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| 1 | BMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repair显示文摘Calvarial bones are connected by fibrous sutures. These sutures provide a niche environment that includes mesenchymal stem cells(MSCs), osteoblasts, and osteoclasts, which help maintain calvarial bone homeostasis and repair. Abnormal function of osteogenic cells or diminished MSCs within the cranial suture can lead to skull defects, such as craniosynostosis. Despite the important function of each of these cell types within the cranial suture, we have limited knowledge about the role that crosstalk between them may play in regulating calvarial bone homeostasis and injury repair. Here we show that suture MSCs give rise to osteoprogenitors that show active bone morphogenetic protein(BMP) signalling and depend on BMP-mediated Indian hedgehog(IHH) signalling to balance osteogenesis and osteoclastogenesis activity. IHH signalling and receptor activator of nuclear factor kappa-Β ligand(RANKL) may function synergistically to promote the differentiation and resorption activity of osteoclasts. Loss of Bmpr1a in MSCs leads to downregulation of hedgehog(Hh) signalling and diminished cranial sutures. Significantly, activation of Hh signalling partially restores suture morphology in Bmpr1a mutant mice, suggesting the functional importance of BMP-mediated Hh signalling in regulating suture tissue homeostasis. Furthermore, there is an increased number of CD200+ cells in Bmpr1a mutant mice, which may also contribute to the inhibited osteoclast activity in the sutures of mutant mice. Finally, suture MSCs require BMPmediated Hh signalling during the repair of calvarial bone defects after injury. Collectively, our studies reveal the molecular and cellular mechanisms governing cell–cell interactions within the cranial suture that regulate calvarial bone homeostasis and repair. | Yuxing Guo Yuan Yuan Ling Wu Thach-Vu Ho Junjun Jing Hideki Sugii Jingyuan Li Xia Han Jifan Feng Chuanbin Guo Yang Chai | 2018 | Bone Research2018，6，4： | 12 |
| 2 | Forecast scheme and strategy for extended-range predictable components显示文摘Although extended-range forecasting has exceeded the limit of daily predictability of weather,there are still partially predictable characteristics of meteorological fields in such forecasts.A targeted forecast scheme and strategy for extended-range predictable components is proposed.Based on chaotic characteristics of the atmosphere,predictable components and unpredictable random components are separated by using the standpoint of error growth in a numerical model.The predictable components are defined as those with slow error growth at a given range,which are not sensitive to small errors in initial conditions. A numerical model for predictable components(NMPC)is established,by filtering random components with poor predictability.The aim is to maintain predictable components and avoid the influence of rapidly growing forecast errors on small scales. Meanwhile,the analogue-dynamical approach(ADA)is used to correct forecast errors of predictable components,to decrease model error and statistically take into account the influence of random components.The scheme is applied to operational dynamical extended-range forecast(DERF)model of the National Climate Center of China Meteorological Administration (NCC/CMA).Prediction results show that the scheme can improve forecast skill of predictable components to some extent, especially in high predictability regions.Forecast skill at zonal wave zero is improved more than for ultra-long waves and synoptic-scale waves.Results show good agreement with predictability of spatial scale.As a result,the scheme can reduce forecast errors and improve forecast skill,which favors operational use. | ZHENG ZhiHai HUANG JianPing FENG GuoLin CHOU JiFan | 2013 | Science China Earth Sciences2013，56，5： | 9 |
| 3 | Dynamic-statistics combined forecast scheme based on the abrupt decadal change component of summer precipitation in East Asia显示文摘基于 19832011 CMAP 数据,在东亚的降水异例和它的附近的海区域(此后叫的东亚为短) 在 1999 前表明 ++ 模式并且 + 模式以后;这个十的变化在相应 EOF3 部件主要被包含。然而, NCC_CGCM 预报结果是相当不同的,它在 1999 前揭示 ++ 模式并且 ++ 模式以后。同时,基于这些关键 SST 区域改进 NCC_CGCMs 预报精确性的概率被讨论,并且动态统计的联合预报计划为增加在东亚在夏天降水包含的十的变化的信息被构造。独立样品预报结果显示这个预报计划罐头有效地修改十的变化信息在东亚在夏天降水包含了的 NCC_CGCMs (特别在 30 敢琠敨攠癮 的区域吗?? | GONG ZhiQiang ZHAO JunHu FENG GuoLin CHOU JiFan | 2015 | Science China Earth Sciences2015，58，3： | 7 |
| 4 | Extracting predictable components and forecasting techniques in extended-range numerical weather prediction显示文摘This paper refers to the CNOP-related algorithms and formulates the practical method and forecast techniques of extracting predictable components in a numerical model for predictable components on extended-range scales.Model variables are divided into predictable components and unpredictable chaotic components from the angle of model prediction error growth.The predictable components are defined as those with a slow error growth at a given range.A targeted numerical model for predictable components is established based on the operational dynamical extended-range forecast(DERF)model of the National Climate Center.At the same time,useful information in historical data are combined to find the fields for predictable components in the numerical model that are similar to those for the predictable components in historical data,reducing the variable dimensions in a similar judgment process and further correcting prediction errors of predictable components.Historical data is used to obtain the expected value and variance of the chaotic components through the ensemble forecast method.The numerical experiment results show that this method can effectively improve the forecast skill of the atmospheric circulation field in the 10–30 days extended-range numerical model and has good prospects for operational applications. | WANG QiGuang CHOU JiFan FENG GuoLin | 2014 | Science China Earth Sciences2014，57，7： | 1 |
| 5 | An overview of the Semi-arid Climate and Environment Research Observatory over the Loess Plateau显示文摘 | Jianping Huang Wu Zhang Jinqing Zuo Jianrong Bi Jinsen Shi Xin Wang Zhoulin Chang Zhongwei Huang Su Yang Beidou Zhang Guoyin Wang Guanghong Feng Jiuyi Yuan Lei Zhang Hongchao Zuo Shigong Wang Congbin Fu Chou Jifan | | 0，2008，： | 1 |
| 6 | Ferromagnetism induced by intrinsic defects and carbon substitution in single-walled ZnO nanotube显示文摘 | Feng Gao Jifan Hu Jihua Wang Chuanlu Yang Hongwei Qin | 2010 | Chemical Physics Letters2010，，： | 1 |
| 7 | Synergistic lubrication of few-layer Ti_(3)C_(2)T_(x)/MoS_(2) heterojunction as a lubricant additive显示文摘The few-layer Ti_(3)C_(2)T_(x)/MoS_(2) heterostructure was successfully prepared via vertically growing of MoS_(2) nanosheets on the few-layer Ti3C2Tx matrix using hydrothermal method.The tribological properties as additive in mineral oil(150N)were evaluated in detail.The 0.3 wt% of few-layer Ti_(3)C_(2)T_(x)/MoS_(2) heterostructure addition amount can reduce the friction and wear of 150N by 39% and 85%,respectively.Moreover,the enhancement effect of few-layer Ti_(3)C_(2)T_(x)/MoS_(2) on tribological properties of 150N is superior to that of few-layer Ti_(3)C_(2)T_(x),MoS_(2) nanosheets,and their mechanical mixture.Based on the characterization and analysis of wear debris and wear track,such excellent tribological properties of the few-layer Ti_(3)C_(2)T_(x)/MoS_(2) heterostructure derive from its structural advantage toward good dispersion,the synergistic lubrication of Ti_(3)C_(2)T_(x) and MoS_(2) nanosheets during the rubbing process,and the formation of tribo-film. | Peng FENG Yanping REN Yuting LI Jifan HE Zhuang ZHAO Xiaoliang MA Xiaoqiang FAN Minhao ZHU | 2022 | Friction2022，10，12： | 1 |
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