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| 1 | Genetic correction of p-thalassemia patient-specific iPS cells and its use in improving hemoglobin production in irradiated SCID mice显示文摘 | Yixuan Wang Chen-Guang Zheng Yonghua Jiang Jiqin Zhang Jiayu Chen Chao Yao Qingguo Zhao Sheng Liu Ke Chen Juan Du Ze Yang Shaorong Gao | 2012 | Cell Research2012，22，4： | 27 |
| 2 | Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants显示文摘 | Lei Yang Xiaohui Zhang Liren Wang Shuming Yin Biyun Zhu Ling Xie Qiuhui Duan Huiqiong Hu Rui Zheng Yu Wei Liangyue Peng Honghui Han Jiqin Zhang Wenjuan Qiu Hongquan Geng Stefan Siwko Xueli Zhang Mingyao Liu Dali Li | 2018 | Protein & Cell2018，9，9： | 13 |
| 3 | S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance显示文摘最近的研究证明 UHRF1 被指向 DNMT1 到 DNA 复制 foci 为 DNA methylation 维护要求,大概通过它的唯一的半甲醇化物有 DNMT1 的 DNA 有约束力的活动和相互作用。UHRF2, UHRF 家庭蛋白质的另一个成员,高度类似于在顺序和结构的 UHRF1,关于它在 DNA methylation 的角色的涨的问题。在这研究,我们证明 UHRF2 象 UHRF1 一样,也优先地绑在 methylated histone H3 离氨酸 9 (H3K9 ) 通过它的保存 tudor,通过 SET 和戒指的领域和半甲醇化物 DNA 联系了领域。象 UHRF1 一样, UHRF2 在 pericentric heterochromatin 被充实。heterochromatin 本地化取决于到大程度它的 methylated H3K9 有约束力的活动并且到它的 methylated 上的更少的程度 DNA 有约束力的活动。Coimmunoprecipitation 实验证明 UHRF1 和 UHRF2 与 DNMT1, DNMT3a, DNMT3b 和 G9a 交往。尽管有所有这些保存功能,我们发现 UHRF2 不能在 Uhrf1 空老鼠救 DNA methylation 缺点胚胎的干细胞。这个罐头在房间周期的 S 阶段期间为 UHRF2 被归因于无能到成员 DNMT1 到复制 foci。确实,我们发现当 UHRF1 在房间以一种 S 阶段依赖者方式与 DNMT1 交往时, UHRF2 不做。因此,我们的学习证明 UHRF2 和 UHRF1 不在 DNA methylation 维护是机能上地冗余的并且作为为 DNA methylation 指向 DNMT1 的关键规章的机制揭示在 UHRF1 和 DNMT1 之间的 cell-cycle-dependent 相互作用。 | Jiqin Zhang Qinqin Gao Pishun Li Xiaoli Liu Yuanhui Jia Weicheng Wu Jiwen Li Shuo Dong Haruhiko Koseki Jiemin Wong | 2011 | Cell Research2011，21，12： | 12 |
| 4 | Stem cell lineage in body layer specialization and vascular patterning of rice root and leaf显示文摘Since the first appearance of vascular plants during evolution, the plant body has become specialized for adaption to land conditions. Much of our knowledge of plant body specialization and the origins of tissues from stem cells have been obtained from studies on the dicot Arabidopsis thaliana. However, less is known about plant body specialization in monocots, another important branch of angiosperms. In this study, we analyzed stem cell lineage and differentiation during development of the root and leaf of the monocot model plant rice(Oryza sativa). Our results showed that three body layers of rice are established from stem cells accompanied by progressively reduced pluripotency. Layer 1(L1) is a single-cell layer of epidermis; L2 is the cortex/endodermis in the root and the mesophyll in the leaf; and L3 is the site of vascular initiation. At least two common steps in vascular development are shared between rice root and leaf. The preprocambium divides to form the procambium and root pericycle or leaf outer sheath. The procambium further differentiates into the xylem, phloem and circumambient cells. We found that the outer sheath of leaf vascular bundles originates not only from the preprocambium of L3,but also from the mesophyll precursor cells of L2. In addition, WUSCHEL-RELATED HOMEOBOX(WOX)genes are expressed in not only the stem cell niche but also metaxylem precursor in rice. This pattern differs from that of homologs in Arabidopsis, suggesting that WOX functions have been recruited in different stem cells in dicots and monocots. | Minhuan Zeng Bo Hu Jiqin Li Guifang Zhang Ying Ruan Hai Huang Hua Wang Lin Xu | 2016 | Science Bulletin2016，61，11： | 5 |
| 5 | Development of 101 Novel EST-Derived Single Nucleotide Polymorphism Markers for Zhikong Scallop (Chlamys farreri)显示文摘Zhikong scallop(Chlamys farreri) is an important maricultured species in China.Many researches on this species,such as population genetics and QTL fine-mapping,need a large number of molecular markers.In this study,based on the expressed sequence tags(EST),a total of 300 putative single nucleotide polymorphisms(SNPs) were selected and validated using high resolution melting(HRM) technology with unlabeled probe.Of them,101(33.7%) were found to be polymorphic in 48 individuals from 4 populations.Further evaluation with 48 individuals from Qingdao population showed that all the polymorphic loci had two alleles with the minor allele frequency ranged from 0.046 to 0.500.The observed and expected heterozygosities ranged from 0.000 to 0.925 and from 0.089 to 0.505,respectively.Fifteen loci deviated significantly from Hardy-Weinberg equilibrium and significant linkage disequilibrate was detected in one pair of markers.BLASTx gave significant hits for 72 of the 101 polymorphic SNP-containing ESTs.Thirty four polymorphic SNP loci were predicted to be non-synonymous substitutions as they caused either the change of codons(33 SNPs) or pretermination of translation(1 SNP).The markers developed can be used for the population studies and genetic improvement on Zhikong scallop. | LI Jiqin BAO Zhenmin LI Ling WANG Xiaojian WANG Shi HU Xiaoli | 2013 | Journal of Ocean University of China2013，12，3： | 2 |
| 6 | An Implementation of Full Cycle Strategy Using Dynamic Blending for Rapid Refresh Short-range Weather Forecasting in China显示文摘The partial cycle(PC)strategy has been used in many rapid refresh cycle systems(RRC)for regional short-range weather forecasting.Since the strategy periodically reinitializes the regional model(RM)from the global model(GM)forecasts to correct the large-scale drift,it has replaced the traditional full cycle(FC)strategy in many RRC systems.However,the extra spin-up in the PC strategy increases the computer burden on RRC and generates discontinuous smallscale systems among cycles.This study returns to the FC strategy but with initial fields generated by dynamic blending(DB)and data assimilation(DA).The DB ingests the time-varied large-scale information from the GM to the RM to generate less-biased background fields.Then the DA is performed.We applied the new FC strategy in a series of 7-day batch forecasts with the 3-hour cycle in July 2018,and February,April,and October 2019 over China using a Weather Research and Forecast(WRF)model-based RRC.A comparison shows that the new FC strategy results in less model bias than the PC strategy in most state variables and improves the forecast skills for moderate and light precipitation.The new FC strategy also allows the model to reach a balanced state earlier and gives favorable forecast continuity between adjacent cycles.Hence,this new FC strategy has potential to be applied in RRC forecast systems to replace the currently used PC strategy. | Jin FENG Min CHEN Yanjie LI Jiqin ZHONG | 2021 | Advances in Atmospheric Sciences2021，38，6： | 2 |
| 7 | Hydrogen sulfide emission from two large pig finishing buildings with long term high frequency measurements显示文摘 | Ni Jiqin Heber A J Lim T T | 2002 | Journal of Agricultural Science2002，138，2： | 1 |
| 8 | Effect of swine manure dilution on ammonia, hydrogen sulfide, carbon dioxide, and sulfur dioxide releases显示文摘 | Ni Jiqin Heber A J Sutton A L et a1 | 2010 | Science of the Total Environment2010，408，23： | 1 |
| 9 | Compara- tive Research on GPS Height Fitting Methods Based on Neural Network 显示文摘 | Niu Zhihong Song Mengbo Chen Jiqin | 2012 | Procedia Engineering2012，28，： | 1 |
| 10 | P-probabilities and its applications显示文摘 | Liu Jiqin | 2010 | An International Journal Advances in Systems Science and Applications2010，10，2： | 1 |
| 11 | The properties of two-direction S-rough fuzzy sets 显示文摘 | LIU Jiqin | 2009 | The Sixth International Conference on Fuzzy Systems and Knowledge Discovery2009，6，： | 1 |
| 12 | P-probabilities and its applications显示文摘 | Liu Jiqin | 2010 | An International Journal Advances in Systems Science and Applications2010，10，2： | 1 |
| 13 | 显示文摘 | Zhu Jiqin Wang Fuan | 2003 | J Chem Ind Eng (China)2003，54，5： | 1 |
| 14 | P-probabilities and its applications 显示文摘 | LIU Jiqin | 2010 | An International Journal Advances in Systems Science and Applications2010，10，2： | 1 |
| 15 | P-probailities and its application显示文摘 | LIU Jiqin | 2010 | An International Journal Advances in Systems Science and Applications2010，10，2： | 1 |
| 16 | Existence and uniqueness of solutions of initial value problems for nonlinear fractional differential e- quations显示文摘 | Jiqin Deng Lifeng Ma | 2010 | Applied Mathematics Letters2010，23，： | 1 |
| 17 | ROS - induced ZNF580 expres- sion: a key role for H202/NF -kappaB signaling pathway in vascular endothelial inflammation显示文摘 | Dangli R Hekong W Jiqin L | 2012 | Mol Cell Biochem2012，359，12： | 1 |
| 18 | P-Probabilities and its application 显示文摘 | LIU Jiqin | 2010 | An International Journal Advances in Systems Science and Applications2010，10，2： | 1 |
| 19 | Circular RNA vaccine in disease prevention and treatment显示文摘CircRNAs are a class of single-stranded RNAs with covalently linked head-to-tail topology.In the decades since its initial discovery,their biogenesis,regulation,and function have rapidly disclosed,permitting a better understanding and adoption of them as new tools for medical applications. | Dun Niu Yaran Wu Jiqin Lian | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 1 |
| 20 | The rice ERF transcription factor OsERF922 negatively regulates resistance to Magnaporthe oryzae and salt tolerance显示文摘 | Dongfeng Liu Xujun Chen Jiqin Liu Jianchun Ye Zejian Guo | 2012 | Journal of Experimental Botany2012，，10： | 1 |
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