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| 1 | Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis显示文摘AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis.METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA), CLIF Consortium Organ Failure score(CLIF-C OFs), Maddrey'sdiscriminant function(DF), age, bilirubin, international normalized ratio and creatinine score(ABIC), Glasgow Alcoholic Hepatitis Score(GAHS), model for end-stage liver disease(MELD), and MELD-Na.RESULTS Of 264 patients, 32(12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86(0.81-0.90), 0.89(0.84-0.92), 0.79(0.74-0.84), 0.78(0.72-0.83), 0.81(0.76-0.86), 0.83(0.78-0.88), and 0.83(0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality.CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis. | Hee Yeon Kim Chang Wook Kim Tae Yeob Kim Do Seon Song Dong Hyun Sinn Eileen L Yoon Young Kul Jung Ki Tae Suk Sang Soo Lee Chang Hyeong Lee Tae Hun Kim Jeong Han Kim Hyung Joon Yim Sung Eun Kim Soon Koo Baik Byung Seok Lee Jae Young Jang Young Seok Kim Sang Gyune Kim Jin Mo Yang Joo Hyun Sohn Heon Ju Lee Seung Ha Park Eun Hee Choi Dong Joon Kim Korean Acute-on-Chronic Liver Failure Study Group | 2016 | World Journal of Gastroenterology2016，22，41： | 5 |
| 2 | Predictors for difficult cecal insertion in colonoscopy: The impact of obesity indices显示文摘AIM To identify the factors influencing cecal insertion time(CIT) and to evaluate the effect of obesity indices on CIT. METHODS We retrospectively reviewed the data for participants who received both colonoscopy and abdominal computed tomography(CT) from February 2008 to May 2008 as part of a comprehensive health screening program. Age, gender, obesity indices [body mass index(BMI), waist-to-hip circumference ratio(WHR), waist circumference(WC), visceral adipose tissue(VAT)volume and subcutaneous adipose tissue(SAT) volume on abdominal CT], history of prior abdominal surgery, constipation, experience of the colonoscopist, quality of bowel preparation, diverticulosis and time required to reach the cecum were analyzed. CIT was categorized as longer than 10 min(prolonged CIT) and shorter than or equal to 10 min, and then the factors that required a CIT longer than 10 min were examined.RESULTS A total of 1678 participants were enrolled. The mean age was 50.42 ± 9.931 years and 60.3% were men. The mean BMI, WHR, WC, VAT volume and SAT volume were 23.92 ± 2.964 kg/m2, 0.90 ± 0.076, 86.95 ± 8.030 cm, 905.29 ± 475.220 cm3 and 1707.72 ± 576.550 cm3, respectively. The number of patients who underwent abdominal surgery was 268(16.0%). Colonoscopy was performed by an attending physician alone in 61.9% of cases and with the involvement of a fellow in 38.1% of cases. The median CIT was 7 min(range 2-56 min, IQR 5-10 min), and mean CIT was 8.58 ± 5.291 min. Being female, BMI, VAT volume and involvement of fellow were significantly associated with a prolonged CIT in univariable analysis. In multivariable analysis, being female(OR = 1.29, P = 0.047), lower BMI(< 23 kg/m2)(OR = 1.62, P = 0.004) or higher BMI(≥ 25 kg/m2)(OR = 1.80, P < 0.001), low VAT volume(< 500 cm3)(OR = 1.50, P = 0.013) and fellow involvement(OR = 1.73, P < 0.001) were significant predictors of prolonged CIT. In subgroup analyses for gender, lower BMI or higher BMI and fellow involvement were predictors for prolonged CIT in both genders. However, low VAT volume was associated with prolonged CIT in only women(OR = 1.54, P = 0.034).CONCLUSION Being female, having a lower or higher BMI than the normal range, a low VAT volume, and fellow involvement were predictors of a longer CIT. | Soo Yun Moon Byung Chang Kim Dae Kyung Sohn Kyung Su Han Bun Kim Chang Won Hong Bum Joon Park Kum Hei Ryu Ji Hyung Nam | 2017 | World Journal of Gastroenterology2017，23，13： | 3 |
| 3 | An observational study suggesting clinical benefit for adjuvant postoperative chemoradiation in a population of over 500 cases after gastric resection with D2 nodal dissection for adenocarcinoma of the stomach显示文摘 | Sung Kim Do Hoon Lim Jeeyun Lee Won Ki Kang John S. MacDonald Chan Hyung Park Se Hoon Park Se-Hoon Lee Kihyun Kim Joon Oh Park Won Seog Kim Chul Won Jung Young Suk Park Young-Hyuck Im Tae Sung Sohn Jae Hyung Noh Jin Seok Heo Yong Il Kim Chul Keun Park Keu | 2005 | International Journal of Radiation Oncology Biology Physics2005，，5： | 1 |
| 4 | Relation of Soft Plaque and Elevated Preprocedural High-Sensitivity C-Reactive Protein Levels to Incidence of In-Stent Restenosis After Successful Coronary Artery Stenting显示文摘 | Young Joon Hong Myung Ho Jeong Sang Yup Lim Sang Rok Lee Seo Na Hong Kye Hun Kim Il Suk Sohn Hyung Wook Park Ju Han Kim Weon Kim Youngkeun Ahn Jeong Gwan Cho Jong Chun Park Jung Chaee Kang | 2006 | The American Journal of Cardiology2006，，3： | 1 |
| 5 | Predictive factors for interferon and ribavirin combination therapy in patients with chronic hepatitis C显示文摘瞄准:为干扰素(IFN ) 证实预兆的因素为有丙肝的长期的肝炎病人的 -alpha 和 ribavirin 联合治疗病毒(HCV ) 遗传型 1b。方法:从感染 HCV 遗传型 1b 的 50 个病人的 HCV RNA 被决定区域(ISDR ) 的干扰素敏感克隆并且定序学习, PKR-eIF2alpha 磷酸化相同领域(PePHD ) 。病人们为 6 瞬间与 IFN-alpha 和 ribavirin 被对待并且由治疗的有效性组织了。许多因素被分析。结果:我们的数据证明年龄, HCV RNA 效价,和 ISDR 类型能为联合 IFN-alpha 和 ribavirin 功效被用作预兆的因素。表示特性地,仅仅当联合治疗是有效的时,在 PePHD 的变化出现了。另外的因素,例如性别和丙氨酸, aminotransferase (中高音) 铺平,不与它的功效有关。好久调整并且 HCV RNA titer 显示 ISDR 类型是最有势力预兆的因素。结论:HCV RNA ISDR 类型是为在朝鲜病人预言 IFN-alpha 和 ribavirin 联合治疗的功效的一个重要因素。 | Joonho Yoon Jong In Lee Soon Koo Baik Kwang Ho Lee Joon Hyung Sohn Hyean-Woo Lee Jun Namkung Sei Jin Chang Jong-Whan Choi Hyun-Won Kim Byung-Il Yeh | 2007 | World Journal of Gastroenterology2007，13，46： | 1 |
| 6 | Pentoxifylline versus corticosteroid to treat severe alcoholic hepatitis: A randomised, noninferiority, open trial显示文摘 | Seung Ha Park Dong Joon Kim Young Seok Kim Hyung Joon Yim Won Young Tak Heon Ju Lee Joo Hyun Sohn Ki Tae Yoon In Hee Kim Hyoung Su Kim Soon Ho Um Soon Koo Baik June Sung Lee Ki Tae Suk Sang Gyune Kim Sang Jun Suh Soo Young Park Tae Yeob Kim Jae Young Jang | 2014 | Journal of Hepatology2014，，： | 1 |
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