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| 1 | Age of Anzishan granulites in the Mianxian-Lueyang suture zone of Qingling orogen:With a discussion of the timing of final assembly of Yangtze and North China craton blocks显示文摘Many granulite blocks have been recently dis-covered in the Anzishan area, Mianxian County, ShaanxiProvince, in the central segment of the Manxian-Lueyangsuturc zone. Sm-Nd isochron and 40 Ar39 Ar ages of mineralsamples of granulites from this area are reported in the note.The granulite mineral samples give a Sm-Nd isochron age oft=(206 ± 55) Ma (2σ), with INd = 0.51302±7(2σ) and MSWD =1.6, and a biotite 40Ar/39 Ar plateau age of (199.7±l.7) Ma(2σ). The formation and uplift of the granulites were relatedto subduction of the Yangtze block beneath the SouthQinling microcontinent and their collision and the finalamalgamation of the Yangtze and Sino-Korean craton blocksin the Indosinian, and their age is consistent with or close tothose of the Dabie ultrahigh-pressure and high-pressuremetamorphic rocks, so have great tectonic significance. | ZHANG Zongqing ZHANG Guowei TANG SuohaiV XU Jifeng YANG Yongcheng WANG Jinhui | 2002 | Chinese Science Bulletin2002，47，22： | 19 |
| 2 | Analysis of microsatellites in major crops assessed by computational and experimental approaches显示文摘 | Lifeng Gao Jifeng Tang Hongwei Li Jizeng Jia | 2003 | Molecular Breeding2003，，3： | 1 |
| 3 | Absorptive and disseminative capacity: Knowledge transfer in intra-organization networks显示文摘 | Jifeng Mu Fangcheng Tang Douglas L. MacLachlan | 2009 | Expert Systems With Applications2009，，1： | 1 |
| 4 | Disseminative capacity, organizational structure and knowledge transfer显示文摘 | Fangcheng Tang Jifeng Mu Douglas L. MacLachlan | 2009 | Expert Systems With Applications2009，，2： | 1 |
| 5 | Absorptive and disseminative capability: knowledge transfer in intra-organization networks显示文摘 | MU JIFENG TANG FANGCHENG MACLACHLAN DOUGLAS L | 2010 | Expert Systems with Applications2010，37，： | 1 |
| 6 | RNA interference blocking the apoptosis in HEK293 cells induced by overexpression of alpha-synuclein显示文摘BACKGROUND:Overexpression ofα-synuclein can induce cell apoptosis.RNA interference(RNAi) may block specific gene function and cause gene silencing. OBJECTIVE:To construct a specific and effective RNAi plasmid for theα-synuclein gene and investigate if RNAi can block apoptosis in HEK293 cells,induced by overexpression of wild-typeα-synuclein. DESIGN,TIME AND SETTING:A contrast experiment based on genetically engineered cytobiology was performed at the State Key Lab of Medical Genetics of China,Xiangya Medical College of Central South University,between October 2004 and October 2008. MATERIALS:HEK293 cells and pBSHH1 plasmid were provided by the State Key Lab of Medical Genetics of China;OligDNA sequence by Sagon Bioengineering Company,Shanghai; Lipofectamine 2000 by Invitrogen,USA;α-synuclein monoclonal antibody,Hoechst 33258,and MTT; by Sigma,USA;Horseradish peroxidase-coupled goat anti-rat IgG by KPL,USA;FACSan flow cytometry by BD,USA. METHODS:Four target sites were used to construct hairpin RNA pBSHH1 vectors-pSYNi-1, pSYNi-2,pSYNi-3 and pSYNi-4-which were cloned in the pBSHH1 plasmid.HEK293 cells were transfected using Lipofectamine 2000.In addition,a non-transfect group and a negative plasmid transfect group were established.The cultured HEK293 cells were processed as follows: transfection of blank plasmid(blank control group),transfection ofα-synuclein-pEGFP and RNAi negative vector(negative control group),and transfection ofα-synuclein-pEGFP and pSYNi-1 (transfection group).Cells in all groups were transfected with Lipofectamine 2000 for 48 hours. MAIN OUTCOME MEASURES:Expression ofα-synuclein mRNA and protein were detected by RT-PCR and Western blot.Cell morphology was observed under an inverted fluorescence microscope;cell viability was measured using MTT method;and cell apoptosis was determined with Annexin V-PE flow cytometry. RESULTS:α-synuclein mRNA and protein expressions were significantly decreased in the pSYNi-1 group when compared with the non-transfect and negative plasmid transfect groups(P<0.05).The expressions were partially decreased in the pSYNi-2 group,but there was no significant difference in the pSYNi-3 and pSYNi-4 groups.Hoechst staining indicated that cell nuclei were enlarged in the negative control group,coloring was not uniform,and chromatin was accumulated and appeared spot-like.The nucleus coloring was uniform in the transfection group compared to negative control group.Cell viability in the negative control group was significantly lower than blank control group with cell apoptosis being significantly increased(P<0.05).In comparison with negative control group, cell viability was significantly increased in the transfection group and cell apoptosis was significantly decreased(P<0.05). CONCLUSION:pSYNi-1 can inhibitα-synuclein gene expression and block apoptosis of HEK293 cells induced by overexpression of wild-typeα-synuclein. | Tao Chen Beisha Tang Xiaoping Liao Guoqiang Wen Xinxiang Yan Jifeng Guo Yuhu Zhang Feng Ouyang Zhigang Long Li Cao Jing Li | 2009 | Neural Regeneration Research2009，4，7： | 1 |
| 7 | Implication of network size and structure onorganizations' knowledge transfer显示文摘 | FANGCHENG TANG JIFENG MU DOUGLAS L MA-CLACHLAN | 2008 | Expert Systemswith Applications2008，34，2： | 1 |
| 8 | Analysis of microsatellites in major crops assessed by computational and experimental approaches显示文摘 | Lifeng Gao Jifeng Tang Hongwei Li Jizeng Jia | 2003 | Molecular Breeding2003，，3： | 1 |
| 9 | Absorptive and Disseminative Capacity: Knowledge Transfer in Intra- organization Networks 显示文摘 | Jifeng Mu Fangcheng Tang Douglas L Maclachlan | 2010 | Expert Systems with Applications2010，37，： | 1 |
| 10 | Disseminative Capacity, Organization Structure and Knowledge Transfer显示文摘 | Tang Fangcheng Mu Jifeng Douglas L Maclachlan | 2010 | Expert Systems with Applications2010，37，： | 1 |
| 11 | Absorptive and disseminative capacity:Knowledge transfer in intra-organization networks 显示文摘 | Jifeng Mua Fangcheng Tang Douglas L MacLachlan | 2009 | Expert Systems with Applications2009，13，5： | 1 |
| 12 | Petrology and geochemistry of Zijinshan alkaline intrusive complex in Shanxi Province, western North China Craton: Implication for magma mixing of different sources in an extensional regime显示文摘 | Ying Jifeng Zhang Hongfu Sun Min Tang Yunjie Zhou Xinhua Liu Xiaoming | 2007 | Lithos2007，98，14： | 1 |
| 13 | Absorptive and disseminative capacity: Knowledge transfer in intra-organization networks 显示文摘 | Mu Jifeng Tang Fangcheng MacLachlan D L | 2010 | Expert Systems with Applications2010，37，1： | 1 |
| 14 | Disseminative capacity, organizational structure and knowledge transfer 显示文摘 | Tang Fangcheng Mu Jifeng MacLachlan D L | 2010 | Expert Systems with Applications2010，37，2： | 1 |
| 15 | Analasis of microsatellites in major crops assessed by compμtational and experimental approaches显示文摘 | Lifeng Gao Jifeng Tang Hongwei Li | 2003 | Molecμlar Breeding2003，12，： | 1 |
| 16 | Implication of network size and structure on organizations' knowledge transfer 显示文摘 | Tang Fangcheng Mu Jifeng MacLachlan D L | 2008 | Expert Systems with Applications2008，34，2： | 1 |
| 17 | Ab- sorptive and Disseminative Capacity:Knowledge Transfer in In- tra-organization Networks 显示文摘 | Jifeng Mu Fangcheng Tang Douglas L Maclachlan | 2010 | Expert Systems with Applica- tions2010，37，： | 1 |
| 18 | Im- plication of Network Size and Structure on Organizations' Knowledge Transfer 显示文摘 | Fangcheng Tang Jifeng Mu Douglas L MacLachlan | 2008 | Expert Systems with Applications2008，34，2： | 1 |
| 19 | The relationship between treatment-induced hypertension and efficacy of anlotinib in recurrent or metastatic esophageal squamous cell carcinoma显示文摘Objective:In this post-hoc analysis,we evaluated anlotinib treatment-induced hypertension as a potential predictive factor of efficacy in esophageal squamous cell carcinoma(ESCC)patients.Methods:A total of 109 patients enrolled in the anlotinib group in a phase 2 trial were included.The tumor response was assessed by computed tomography at week 3,week 6,and then every 6 weeks until progressive disease was observed.The primary endpoint of the study was progression free survival(PFS).The secondary endpoints included overall survival(OS)and objective response rate(ORR).Results:In all patients,the median PFS was 3.02 months[95%confidence interval(CI):2.63–3.65 months]and the OS was 6.11 months(95%CI:4.40–7.79 months).The ORR was 7.34%(95%CI:3.22%–13.95%).A total of 59(54%)patients were diagnosed with treatment-induced hypertension(Group A),and the remaining patients(n=50,46%)were in Group B.Baseline prognostic factors were similar between the 2 groups.Patients in Group A had a longer PFS and OS and higher ORR.When stratifying patients using a previously known history of hypertension,treatment-induced hypertension was a predictor only for patients without previous hypertension,who had longer PFS[hazard ratio(HR):0.40,95%CI:0.24–0.68]and OS(HR:0.37,95%CI:0.21–0.67).Conclusions:We showed,for the first time,a correlation between treatment-induced hypertension and better prognoses in recurrent or metastatic ESCC patients treated with anlotinib,without a previously known history of hypertension.Treatment-induced hypertension may be a simple and low cost predictor for anlotinib antitumor efficacy in these patients,which may also reflect the intended target inhibition. | Yan Song Juxiang Xiao Wentao Fang Ping Lu Qingxia Fan Yongqian Shu Jifeng Feng Shu Zhang Yi Ba Yang Zhao Ying Liu Chunmei Bai Yuxian Bai Yong Tang Jie He Jing Huang | 2021 | Cancer Biology & Medicine2021，18，2： | 1 |
| 20 | Homologous analysis of SSR-ESTs and transferability of wheat SSR-EST markers across barley, rice and maize显示文摘 | Jifeng Tang Lifeng Gao Yongsheng Cao Jizeng Jia | 2006 | Euphytica2006，，1： | 1 |
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