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| 1 | Iron metabolism in the mononuclear phagocyte system显示文摘身体铁动态平衡的维护要求铁新陈代谢的多重规章的机制的协作。单音的原子吞噬细胞系统(MPS,单核白血球,巨噬细胞,和他们的先锋房间镇静) 在铁动态平衡的维护是关键的。铁再循环被专业化巨噬细胞经由年老的红血球的吞没执行。巨噬细胞的铁店取决于恢复并且出口的铁的层次。然而,在巨噬细胞位于铁动态平衡下面的分子的机制糟糕被理解。描绘自然联系抵抗的巨噬细胞蛋白质 1 的功能和规定(Nramp1 ) 的最近的研究,二价的金属 transporter 1 (DMT1 ) ,连接 HLA 的 hemechromatosis 基因(HFE ) , ferroportin 1 (FPN1 ) ,并且 hepcidin 很快在 MPS 铁处理的分子的水平上正在扩展我们的知识。这些研究关于铁动态平衡和铁相关的疾病的分子的机制正在加深我们的理解。 | Weina Kong Xianglin Duan Zhenhua Shi Yanzhong Chang | 2008 | Progress in Natural Science:Materials International2008，18，10： | 5 |
| 2 | Ascorbate antagonizes nickel ion to regulate JMJD1A expression in kidney cancer cells显示文摘histone demethylase Jumonji 包含域的蛋白质 1A (JMJD1A ) 的反常表示与许多种癌症被联系。JMJD1A 也是 hypoxic 反应基因,它的表示被组织缺氧可诱导的 factor-1 (HIF-1 ) 调整。在这研究,我们在开发和组织缺氧小径决定了 JMJD1A 的角色。我们也测量了 JMJD1A 和二组织缺氧因素葡萄糖 transporter 的表示 1 ( GLUT1 )并且在 786-0 和 HEK293 细胞的脉管的 endothelial 生长因素( VEGF )为 24 h 与 NiCl2 ( 2.5100 M )的不同集中对待,并且发现 JMJD1A mRNA 和蛋白质与 NiCl2 的增加的集中是起来调整的。我们然后观察到 ascorbate 能延迟以通过减少的一种剂量依赖者方式的导致 NiCl2 的 JMJD1A 表示的起来调整的效果 HIF-1 的稳定性蛋白质。Immunohistochemical 分析进一步证明 ascorbate 在 786-0, HEK293,和 OS-RC-2 房间反对了 JMJD1A 表示的导致 Ni2+ 的起来规定。这些调查结果建议 Ni2+ 和 ascorbate 能调整 histone demethylase JMJD1A 的表示,它为癌症开发或抑制是重要的。 | Xiaoqiang Guo Jingxiao Lu Yuejia Wang Yaoting Gui Xianglin Duan Zhiming Cai | 2012 | Acta Biochimica et Biophysica Sinica2012，44，4： | 5 |
| 3 | Regulation of histone demethylase KDM6B by hypoxia-inducible factor-2α显示文摘离氨酸(K) 特定的 demethylase 6B (KDM6B ) 是 histone H3K27 demethylase,它明确地催化 H3 lysine-27 tri/dimethylation (H3K27me3/2 ) 的 demethylation。KDM6B 能由支持与 RNA 聚合酶 II 和相关延伸因素被联系的 transcriptional 延伸激活基因抄写。KDM6B 因此为基因表示的规定是重要的。以前的研究显示了象 KDM3A, KDM4B,和 KDM4C 那样的几 histone demethylases 被组织缺氧可诱导的因素(HIF ) 调整。但是, KDM6B 上的组织缺氧的效果充分没被理解。在这研究,我们发现 KDM6B mRNA 和蛋白质的表示层次在组织缺氧下面是平常地起来调整的(1% O 2) 或模仿组织缺氧(desferrioxamine mesylate 或 CoCl 2 处理)(P < 0.05 ) 。RNAi 的结果证明 KDM6B 的起来规定依赖于 HIF-2,然而并非在 HIF-1 上。染色质 immunoprecipitation 试金的结果显示在 KDM6B 倡导者(4041 ~ 4037 ) 有一个组织缺氧反应元素。Co-IP 试金的结果显示 KDM6B 能与 HIF-2 或 HIF-1 形成建筑群。击倒的实验暗示 KDM6B 是为 HIF-2 目标基因的一个潜在的管理者。这些数据证明 KDM6B 是 HIF-2 调整的新组织缺氧反应基因。我们的结果也证明 KDM6B 是 HIF- 的潜在的激活剂,它为组织缺氧反应基因的激活是重要的。 | Xiaoqiang Guo Zha ntao Tian Xuliang Wang Shuhong Pan Weiren Huang Yongqing Shen Yaoting Gui Xianglin Duan Zhiming Cai | 2015 | Acta Biochimica et Biophysica Sinica2015，47，2： | 5 |
| 4 | Onshore-offshore wind energy resource evaluation based on synergetic use of multiple satellite data and meteorological stations in Jiangsu Province,China显示文摘The demand for efficient and cost-effective renewable energy is increasing as traditional sources of energy such as oil,coal,and natural gas,can no longer satisfy growing global energy demands.Among renewable energies,wind energy is the most prominent due to its low, manageable impacts on the local environment.Based on meteorological data from 2006 to 2014 and multi-source satellite data (i.e.,Advanced Scatterometer,Quick Scatterometer,and Windsat)from 1999 to 2015,an assessment of the onshore and offshore wind energy potential in Jiangsu Province was performed by calculating the average wind speed,average wind direction,wind power density, and annual energy production (AEP).Results show that Jiangsu has abundant wind energy resources,which increase from inland to coastal areas.In-onshore areas, wind power density is predominantly less than 200 W/m^2, while in offshore areas,wind power density is concentrates in the range of 328-500 W/m^2.Onshore areas comprise more than 13,573.24 km^2,mainly located in eastern coastal regions with good wind farm potential The total wind power capacity in onshore areas could be as much as 2.06×10^5 GWh.Meanwhile,offshore wind power generation in Jiangsu Province is calculated to reach 2×10^6 GWh, which is approximately four times the electricity demand of the entire Jiangsu Province.This study validates the effective application of Advanced Scatterometer,Quick Scatterometer,and Windsat data to coastal wind energy monitoring in Jiangsu.Moreover,the methodology used in this study can be effectively applied to other similar coastal zones. | Xianglin WEI Yuewei DUAN Yongxue LIU Song JIN Chao SUN | 2019 | Frontiers of Earth Science2019，13，1： | 4 |
| 5 | Weakened interlayer coupling in two-dimensional MoSe2 flakes with screw dislocations显示文摘The screw dislocations are intriguing defects that are often observed in natural and artificial materials. The dislocation spirals break the reflection and inversion symmetries of the lattices and modify the interlayer coupling in layer-structured materials, inducing additional complexity in layer stacking and thus novel properties in materials. Here, we report on the interlayer coupling of two-dimensional (2D) MoSe2 flakes with screw dislocations by atomic force microscopy (AFM), Raman spectra and photoluminescence (PL) spectra. By controlling the supersaturation conditions, 2D MoSe2 flakes with screw dislocations are grown on amorphous SiO2 substrates by chemical vapor deposition (CVD). AFM measurements reveal that the interlayer spacing in such 2D MoSe2 flakes with screw dislocation is slightly widened with respect to the normal AA- or AB-stacked ones due to the presence of the screw dislocations. Raman and PL spectra show that the interlayer coupling is weaker and thus the band gap is wider than that in the normal AA- or AB-stacked ones. Our work demonstrates that the interlayer coupling of 2D transition metal dichalcogenides (TMDCs) flakes can be tuned by the induction of screw dislocations, which is very helpful for developing novel catalysts and electronic devices. | Xiangzhuo Wang Huixia Yang Rong Yang Qinsheng Wang Jingchuan Zheng Lu Qiao Xianglin Peng Yongkai Li Dongyun Chen Xiaolu Xiong Junxi Duan Guangyu Zhang Jie Ma Junfeng Han Wende Xiao Yugui Yao | 2019 | Nano Research2019，12，8： | 1 |
| 6 | Nitric oxide contributes to the regulation of iron metabolism in skeletal muscle in vivo and in vitro显示文摘 | Haitao Wang Xianglin Duan Jianguo Liu Huanbin Zhao Yuqian Liu Yanzhong Chang | 2010 | Molecular and Cellular Biochemistry (-)2010，，1： | 1 |
| 7 | Ultra-small Pd clusters supported by chitin nanowires as highly efficient catalysts显示文摘 | Xianglin Pei Yi Deng Bo Duan Ting-Shan Chan Jyh-Fu Lee Aiwen Lei Lina Zhang | 2018 | Nano Research2018，11，6： | 1 |
| 8 | Gene expression profiles of sodium-dependent vitamin C transporters in mice after alcohol consumption显示文摘含酒精的肝疾病(ALD ) 是在西方的国家的一个严肃的肝问题。我们的以前的学习证明了维生素 C 在 ALD 起一个保护的作用。维生素 C 动态平衡被钠依赖者维生素 C transporters (SVCT ) 紧调整 1 和 2。但是在 ALD 的二 SVCT 的角色少些被理解。在这研究,我们在白酒消费以后在老鼠检验了二 SVCT 的表示模式。我们的结果建议那白酒消费显然在肾和肠在肝和 SVCT1 增加了二 SVCT 的表示,它为维生素 C 吸收是重要的。维生素 C 补充增加了 sera 维生素 C 内容并且改善 ALD 的症状。肠的吸收和肾的重吸收由 SVCT1 调停了是关键因素在酒精以后增加 sera 维生素 C 内容消费。我们建议两反应的氧种和低维生素 C 集中调整 SVCT 的表示,并且维生素 C 的保护的角色被压制组织缺氧可诱导的 factor-1 的稳定性调停。因此,我们的学习为在 ALD 并且为在 ALD 治疗的另外的抗氧化剂的更好的使用的维生素 C 动态平衡的理解是重要的。 | Xiaoqiang Guo Yuejia Wangi Yongqing Shen Yingjie Gao Yanzhong Chang Xianglin Duan | 2013 | Acta Biochimica et Biophysica Sinica2013，45，11： | 0 |
| 9 | Request pattern change-based cache pollution attack detection and defense in edge computing显示文摘Through caching popular contents at the network edge,wireless edge caching can greatly reduce both the content request latency at mobile devices and the traffic burden at the core network.However,popularity-based caching strategies are vulnerable to Cache Pollution Attacks(CPAs)due to the weak security protection at both edge nodes and mobile devices.In CPAs,through initiating a large number of requests for unpopular contents,malicious users can pollute the edge caching space and degrade the caching efficiency.This paper firstly integrates the dynamic nature of content request and mobile devices into the edge caching framework,and introduces an eavesdroppingbased CPA strategy.Then,an edge caching mechanism,which contains a Request Pattern Change-based Cache Pollution Detection(RPC2PD)algorithm and an Attack-aware Cache Defense(ACD)algorithm,is proposed to defend against CPAs.Simulation results show that the proposed mechanism could effectively suppress the effects of CPAs on the caching performance and improve the cache hit ratio. | Junwei Wang Xianglin Wei Jianhua Fan Qiang Duan Jianwei Liu Yangang Wang | 2023 | Digital Communications and Networks2023，9，5： | 0 |
| 10 | Sodium glutamate and gamma-aminobutyric acid affect iron metabolism in the rat caudate putamen显示文摘Glutamic acid and gamma-aminobutyric acid (GABA) influence iron content in the substantia nigra and globus pallidus, although the mechanisms of action remain unclear. The present study measured iron content and changes in divalent metal transporter 1 (DMT1) and hephaestin expression in the substantia nigra and caudate putamen, and explored the effects of GABA and glutamic acid on iron metabolism. Results demonstrated that iron content and DMT1 non iron response element [DMT1(-IRE)] expression were significantly greater but hephaestin expression was significantly lower in the caudate putamen of the monosodium glutamate group compared with the control group. No significant difference in iron content was detected between the GABA and control groups. DMT1(-IRE) expression was significantly reduced, but hephaestin expression was significantly increased in the GABA group compared with the control group. In addition, there was no significant difference in tyrosine hydroxylase expression between monosodium glutamate and GABA groups and the control group. These results suggested that glutamate affected iron metabolism in the caudate putamen by increasing DMT1(-IRE) and decreasing hephaestin expression. In addition, GABA decreased DMT1(-IRE) expression in the caudate putamen. | Na Wang Peng Guan Fei Li Yujian Fu Xianglin Duan Yanzhong Chang | 2010 | Neural Regeneration Research2010，5，21： | 0 |
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