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| 1 | Dual color optogenetic control of neural populations using low-noise,multishank optoelectrodes显示文摘Optogenetics allows for optical manipulation of neuronal activity and has been increasingly combined with intracellular and extracellular electrophysiological recordings.Genetically-identified classes of neurons are optically manipulated,though the versatility of optogenetics would be increased if independent control of distinct neural populations could be achieved on a sufficient spatial and temporal resolution.We report a scalable multisite optoelectrode design that allows simultaneous optogenetic control of two spatially intermingled neuronal populations in vivo.We describe the design,fabrication,and assembly of low-noise,multisite/multicolor optoelectrodes.Each shank of the four-shank assembly is monolithically integrated with 8 recording sites and a dualcolor waveguide mixer with a 7×30μm cross-section,coupled to 405 nm and 635 nm injection laser diodes(ILDs)via gradient-index(GRIN)lenses to meet optical and thermal design requirements.To better understand noise on the recording channels generated during diode-based activation,we developed a lumped-circuit modeling approach for EMI coupling mechanisms and used it to limit artifacts to amplitudes under 100μV upto an optical output power of 450μW.We implanted the packaged devices into the CA1 pyramidal layer of awake mice,expressing Channelrhodopsin-2 in pyramidal cells and ChrimsonR in paravalbumin-expressing interneurons,and achieved optical excitation of each cell type using sub-mW illumination.We highlight the potential use of this technology for functional dissection of neural circuits. | Komal Kampasi Daniel F.English John Seymour Eran Stark Sam McKenzie Mihály Vöröslakos György Buzsáki Kensall D.Wise Euisik Yoon | 2018 | Microsystems & Nanoengineering2018，4，1： | 8 |
| 2 | NOD2 and ATG16L1 polymorphisms affect monocyte responses in Crohn's disease显示文摘AIM:To assess whether polymorphisms in NOD2 and ATG16L1 affect cytokine responses and mycobacterium avium subspecies paratuberculosis (MAP) survival in monocytes from Crohn's disease (CD) patients.METHODS:Monocytes were isolated from peripheral blood of CD patients of known genotype for common single nucleotide polymorphisms of NOD2 and ATG16L1.Monocytes were challenged with MAP and bacterial persistence assessed at subsequent time-points.Cytokine responses were assayed using a Milliplex multi-analyte profiling assay for 13 cytokines.RESULTS:Monocytes heterozygous for a NOD2 polymorphism (R702W,P268S,or 1007fs) were more permissive for growth of MAP (P=0.045) than those without.There was no effect of NOD2 genotype on subsequent cytokine expression.The T300A polymorphism ofATG16L1 did not affect growth of MAP in our model (P=0.175),but did increase expression of cytokines interleukin (IL)-10 (P=0.047) and IL-6 (P=0.019).CONCLUSION:CD-associated polymorphisms affected the elimination of MAP fromex vivo monocytes (NOD2),or expression of certain cytokines (ATG16L1),implying independent but contributory roles in the pathogenesis of CD. | Dylan M Glubb Richard B Gearry Murray L Barclay Rebecca L Roberts John Pearson Jacqui I Keenan Judy McKenzie Robert W Bentley | 2011 | World Journal of Gastroenterology2011，17，23： | 2 |
| 3 | How Cost-Elastic Are Remittances? Estimates from Tongan Migrants in New Zealand 显示文摘 | Gibson John David McKenzie and Halahingano Rohorua | 2006 | Pacific and Asian Journal of Energy2006，21，1： | 1 |
| 4 | Reversible cell surface expression of CD38 on CD34-positive human hematopoietic repopulating cells显示文摘 | Joby L. McKenzie Olga I. Gan Monica Doedens John E. Dick | 2007 | Experimental Hematology2007，，9： | 1 |
| 5 | Familial idiopathic basal ganglia calcification (Fahr’s disease) without neurological, cognitive and psychiatric symptoms is not linked to the IBGC1 locus on chromosome 14q显示文摘 | Henry Brodaty Philip Mitchell Georgina Luscombe John B. Kwok Renee F. Badenhop Rod McKenzie Peter R. Schofield | 2002 | Human Genetics2002，，1： | 1 |
| 6 | An initial farmer evaluation of a NIOSH AutoROPS prototype显示文摘 | John Etherton E A McKenzie Jr Tim Lutz | 2004 | International Journal of Industrial Ergonomics2004，34，： | 1 |
| 7 | Combined Lung and Liver Transplantation: The United States Experience显示文摘 | Neal R. Barshes Daniel J. DiBardino E Dean McKenzie Timothy C. Lee Stephen A. Stayer George B. Mallory Saul J. Karpen Ruben E. Quiros-Tejeira Beth A. Carter Charles D. Fraser John A. Goss | 2005 | Transplantation2005，，9： | 1 |
| 8 | The microeconomic determinants of emigration and return migration of the best and brightest: Evidence from the Pacific显示文摘 | John Gibson David McKenzie | 2009 | Journal of Development Economics2009，，1： | 1 |
| 9 | Acute Oxalate Nephropathy Secondary to Orlistat‐Induced Enteric Hyperoxaluria显示文摘 | Tony K Kwan Steve J Chadban Paul R McKenzie John R Saunders | 2013 | Nephrology2013，，3： | 1 |
| 10 | The microeconomic determinants of emigration and return migration of the best and brightest: Evidence from the Pacific显示文摘 | John Gibson David McKenzie | 2009 | Journal of Development Economics2009，，1： | 1 |
| 11 | A D α 6 knockout strain of Drosophila melanogaster confers a high level of resistance to spinosad显示文摘 | Trent Perry John A. McKenzie Philip Batterham | 2006 | Insect Biochemistry and Molecular Biology2006，，2： | 1 |
| 12 | A land of milk and honey with streets pavedwith gold: Do emigrants have over-optimistic expec原tations about incomes abroad 显示文摘 | McKenzie David Gibson John StillmanSteven | 2013 | Journal of Develop原ment Economics2013，，5： | 1 |
| 13 | 农产品质量安全 期待明天会更好显示文摘在食品安全事件日益受到关注的当下,'买什么放心,吃什么安全'成为大家最为关心的话题。其中,农产品作为大家生活中最基础的必需品,其质量是否能让我们安心,尤为重要。本期《特别报道》栏目特邀行业专家,全面解读我国农产品质量安全现状,分析农产品质量安全体系及标准的制定和执行,为切实提高农产品质量提供有益的建议,促进我国农产品质量快速提升。 | 逯文娟 马增俊 马文峰 王锐 John McKenzie | 2011 | 食品安全导刊2011，，8： | 0 |
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