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| 1 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 2 | Acute endophthalmitis following intravitreal triamcinolone acetonide injection显示文摘 | Darius M Moshfeghi Peter K Kaiser Ingrid U Scott Jonathan E Sears Matthew Benz Juan P Sinesterra Richard S Kaiser Sophie J Bakri Raj K Maturi Jonathan Belmont Paul M Beer Timothy G Murray Hugo Quiroz-Mercado William F Mieler | 2003 | American Journal of Ophthalmology2003，，5： | 1 |
| 3 | 2001, Catastrophic shifts in ecosystems显示文摘 | SCHEFFER M CARPENTER S JONATHAN A F | 2001 | Nature2001，413，： | 1 |
| 4 | Polyethylene/graphite nanocomposites obtained by in situ polymerization显示文摘 | FABIANA D C F JONATHAN M G NaRA S B | 2010 | Journal of Polymer Science Part A-Polymer Chemistry2010，48，3： | 1 |
| 5 | Variability of the hemocyte parameters of Ruditapes philippinarurn in the field during an annual cycle 显示文摘 | Jonathan F S M Philippe S Christophe L | 2009 | Journal of Experimental Marine Biolo- gy and Ecology2009，377，： | 1 |
| 6 | Unexpected Z- stereoselectivity in the Ramberg-Backlund reaction of diarylsulfones leading to cis-stilbenes : the effect of aryl substituents and application in the synthesis of the integrastatin nucleus 显示文摘 | Jonathan S F Gerard M P Taylor K T | 2005 | Org Biomol Chem2005，3，： | 1 |
| 7 | Acute endophthalmitis following intravitreal triamcinolone acetonide injection显示文摘 | Darius M Moshfeghi Peter K Kaiser Ingrid U Scott Jonathan E Sears Matthew Benz Juan P Sinesterra Richard S Kaiser Sophie J Bakri Raj K Maturi Jonathan Belmont Paul M Beer Timothy G Murray Hugo Quiroz-Mercado William F Mieler | 2003 | American Journal of Ophthalmology2003，，5： | 1 |
| 8 | Control of pathogenic and spoilage microorganisms in fresh-cut fruits and fruit juices by traditional and alternative natural antimicrobials显示文摘 | Rosa M R Jonathan M M Rober S F | 2009 | Comprehensive Reviews in Food Science and Food Safety2009，，8： | 1 |
| 9 | Early and medium-term results for repair of ebstein anomaly显示文摘 | Jonathan M Chen Ralph S Mosca Karen Altmann Beth F Printz Kimara Targoff Pamela A Mazzeo Jan M Quaegebeur | 2004 | The Journal of Thoracic and Cardiovascular Surgery2004，，4： | 1 |
| 10 | Boston Keratoprosthesis Outcomes and Complications显示文摘 | Hall F Chew Brandon D Ayres Kristin M Hammersmith Christopher J Rapuano Peter R Laibson Jonathan S Myers Ya-Ping Jin Elisabeth J Cohen | 2009 | Cornea2009，，9： | 1 |
| 11 | Liver transplantation during global COVID-19 pandemic显示文摘The coronavirus disease 2019(COVID-19)caused by severe acute respiratory disease respiratory syndrome coronavirus-2 has significantly impacted the health care systems globally.Liver transplantation(LT)has faced an unequivocal challenge during this unprecedented time.This targeted review aims to cover most of the clinical issues,challenges and concerns about LT during the COVID-19 pandemic and discuss the most updated literature on this rapidly emerging subject. | Mostafa Alfishawy Nso Nso Mahmoud Nassar Jonathan Ariyaratnam Sakil Bhuiyan Raheel S Siddiqui Matthew Li Howard Chung Amira Al Balakosy Ahmed Alqassieh Tibor Fülöp Vincent Rizzo Ahmed Daoud Karim M Soliman | 2021 | World Journal of Clinical Cases2021，9，23： | 0 |
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