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| 1 | γ-Aminobutyric Acid Regulates Both the Survival and Replication of Human β-Cells显示文摘 | Jide Tian Hoa Dang Zheying Chen Alice Guan Yingli Jin Mark A. Atkinson Daniel L. Kaufman | 2013 | Diabetes2013，，11： | 1 |
| 2 | Design and synthesis of the ring-opened derivative of 3-n-butylphthalide-ferulic acid-glucose trihybrids as potential anti-ischemic agents显示文摘To improve aqueous solubility and anti-ischemic activity of 3-n-butylphthalide(NBP),we designed and synthesized the ring-opened derivative of NBP-ferulic acid-glucose trihybrids(S1-S8).These hybrids inhibited adenosine diphosphate(ADP)-or arachidonic acid(AA)-induced platelet aggregation,among them,S2 was 30-fold more water-soluble,and over 10-fold more potent in inhibition of platelet aggregation,as well as reduced ROS generation and protected primary neuronal cells from OGD/Rinduced damage,in comparison with NB P.Additionally,S2 was more active than its three moieties alone or in combination,suggesting that the activity of S2 may be attributed to the synergistic effects of these moieties.Importantly,in vivo studies indicated that S2 not only possessed good pharmacokinetic profile,but also improved NBP distribution in rodent brain,suggesting that the glucose moiety in S2 may be recognized by glucose transporter 1(GLUT1)on blood-brain barrier(BBB),promoting it to penetrate through BBB.Our findings suggest that S2 may be a promising candidate for the intervention of ischemic stroke,warranting further study. | Jianbing Wu Wei Yin Yinqiu Zhang Hui Ye Yunman Li Jide Tian Zhangjian Huang Yihua Zhang | 2020 | Chinese Chemical Letters2020，31，7： | 1 |
| 3 | Lipopolysaccharide-activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice显示文摘 | Dan Zekzer Lorraine Hanssen | 2001 | Immunol2001，63，2： | 1 |
| 4 | Method for determining climatic design conditions based on the indoor thermal environment risk level显示文摘Currently,climatic design conditions are usually selected according to the frequency of climatic parameters them-selves,which method cannot reflect the indoor thermal environment risk level of the building in design.In this regard,the research proposes to construct the correlation between climatic design conditions and indoor thermal environment risk level,and explore the effect of uncertainty in building thermal performance on this correlation from the perspective of probability,thus realizing the process of selecting the climatic design conditions based on the requirement for indoor thermal environment risk level.Taking Guangzhou in China as an example,the new process of determining climatic design conditions is realized.On this basis,the difference between the traditional method and the present research method is compared.In the Chinese norm method,the indoor thermal environ-ment risk level of the building is between 0 and 0.03%when the climatic design conditions are selected with 0.57%cumulative frequency of occurrence;in the research method,the indoor thermal environment risk level of the building is between 0.2%and 0.6%when the climatic design conditions are selected with 0.57%indoor thermal environment risk level and 100%confidence level.The results indicate that the research method can meet the designer’s expectation for indoor thermal environment risk level in design more directly and accurately. | Xia Wu Zhe Tian Yuanyuan Wang Jide Niu Chengzhi Tian | 2021 | Energy and Built Environment2021，2，1： | 0 |
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