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| 1 | Rapid species identification of pathogenic bacteria from a minute quantity exploiting three-dimensional quantitative phase imaging and artificial neural network显示文摘The healthcare industry is in dire need of rapid microbial identification techniques for treating microbial infections.Microbial infections are a major healthcare issue worldwide,as these widespread diseases often develop into deadly symptoms.While studies have shown that an early appropriate antibiotic treatment significantly reduces the mortality of an infection,this effective treatment is difficult to practice.The main obstacle to early appropriate antibiotic treatments is the long turnaround time of the routine microbial identification,which includes time-consuming sample growth.Here,we propose a microscopy-based framework that identifies the pathogen from single to few cells.Our framework obtains and exploits the morphology of the limited sample by incorporating three-dimensional quantitative phase imaging and an artificial neural network.We demonstrate the identification of 19 bacterial species that cause bloodstream infections,achieving an accuracy of 82.5%from an individual bacterial cell or cluster.This performance,comparable to that of the gold standard mass spectroscopy under a sufficient amount of sample,underpins the effectiveness of our framework in clinical applications.Furthermore,our accuracy increases with multiple measurements,reaching 99.9%with seven different measurements of cells or clusters.We believe that our framework can serve as a beneficial advisory tool for clinicians during the initial treatment of infections. | Geon Kim Daewoong Ahn Minhee Kang Jinho Park DongHun Ryu YoungJu Jo Jinyeop Song Jea Sung Ryu Gunho Choi Hyun Jung Chung Kyuseok Kim Doo Ryeon Chung In Young Yoo Hee Jae Huh Hyun-seok Min Nam Yong Lee YongKeun Park | 2022 | Light(Science & Applications)2022，11，7： | 2 |
| 2 | The effects of network characteristics on performance of innovation clusters显示文摘 | Jinho Choi Ahn Sang -Hyun Min-Seok Cha | 2013 | Expert Systems With Applications2013，，11： | 1 |
| 3 | Multiple-yapsin-deficient mutant strains for high-level production of intact recombinant proteins in Saccharomyces cerevisiae显示文摘 | Eun Young Cho Seon Ah Cheon Hyunah Kim Jinho Choo Dong-Jik Lee Ho Myung Ryu Sang Ki Rhee Bong-Hyun Chung Jeong-Yoon Kim Hyun Ah Kang | 2010 | Journal of Biotechnology2010，，1： | 1 |
| 4 | Business Groups and Corporate Transparency in Emerging Markets: Empirical Evidence from India 显示文摘 | Chinmay Pattnaik James Jinho Chang Hyun Han Shin | 2013 | Asia Pacific Journal of Management2013，，30： | 1 |
| 5 | Characterization of cadmium removal from aqueous solution by biochar produced from a giant Miscanthus at different pyrolytic temperatures显示文摘 | Woong-Ki Kim Taeyong Shim Yong-Seong Kim Seunghun Hyun Changkook Ryu Young-Kwon Park Jinho Jung | 2013 | Bioresource Technology2013，，： | 1 |
| 6 | Molecular Recognition Mediated Fabrication of Protein Nanostructures by Dip-Pen Lithography 显示文摘 | Jinho Hyun Sang Jung Ahn Woo Kyung Lee | 2002 | Nano Lett2002，2，11： | 1 |
| 7 | Restriction of biofouling in membrane filtration using a brush-like polymer containing oligoethylene glycol side chains 显示文摘 | Hyun Jinho Jang Hawon Kim Kyungcheol | 2006 | Journal of Membrane Science2006，282，12： | 1 |
| 8 | Synchronization of an optical frequency comb and a microwave oscillator with 53 zs/Hz^(1/2) resolution and 10^(-20) -level stability显示文摘Precise and stable synchronization between an optical frequency comb(femtosecond mode-locked laser oscillator or microresonator-based comb) and a microwave oscillator is important for various fields including telecommunication, radio astronomy, metrology, and ultrafast X-ray and electron science. Timing detection and synchronization using electro-optic sampling with an interferometer has been actively used for low-noise microwave generation, long-distance timing transfer, comb stabilization, time-of-flight sensing, and laser-microwave synchronization for ultrafast science facilities. Despite its outstanding performance, there has been a discrepancy in synchronization performance of more than 10 dB between the projected shot-noise-limited noise floor and the measured residual noise floor. In this work, we demonstrate the shot-noise-limited performance of an electro-optic timing detector-based comb-microwave synchronization, which enabled an unprecedented residual phase noise floor of -174.5 dBc∕Hz at 8 GHz carrier frequency(i.e., 53 zs∕Hz^(1/2)timing noise floor), integrated rms timing jitter of 88 as(1 Hz to 1 MHz), rms timing drift of 319 as over 12 h, and frequency instability of 3.6 × 10^(-20) over 10,000 s averaging time. We identified that bandpass filtering of the microwave signal and optical pulse repetition-rate multiplication are critical for achieving this performance. | Changmin Ahn Yongjin Na Minji Hyun Jinho Bae Jungwon Kim | 2022 | Photonics Research2022，10，2： | 0 |
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