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| 1 | DMP1 prevents osteocyte alterations,FGF23 elevation and left ventricular hypertrophy in mice with chronic kidney disease显示文摘During chronic kidney disease (CKD),alterations in bone and mineral metabolism include increased production of the hormone fibroblast growth factor 23 (FGF23) that may contribute to cardiovascular mortality.The osteocyte protein dentin matrix protein 1 (DMP1) reduces FGF23 and enhances bone mineralization,but its effects in CKD are unknown.We tested the hypothesis that DMP1 supplementation in CKD would improve bone health,prevent FGF23 elevations and minimize consequent adverse cardiovascular outcomes.We investigated DMP1 regulation and effects in wild-type (WT) mice and the Col4a3^-/- mouse model of CKD.Col4a3^-/- mice demonstrated impaired kidney function,reduced bone DMP1 expression,reduced bone mass,altered osteocyte morphology and connectivity,increased osteocyte apoptosis,increased serum FGF23,hyperphosphatemia,left ventricular hypertrophy (LVH),and reduced survival.Genetic or pharmacological supplementation of DMP1 in Col4a3^-/- mice prevented osteocyte apoptosis,preserved osteocyte networks,corrected bone mass,partially lowered FGF23 levels by attenuating NFAT-induced FGF23 transcription,and further increased serum phosphate.Despite impaired kidney function and worsened hyperphosphatemia,DMP1 prevented development of LVH and improved Col4a3^-/- survival.Our data suggest that CKD reduces DMP1 expression,whereas its restoration represents a potential therapeutic approach to lower FGF23 and improve bone and cardiac health in CKD. | Corey Dussold Claire Gerber Samantha White Xueyan Wang Lixin Qi Connor Francis Maralee Capella Guillaume Courbon Jingya Wang Chaoyuan Li Jian Q. Feng Tamara Isakova Myles Wolf Valentin David Aline Martin | 2019 | Bone Research2019，7，2： | 4 |
| 2 | Shale oil enrichment evaluation and production law in Gulong Sag,Songliao Basin,NE China显示文摘Based on the results of drilling,tests and simulation experiments,the shales of the Cretaceous Qingshankou Formation in the Gulong Sag of the Songliao Basin are discussed with respect to hydrocarbon generation evolution,shale oil occurrence,and pore/fracture evolution mechanism.In conjunction with a substantial amount of oil testing and production data,the Gulong shale oil enrichment layers are evaluated and the production behaviors and decline law are analyzed.The results are drawn in four aspects.First,the Gulong shales are in the stage of extensive hydrocarbon expulsion when R_(0) is 1.0%-1.2%,with the peak hydrocarbon expulsion efficiency of 49.5%approximately.In the low-medium maturity stage,shale oil migrates from kerogen to rocks and organic pores/fractures.In the medium-high maturity stage,shale oil transforms from adsorbed state to free state.Second,the clay mineral intergranular pores/fractures,dissolution pores,and organic pores make up the majority of the pore structure.During the transformation,clay minerals undergo significant intergranular pore/fracture development between the minerals such as illite and illite/smectite mixed layer.A network of pores/fractures is formed by organic matter cracking.Third,free hydrocarbon content,effective porosity,total porosity,and brittle mineral content are the core indicators for the evaluation of shale oil enrichment layers.Class-I layers are defined as free hydrocarbon content equal or greater than 6.0 mg/g,effective porosity equal or greater than 3.5%,total porosity equal or greater than 8.0%,and brittle mineral content equal or greater than 50%.It is believed that the favourable oil layers are Q2-Q3 and Q8-Q9.Fourth,the horizontal wells in the core area of the light oil zone exhibit a high cumulative production in the first year,and present a hyperbolic production decline pattern,with the decline index of 0.85-0.95,the first-year decline rate of 14.5%-26.5%,and the single-well estimated ultimate recovery(EUR)greater than 2.0×10^(4)t.In practical exploration and production,more efforts will be devoted to the clarification of hydrocarbon generation and expulsion mechanisms,accurate testing of porosity and hydrocarbon content/phase of shale under formation conditions,precise delineation of the boundary of enrichment area,relationship between mechanical properties and stimulated reservoir volume,and enhanced oil recovery,in order to improve the EUR and achieve a large-scale,efficient development of shale oil. | SUN Longde CUI Baowen ZHU Rukai WANG Rui FENG Zihui LI Binhui ZHANG Jingya GAO Bo WANG Qingzhen ZENG Huasen LIAO Yuanhui JIANG Hangl | 2023 | Petroleum Exploration and Development2023，50，3： | 1 |
| 3 | Metal-free synthesis of N-sulfonylformamidines via skeletal reconstruction of sulfonyl oximonitriles显示文摘We developed for the first time an unprecedented domino reaction of sulfonyl oximonitriles with secondary amines to streamline the synthesis of N-sulfonylformamidines in decent to high yields under mild reaction conditions.In addition,scale-up experiments and late-stage functionalization of drugs were also performed.Preliminary studies indicate that the loss of a cyano-/benzyloxy-group and a sulfonyl migration process are involved in this reaction. | Feng Li Ziyan Wu Jingjing Wang Siyuan Zhang Jiaxin Yu Zhen Yuan Jingya Liu Renzeng Shen Yao Zhou Lantao Liu | 2022 | Organic Chemistry Frontiers2022，9，3： | 0 |
| 4 | SCENERY:a lightweight block cipher based on Feistel structure显示文摘In this paper,we propose a new lightweight block cipher called SCENERY.The main purpose of SCENERY design applies to hardware and software platforms.SCENERY is a 64-bit block cipher supporting 80-bit keys,and its data processing consists of 28 rounds.The round function of SCENERY consists of 84×4 S-boxes in parallel and a 32× 32 binary matrix,and we can implement SCENERY with some basic logic instructions.The hardware implementation of SCENERY only requires 1438 GE based on 0.18 um CMOS technology,and the software implementation of encrypting or decrypting a block takes approximately 1516 clock cycles 0118-bit microcontrollers and 364 clock cycles on 64-bit processors.Compared with other encryption algorithms,the performance of SCENERY is well balanced for both hardware and software.By the security analyses,SCENERY can achieve enough security margin against known attacks,such as differential cryptanalysis,linear cryptanalysis,impossible differential cryptanalysis and related-key attacks. | Jingya FENG Lang LI | 2022 | Frontiers of Computer Science2022，16，3： | 0 |
| 5 | Bird specimen number linked with species trait and climate niche breadth显示文摘Biological specimens are fundamental for taxonomy and flora/fauna research.More importantly,they also play crucial roles in recording environmental impacts on morphology and behavior,which is vital for biodiversity research and conservation.However,there are few systematic studies on the patterns and drivers of bird specimen number at regional scales.This study is the first attempt to examine the relationships between bird specimen number and species traits as well as climate niche breadth in China,aiming to answer two questions:1)how do species’temperature niche breadth and precipitation niche breadth influence specimen number?2)which trait is most associated with bird specimen number?The associations between bird specimen number and explanatory variables were examined using ordinary least squares,generalized linear models,phylogenetic generalized linear mixed models,and multiple comparisons.The results showed that Muscicapidae was the family with the highest specimen number,and Passeriformes was the order with the highest specimen number.Bird specimen number significantly increased with larger temperature niche breadth and precipitation niche breadth.Specimen number was also positively associated with geographic range size,habitat specificity,hunting vulnerability and clutch size,but negatively associated with body size.These findings suggest that future bird specimen collection should pay more attention to birds with limited ecological niches,large body sizes,and small clutch sizes.This research enhances the use of bird specimen data to study and preserve biodiversity. | Xiaoyu Duan Xiongwei Huang Jingya Zhang Shuo Lv Gang Song Yanping Wang Gang Feng | 2024 | Avian Research2024，15，1： | 0 |
| 6 | Implementation of PRINCE with resource-efficient structures based on FPGAs显示文摘In this era of pervasive computing, low-resource devices have been deployed in various fields. PRINCE is a lightweight block cipher designed for low latency, and is suitable for pervasive computing applications. In this paper, we propose new circuit structures for PRINCE components by sharing and simplifying logic circuits, to achieve the goal of using a smaller number of logic gates to obtain the same result. Based on the new circuit structures of components and the best sharing among components,we propose three new hardware architectures for PRINCE. The architectures are simulated and synthesized on different programmable gate array devices. The results on Virtex-6 show that compared with existing architectures, the resource consumption of the unrolled, low-cost, and two-cycle architectures is reduced by 73, 119, and 380 slices, respectively. The low-cost architecture costs only 137 slices. The unrolled architecture costs 409 slices and has a throughput of 5.34 Gb/s. To our knowledge, for the hardware implementation of PRINCE, the new low-cost architecture sets new area records, and the new unrolled architecture sets new throughput records. Therefore, the newly proposed architectures are more resource-efficient and suitable for lightweight,latency-critical applications. | Lang LI Jingya FENG Botao LIU Ying GUO Qiuping LI | 2021 | Frontiers of Information Technology & Electronic Engineering2021，22，11： | 0 |
| 7 | Study on key management scheme for heterogeneous wireless sensor networks显示文摘Heterogeneous wireless sensor network( HWSN) is composed of different functional nodes and is widely applied. With the deployment in hostile environment,the secure problem of HWSN is of great importance; moreover,it becomes complex due to the mutual characteristics of sensor nodes in HWSN. In order to enhance the network security,an asymmetric key pre-distributed management scheme for HWSN is proposed combining with authentication process to further ensure the network security; meanwhile,an effective authentication method for newly added nodes is presented. Simulation result indicates that the proposed scheme can improve the network security while reducing the storage space requirement efficiently. | 秦丹阳 Ma Jingya Zhang Yan Yang Songxiang Ji Ping Feng Pan | 2018 | High Technology Letters2018，24，4： | 0 |
| 8 | Mg/Ca,Ba/Ca,and S/Ca ratios as environmental and growth proxies for bivalve shells from the Haima cold seep,South China Sea显示文摘Bivalve shell fossils,cemented by authigenic carbonates,are widely spread in the Haima cold seep,Qiongdongnan Basin of the South China Sea(SCS).In this study,we examined an element profile of Gigantidas platifrons in the Haima cold seeps at a water depth of 1381 m.Based on the scanning electron microscope(SEM)analyses,the prismatic layer and nacreous layer were identified,which are characterized by prismatic structure and stratified structure,respectively.In addition,the profile can be subdivided into two parts:altered and unaltered zones.Laser inductively coupled plasma mass spectrometry(LA-ICP-MS)mapping shows that the element concentrations of the altered zones were influenced by the authigenic carbonate rocks,whereas the element concentrations of unaltered zones remain stable.In-situ X-ray diffraction(XRD)analyses show that the mineral constituent of the prismatic layer is mainly composed of aragonite.Along with the growth profile,Mg/Ca ratios of unaltered zones have minor variations,ranging 0.72-0.97 mmol/mol(mean=0.87 mmol/mol),with estimated temperatures of 3.8-4.1℃,indicating that the temperature of the surrounding seawater remains constant and agree with the measured data of 3.9℃which was conducted by a conductivity-temperature-depth system(CTD).The minor variations of Ba/Ca ratios(0.01-0.06 mmol/mol;mean=0.04 mmol/mol)indicate a relatively stabilized salinity of the surrounding seawater.S/Ca ratios show large variations of 0.04-4.15 mmol/mol(mean=1.37 mmol/mol).S/Ca ratios have regular variations which generally correspond to the variations of the Mg/Ca ratios,highlighting that the S/Ca ratios of bivalve shells show the potential to reflect the growth rate of the Gigantides.However,further studies should be carried out on the understanding of the links between the S/Ca ratios and seepage intensity of cold-seep fluids. | Jingya CAO Shengxiong YANG Danling TANG Junxi FENG Jinqiang LIANG | 2023 | Journal of Oceanology and Limnology2023，41，2： | 0 |
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