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| 1 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 2 | Abrasive Waterjet Machining Simulation by Coupling Smoothed Particle Hydrodynamics /Finite Element Method显示文摘In dealing with abrasive waterjet machining(AWJM) simulation,most literatures apply finite element method(FEM) to build pure waterjet models or single abrasive particle erosion models.To overcome the mesh distortion caused by large deformation using FEM and to consider the effects of both water and abrasive,the smoothed particle hydrodynamics(SPH) coupled FEM modeling for AWJM simulation is presented,in which the abrasive waterjet is modeled by SPH particles and the target material is modeled by FEM.The two parts interact through contact algorithm.Utilizing this model,abrasive waterjet with high velocity penetrating the target materials is simulated and the mechanism of erosion is depicted.The relationships between the depth of penetration and jet parameters,including water pressure and traverse speed,etc,are analyzed based on the simulation.The simulation results agree well with the existed experimental data.The mixing multi-materials SPH particles,which contain abrasive and water,are adopted by means of the randomized algorithm and material model for the abrasive is presented.The study will not only provide a new powerful tool for the simulation of abrasive waterjet machining,but also be beneficial to understand its cutting mechanism and optimize the operating parameters. | WANG Jianming GAO Na GONG Wenjun | 2010 | Chinese Journal of Mechanical Engineering2010，23，5： | 10 |
| 3 | Effects of aging treatment on microstructure and mechanical properties of Cr25Ni35Nb and Cr35Ni45Nb furnace tube steel显示文摘Cr25Ni35Nb and Cr35Ni45Nb alloys are usually used in the ethylene cracking furnaces.However,premature failure of furnace tubes often occurs ahead of design life due to elevated temperature exposure conditions (1050-1100 ℃) and aggressive service environment.Effects of exposure temperature and time on microstructure and mechanical properties of Cr25Ni35Nb and Cr35Ni45Nb steel at aging temperature (1200 ℃) with various exposure time were simulated different service times at 1050 ℃.Change of mechanical properties at room temperature and elevated temperature (900 ℃) of the aged Cr25Ni35Nb and Cr35Ni45Nb steel were investigated.Under exposure at 1200 ℃,ultimate tensile and yield strength,elongation of Cr35Ni45Nb steel increase initially and then decrease,however,strength and ductility of Cr25Ni35Nb steel decrease with aging time increasing.Large amount of fine secondary carbide particles precipitated and dispersed in matrix of Cr35Ni45Nb steel,which increased strength and ductility for dispersion strengthening.However,the effect of the dispersion strengthening is weakened by needle-like secondary carbides.Strength and ductility decreased with fine secondary carbide particles growing.For Cr25Ni35Nb steel,few fine secondary carbide particles precipitated and dispersed in the matrix,and needle-like secondary carbides generated in the matrix,which causes strength and ductility decreased with aging time increasing. | Limin SHEN Jianming GONG Yong JIANG Luyang GENG | 2011 | Acta Metallurgica Sinica(English Letters)2011，24，3： | 8 |
| 4 | Corrosion performance of Al–Al2O3 cold sprayed coatings on mild carbon steel pipe under thermal insulation显示文摘This paper focused on the corrosion resistance of cold spray Al–Al_2O_3composite coatings used on carbon steel pipe surfaces under thermal insulation. Al–Al_2O_3coatings were produced on the carbon steel pipe surface by cold spray(CS) technology. Experimental apparatus was built to test the corrosion resistance of coatings beneath mineral wool insulation under isothermal, thermal cycling and wet/dry conditions. The results showed that when α-Al_2O_3 was added in spraying powder, the coating could obtain higher hardness and a denser microstructure. From corrosionunder-insulation(CUI) tests, Al–Al_2O_3CS coatings were proven to be efficient in protecting carbon steel pipe from CUI mainly owning to lamellar microstructures of coatings. There was no evidence to show that α-Al_2O_3 might bring any negative effect on corrosion resistance. Al–Al_2O_3CS coatings were sensitive to the chloride ion concentration. When these coatings were exposed to higher concentrations of NaC l, the coating's exhibited faster degradation. | Xiaomin Bai Jianqun Tang Jianming Gong Xiaoliang Lü | 2017 | Chinese Journal of Chemical Engineering2017，25，4： | 7 |
| 5 | Winter wheat mapping using a random forest classifier combined with multi-temporal and multi-sensor data显示文摘Wheat is a major staple food crop in China.Accurate and cost-effective wheat mapping is exceedingly critical for food production management,food security warnings,and food trade policy-making in China.To reduce confusion between wheat and non-wheat crops for accurate growth stage wheat mapping,we present a novel approach that combines a random forest(RF)classifier with multi-sensor and multi-temporal image data.This study aims to(1)determine whether an RF combined with multi-sensor and multi-temporal imagery can achieve accurate winter wheat mapping,(2)to find out whether the proposed approach can provide improved performance over the traditional classifiers,and(3)examine the feasibility of deriving reliable estimates of winter wheat-growing areas from medium-resolution remotely sensed data.Winter wheat mapping experiments were conducted in Boxing County.The experimental results suggest that the proposed method can achieve good performance,with an overall accuracy of 92.9%and a kappa coefficient(κ)of 0.858.The winter wheat acreage was estimated at 33,895.71 ha with a relative error of only 9.3%.The effectiveness and feasibility of the proposed approach has been evaluated through comparison with other image classification methods.We conclude that the proposed approach can provide accurate delineation of winter wheat areas. | Jiantao Liu Quanlong Feng Jianhua Gong Jieping Zhou Jianming Liang Yi Li | 2018 | International Journal of Digital Earth2018，11，8： | 3 |
| 6 | Research on acoustic emission monitoring of pitting corrosion on 304 stainless steel显示文摘In order to study acoustic emission(AE) characteristics of pitting corrosion on 304 stainless steel under higher than normal temperature,pitting corrosion process of 304 stainless steel in 6%ferric chloride solution at 70°was monitored by AE technology.Conventional parameter-based approach and signal-based analysis were combined to deal with recorded AE signals,and micrographic observation was performed for further verification.The results showed that AE hit and energy increased gradually with time and reached the peak at certain time, and then declined and maintained a stable condition.Signal waveform was mainly composed of low-frequency(< 100 kHz) flexural wave with larger amplitude and energy and high-frequency (> 100 kHz) expansion wave with lower amplitude and energy.The research results have some certain significance for AE monitoring of pitting corrosion on 304 stainless steel under higher than normal temperature. | ZHANG Zhongzheng GONG Jianming LIANG Hua | 2013 | Chinese Journal of Acoustics2013，32，1： | 3 |
| 7 | Simulation of the Accumulation Process of Biogenic Gas Hydrates in the Shenhu Area of Northern South China Sea显示文摘Objective Previous work has largely discussed the relations between sediment structures and accumulation of gas hydrates in the Shenhu area of South China Sea,but has not documented why the gas hydrates occurred at the seafloor topographic highs.Many gas hydrate exploration examples abroad also indicate that the saturation of | LIAO Jing GONG Jianming Lü Wanjun WU Nengyou YUE Baojing LUAN Xiwu HU Gaowei | 2016 | Acta Geologica Sinica(English Edition)2016，90，6： | 3 |
| 8 | Defect passivation by nontoxic biomaterial yields 21% efficiency perovskite solar cells显示文摘Defect passivation is one of the most important strategies to boost both the efficiency and stability of perovskite solar cells(PSCs).Here,nontoxic and sustainable forest-based biomaterial,betulin,is first introduced into perovskites.The experiments and calculations reveal that betulin can effectively passivate the uncoordinated lead ions in perovskites via sharing the lone pair electrons of hydroxyl group,promoting charge transport.As a result,the power conversion efficiencies of the p-i-n planar PSCs remarkably increase from 19.14%to 21.15%,with the improvement of other parameters.The hydrogen bonds of betulin lock methylamine and halogen ions along the grain boundaries and on the film surface and thus suppress ion migration,further stabilizing perovskite crystal structures.These positive effects enable the PSCs to maintain 90%of the initial efficiency after 30 days in ambient air with 60%±5%relative humidity,75%after 300 h aging at 85℃,and 55%after 250 h light soaking,respectively.This work opens a new pathway for using nontoxic and low-cost biomaterials from forest to make highly efficient and stable PSCs. | Shaobing Xiong Tianyu Hao Yuyun Sun Jianming Yang Ruru Ma Jiulong Wang Shijing Gong Xianjie Liu Liming Ding Mats Fahlman Qinye Bao | 2021 | Journal of Energy Chemistry2021，30，4： | 2 |
| 9 | Efficacy and Safety of Cinitapride in the Treatment of Mild to Moderate Postprandial Distress Syndrome–predominant Functional Dyspepsia显示文摘 | Yiqi Du Tun Su Xinmiao Song Jun Gao Duowu Zou Changjing Zuo Weifen Xie Bangmao Wang Zhiguang Zhang Jianming Xu Dean Tian Hesheng Luo Zhenyu Zhang Shaofeng Wang Jianping Chen Jizhong Guo Lei Gong Yanbing Ding Zhaoshen Li | 2014 | Journal of Clinical Gastroenterology2014，，4： | 1 |
| 10 | Molecular diagnosis and treatment of meningiomas:an expert consensus(2022)显示文摘Meningiomas are the most common primary intracranial neoplasm with diverse pathological types and complicated clinical manifestations.The fifth edition of the WHO Classification of Tumors of the Central Nervous System(WHO CNS5),published in 2021,introduces major changes that advance the role of molecular diagnostics in meningiomas.To follow the revision of WHO CNS5,this expert consensus statement was formed jointly by the Group of Neuro-Oncology,Society of Neurosurgery,Chinese Medical Association together with neuropathologists and evidence-based experts.The consensus provides reference points to integrate key biomarkers into stratification and clinical decision making for meningioma patients. | Jiaojao Deng Lingyang Hua Liuguan Bian Hong Chen Ligang Chen Hongwei Cheng Changwu Dou Dangmurenjiapu Geng Tao Hong Hongming Ji Yugang Jiang Qing Lan Gang Li Zhixiong Liu Songtao Qi Yan Qu Songsheng Shi Xiaochuan Sun Hajun Wang Yongping You Hualin Yu Shuyuan Yue Jianming Zhang Xiaohua Zhang Shuo Wang Ying Mao Ping Zhong Ye Gong Group of Neuro-Oncology Society of Neurosurgery Chinese Medical Association | 2022 | Chinese Medical Journal2022，135，16： | 1 |
| 11 | The Effect of Filler Metal Thickness on Residual Stress and Creep for Stainless-Steel Plate-Fin Structure显示文摘 | Jiang Wenchun Gong Jianming Chen Hu | 2008 | International Journal of Pressure Vessels and Piping2008，85，8： | 1 |
| 12 | Gas Sources for Natural Gas Hydrates in the Permafrost Region of the Qilian Mountains显示文摘Objective As a new type of gas hydrates,the natural gas hydrates in the perfost region of the Qilian Mountains are characterized by their shallow burial depth,welldeveloped coal seam,high content of heavy hydrocarbons and multiple sets of mature and over-mature source rocks.Gas sources of these gas hydrates in the study area include coal-type gas and oil-type gas.However,there is | JIANG Yubo GONG Jianming | 2016 | Acta Geologica Sinica(English Edition)2016，90，5： | 1 |
| 13 | Modelling of temperature field and residual stress of vacuum brazing for stainless steel plate-fin structure 显示文摘 | Jiang Wenchun Gong Jianming Tu Shandong | 2009 | Journal of Materials Processing Technology In Press2009，209，2： | 1 |
| 14 | The influence of long-term aging on microstructures and static mechanical properties of P92 steel at room temperature显示文摘 | Xiaofeng Guo Jianming Gong Yong Jiang Dongsong Rong | 2013 | Materials Science & Engineering A2013，，： | 1 |
| 15 | Chemical aging of the silicone rubber in a simulated and three accelerated proton exchange membrane fuel cell environments 显示文摘 | LI Guo TAN Jinzhu GONG Jianming | 2012 | Journal of Power Sources2012，，： | 1 |
| 16 | Effect of brazing tem- perature on tensile strength and microstructure for a stainless steel plate-fin structure 显示文摘 | Jiang Wenchun Gong Jianming Tu S T | 2011 | Materials and Design2011，32，2： | 1 |
| 17 | Discovery of novel 4-(2-fluorophenoxy)quinoline derivatives bearing 4-oxo-1,4-dihydrocinnoline-3-carboxamide moiety as c-Met kinase inhibitors显示文摘 | Sai Li Yanfang Zhao Kewen Wang Yali Gao Jianming Han Bingbing Cui Ping Gong | 2013 | Bioorganic & Medicinal Chemistry2013，，11： | 1 |
| 18 | Experimental and simulated characterization of creep behavior of P92 steel with prior cyclic loading damage显示文摘The effect of prior cyclic loading on creep behavior of P92 steel was investigated. Creep tests on prior cyclic loading exposure specimens were performed at 650?C and 130 MPa. In order to clarify the influence of prior cyclic loading on creep behavior, optical microscope, scanning electron microscope and transmission electron microscope were used. Experimental results indicate that the prior cyclic loading degrades the creep strength significantly. However, the degradation tends to be saturated with further increase in prior cyclic loading. From the view of microstructural evolution, the recovery of martensite laths takes place during prior cyclic loading exposure. This facilitates the dislocation movement during the following creep process. Therefore, premature rupture of creep test occurs. Additionally, saturated behavior of degradation can be attributed to the near completed recovery of martensite laths. Based on the effect of prior cyclic loading, a newly modified Hayhurst creep damage model was proposed to consider the prior cyclic loading damage. The main advantage of the proposed model lies in its ability to directly predict creep behavior with different levels of prior cyclic loading damage. Comparison of the predicted and experimental results shows that the proposed model can give a reasonable prediction for creep behavior of P92 steel with different level of prior cyclic loading damage. | Wei Zhang Xiaowei Wang Jianming Gong Yong Jiang Xin Huang | 2017 | Journal of Materials Science & Technology2017，33，12： | 1 |
| 19 | The effectof filler metal thickness on residual stress and creep for stainless-steel plate-fin structure显示文摘 | JIANG WENCHUN GONG JIANMING CHEN HU | 2008 | International Journal of Pressure Vessels and Piping2008，85，8： | 1 |
| 20 | Damage prediction of HP40Nb steel with coupled creep and carburization based on the continuum damage mechanics显示文摘HP40Nb steel,used as a candidate material for ethylene cracking furnace tube,suffers creep and carburization damage from the complex environment of high temperature,high carbon potential and low oxygen partial pressure,and they lead to failure of the furnace tubes ahead of designed life.In order to investigate damage evolution under the complex condition,coupled creep damage and carburization damage constitutive equations were developed according to continuum damage mechanics theory.Based on the finite element ABAQUS code,user subroutines were developed for analyzing damage evolution of ethylene furnace tube under the action of coupled creepcarburization.The results show that carburization accelerates the damage process dramatically,damage value reaches the critical value along the inner surface after serving for 75,000 h under the action of creep-carburization,meanwhile the damage value is only 0.53 along the outer surface after operating the same time under the action of creep alone,which means that microcracks are generated along the inner surface under the action of coupled creep-carburization,fracture begins along the outer surface of tube under the action of creep alone. | Limin SHEN Jianming GONG Yong JIANG Luyang GENG | 2012 | Acta Metallurgica Sinica(English Letters)2012，25，4： | 1 |
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