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8篇 您的检索式：作者名="Brian Doyle"

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		题名	作者	年代	出处	被引量
	1	Natural products as antibacterial agents显示文摘	GAlL B MAHADY YUE HUANG BRIAN J DOYLE	2008	Studies in Natural Products Chemistry2008，，35：	1
	2	Aberrant DNA Methylation in Hereditary Nonpolyposis Colorectal Cancer Without Mismatch Repair Deficiency显示文摘	Ajay Goel Rosa M. Xicola Thuy–Phuong Nguyen Brian J. Doyle Vanessa R. Sohn Prathap Bandipalliam Laura S. Rozek Josep Reyes Carmen Cordero Francesc Balaguer Antoni Castells Rodrigo Jover Montserrat Andreu Sapna Syngal C. Richard Boland Xavier Llor	2010	Gastroenterology2010，，5：	1
	3	Evaluation of a novel bioartificial liver in rats with complete liver ischemia: treatment efficacy and species-specific α-GST detection to monitor hepatocyte viability显示文摘	Leonard M Flendrig Robert A.F.M Chamuleau Martinus A.W Maas Joost Daalhuisen Brian Hasset Cormac G Kilty Sean Doyle Nita C.J.J Ladiges George G.A J?rning John W.la Soe Dirkje Sommeijer Anje A.te Velde	1999	Journal of Hepatology1999，，2：	1
	4	Biogeochemical response of organic-rich freshwater marshes in the Louisiana delta plain to chronic river water influx显示文摘	Christopher M. Swarzenski Thomas W. Doyle Brian Fry Thomas G. Hargis	2008	Biogeochemistry2008，，1：	1
	5	Preliminary results of a phase I trial of prophylactic ethanol-lock administration to prevent mediport catheter-related bloodstream infections显示文摘	Mark L. Kayton Edward G. Garmey Nicole M. Ishill Nai-Kong V. Cheung Brian H. Kushner Kim Kramer Shakeel Modak Carol Rossetto Courtney Hennelly Melissa Parra Doyle Shoshana Rosenberg Olga Santoro Michael P. La Quaglia	2010	Journal of Pediatric Surgery2010，，10：	1
	6	Biogeochemical response of organic-rich freshwater marshes in the Louisiana delta plain to chronic river water influx显示文摘	Christopher M. Swarzenski Thomas W. Doyle Brian Fry Thomas G. Hargis	2008	Biogeochemistry2008，，1：	1
	7	Altered tryptophan hydroxylase 2 expression in enteric serotonergic nerves in Hirschsprung's-associated enterocolitis显示文摘AIM: To determine if expression of colonic tryptophan hydroxylase-2(TPH2), a surrogate marker of neuronal 5-hydroxytryptamine, is altered in Hirschsprung's-associated enterocolitis. METHODS: Entire resected colonic specimens were collected at the time of pull-through operation in children with Hirschsprung's disease(HSCR, n = 12). Five of these patients had a history of pre-operative Hirschsprung's-associated enterocolitis(HAEC). Controls were collected at colostomy closure in children with anorectal malformation(n = 10). The distribution of expression of TPH2 was evaluated using immunofluorescence and confocal microscopy. Protein expression of TPH2 was quantified using western blot analysis in the deep smooth muscle layers. RESULTS: TPH2 was co-expressed in nitrergic and cholinergic ganglia in the myenteric and submucosal plexuses in ganglionic colon in HSCR and healthy controls. Co-expression was also seen in submucosal interstitial cells of Cajal and PDGFRα+ cells. The density of TPH2 immuno-positive fibers decreased incrementally from ganglionic bowel to transition zonebowel to aganglionic bowel in the myenteric plexus. Expression of TPH2 was reduced in ganglionic bowel in those affected by pre-operative HAEC compared to those without HAEC and healthy controls. However, expression of TPH2 was similar or high compared to controls in the colons of children who had undergone diverting colostomy for medically refractory HAEC.CONCLUSION: Altered TPH2 expression in colonic serotonergic nerves of patients with HSCR complicated by HAEC may contribute to intestinal secretory and motor disturbances, including recurrent HAEC.	David Coyle Justin M Murphy Brian Doyle Anne Marie O’Donnell John Gillick Prem Puri	2016	World Journal of Gastroenterology2016，22，19：	0
	8	基于定制MOOC与中外联合课堂的混合教学模式探究显示文摘针对国际化课程建设中慕课现阶段还未能起到较好支撑作用的情况,提出基于定制MOOC与中外联合课堂的混合教学模式,以移动互联网技术课程为例,介绍在教学资源建设、授课模式改革、考核模式创新方面的教学创新实践,最后通过教学效果分析说明该教学模式的有效性。	江志英王嘉薪卢罡 Paul Doyle Brian Gillespie	2023	计算机教育2023，，10：	0

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