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4篇 您的检索式：作者名="John Gillick"

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		题名	作者	年代	出处	被引量
	1	Distinct signaling mechanisms of mTORC1 and mTORC2 in glioblastoma multiforme: A tale of two complexes显示文摘	Meena Jhanwar-Uniyal John L. Gillick Jayson Neil Michael Tobias Zachary E. Thwing Raj Murali	2015	Advances in Biological Regulation2015，，：	1
	2	Delayed diagnosis of imperforate anus: an unacceptable morbidity显示文摘	Carmen Turowski Jens Dingemann John Gillick	2010	Pediatric Surgery International2010，，11：	1
	3	Long-term complications following operative intervention for intestinal malrotation: a 10-year review显示文摘	Yousef El-Gohary Mohamed Alagtal John Gillick	2010	Pediatric Surgery International2010，，2：	1
	4	Altered tryptophan hydroxylase 2 expression in enteric serotonergic nerves in Hirschsprung's-associated enterocolitis显示文摘AIM: To determine if expression of colonic tryptophan hydroxylase-2(TPH2), a surrogate marker of neuronal 5-hydroxytryptamine, is altered in Hirschsprung's-associated enterocolitis. METHODS: Entire resected colonic specimens were collected at the time of pull-through operation in children with Hirschsprung's disease(HSCR, n = 12). Five of these patients had a history of pre-operative Hirschsprung's-associated enterocolitis(HAEC). Controls were collected at colostomy closure in children with anorectal malformation(n = 10). The distribution of expression of TPH2 was evaluated using immunofluorescence and confocal microscopy. Protein expression of TPH2 was quantified using western blot analysis in the deep smooth muscle layers. RESULTS: TPH2 was co-expressed in nitrergic and cholinergic ganglia in the myenteric and submucosal plexuses in ganglionic colon in HSCR and healthy controls. Co-expression was also seen in submucosal interstitial cells of Cajal and PDGFRα+ cells. The density of TPH2 immuno-positive fibers decreased incrementally from ganglionic bowel to transition zonebowel to aganglionic bowel in the myenteric plexus. Expression of TPH2 was reduced in ganglionic bowel in those affected by pre-operative HAEC compared to those without HAEC and healthy controls. However, expression of TPH2 was similar or high compared to controls in the colons of children who had undergone diverting colostomy for medically refractory HAEC.CONCLUSION: Altered TPH2 expression in colonic serotonergic nerves of patients with HSCR complicated by HAEC may contribute to intestinal secretory and motor disturbances, including recurrent HAEC.	David Coyle Justin M Murphy Brian Doyle Anne Marie O’Donnell John Gillick Prem Puri	2016	World Journal of Gastroenterology2016，22，19：	0

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