leukemia cells,and three patients achieved bone marrow remission (minimal residual disease negative). The efficacy of CD19-CAR-T therapy on B-ALL was positively correlated with the abundance of CAR and immune cell subpopulations,e.g.,CD8+T cells and natural killer (NK) cells,in the bone marrow. Additionally,CD19-CAR-T therapy mainly influenced the expression of genes linked to cell cycle and immune response pathways,including the NK cell mediated cytotoxicity and NOD-like recep-tor signaling pathways. The regulatory network analyses revealed that microRNAs (e.g.,miR-148a-3p and miR-375),acting as oncogenes or tumor suppressors,could regulate the crosstalk between the genes encoding transcription factors (TFs,e.g.,JUN and FOS) and histones (e.g.,HIST1H4A and HIST2H4A) involved in CD19-CAR-T therapy. Furthermore,many long non-coding RNAs showed a high degree of co-expression with TFs or histones (e.g.,FOS and HIST1H4B) and were associated with immune processes. These transcriptome analyses provided important clues for fur-ther understanding the gene expression and related mechanisms underlying the efficacy of CAR-T immunotherapy.Qiong Zhang Hui Hu Si-Yi Chen Chun-Jie Liu Fei-Fei Hu Jianming Yu Yaohui Wu An-Yuan Guo 2019Genomics, Proteomics & Bioinformatics2019,17,2:2
19Effect of coagulation temperature on structures and properties of poly(p-phenylene benzobisoxazole) (DHPBO) fibers during dry-jet wet-spinning process显示文摘The effect of coagulation temperature on the morphology, microstructures and mechanical properties of dihydroxy poly(p-phenylene benzobisoxazole) (DHPBO) fibers was investigated during dry-jet wet- spinning process, in which the coagulation bath concentration and drawn ratio were kept as 10 wt% of PPA in water and 1.7, respectively. The structures and mechanical properties of the as-spun DHPBO fibers were characterized by FTIR, XRD, SEM, and single fiber tensile testing. The results indicated that in PPA/H2O coagulation system, when the coagulation temperature was 25℃, highly crystallized DHPBO as-spun fibers possessing fine crystallites, circular and smooth morphology, and excellent mechanical properties could be achieved.Tao Zhang JunHong Jin DaYong Hu ShengLin Yang Guang Li JianMing Jiang 2009Science China(Technological Sciences)2009,52,4:2
202021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5hubwvbf5fnn0c6ucq.ffgz.tsg.suse.edu.cn/A978).Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun 2022Chinese Medical Journal2022,,8:2
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