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| 1 | Combination therapy using microwave ablation and d-mannose-chelated iron oxide nanoparticles inhibits hepatocellular carcinoma progression显示文摘Despite being a common therapy for hepatocellular carcinoma(HCC),insufficient thermal ablation can leave behind tumor residues that can cause recurrence.This is believed to augment M2 inflammatory macrophages that usually play a pro-tumorigenic role.To address this problem,we designed D-mannose-chelated iron oxide nanoparticles(man-IONPs) to polarize M2-like macrophages into the antitumor Ml phenotype.In vitro and in vivo experiments demonstrated that man-IONPs specifically targeted M2-like macrophages and accumulated in peri-ablation zones after macrophage infiltration was augmented under insufficient microwave ablation(MWA).The nanoparticles simultaneously induced polarization of pro-tumorigenic M2 macrophages into antitumor M1 phenotypes,enabling the transformation of the immunosuppressive microenvironment into an immunoactivating one.Post-MWA macrophage polarization exerted robust inhibitory effects on HCC progression in a well-established orthotopic liver cancer mouse model.Thus,combining thermal ablation with man-IONPs can salvage residual tumors after insufficient MWA.These results have strong potential for clinical translation. | Rui Cui Luo Wang Dongyun Zhang Kun Zhang Jianping Dou Linan Dong Yixuan Zhang Jiapeng Wu Longfei Tan Jie Yu Ping Liang | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 2 |
| 2 | Microstructure in the Semi-solid State and Mechanical Properties of AZ80 Magnesium Alloy Reheated from the As-cast and Extruded States显示文摘The multi-axial forging(MAF) process was introduced into the strain induced metal activation(SIMA) process to replace conventional forging.Microstructure evolution of MAF formed AZ80 magnesium alloy during partial remelting was investigated.Furthermore,the tensile mechanical properties for AZ80 magnesium alloy thixoextruded from the starting materials treated by MAF were determined.For comparison,as-cast AZ80 magnesium alloy was also thixoextruded.The results show that the SIMA route produced ideal,fine semi-solid microstructure,in which almost completely spheroidal primary solid grains had a little amount of entrapped liquid.The microstructure of the as-cast alloy in the semi-solid state is less spheroidized compared with the MAF alloy under the similar isothermal holding conditions.With prolonged holding time,the size of the solid grain increases and the degree of spheroidization is improved in the MAF formed alloys.However,the solid grain size of the as-cast alloys decreases initially,and then increases with further increasing temperature.The tensile mechanical properties for AZ80 magnesium alloy thixoextruded from the starting material produced by MAF are better than those of AZ80 magnesium alloy thixoextruded from the starting material produced by casting.The ultimate tensile strength,yield strength and elongation of the alloy thixoextruded from the starting material produced by MAF are 314 MPa,238 MPa and 14%,respectively. | Wenyong JIANG Tian CHEN Liping WANG Yicheng FENG Yan ZHU Kaifeng WANG Jiapeng LUO Shouwei ZHANG | 2013 | Acta Metallurgica Sinica(English Letters)2013，26，4： | 1 |
| 3 | An almost full reversible lithium-rich cathode: Revealing the mechanism of high initial coulombic efficiency显示文摘Low initial Coulombic efficiency (ICE) is an important impediment to practical application of Li-rich layered oxides (LLOs), which is due to the irreversible oxygen release. It is generally considered that surface oxygen vacancies are conducive to the improvement of ICE of LLOs. To reveal the relation of oxygen vacancies and ICE, sample PLO (Li-Mn-Cr-O) and its treated product (TLO) are comprehensive investigated in this work. During the treated process, part of oxygen atoms return to original constructed vacancies. It makes oxygen vacancies in sample TLO much poorer than those in sample PLO, and induces the formation of Li-poor spinel-layered integrated structure. Electrochemical measurement indicates the ICE of sample PLO is only 80.8%, while sample TLO is almost full reversible with the ICE of ~97.1%. In term of high-energy X-ray diffraction, scanning transmission electron microscopy, X-ray photoelectron spectroscopy and synchrotron hard/soft X-ray absorption spectroscopy, we discover that the ICE is difficult to be improved significantly just by building oxygen vacancies. LLOs with high ICE not only have to construct suitable oxygen vacancies, but also require other components with Li-poor structure to stabilize oxygen. This work provides deep insight into the mechanism of high ICE, and will contribute to the design and development of LLOs for next-generation high-energy lithium-ion batteries. | Dong Luo Jianming Fan Zhuo Yao Huixian Xie Jiaxiang Cui Yajun Yang Xiaokai Ding Jiapeng Ji Shuxing Wu Ming Ling Chenyu Liu Zhan Lin | 2021 | Journal of Energy Chemistry2021，30，11： | 1 |
| 4 | Modification of the substrate specificity of leucine dehydrogenase by site‑directed mutagenesis based on biocomputing strategies显示文摘Synthesis of chiral amines by amine dehydrogenase has the advantages of environmental friendliness,high stereoselectivity,and mild reaction conditions.However,amine dehydrogenase has low catalytic activity,which greatly limits its application in the large-scale synthesis of chiral amines.In this study,a novel amine dehydrogenase was obtained by modifying the substrate specificity of leucine dehydrogenase via computer-aided protein engineering strategy.Furthermore,conservation analysis,homology modeling and molecular docking analysis were carried out via biocomputing strategy to select the mutation sites,and the mutants L52S and T143C were obtained.The enzyme activities of the two mutants to 2-pentanone were 1.55 U/mg and 2.06 U/mg,respectively.The enzyme activity of the latter was 188%and the Tm value was 2.55°Chigher than those of the original mutant,which laid a foundation for the efficient preparation of chiral amines by using this novel enzyme. | Jiapeng Lu Zengyu Wang Yingying Jiang Zhoutong Sun Wei Luo | 2023 | Systems Microbiology and Biomanufacturing2023，3，2： | 0 |
| 5 | Regulating local chemistry in ZrCo-based orthorhombic hydrides via increasing atomic interference for ultra-stable hydrogen isotopes storage显示文摘Developing a universal and reliable strategy for the modulation of composition and structure of energy storage materials with stable cycling performance is vital for hydrogen and its isotopes storage advanced system,yet still challenging.Herein,an ultra-stable lattice structure is designed and verified to increase atomic chaos and interference for effectively inhibiting disproportionation reaction and improving cycling stability in ZrCo-based hydrogen isotopes storage alloy.After screening in terms of configuration entropy calculation,we construct Zr_(1-2)Nb_(x)Co_(1-2x)Cu_(x)Ni_(x)(x=0.15,0.2,0.25) alloys with increased atomic chaos,and successfully achieve stable isostructural de-/hydrogenation during 100 cycles,whose cycling capacity retentions are above 99%,much higher than 22.4%of pristine ZrCo alloy.Both theoretical analysis and experimental evidences indicate the high thermo-stability of orthorhombic lattice in Zr_(0.8)Nb_(0.2)Co_(0.6)Cu_(0.2)Ni_(0.2) alloy.Notably,the increased atomic chaos and interference in Zr_(0.8)Nb_(0.2)Co_(0.6)Cu_(0.2)Ni_(0.2) alloy causes regulation in hydrogen local chemical neighborhood,thereby confusing the hydrogen release order,which effectively eliminates lattice distortion and unlocks an ultrastable lattice structure.This study provides a new and comprehensive inspiration for hydrogen atoms transport behaviors and intrinsic reason of stable orthorhombic transformation,which can contribute to paving the way for other energy storage materials modulation. | Zhaoqing Liang Zhendong Yao Ruhong Li Xuezhang Xiao Zhichao Ye Xuancheng Wang Jiacheng Qi Jiapeng Bi Xiulin Fan Huaqin Kou Wenhua Luo Changan Chen Lixin Chen | 2022 | Journal of Energy Chemistry2022，31，6： | 0 |
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