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| 1 | Salivary exosomal PSMA7: a promising biomarker of inflammatory bowel disease显示文摘煽动性的肠疾病(IBD ) 是包括中国在亚洲增加的流行的世界范围的肠的免疫者不正常的疾病。它是有未知原因的胃肠的道的长期的疾病。Exosomes 是在各种各样的身体液体的小泡。他们有 40-120 的直径 ? nm,并且他们的功能之一是各种各样的物质的长途的转移。在这研究,我们与 IBD 并且在健康控制在病人调查了唾液的 exosomes 的内容与 IBD 在病人探索新 biomarker。在这研究,整个口水与 IBD 从病人被获得(ulcerative 大肠炎(UC ) , n ?=? 37;Crohns 疾病(CD ) , n ?=? 11 ) 并且显然健康的个人(HC, n ?=? 10 ) 。唾液的 exosomes 从样品被提取,并且在 exosomes 以内的蛋白质被液体用色层法分离团分光计(LC-MS/MS ) 识别。结果证明超过 2000 蛋白质与 IBD 从病人在唾液的 exosomes 被检测。通过基因本体论分析,我们发现(PSMA7 ) proteasome 子单元 alpha 类型 7 与 IBD 和健康控制显示出病人之间的特别显著的差别,因为它的表达式水平在 CD 和 UC 组是高得多的。这 exosomal 蛋白质与 proteasome 活动和煽动性的回答有关。我们因此断定在这研究,唾液的 exosomal PSMA7 在在从有 IBD 的题目的唾液的 exosomes 的高水平是在场的。免除病人 colonoscopy 的疼痛能是很有希望的 biomarker。 | Xiaowen Zheng Feng Chen Qian Zhang Yulan Liu Peng You Shan Sun Jiuxiang Lin Ning Chen | 2017 | Protein & Cell2017，8，9： | 19 |
| 2 | Surface nanostructures orienting self-protection of an orthodontic nickel-titanium shape memory alloys wire显示文摘Shape memory alloys (SMA) have been applied to a wide variety of applications in a number of different fields such as aeronautical applications, sensors/actuators, medical sciences as well as orthodontics. It is a hot topic to enhance the anti-corrosion ability of orthodontic wires for clinical applications. In this letter, a very nice fractal structure, micro-domains with identical nanometer sized grooves, was ob- tained on the surfaces of the orthodontic wires with an oxygen plasma and acid corrosion. The concave parts of the grooves were dominated by titanium and convex parts were the same as the bulk wires. The micro-nano fractal structure generated a hydrophobic surface with the largest contact angle to water being about 157°. The titanium dominated nanolayer and the hydrophobicity of the surface resulted in jointly the great improvement of the anti-corrosion ability of the orthodontic wires. Because the fractal structures of the wires were formed automatically when they immersed in acidic environment, hence, the self-protection of the oxygen plasma-treated orthodontic wires in acidic environment indicates their potential applications in orthodontics, and should be also inspirable for other applications of SMA materials. | NIE Qiong JI ZhuoYu LIN JiuXiang HU WenPing | 2007 | Chinese Science Bulletin2007，52，21： | 4 |
| 3 | DNA methylation profile is associated with the osteogenic potential of three distinct human odontogenic stem cells显示文摘Among the various sources of human autologous stem cells,stem cells isolated from dental tissues exhibit excellent properties in tissue engineering and regenerative medicine.However,the distinct potential of these odontogenic cell lines remains unclear.In this study,we analyzed DNA methylation patterns to determine whether specific differences existed among three different odontogenic cell types.Using the HumanMethylation450 Beadchip,the whole genomes of human dental pulp stem cells(DPSCs),periodontal ligament stem cells(PDLSCs),and dental follicle progenitor cells(DFPCs)were compared.Then,the osteogenic potential of these cells was evaluated both in vitro and in vivo,and the methylation levels of certain genes related to bone formation differed among the three cell lines.P values less than 0.05 were considered to indicate statistical significance.The three cell types showed highly similar DNA methylation patterns,although specific differences were identified.Gene ontology analysis revealed that one of the most significantly different gene categories was related to bone formation.Thus,expression of cell surface epitopes and osteogenic-related transcription factors as well as the bone formation capacity were compared.The results showed that compared with DFPCs and DPSCs,PDLSCs had higher transcription levels of osteogenic-related factors,a higher in vitro osteogenic potential,and an increased new bone formation capacity in vivo.In conclusion,the results of this study suggested that the differential DNA methylation profiles could be related to the osteogenic potential of these human odontogenic cell populations.Additionally,the increased osteogenic potential of PDLSCs might aid researchers or clinicians in making better choices regarding tissue regeneration and clinical therapies. | Tingting Ai Jieni Zhang Xuedong Wang Xiaowen Zheng Xueyan Qin Qian Zhang Weiran Li Wei Hu Jiuxiang Lin Feng Chen | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 3 |
| 4 | Machine Learning Models for Genetic Risk Assessment of Infants with Non-syndromic Orofacial Cleft显示文摘The isolated type of orofacial cleft, termed non-syndromic cleft lip with or without cleft palate(NSCL/P), is the second most common birth defect in China, with Asians having the highest incidence in the world. NSCL/P involves multiple genes and complex interactions between genetic and environmental factors, imposing difficulty for the genetic assessment of the unborn fetus carrying multiple NSCL/P-susceptible variants. Although genome-wide association studies(GWAS)have uncovered dozens of single nucleotide polymorphism(SNP) loci in different ethnic populations, the genetic diagnostic effectiveness of these SNPs requires further experimental validation in Chinese populations before a diagnostic panel or a predictive model covering multiple SNPs can be built. In this study, we collected blood samples from control and NSCL/P infants inHan and Uyghur Chinese populations to validate the diagnostic effectiveness of 43 candidate SNPs previously detected using GWAS. We then built predictive models with the validated SNPs using different machine learning algorithms and evaluated their prediction performance. Our results showed that logistic regression had the best performance for risk assessment according to the area under curve. Notably, defective variants in MTHFR and RBP4, two genes involved in folic acid and vitamin A biosynthesis, were found to have high contributions to NSCL/P incidence based on feature importance evaluation with logistic regression. This is consistent with the notion that folic acid and vitamin A are both essential nutritional supplements for pregnant women to reduce the risk of conceiving an NSCL/P baby. Moreover, we observed a lower predictive power in Uyghur than in Han cases, likely due to differences in genetic background between these two ethnic populations.Thus, our study highlights the urgency to generate the HapMap for Uyghur population and perform resequencing-based screening of Uyghur-specific NSCL/P markers. | Shi-Jian Zhang Peiqi Meng Jieni Zhang Peizeng Jia Jiuxiang Lin Xiangfeng Wang Feng Chen Xiaoxing Wei | 2018 | Genomics, Proteomics & Bioinformatics2018，16，5： | 3 |
| 5 | Comparison of intermaxillary toothsize discrepancies among different malocclusion groups 显示文摘 | Nie Qiong Lin Jiuxiang | 1999 | Am J Orthod Dentofacial Or-thop1999，116，： | 1 |
| 6 | Preliminary investigation of nonsurglcaltreatment of severe skeletal class Ⅲ malocclusion in the permanent dentition显示文摘 | Lin Jiuxiang Gu Yan | 2003 | The Angle Orthodontist2003，73，： | 1 |
| 7 | Preliminary investigation of nonsurgieal treatment of severe skeletal class Ⅲ malocclusion in the permanent dentition显示文摘 | Jiuxiang Lin Yan Gu | 2003 | Angle Orthod2003，73，4： | 1 |
| 8 | Validation of a three-dimensionalfacial scanning system based on structured light techniques显示文摘 | Lili Ma Tianmin Xu Jiuxiang Lin | 2009 | Computer Methods and Programs in Biomedicine2009，94，3： | 1 |
| 9 | Torque control of the maxillary incisors in lingual and labial orthodontics: A 3-dimensional finite element analysis显示文摘 | Wei Liang Qiguo Rong Jiuxiang Lin Baohua Xu | 2009 | American Journal of Orthodontics & Dentofacial Orthopedics2009，，3： | 1 |
| 10 | Lower second molar extraction in correction of severe skeletal Class Ili malocclusion显示文摘 | Jiuxiang Lin Yan Gu | | Angle Orthodontist Vol 76 No 20，8391，： | 1 |
| 11 | Comparison of intermaxillary tooth size discrepancies among different malocclusion groups显示文摘 | Qiong Nie Jiuxiang Lin | 1999 | Am J Orthod Dentofacial Orthop1999，116，5： | 1 |
| 12 | Validation of a three-dimensional facial scanning system based on structured light techniques显示文摘 | Lili Ma Tianmin Xu Jiuxiang Lin | 2009 | Computer Methods and Programs in Biomedicine2009，3，3： | 1 |
| 13 | Identification of rare PTCH1 nonsense variant causing orofacial cleft in a Chinese family and an up-to-date genotype- phenotype analysis显示文摘The Patched 1(PTCH1)gene encodes a membrane receptor involved in the Hedge-hog(Hh)signaling pathway,an abnormal state of which may result in congenital defects or hu-man tumors.In this study,we conducted whole-exome sequencing on a three-generation Chinese family characterized with variable penetrance of orofacial clefts.A rare heterozygous variant in the PTCH1 gene(c.2833C>T p.R945X)was identified as a disease-associated mutation.Structural modeling revealed a truncation starting from the middle of the second extracellular domain of PTCH1 protein.This may damage its ligand recognition and sterol transportation abilities,thereby affecting the Hh signaling pathway.Biochemical assays indi-cated that the R945X protein had reduced stability compared to the wild-type in vitro.In addi-tion,we reviewed the locations and mutation types of PTCH1 variants in individuals with clefting phenotypes,and analyzed the associations between clefts and locations or types of variants within PTCH1.Our findings provide further evidence that PTCH1 variants result in or-ofacial clefts,and contributed to genetic counseling and clinical surveillance in this family. | Wenjie Zhong Huaxiang Zhao Wenbin Huang Mengqi Zhang Qian Zhang Yue Zhang Chong Chen Zulihumaer Nueraihemaiti Dilifeire Tuerhong Huizhe Huang Gulibaha Maimaitili Feng Chen Jiuxiang Lin | 2021 | Genes & Diseases2021，8，5： | 1 |
| 14 | Preliminary investigation of nonsurgiealt reatment of severe skeletal class Ⅲ malocclusion in the permanent dentition显示文摘 | Jiuxiang Lin Yan Gu | 2003 | Angle orthodontist2003，73，4： | 1 |
| 15 | Preliminary investigation of nonsurgical treatment of severe skeletal class Ⅲ malocclusion in the pemla2nent dentition显示文摘 | Jiuxiang Lin Yan Gu | 2003 | Angle orthodontist2003，75，4： | 1 |
| 16 | Controlled growth of two-dimensional InAs single crystals via van der Waals epitaxy显示文摘Two-dimensional(2D)indium arsenide(InAs)is promising for future electronic and optoelectronic applications such as highperformance nanoscale transistors,flexible and wearable devices,and high-sensitivity broadband photodetectors,and is advantageous for its heterogeneous integration with Si-based electronics.However,the synthesis of 2D InAs single crystals is challenging because of the nonlayered structure.Here we report the van der Waals epitaxy of 2D InAs single crystals,with their thickness down to 4.8 nm,and their lateral sizes up to~37μm.The as-grown InAs flakes have high crystalline quality and are homogenous.The thickness can be tuned by growth time and temperature.Moreover,we explore the thickness-dependent optical properties of InAs flakes.Transports measurement reveals that 2D InAs possesses high conductivity and high carrier mobility.Our work introduces InAs to 2D materials family and paves the way for applying 2D InAs in high-performance electronics and optoelectronics. | Jiuxiang Dai Teng Yang Zhitong Jin Yunlei Zhong Xianyu Hu Jingyi Zou Weigao Xu Tao Li Yuxuan Lin Xu Zhang Lin Zhou | 2022 | Nano Research2022，15，11： | 1 |
| 17 | Validation of a three-dimensional facial scanning system based on structured light techniques显示文摘 | Ma Lili Xu Tianmin Lin Jiuxiang | 2009 | Computer Methods and Programs in Biomedicine2009，94，3： | 1 |
| 18 | Dental Arch Width Stability after Quadhelix and Edgewise Treatment in Complete Unilateral Cleft Lip and Palate显示文摘 | Weiran Li Jiuxiang Lin | | 0，，06： | 1 |
| 19 | A novel FZD6 mutation revealed the cause of cleft lip and/or palate in a Chinese family显示文摘Cleft lip and/or palate(CL/P)is a most common craniofacial birth defect which has multifactorial etiology.In our study,we aimed to discover the underlying etiological gene variation in a Chinese family diagnosed as non-syndromic CL/P(NSCL/P).The blood sample of the proband and her parents were detected by whole exome sequencing.The Mendelian inheritance pattern,allele frequency,variation location,function analysis and literature search were applied to filtrate and screen the mutation.Besides,the candidates were confirmed by Sanger sequencing.We meanwhile explored the conservative analysis and protein homology simulation.As a result,a start-lost mutation c.1A>GAtg/Gtg in the Frizzled-6(FZD6)gene predicting p.Met1 was detected.The variation has not been reported before and was predicted to be harmful.The alteration caused missing of two starting amino acids that are evolutionarily conserved for FZD6 protein.Moreover,the specific structure of the mutant protein obviously changed according to the results of the homologous model.In conclusion,the results suggest c.1A>GAtg/Gtg in the FZD6(NM_001164616)might be the genetic etiology for non-syndromic CL/P in this pedigree.Furthermore,this finding provided new etiologic information,supplementing the evidence that FZD6 is a strong potential gene for CL/P. | Jieni Zhang Huaxiang Zhao Wenbin Huang Fengqi Song Wenjie Zhong Mengqi Zhang Yunfan Zhang Zhibo Zhou Jiuxiang Lin Feng Chen | 2020 | Genes & Diseases2020，7，3： | 0 |
| 20 | Rare loss-of-function variants in FLNB cause non-syndromic orofacial clefts显示文摘Orofacial clefts (OFCs) are the most common congenital craniofacial disorders, of which the etiology is closely related to rare coding variants. Filamin B (FLNB) is an actin-binding protein implicated in bone formation. FLNB mutations have been identified in several types of syndromic OFCs and previous studies suggest a role of FLNB in the onset of non-syndromic OFCs (NSOFCs). Here, we report two rare heterozygous variants (p.P441T and p.G565R) in FLNB in two unrelated hereditary families with NSOFCs. Bioinformatics analysis suggests that both variants may disrupt the function of FLNB. In mammalian cells, p.P441T and p.G565R variants are less potent to induce cell stretches than wild type FLNB, suggesting that they are loss-of-function mutations. Immunohistochemistry analysis demonstrates that FLNB is abundantly expressed during palatal development. Importantly, Flnb^(−/−) embryos display cleft palates and previously defined skeletal defects. Taken together, our findings reveal that FLNB is required for development of palates in mice and FLNB is a bona fide causal gene for NSOFCs in humans. | Wenbin Huang Shiying Zhang Jiuxiang Lin Yi Ding Nan Jiang Jieni Zhang Huaxiang Zhao Feng Chen | 2024 | Journal of Genetics and Genomics2024，51，2： | 0 |
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