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| 1 | Nonlinear Bend Stiffener Analysis Using A Simple Formulation and Finite Element Method显示文摘Flexible marine risers are commonly used in deepwater floating systems.Bend stiffeners are designed to protect flexible risers against excessive bending at the connection with the hull.The structure is usually analyzed as a cantilever beam subjected to an inclined point load.As deflections are large and the bend stiffener material exhibits nonlinear stress-strain characteristics,geometric and material nonlinearities are important considerations.A new approach has been developed to solve this nonlinear problem.Its main advantage is its simplicity;in fact the present method can be easily implemented on a spreadsheet.Finite element analysis using ABAQUS is performed to validate the method.Solid elements are used for the bend stiffener and flexible pipe.To simulate the near inextensibility of flexible risers,a simple and original idea of using truss elements is proposed.Through a set of validation studies,the present method is found to be in a good agreement with the finite element analysis.Further,parametric studies are performed by using both methods to identify the key parameters and phenomena that are most critical in design.The most important finding is that the common practice of neglecting the internal steel sleeve in the bend stiffener analysis is non-conservative and therefore needs to be reassessed. | TONG Dong Jin LOW Ying Min SHEEHAN John M | 2011 | China Ocean Engineering2011，25，4： | 6 |
| 2 | Autoimmune hepatitis:Appraisal of current treatment guidelines显示文摘Autoimmune hepatitis affects patients of all ages and gender, across all geographic regions. Although still rare, its incidence and prevalence are increasing. Genetic predisposition conveyed by human leucocyte antigen is a strong risk factor for the disease and may be responsible in part for the wide variation in presentation in different geographic regions. Our understanding of the underlying pathogenic mechanisms is evolving and may lead to development of more targeted immunotherapies. Diagnosis is based on elevated levels of serum aminotransferases, gamma globulins, autoantibodies and characteristic findings on histology. Exclusion of other causes of chronic hepatitis is important.Although undiagnosed disease is associated with poor outcomes, it is readily treatable with timely immunosuppressive therapy in the majority of patients.International guidelines are available to guide management but there exists a disparity in the standard treatment regimens. This minireview aims to review the available guidelines and summarize the key recommendations involved in management of this complex autoimmune disease. | Dhruv Lowe Savio John | 2018 | World Journal of Hepatology2018，10，12： | 5 |
| 3 | 儿童扩张型心肌病的发病率、病因及预后显示文摘背景:扩张型心肌病(dilated cardiomyopathy,DCM)是儿童心肌病最常见的类型,也是小儿心脏移植最常见的原因。但是,目前尚不清楚儿童DCM的流行病学特点和临床过程。
目的:详细描述儿童DCM的发病率、病因、预后及相关危险因素。
设计及地点:本项以人群为基础的前瞻性纵向队列研究入选1996年1月至2003年2月在89个儿科心脏中心诊断为DCM的儿童以及1990年1月至1995年12月在北美大型三级治疗中心诊断的患儿。
参试者:共入选1426例来自美国和加拿大的18岁以下DCM患儿。通过严格的超声心动图和/或病理学标准来诊断原发性DCM。因内分泌、免疫、药物中毒及其他原因患病者除外。
主要观测指标:每年每10万儿童的发病率、死亡率和心脏移植率。
结果:18岁以下儿童DCM每年的总发病率为0.57/10万,男孩的年发病率高于女孩(分别为0.66/10万和0.47/10万;P〈0.001),黑人的年发病率高于白人(分别为0.98/10万和0.46/10万;P〈0.001),婴儿(〈1岁)的年发病率高于儿童(分别为4.40/10万和0.34/10万;P〈0.001)。绝大部分属特发性,最常见的病因为心肌炎(46%)和神经肌肉性疾病(26%)。1年和5年死亡/移植率分别为31%和46%。死亡/移植的独立危险因素包括患儿诊断DCM时年龄较大、伴有充血性心力衰竭、左室收缩期Z评分较低以及DCM的病因(P均〈0.001)。
结论:儿童DCM有其多样性。患儿预后主要取决于病因、年龄和心力衰竭状况。人种、性别和年龄对发病率有一定影响。大部分患儿无明确病因,限制了特异性治疗。 | Jeffrey A. Towbin April M. Lowe Steven D. Colan Lynn A. Sleeper E. John Orav Sarah Clunie Jane Messere Gerald F. Cox Paul R. Lurie Daphne Hsu Charles Canter James D. Wilkinson Steven E. Lipshultz 康俊萍(译) 马长生(校) | 2007 | 美国医学会杂志(中文版)2007，26，4： | 3 |
| 4 | The Global Stratotype Section and Point (GSSP) for the base of the Holocene Series/Epoch (Quaternary System/Period) in the NGRIP ice core显示文摘 | Mike Walker Sigfus Johnsen Sune Olander Rasmussen Jorgen-Peder Steffensen Trevor Popp Philip Gibbard Wim Hoek John Lowe John Andrews Svante Bjorck Les Cwynar Konrad Hughen Peter Kershaw Bernd Kromer Thomas Litt David J. Lowe Takeshi Nakagawa Rewi Newnham Jakob Schwander | 2008 | Episodes2008，31，2： | 3 |
| 5 | MAINTENANCE BACILLUS CALMETTE-GUERIN IMMUNOTHERAPY FOR RECURRENT TA, T1 AND CARCINOMA IN SITU TRANSITIONAL CELL CARCINOMA OF THE BLADDER: A RANDOMIZED SOUTHWEST ONCOLOGY GROUP STUDY显示文摘 | DONALD L. LAMM BRENT A. BLUMENSTEIN JOHN D. CRISSMAN JAMES E. MONTIE JAMES E. GOTTESMAN BRUCE A. LOWE MICHAEL F. SAROSDY ROBERT D. BOHL H. BARTON GROSSMAN THOMAS M. BECK JOSEPH T. LEIMERT E. DAVID CRAWFORD | 2000 | The Journal of Urology2000，，4： | 2 |
| 6 | An Analysis of Prospective Risk Factors for Aortic Stiffness in Men: 20-Year Follow-Up From the Caerphilly Prospective Study显示文摘 | Carmel M. McEniery Michael Spratt Margaret Munnery John Yarnell Gordon D. Lowe Ann Rumley John Gallacher Yoav Ben-Shlomo John R. Cockcroft Ian B. Wilkinson | 2010 | Hypertension2010，，1： | 2 |
| 7 | Dependence of Achievable Plan Quality on Treatment Technique and the Planning Goal Refinement: A Head-and-Neck IMRT Application显示文摘 | X. Sharon Qi Dan Ruan Steve P. Lee Andrew Pham Patrick Kupelian Daniel A. Low Michael Steinberg John Demarco | 2014 | International Journal of Radiation Oncology, Biology, Physics2014，，： | 1 |
| 8 | An XPS and ToF-SIMS investigation of the outermost nanometres of a poly (vinyiidene difluoride) coating 显示文摘 | Steven J Hinder Chris Lowe John F Watts | 2007 | Progress in Organic Coatings2007，，60： | 1 |
| 9 | Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity显示文摘Pten controls a signaling axis that is implicated to regulate cell proliferation,growth,survival,migration,and metabolism.The molecular mechanisms underlying the specificity of Pten responses to such diverse cellular functions are currently poorly understood.Herewe report the control of Pten activity and signaling specificity during the cell cycle by Ndfip1 regulation of Pten spatial distribution.Genetic deletion of Ndfip1 resulted in a loss of Pten nuclear compartmentalization and increased cell proliferation,despite cytoplasmic Pten remaining active in regulating PI3K/Akt signaling.Cells lacking nuclear Pten were found to have dysregulated levels of Plk1 and cyclin D1 that could drive cell proliferation.In vivo,transgene expression of Ndfip1 in the developing brain increased nuclear Pten and lengthened the cell cycle of neuronal progenitors,resulting in microencephaly.Our results show that local partitioning of Pten from the cytoplasm to the nucleus represents a key mechanism contributing to the specificity of Pten signaling during cell proliferation. | Jason Howitt Ley-Hian Low Ulrich Putz Anh Doan Jenny Lackovic Choo-Peng Goh Jenny Gunnersen John Silke Seong-Seng Tan | 2015 | Journal of Molecular Cell Biology2015，7，2： | 1 |
| 10 | Bacteria as tumour-targeting vectors显示文摘 | John M Pawelek K Brooks Low David Bermudes | 2003 | THE LANCET2003，4，： | 1 |
| 11 | 5‐cm‐Precision aircraft ocean altimetry using GPS reflections显示文摘 | Stephen T. Lowe Cinzia Zuffada Yi Chao Peter Kroger Larry E. Young John L. LaBrecque | 2002 | Geophys. Res. Lett2002，，10： | 1 |
| 12 | The Modem Language Association and Humane Scholarship 显示文摘 | Lowes John Livingston | 1933 | PMLA1933，48，： | 1 |
| 13 | Epidemiology and Cause-Specific Outcome of Hypertrophic Cardiomyopathy in Children: Findings From the Pediatric Cardiomyopathy Registry显示文摘 | Steven D. Colan Steven E. Lipshultz April M. Lowe Lynn A. Sleeper Jane Messere Gerald F. Cox Paul R. Lurie E John Orav Jeffrey A. Towbin | 2007 | Circulation2007，，6： | 1 |
| 14 | Cross-layer design in mulfihop wireless networks显示文摘 | Lijun Chen Steven H Low John C Doylea | 2011 | Computer Networks2011，55，2： | 1 |
| 15 | The chemotherapy of leprosy late results of treatment with sulphone,and with thiosemicarbazone显示文摘 | John Lowe | 1954 | The Lancet1954，264，6847： | 1 |
| 16 | Small Firms, R&D, Technology and Innovation in the UK: a literature Review 显示文摘 | Kurt Hoffman Milady Parejo John Bessant and LOw Perren | 1998 | Technovation1998，18，01： | 1 |
| 17 | Deep groundwater flow and geochemical processes in limestone aquifers: evidence from thermal waters in Derbyshire, England, UK 显示文摘 | John Gunn Simon H BottreU David J Lowe | 2006 | Hydrogeology Journal2006，14，6： | 1 |
| 18 | Thermal cycling aging effects on Sn - Ag - Cu solder joint microstucture IMC and strength 显示文摘 | Pang John H L Low T H Xiong B S | 2004 | Thin Solid Films2004，，： | 1 |
| 19 | The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane显示文摘 | Athar H Chishti Anthony C Kim Shirin M Marfatia Mohini Lutchman Manjit Hanspal Hitesh Jindal Shih-Chun Liu Philip S Low Guy A Rouleau Narla Mohandas Joel A Chasis John G Conboy Phillipe Gascard Yuichi Takakuwa Shu-Ching Huang Edward J Benz Jr Anthony Bret | 1998 | Trends in Biochemical Sciences1998，，8： | 1 |
| 20 | An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer显示文摘 | Lars Zender Wen Xue Johannes Zuber Camile P. Semighini Alexander Krasnitz Beicong Ma Peggy Zender Stefan Kubicka John M. Luk Peter Schirmacher W. Richard McCombie Michael Wigler James Hicks Gregory J. Hannon Scott Powers Scott W. Lowe | 2008 | Cell2008，，5： | 1 |
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