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| 1 | Inhibition of growth and metastasis of triple-negative breast cancer targeted by Traditional Chinese Medicine Tubeimu in orthotopic mice models显示文摘Objective: Triple-negative breast cancer(TNBC) is highly invasive and metastatic, which is in urgent need of transformative therapeutics. Tubeimu(TBM), the rhizome of Bolbostemma paniculatum(Maxim.) Franquet, is one of the Chinese medicinal herbs used for breast diseases since the ancient times. The present study evaluated the efficacy, especially the anti-metastatic effects of the dichloromethane extract of Tubeimu(ETBM) on TNBC orthotopic mouse models and cell lines.Methods: We applied real-time imaging on florescent orthotopic TNBC mice model and tested cell migration and invasion abilities with MDA-MB-231 cell line. Digital gene expression sequencing was performed and Kyoto Encyclopedia of Genes and Genomes(KEGG) analysis applied to explore the pathways influenced by ETBM.Moreover, quantitative real-time polymerase chain reactions(q RT-PCR) and Western blot were delivered to confirm the gene expression changes.Results: ETBM exhibited noticeable control on tumor metastasis and growth of TNBC tumors with no obvious toxicity. In compliance with this, it also showed inhibition of cell migration and invasion in vitro. Its impact on the changed biological behavior in TNBC may be a result of decreased expression of integrin β1(ITGβ1), integrin β8(ITGβ8) and Rho GTPase activating protein 5(ARHGAP5), which disabled the focal adhesion pathway and caused change in cell morphology.Conclusions: This study reveals that ETBM has anti-metastatic effects on MDA-MB-231-GFP tumor and may lead to a new therapeutic agent for the integrative treatment of highly invasive TNBC. | Jingxiao Wang Xinjie Yang Haibo Han Limin Wang Weiqian Bao Shanshan Wang Robert M.Hoffman Meng Yang Hui Qi Chao An Kaiwen Hu | 2018 | Chinese Journal of Cancer Research2018，30，1： | 8 |
| 2 | Effect of Heat Treatment on Silica Aerogels Prepared via Ambient Drying显示文摘硅石 aerogels 在由 usingethanol/trimethylchlorosilane ( TMCS )的周围的弄干被准备作为毛孔水交换和表面 modificationof ,在 drying.The 前的湿胶化获得了的 /heptane 答案像海绵的结构 withuniform 毛孔尺寸 distribution.The 在 hydrophobicity 上热处理完成的硅石 aerogels 展览,特定的 surfacearea 和另外的性质是显示的 investigated.The 结果 silicaaerogels 的 hydrophobicity 能被维持直到增加 heati 的 350 °C . | Fei SHI Lijiu WANG Jingxiao LIU Miao ZENG | 2007 | Journal of Materials Science & Technology2007，23，3： | 7 |
| 3 | Ascorbate antagonizes nickel ion to regulate JMJD1A expression in kidney cancer cells显示文摘histone demethylase Jumonji 包含域的蛋白质 1A (JMJD1A ) 的反常表示与许多种癌症被联系。JMJD1A 也是 hypoxic 反应基因,它的表示被组织缺氧可诱导的 factor-1 (HIF-1 ) 调整。在这研究,我们在开发和组织缺氧小径决定了 JMJD1A 的角色。我们也测量了 JMJD1A 和二组织缺氧因素葡萄糖 transporter 的表示 1 ( GLUT1 )并且在 786-0 和 HEK293 细胞的脉管的 endothelial 生长因素( VEGF )为 24 h 与 NiCl2 ( 2.5100 M )的不同集中对待,并且发现 JMJD1A mRNA 和蛋白质与 NiCl2 的增加的集中是起来调整的。我们然后观察到 ascorbate 能延迟以通过减少的一种剂量依赖者方式的导致 NiCl2 的 JMJD1A 表示的起来调整的效果 HIF-1 的稳定性蛋白质。Immunohistochemical 分析进一步证明 ascorbate 在 786-0, HEK293,和 OS-RC-2 房间反对了 JMJD1A 表示的导致 Ni2+ 的起来规定。这些调查结果建议 Ni2+ 和 ascorbate 能调整 histone demethylase JMJD1A 的表示,它为癌症开发或抑制是重要的。 | Xiaoqiang Guo Jingxiao Lu Yuejia Wang Yaoting Gui Xianglin Duan Zhiming Cai | 2012 | Acta Biochimica et Biophysica Sinica2012，44，4： | 5 |
| 4 | Hydrothermal Synthesis of Cs_xWO_3 and the Effects of N_2 Annealing on its Microstructure and Heat Shielding Properties显示文摘Cesium tungsten bronze(Cs_xWO_3) powders were synthesized by hydrothermal reaction at 190 ℃ by using sodium tungstate and cesium carbonate as raw materials,and the effects of N_2 annealing on the microstructure and near-infrared(NIR) shielding as well as heat insulation properties of Cs_xWO_3 were investigated.The results indicated that the synthesized Cs_xWO_3 powders exhibited hexagonal Cs_(0.32)WO_3crystal structure,and subsequent N_2 annealing could further improve the crystallinity of CsxW03 particles.Moreover,the NIR shielding and heat insulation properties of Cs_xWO_3 could be further improved after N_2annealing at appropriate temperature for a period of time.Particularly,the 500 ℃-annealed Cs_xWO_3 products in the N_2 atmosphere showed the best NIR shielding and heat insulation properties.When the N_2 annealing temperature was higher than 700 ℃,the NIR shielding properties decreased again.The 800 ℃-annealed samples in the N_2 atmosphere showed higher visible light transmittance,however,the NIR shielding properties were lower than that of the non-annealed samples. | Fei Shi Jingxiao Liu Xiaoli Dong Qiang Xu Jiayu Luo Hongchao Ma | 2014 | Journal of Materials Science & Technology2014，30，4： | 5 |
| 5 | Synthesis of Chitosan-Hydroxyapatite Composites and Its Effect on the Properties of Bioglass Bone Cement显示文摘Chitosan-hydroxyapatite(CS-HA) composite powders were synthesized via in situ co-precipitation method,through the reaction of Ca(NO3)2 and H3PO4 in the simulated body fluid(SBF) containing appropriate amount of chitosan.The thermal evolution,microstructure and morphology were studied by TG-DTA(thermogravimetry-differential thermal analysis),XRD(X-ray diffraction),FTIR(Fourier transform infrared spectroscopy) and TEM(transmission electron microscopy).The in vitro bioactivity test showed that the obtained CS-HA composites had higher capability of inducing calcium ions deposition.Effects of CS-HA composites on the bioactivity and compressive strength of bioglass bone cement were investigated.The results indicated that the bioactivity of bioglass bone cement could be improved further when CS-HA composite powders were added into the cement,and appropriate amount of CS-HA additive was favorable for compressive strength improvement of bioglass bone cement. | Jingxiao Liu Fei Shi Ling Yu Liting Niu Shanshan Gao | 2009 | Journal of Materials Science & Technology2009，25，4： | 3 |
| 6 | Maximum Entropy Approach for Solving Pessimistic Bilevel Programming Problems显示文摘Bilevel programming problems are of growing interest both from theoretical and practical points of view.In this paper,we study a pessimistic bilevel programming problem in which the set of solutions of the lower level problem is discrete.We first transform such a problem into a single-level optimization problem by using the maximum-entropy techniques.We then present a maximum entropy approach for solving the pessimistic bilevel programming problem.Finally,two examples illustrate the feasibility of the proposed approach. | ZHENG Yue ZHUO Xiangzhi CHEN Jingxiao | 2017 | Wuhan University Journal of Natural Sciences2017，22，1： | 3 |
| 7 | Molecular identification of Echinococcus species from eastern and southern Qinghai, China, based on the mitochondrial cox1 gene显示文摘 | Junying Ma Hu Wang Gonghua Lin Philip S. Craig Akira Ito Zhenyuan Cai Tongzuo Zhang Xiumin Han Xiao Ma Jingxiao Zhang Yufang Liu Yanmei Zhao Yongshun Wang | 2012 | Parasitology Research2012，，1： | 2 |
| 8 | Ecological damage of submerged macrophyte Myriophyllum spicatum by cell extracts from microcystin(MC)-and non-MC-producing cyanobacteria,Microcystis显示文摘To explore how decomposed Microcystis-dominant cyanobacterial blooms affect submerged macrophytes,the submerged plant Myriophyllum spicatum was exposed to cell extracts from microcystin(MC)-and non-MC-producing Microcystis strains in a laboratory experiment.Results showed that both Mcracystis cell extracts exerted obvious damages to plant biomass,photosynthesis,primary and secondary metabolism measures,and resistance of plant antioxidant systems,with MC-producing Microcystis having stronger effects due to the presence of MCs.Cyanotoxins other than MCs responsible for the negative effects from both strains needs further identification.The Shannon diversity and Chao1 indices of epiphytic and planktonic bacteria were decreased by the cell extracts from both Microcystis strains.However,epiphytic and planktonic bacterial communities responded differently to cell extracts at the genus level.The dominant genera of planktonic bacteria including Enterobacter,Pseudomonas,and Novosphingobium from phylum Proteobacteria,Chryseobacterium from phylum Bacteroidetes,and Microbacterium from Actinobacteriota in the treatments with cell extracts were previously reported to have strains with algicidal and MC-degrading capabilities.B acterial genes associated with energy production and conversion,amino acid transport and metabolism,and inorganic ion transport and metabolism,were more abundant in both treatments than the control for planktonic bacteria,but less abundant for epiphytic bacteria.We speculate that planktonic bacterial communities have the potential to use and degrade substances derived from Microcystis cell extracts,which may be beneficial for M.spicatum to alleviate damages from Microcystis.Further research is needed to verify the structure and function dynamics of epiphytic and planktonic bacteria in the interaction between cyanobacteria and submerged macrophytes. | Yunni GAO Hui YANG Xiaofei GAO Mei LI Man ZHANG Jing DONG Jingxiao ZHANG Longfei LI Xuejun LI Michele A BURFORD | 2022 | Journal of Oceanology and Limnology2022，40，5： | 2 |
| 9 | 显示文摘 | Liu Jingxiao Yang Dazhi Shi Fei | 2003 | Thin Solid Films2003，429，： | 1 |
| 10 | Identification and characterization of novel fusion genes in prostate cancer by targeted RNA capture and next-generation sequencing显示文摘Gene fusions play critical roles in the development and progression of prostate cancer,and have been used as molecular biomarkers for diagnosis of the malignant disease.To further explore the novel fusions in prostate cancer,we performed targeted RNA capture and next-generation sequencing in a cohort of 52 prostate cancer patients,identified and validated 14 fusion events (7 types of fusion genes)in 12 cases,including three novel fusion genes.We characterized a chromosome rearrangement-induced trigenic KLK2-DGKB-ETV1 fusion,which may function as a noncoding RNA to upregulate the expression of the wild-type ETV1 protein in the tumor tissue. Additionally,we detected two novel fusion forms of HNRNPA2B1-ETV1 and SLC45A2-AMACR fusions,respectively.Interestingly,fusion events participated by kinase genes,which frequently occurred in other human cancers,were not present in these prostate cancer cases,suggesting discrepant gene fusion patterns in different cancers.These findings expand the genetic spectrum of prostate cancer and provide insight into diagnosis of this prevalent disease. | Jie Yang Yun Chen Jingxiao Lu Xingxing Wang Lu Wang Jialong Liang Zhong Sheng Sun | 2018 | Acta Biochimica et Biophysica Sinica2018，50，11： | 1 |
| 11 | Telomerase Reverse Transcriptase Gene Promoter Mutations Help Discern the Origin of Urogenital Tumors: A Genomic and Molecular Study显示文摘 | Song Wu Peide Huang Chong Li Yi Huang Xianxin Li Yongqiang Wang Chao Chen Zhaojie Lv Aifa Tang Xiaojuan Sun Jingxiao Lu Weiping Li Jie Zhou Yaoting Gui Fangjian Zhou Daping Wang Zhiming Cai | 2013 | European Urology2013，，： | 1 |
| 12 | Synthesis and characterization of silica aerogels by a novel fast ambient pressure drying process显示文摘 | SHI Fei WANG Lijiu LIU Jingxiao | 2006 | Mater Lett2006，60，： | 1 |
| 13 | 显示文摘 | Jin Ruimin Lu Jingxiao Wang Haiyan | 2005 | J Semiconductor Photonics and Technology2005，，6： | 1 |
| 14 | Effect of power density on the properties of μc-Si:H deposited by VHF-PECVD 显示文摘 | Guo Xuejun Lu Jingxiao Wen shutang | 2008 | Chinese journal of semiconductors2008，29，6： | 1 |
| 15 | Microstructure and electrical-optical properties of cesium tungsten oxides synthesized by solvothermal reaction followed by ammonia annealing显示文摘 | Liu Jingxiao Ando Y Dong Xiaoli | 2010 | Journal of Solid State Chemistry2010，13，10： | 1 |
| 16 | Metallic and highly conducting two-dimensional atomic arrays of sulfur enabled by molybdenum disulfide nanotemplate显示文摘Element sulfur in nature is an insulating solid.While it has been tested that one-dimensional sulfur chain is metallic and conducting,the investigation on two-dimensional sulfur remains elusive.We report that molybdenum disulfide layers are able to serve as the nanotemplate to facilitate the formation of two-dimensional sulfur.Density functional theory calculations suggest that confined inbetween layers of molybdenum disulfide,sulfur atoms are able to form two-dimensional triangular arrays that are highly metallic.As a result,these arrays contribute to the high conductivity and metallic phase of the hybrid structures of molybdenum disulfide layers and two-dimensional sulfur arrays.The experimentally measured conductivity of such hybrid structures reaches up to 223 S/m.Multiple experimental results,including X-ray photoelectron spectroscopy(XPS),transition electron microscope(TEM),selected area electron diffraction(SAED),agree with the computational insights.Due to the excellent conductivity,the current density is linearly proportional to the scan rate until 30,000 mV s^(−1) without the attendance of conductive additives.Using such hybrid structures as electrode,the two-electrode supercapacitor cells yield a power density of 10^(6) Wh kg^(−1) and energy density ~47.5 Wh kg^(−1) in ionic liquid electrolytes.Our findings offer new insights into using two-dimensional materials and their Van der Waals heterostructures as nanotemplates to pattern foreign atoms for unprecedented material properties. | Shuze Zhu Xiumei Geng Yang Han Mourad Benamara Liao Chen Jingxiao Li Ismail Bilgin Hongli Zhu | 2017 | npj Computational Materials2017，，1： | 1 |
| 17 | The extended finite element method for dynamic fractures 显示文摘 | ZI Goangseup CHEN Hao XU Jingxiao | 2005 | Shock and Vibration2005，12，1： | 1 |
| 18 | Dynamic crack propagation based on loss of hyperbolicity and a new discontinuous enrichment显示文摘 | Belytschko T Chen Hao Xu Jingxiao | 2003 | International Journal for Numerical Methods in Engineering2003，58，12： | 1 |
| 19 | Pore structure characterization of TiO2-SiO2 composite aerogel prepared via ambient pressure drying by sol pre-modification process 显示文摘 | Liu Jingxiao Bai Lunan Shi Fei | 2012 | Advanced Materials Research2012，11，524： | 1 |
| 20 | Verification of a model of thermal storage incorporated with an extended lumped capacitance method for various solid–fluid structural combinations显示文摘 | Peiwen Li Ben Xu Jingxiao Han Yongping Yang | 2014 | Solar Energy2014，，： | 1 |
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