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| 1 | Thymosin alpha 1:A comprehensive review of the literature显示文摘Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying,enhancing,and restoring immune function.Thymosin alpha 1 has been utilized in the treatment of immunocompromised states and malignancies,as an enhancer of vaccine response,and as a means of curbing morbidity and mortality in sepsis and numerous infections.Studies have postulated that thymosin alpha 1 could help improve the outcome in severely ill corona virus disease 2019 patients by repairing damage caused by overactivation of lymphocytic immunity and how thymosin alpha 1 could prevent the excessive activation of T cells.In this review,we discuss key literature on the background knowledge and current clinical uses of thymosin alpha 1.Considering the known biochemical properties including antibacterial and antiviral properties,timehonored applications,and the new promising findings regarding the use of thymosin,we believe that thymosin alpha 1 deserves further investigation into its antiviral properties and possible repurposing as a treatment against severe acute respiratory syndrome coronavirus-2. | Asimina Dominari Donald Hathaway III Krunal Pandav Wanessa Matos Sharmi Biswas Gowry Reddy Sindhu Thevuthasan Muhammad Adnan Khan Anoopa Mathew Sarabjot Singh Makkar Madiha Zaidi Michael Maher Mourad Fahem Renato Beas Valeria Castaneda Trissa Paul John Halpern Diana Baralt | 2020 | World Journal of Virology2020，9，5： | 11 |
| 2 | Trends in outpatient breast cancer surgery among Medicare fee-for-service patients in the United States from 1993 to 2002显示文摘The practice of outpatient breast cancer surgery has been controversial in the United States. This study aimed to update time trends and geographic variation in outpatient breast cancer surgery among elderly Medicare fee-for-service women in the United States. Using the 1993-2002 linked Surveillance, Epidemiology and End Results (SEER)-Medicare claims data and the Area Resource Files, we identified 2 study samples, including the women whose breast cancers were the first-ever-diagnosed cancer at age 65 years or older from 9 regions continuously covered by the SEER registries since 1993. The first sample included the women receiving unilateral mastectomy for stage 0-IV cancer; the second included the women receiving the breast-conserving surgery with lymph node dissection (BCS/LND) for stage 0-II cancer. The proportions of patients receiving outpatient surgery increased from 3.2% to 19.4% for mastectomy and from 48.9% to 77.8% for BCS/LND from 1993 to 2002. We observed substantial geographic variation in the average proportion of the patients receiving outpatient surgery in the studied areas across the 10-year period, ranging from 3.9% in Connecticut to 27.2% in Utah for mastectomy and from 54.7% in Hawaii to 78.1% in Seattle, Washington, for BCS/LND. As the popularity of outpatient breast cancer surgery continues to grow, more evidence-based analyses related to quality and outcomes of outpatient breast cancer surgery among various populations are needed in order to facilitate the public debates about state and federal mandated health benefit legislations. | John Bian1 Michael T. Halpern | 2011 | Chinese Journal of Cancer2011，30，3： | 2 |
| 3 | Optical Coherence Tomography to Identify Intramucosal Carcinoma and High-Grade Dysplasia in Barrett’s Esophagus显示文摘 | John A. Evans John M. Poneros Brett E. Bouma Jason Bressner Elkan F. Halpern Milen Shishkov Gregory Y. Lauwers Mari Mino–Kenudson Norman S. Nishioka Guillermo J. Tearney | 2006 | Clinical Gastroenterology and Hepatology2006，，1： | 1 |
| 4 | Optical Coherence Tomography to Identify Intramucosal Carcinoma and High-Grade Dysplasia in Barrett’s Esophagus显示文摘 | John A. Evans John M. Poneros Brett E. Bouma Jason Bressner Elkan F. Halpern Milen Shishkov Gregory Y. Lauwers Mari Mino–Kenudson Norman S. Nishioka Guillermo J. Tearney | 2006 | Clinical Gastroenterology and Hepatology2006，，： | 1 |
| 5 | The scientific rediscovery of an ancient Chinese herbal medicine:Cordyceps sinensis:part I显示文摘 | ZHU J S HALPERN G M JOHNS K | 1998 | Journal of Alternative and Complementary Medicine1998，4，： | 1 |
| 6 | The scientific rediscovery of a precious ancient Chinese herbal regimen:Cordyceps sinensis:part II显示文摘 | ZHU J S HALPERN G M JOHNS K | 1998 | Journal of Alternative and Complementary Medicine1998，4，： | 1 |
| 7 | Science in support of ecosystem-based management for the US West Coast and beyond显示文摘 | Sarah E. Lester Karen L. McLeod Heather Tallis Mary Ruckelshaus Benjamin S. Halpern Phillip S. Levin Francisco P. Chavez Caroline Pomeroy Bonnie J. McCay Christopher Costello Steven D. Gaines Amber J. Mace John A. Barth David L. Fluharty Julia K. Parrish | 2009 | Biological Conservation2009，，3： | 1 |
| 8 | The scientific rediscovery of a precious ancient Chinese herbal regimen: Cordyceps sinensis: part II显示文摘 | Zhu J S Halpern G M Johns K | 1998 | Journal of Alternative and Complementary Medicine1998，4，： | 1 |
| 9 | 地方性克汀病神经电生理学损伤初探显示文摘本文报道87例地方性克汀病人(粘肿型46例、神经型19例、混合型22例)的神经电生理学检查结果。除尺运动神经外.各型(?)者的被检外周神经传导速度多数正常;除腓肠感觉神经外,其它各被检外周神经的动作电位幅度均明显高于对照组(P<0.001)。听觉传导路在耳蜗;躯体感觉神经系统在臂丛;以及楔束核及(?)脑等部位皆有不同程度的损伤。就共整个神经电生理学损伤而言,尤以混合型为严重和广泛,而粘肿型也存在着损伤。三型的脊髓中枢感觉传导路似未受到严重损害。 | 刘建立 王振华 金成恩 吴伯铭 Pierre Halpern Lee Lim Glen Maberly John Morris | 1989 | 中国地方病防治1989，4，5： | 0 |
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