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1最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL 2014神经病学与神经康复学杂志2014,11,3:31
2Diagnostic and prognostic value of glycosyltransferase mRNA in glioblastoma multiforme patients.显示文摘Oblinger JL Pearl DK Boardman CL Saqr H Prior TW Scheithauer BW Jenkins RB Burger PC Yates AJ 2006中国神经肿瘤杂志2006,4,2:5
3非甾体抗炎药应用中,环氧合酶2、不对称二甲基精氨酸与心血管危害的关系显示文摘已有大规模、安慰剂对照试验确定了非甾体类抗炎药(nonsteroidal anti—inflammatory drugs,NSAIDs)具有心血管危害性:这归因于环氧合酶2(cyclooxygenase,COX-2)的心脏保护产物受到抑制,尤其是前列环素(prostacyclin,PG12)。NSAID降低心脏保护作用的另一种机制可能是通过增强肾脏中甲基精氨酸的形成来限制一氧化氮在整个脉管系统中的作用。Ricciotti E Castro C Tang SY Briggs WTE West JA Malik D Rhoades SD Meng H Li X Lahens NF Sparks JA Karlson EW Weljie AM Griffin JL FitzGerald GA6 刘青 叶鹏 2018中华高血压杂志2018,26,9:3
4星形胶质细胞转录组分析指导的脑卒中靶标鉴定显示文摘星形胶质细胞支持正常的脑功能,但在卒中等病理条件下,星形胶质细胞反应性激活,其也可能参与神经退行性改变。反应性星形胶质细胞增生对机体有益或有害,与环境背景有关,但其分子基础仍未得到充分解释。借助RiboTag技术,我们在特异性地短暂性大脑中动脉闭塞(tMCAO)72h后的小鼠星形胶质细胞中,纯化翻译mRNA,构建卒中特异性星形胶质细胞翻译组数据库。我们发现,与对照组脑组织相比,tMCAO后的反应性星形胶质细胞显示与A2表型相关的转录物的富集,这与神经保护相关。星形胶质细胞也会上调大量潜在的神经毒性基因。我们共鉴定了1003个基因和38个转录因子的差异表达,其中Stat3,Sp1和Spi1变化最明显。为了进一步探索Stat3介导的通路对卒中发病机制的影响,我们选择星形胶质细胞特异性条件性缺失Stat3的小鼠制造tMCAO模型,发现这些小鼠的局灶性缺血卒中体积减少,且梗死72h后小鼠的运动结果改善。综上所述,本研究扩展了新兴的星形胶质细胞特异性靶向卒中治疗数据库,并肯定了星形胶质细胞是脑功能的关键保障细胞。Rakers C Schleif M Blank N Matu?ková H Ulas T H?ndler K Torres SV Schumacher T Tai K Schultze JL Jackson WS Petzold GC 聂昊 2019神经损伤与功能重建2019,14,6:2
5Factors affecting mortality in biliary tract surgery显示文摘Pitt H amero JL ostier RG t al 1981Am J Surg1981,141,:2
6Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer 显示文摘 Yang Y Horton JL 1997J Clin Invest1997,100,8:1
7A 165 kD membrane antigen mediateing fibronectin - vinculin interaction is involved in murine odontoblast differentiation 显示文摘 Kubler MD Fausser JL 1990Differentiation1990,44,1:1
8Colitis cystica profunda imaging diagnosis and conservative treatment report of two cases显示文摘Valenzuela M Martin-Ruiz JL Alvarez-Cienfuegos H 1996Dis Colon Rectum1996,39,5:1
9Mucin-associated sialosyl-Tn antigen expression in gastric cancer correlates with an adverse outcome显示文摘Werther JL MacMurray SR Bruckner H 1994Br J Cancer1994,69,3:1
10Antipsychoti-c-induced weight gain:a comprehensive research synthesis显示文摘ALISON DB MENTORE JL MOONSEONG H 0,,:1
11Effect of sympathetic nerve block on acute inflammatorypain and hyperalgesia显示文摘Pedersen JL Rung GW Kehlet H 1977Anesthesi- ology1977,86,2:1
12Enan-tioselective access to chiral drugs by using asymmetric hydrogenation catalyzed by Rh(P-OP)complexes 显示文摘Etayo P Nunez-Rico JL Fernandez-Perez H 2011Chem EurJ2011,17,13:1
13Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding proteinlc (SREBP-lc) gene by antagonizing ligand-dependent activation of the LXR显示文摘Ou J Tu H Shan B Luk A DeBose-Boyd RA Bashmakov Y Goldstein JL Brown MS 0,,11:1
14Bortezomib plus dexamethasone is superior to vincristine plus doxorubicin plus dexamethasone as induction treatment prior to autologous stem-cell transplantation in newly diagnosed multiple myeloma:results of the IFM 2005-01 phase Ⅲ trial显示文摘Harousseau JL Attal M Avet-Loiseau H 0,,:1
152012 ACCF/AHA focused update of the guideline for the management of patients with unstable angina/non-ST-elevation myocardial infarction (updating the 2007 guideline and replacing the 2011 focused update): A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines 显示文摘Jneid H Anderson JL Wright RS 2012J Am Coll Cardiol2012,60,7:1
16GABA is the principla fast-acting excitatory transmitter in the neonatal brain显示文摘Leinekgel X Khalilov I McLean H Caillard 0 Gaiarsa JL Ben-Ari Y Khazipov R 1999Adv Neurol1999,79,:1
17The carboxy- terminal extension of the collagen binding domain of fibronectin mediate interaction with a 165 kD membrane protein involved in odontoblast differentiation 显示文摘 Fausser JL Akiyama SK 1992Differentiation1992,49,2:1
18In vitro selection for enzymatic activity:a model study using adenylate cyclase显示文摘 Ladant D Jestin JL 2003J Mol Biol2003,332,:1
19Prediction of immunodominant helper T cell antigenic sites from the primary sequence 显示文摘Margalit H Spouge JL Cornette JL 1987J Immunol1987,138,7:1
20Combination of photon and proton radiation therapy for chordomas and chondrosarcomas of the skull base:the Centre de Protontherapie D'Orsay experience显示文摘Noel G Habrand JL Mammar H 2001Int J Radiat Oncol Biol Phys2001,51,2:1
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