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您的检索式：作者名="Jianqin Wan"
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| 1 | Punicalagin Inhibits Inflammation in LPS-Induced RAW264.7 Macrophages via the Suppression of TLR4-Mediated MAPKs and NF-κB Activation显示文摘 | Xiaolong Xu Peng Yin Changrong Wan Xinlu Chong Mingjiang Liu Peng Cheng Jiajia Chen Fenghua Liu Jianqin Xu | 2014 | Inflammation2014，，3： | 2 |
| 2 | Overview and preliminary idea for building Digital Earth with Grid computing technology显示文摘Digital Earth is an important field of information technology and a research frontier of geosciences in the 21st century.So far,the Grid computing technique is one of the best solutions for Digital Earth infrastructure.Digital Earth can only be realised through the interaction of people,heterogeneous computing resources,information systems,and instruments,all of which are geographically and organisationally dispersed.Earth observation(EO)includes information acquisition,processing and applications.Information acquisition provides a vast amount of spatial data for building the fabric resource infrastructure.Information processing means that spatial information processing middleware is used with large amounts of secure Grid computing resources for real-time processing of all kinds of spatial data.We are currently working on the development of coremiddleware for EO data processing and applications for the Digital Earth Prototype System,which is available in the Institute of Remote Sensing Applications(IRSA),Chinese Academy of Sciences(CAS)The further results will be available soon. | Yong Xue Huadong Guo Wei Wan Jianqin Wang Ying Luo | 2008 | International Journal of Digital Earth2008，1，2： | 2 |
| 3 | Macrophage membrane-biomimetic adhesive polycaprolactone nanocamptothecin for improving cancer-targeting efficiency and impairing metastasis显示文摘The recent remarkable success and safety of mRNA lipid nanoparticle technology for producing severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)vaccines has stimulated intensive efforts to expand nanoparticle strategies to treat various diseases.Numerous synthetic nanoparticles have been developed for pharmaceutical delivery and cancer treatment.However,only a limited number of nanotherapies have enter clinical trials or are clinically approved.Systemically administered nanotherapies are likely to be sequestered by host mononuclear phagocyte system(MPS),resulting in suboptimal pharmacokinetics and insufficient drug concentrations in tumors.Bioinspired drug-delivery formulations have emerged as an alternative approach to evade the MPS and show potential to improve drug therapeutic efficacy.Here we developed a biodegradable polymer-conjugated camptothecin prodrug encapsulated in the plasma membrane of lipopolysaccharide-stimulated macrophages.Polymer conjugation revived the parent camptothecin agent(e.g.,7-ethyl-10-hydroxy-camptothecin),enabling lipid nanoparticle encapsulation.Furthermore,macrophage membrane cloaking transformed the nonadhesive lipid nanoparticles into bioadhesive nanocamptothecin,increasing the cellular uptake and tumor-tropic effects of this biomimetic therapy.When tested in a preclinical murine model of breast cancer,macrophage-camouflaged nanocamptothecin exhibited a higher level of tumor accumulation than uncoated nanoparticles.Furthermore,intravenous administration of the therapy effectively suppressed tumor growth and the metastatic burden without causing systematic toxicity.Our study describes a combinatorial strategy that uses polymeric prodrug design and cell membrane cloaking to achieve therapeutics with high efficacy and low toxicity.This approach might also be generally applicable to formulate other therapeutic candidates that are not compatible or miscible with biomimetic delivery carriers. | Kangkang Ying Yifeng Zhu Jianqin Wan Chenyue Zhan Yuchen Wang Binbin Xie Peirong Xu Hongming Pan Hangxiang Wang | 2023 | Bioactive Materials2023，，2： | 1 |
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