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| 1 | Re-Os and U-Pb Geochronology of the Erlihe Pb-Zn Deposit,Qinling Orogenic Belt,Central China,and Constraints on Its Deposit Genesis显示文摘The Erlihe Pb-Zn deposit is an important mine of the Pb-Zn metallogenic zone in the South Qinling Orogen.It has been considered a sedimentary exhalative deposit in previous investigations because the ore body occurs concordantly at the transitional location of an upright fold.Re and Os isotopic analyses for paragenetic pyrites with sphalerite and galena from the ore body have been used to determine the timing of mineralization and to trace the source of metallogenic materials.The Re-Os isotopic data of four pyrite samples construct an isochron,yielding a weighted average age of 226±17 Ma(mean square weighted deviation=1.7),which is considered the main mineralization age.A dioritic porphyrite vein sample,showing weaker mineralization,was also dated using the SHRIMP zircon UPb isotopic method to constrain the youngest metallogenic age of the ore deposit,because it distributes along a group of tensional joints cutting not only the upright fold in the deposit field,but also the main ore bodies.The dioritic porphyrite sample yields a weighted mean ^(206)Pb/^(238)U age of 221±3 Ma,which is slightly younger than the Re-Os isotopic isochron age of the pyrites,considered as the upper age limit of the mineralization,namely the ending age of the mineralization.The Os isotopic compositions of sulfide minerals distribute within a range between Os isotopic compositions of the crust and the mantle, indicating that the ore deposit can be derived from magma-related fluid,and the metallogenic materials are most likely derived from the mixing source of the crust and the mantle.The Erlihe Pb-Zn deposit and associated dioritic porphyrite vein,important records of Qinling tectonic-magmatism-mineralization activities,were formed during the Triassic collisional orogeny processes. | ZHANG Fan LIU Shuwen LI Qiugen SUN Yali WANG Zongqi YAN Quanren YAN Zhen | 2011 | Acta Geologica Sinica(English Edition)2011，85，3： | 30 |
| 2 | Ages of the Laocheng Granitoids and Crustal Growth in the South Qinling Tectonic Domain,Central China:Zircon U-Pb and Lu-Hf Isotopic Constraints显示文摘Laocheng granitoid pluton 位于 Qinling erogenic 带的南方 Qinling 构造领域,南部的 Shaanxi 省,并且由石英闪长岩, granodiorite 和 monzogranite 主要组成。LA-ICP-MS 锆石 U-Pb 与阴极射线发光图象一起,同位素的标明日期表明石英闪长岩和 granodiorite 是从 220 妈的 emplaced 到 216 妈,当 monzogranite 是在 210 妈的 emplaced 时。在原处,锆石 Hf 同位素的分析证明从 8.1 的石英闪长岩和到 +1.3 的 granodiorite 范围的 Hf (t)价值,和单个阶段的 Hf 从 809 妈为年龄建模到 1171 妈,当 monzogranite 的 Hf (t)价值是 14.5 到 +16.7 和单个阶段的 Hf 时,从 189 妈为年龄建模到 1424 妈。这些 Hf 同位素的特征表明石英闪长岩, granodiorite 和 monzogranite 从混合从弄空的披风和更低的大陆的部分融化导出的岩浆被形成外壳的材料,并且在 Neoproterozoic ( 800 妈)和 Indosinian ( 210 妈)期间有大陆人外壳生长的二个阶段分别地,时代在 Qinling orogrnic 的南方 Qinling 构造领域系上带子,华中。 | YANG Pengtao LIU Shuwen LI Qiugen ZHANG Fan WANG Zongqi WANG Dongsheng WANG Ruiting YAN Quanren YAN Zhen | 2011 | Acta Geologica Sinica(English Edition)2011，85，4： | 15 |
| 3 | Zircon U-Pb and geochemical analyses for leucocratic intrusive rocks in pillow lavas in the Danfeng Group,north Qinling Mountains,China显示文摘Field observation showed that there are many irregular leucocratic intrusive rocks in pillow lavas in the Danfeng Group in the Xiaowangjian area, north Qinling orogenic belt. Photomicrographs indicated that the protoliths of those altered leucocratic intrusive rocks are dioritic rocks. Geochemical analyses showed that pillow lavas have a range of SiO2 from 47.35% to 51.20%, low abundance of TiO2 from 0.97% to 1.72%, and percentages of MgO (MgO#=41―49). Chondrite-normalized REE patterns of pillow lavas are even, indicative of a weak differentiation between LREE and HREE (La/YbN=1.52―0.99). N-MORB-normalized trace element abundances showed that pillow lavas are enriched in incompatible elements (e.g., K, Rb, and Ba). Leucocratic intrusive rocks in pillow lavas have a wide range of SiO2 from 53.85%―67.20%, low abundances of TiO2 from 0.51%―1.10%, and MgO (MgO#=40―51), and higher percentages of Al2O3 (13.32%―16.62%) and concentration of Sr (342-539 μg/g), ratios of Na2O/K2O (2―7) and Sr/Y (17―28). Chondrite-normalized REE patterns of leucocratic intrusive rocks showed highly differentiation between LREE and HREE (La/YbN=12.26―19.41). N-MORB-normalized trace element abundances showed that leucocratic intrusive rocks are enriched in incompatible elements (e.g., K, Rb, and Ba), and significantly depleted in HFSE (e.g., Nb, Ta, Zr and Ti), indicative of a relationship to subduction. Isotopically, leucocratic intrusive rocks have a similar εNd(t) (+7.45―+13.14) to that of MORB (+8.8―+9.7), which indicates that those leucocratic intrusive rocks sourced from depleted mantle most likely. SHRIMP U-Pb analyses for zircon showed that those leucocratic intrusive rocks were formed at 442±7 Ma, yielding an age of subduction in the early Paleozoic in the north Qinling orogenic belt. | Yan QuanRen Chen JunLu Wang ZongQi Yan Zhen Wang Tao Li QiuGen Zhang ZongQing Jiang ChunFa | 2008 | Science China Earth Sciences2008，51，2： | 14 |
| 4 | Efficacy of platinum in advanced triple-negative breast cancer with germline BRCA mutation determined by next generation sequencing显示文摘Objective:To compare the efficacy of platinum-and non-platinum-based regimens as first-line treatment for advanced triple-negative breast cancer(TNBC)and analyze the relationship between their efficacy and BRCA gene status.Methods:Retrospectively analyze clinical data of 220 patients diagnosed pathologically with advanced TNBC and treated at the Department of Breast Oncology,Peking University Cancer Hospital from 2013 to 2018 and evaluate the efficacy of chemotherapy.A total of 114 patients had BRCA1/2 gene tested by next generation sequencing(NGS)using peripheral blood,and we analyzed the correlation between their efficacy and BRCA1/2 gene status.Results:Non-platinum-based chemotherapy(NPCT)was administered to 129 and platinum-based chemotherapy(PBCT)to 91 study patients.The clinical benefit rate(CBR)and median progression-free survival(PFS)were not statistically different between NPCT and PBCT groups.The median overall survival(OS)was 30.0 and 22.5 months for PBCT and NPCT group,respectively[P=0.090,hazard ratios(HR)=0.703].BRCA status was assessed in 114 patients,14 of whom had deleterious germline BRCA1/2(g BRCA)mutations(seven in each group).In PBCT group,the CBR was 85.7%and 35.1%for patients with and without deleterious g BRCA mutations,respectively(P=0.039).The median PFS were 14.9 and 5.3 months and median OS were 26.5 and 15.5 months for patients with and without deleterious g BRCA mutations,respectively(P=0.001,P=0.161,respectively).Patients in PBCT group had significantly greater rates of grade 3-4 anemia(5.5%vs.0%)and thrombocytopenia(8.8%vs.0%),whereas palmar-plantar erythrodysesthesia(12.4%vs.0%)and peripheral neuropathy(8.6%vs.1.1%)occurred more frequently in NPCT group.Conclusions:Platinum-based regimens are more effective in patients with deleterious g BRCA mutations,but no difference in patients without BRCA gene mutations,so non-platinum is an option in patients without BRCA gene mutations considering the toxicity and side effect.And we recommend that patients with advanced TNBC should have BRCA gene test. | Nan Wang Kun Li Wenfa Huang Weiyao Kong Xiaoran Liu Weijie Shi Feng Xie Hanfang Jiang Guohong Song Lijun Di Quanren Wang Jianjun Yu Huiping Li | 2020 | Chinese Journal of Cancer Research2020，32，2： | 7 |
| 5 | Indosinian Tectonic Setting of the Southern Yidun Arc: Constraints from SHRIMP Zircon Chronology and Geochemistry of Dioritic Porphyries and Granites显示文摘granitoid 和 dioritic 侵入的一个团在 southernYidun 弧,代表性的 Indosinian 侵入在 Daocheng 县和忧郁在之中包括 Dongco 和 Maxionggougranitoid 侵入被散布深渊侵入进弧火山岩的侵入接近 Xiangcheng 镇。Dongco 和 Maxionggou granitoid 侵入主要在于 ofporphyraceous monzogranites, megacryst monzogranites 和细晶岩花岗石。Xiangcheng hypabyssalintrusions 由 dioritic 斑岩主导地组成。224+-3 妈 and222+-3 妈的虾锆石年龄分别地为 Dongco granitoid 侵入和 Xiangcheng dioriticporphyries 被获得了。Xiongcheng dioritic 斑岩显示出计算碱的 geochemicalfeature,并且被更高的 Sr/Y 描绘比率,使干涸的 Nb, Ta, P 和 Ti,充实的 LILE,和更低的 epsilon_Nd (t)( 建议他们可能从显然是的披风来源岩浆被导出的 =-3.27), 由大陆污染了外壳的材料。然而, Dongco 和 Maxionggougranitoids 与一个 per-metaluminous 特征属于高钾的计算碱的系列,并且被更高的CaO/(西格马 FeO+MgO )和Al_2O_3/(西格马FeO+ MgO )描绘比率,更低( La/Yb ) _n andSr/Y 比率,使干涸的 Nb , Ta , Sr , P 和 Ti ,充实的 LILE ,和很低的 epsilon_Nd (t)( granitoids 可能从主要硬砂岩的大陆地壳材料的部分融化被导出的= -8.10),indicating 。Dongco 和 Maxionggou granitoids 的岩石成因论暗示在 Zongza 大陆块(ZCB ) 和 Yangtze 古地台(WMYZC ) 的西方的边缘之间有一个海洋的外壳。并且海洋的外壳平板在 Indosinian 时代期间向西代替 ducted,生产 anAndes 类型大陆在 WMSCC 的边缘的弧和背弧盆。然后,关上的海洋盆地和左首地侧面的碰撞发生在 ca。在 ZCB 和 WMYZC 之间的 224 马马,引起产生 theDongco 和 Maxionggou 侵入的 granitoid 岩浆的在背弧盆的沉积的部分融化。 | LIU Shuwen WANG Zongqi YAN Quanren LI Qiugen ZHANG Dehui | 2006 | Acta Geologica Sinica(English Edition)2006，80，3： | 6 |
| 6 | PhaseⅠdose-escalation and expansion study of PARP inhibitor,fluzoparib(SHR3162),in patients with advanced solid tumors显示文摘Objective:Fluzoparib(SHR3162)is a novel,potent poly(ADP-ribose)polymerases(PARP)1,2 inhibitor that showed anti-tumor activity in xenograft models.We conducted a phaseⅠ,first-in-human,dose-escalation and expansion(D-Esc and D-Ex)trial in patients with advanced solid cancer.Methods:This was a 3+3 phaseⅠD-Esc trial with a 3-level D-Ex at 5 hospitals in China.Eligible patients for DEsc had advanced solid tumors refractory to standard therapies,and D-Ex enrolled patients with ovarian cancer(OC).Fluzoparib was administered orally once or twice daily(bid)at 11 dose levels from 10 to 400 mg/d.Endpoints included dose-finding,safety,pharmacokinetics,and antitumor activity.Results:Seventy-nine patients were enrolled from March,2015 to January,2018[OC(47,59.5%);breast cancer(BC)(16,20.3%);colorectal cancer(8,10.1%),other tumors(8,10.1%)];48 patients were treated in the D-Esc arm and 31 in the D-Ex arm.The maximum tolerated dose(MTD)was 150 mg bid,with a half-life of 9.14 h.Grade 3/4 adverse events included anemia(7.6%)and neutropenia(5.1%).The objective response rate(ORR)was 30%(3/10)in patients with platinum-sensitive OC and 7.7%(1/13)in patients with BC.Among patients treated with fluzoparib≥120 mg/d,median progression-free survival(m PFS)was 7.2[95%confidence interval(95%CI),1.8-9.3]months in OC,9.3(95%CI,7.2-9.3)months in platinum-sensitive OC,and 3.5(range,2.0-28.0)months in BC.In patients with germline BC susceptibility gene mutation(g BRCAMut)(11/43 OC;2/16 BC),m PFS was 8.9 months for OC(range,1.0-23.2;95%CI,1.0-16.8)and 14 and 28 months for BC(those two patients both also had somatic BRCAMut).Conclusions:The MTD of fluzoparib was 150 mg bid in advanced solid malignancies.Fluzoparib demonstrated single-agent antitumor activity in BC and OC,particularly in BRCAMut and platinum-sensitive OC. | Huiping Li Rongrui Liu Bin Shao Ran Ran Guohong Song Ke Wang Yehui Shi Jihong Liu Wenjing Hu Fu Chen Xiaoran Liu Gairong Zhang Chuanhua Zhao Ru Jia Quanren Wang Hope S.Rugo Yifan Zhang Guangze Li Jianming Xu | 2020 | Chinese Journal of Cancer Research2020，32，3： | 4 |
| 7 | Equilibrium between Clinopyroxene and Host Rocks:Implication for the Magmatic Source and Evolution of Alkali Basalts of the Taohekou Formation in the Northern Daba Mountains,China显示文摘Taohekou 形成是在北 Daba 山在早志留纪形成的一个暴烈沉积的岩层,中国。与主导的碱暗岩和次要的披风捕虏体,暴烈的岩石在 clinopyroxene 斑晶被充实。Geochemical 分析证明从不同岩相的 clinopyroxenes 的作文有一种靠近的亲密关系。从到 amygdaloidal 暗岩的粗糙的斑状的暗岩,枕头或好斑状的暗岩有在 clinopyroxenes (包括的斑晶, microcrystal 和 xenocryst ) 的作文在场的班机关联。所有 clinopyroxenes 除了在披风捕虏体的 clinopyroxenes,显示出踪迹元素和 REE 的一个类似的模式,它显示他们是从血缘的岩浆的连续部分结晶化的可能的产品。然而,在披风捕虏体的 Clinopyroxenes 是披风 xenocrysts。clinopyroxenes 的结晶化压力逐渐地从披风捕虏体,深层的 xenocryst,粗糙的 porphritic 暗岩,枕头或好 porphritic 暗岩减少,到 amygdaloidal 暗岩,它分别地是 1.924.41 GPa, 1.182.36 GPa, 1.132.05 GPa, 0.440.62 GPa 和 0.140.28 GPa。计算结果建议主要岩浆比 68 km 深从一个披风区域发源并且在 3768 km, 1520 km 和 59 km 的间隔停滞在期间它的上升。碱暗岩被增加 Si 的集中描绘并且与 magmatic 进化碱。同时,他们显著地在 LREE 被充实,并且踪迹元素和 REE 的模式类似于海洋的岛暗岩的那些。 | XIANG Zhongjin YAN Quanren YAN Zhen WANG Zongqi WANG Tao ZHANG Yingli QIN Xiaofeng | 2011 | Acta Geologica Sinica(English Edition)2011，85，1： | 3 |
| 8 | Discovery of late Paleozoic fossils in tectonic blocks of the Dabao Formation in the South Qinling Orogenic Belt and their significance显示文摘The Dabao Formation in the South Qinling Orogenic Belt was previously regarded as Ordovician in age and consists of clastic matrix and blocks of siltstone,limestone,chert,and volcanic rocks.However,some Middle Devonian corals,conodonts,and other fossil fragments within the limestone blocks were discovered in recent field investigations,indicating that the Dabao Formation was formed during late Paleozoic.Combined with other regional geological data,the Dabao Formation in the Southern Qinling Orogenic Belt is considered to be a late Paleozoic or early Mesozoic accretionary complex. | WANG Tao WANG ZongQi YAN Zhen YAN QuanRen ZHANG YingLi XIANG ZhongJin | 2011 | Science China Earth Sciences2011，54，7： | 3 |
| 9 | Devonian Sedimentary Environments and Provenance of the Qinling Orogen: Constraints on Late Paleozoic Southward Accretionary Tectonics of the North China Craton显示文摘 | Zhen Yan Zongqi Wang Quanren Yan Tao Wang Wenjiao Xiao Jiliang Li Fanglin Han Junlu Chen Yongcheng Yang | 2006 | International Geology Review2006，，7： | 1 |
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