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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Non-functional neuroendocrine tumors of the pancreas: Advances in diagnosis and management显示文摘Nonfunctional neuroendocrine tumors of the pancreas(NF-PNETs) are a heterogeneous group of neoplasms. Although rare, the incidence of NF-PNETs is increasing significantly. The classification of PNETs has evolved over the past decades and is now based on a proliferation grading system. While most NF-PNETs are slow growing, tumors with more aggressive biology may becomeincurable once they progress to unresectable metastatic disease. Tumors of higher grade can be suspected preoperatively based on the presence of calcifications, hypoenhancement on arterial phase computed tomography, positron emission technology avidity and lack of octreotide scan uptake. Surgery is the only curative treatment and is recommended for most patients for whom complete resection is possible. Liver-directed therapies(thermal ablation, transarterial embolization) can be useful in controlling unresectable hepatic metastatic disease. In the presence of unresectable progressive disease, somatostatin analogues, everolimus and sunitinib can prolong progression-free survival. This article provides a comprehensive review of NF-PNETs with special emphasis on recent advances in diagnosis and management. | Jordan M Cloyd George A Poultsides | 2015 | World Journal of Gastroenterology2015，21，32： | 11 |
| 3 | Abnormal immunoreactivity of the E-cadherin-catenin complex in gastric carcinoma: Relationship with patient survival显示文摘 | A Jawhari S Jordan S Poole P Browne M Pignatelli MJ Farthing | 1997 | Gastroenterology1997，，1： | 2 |
| 4 | Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation显示文摘 | Jordan M Schallhorn A Wurm FM | 1996 | Nucleic Acids Res1996，24，： | 1 |
| 5 | Latent dirichlet allocation显示文摘 | Blei D Ng A Jordan M | 2003 | Journal of Machine Learning Research2003，3，1： | 1 |
| 6 | Latent Dir/chlet allocation显示文摘 | Blei D M Ng A Y Jordan M I | 2003 | Journal of Machine Learning Research2003，3，： | 1 |
| 7 | Latent Dirichlet Allocation 显示文摘 | BLEI D M NG A Y JORDAN M I | 2003 | the Journal of Machine Learning Research2003，，3： | 1 |
| 8 | Effect of harvest maturity,storage,and cultivar on strawberry fruit aroma volatiles显示文摘 | FORNEY C F JORDAN M A | 1995 | HortScience1995，30，： | 1 |
| 9 | Uterine serous papillary carcinoma:histopathologic changes within the female genital tract显示文摘 | Jordan LB Abdul-kader M A1-Nafussi A | 2001 | Int J Gynecol Cancer2001，11，4： | 1 |
| 10 | Active learning with statistical models 显示文摘 | D A Cohn Z Ghahramani M I Jordan | 1996 | Journal of Artificial Intelligence research1996，4，： | 1 |
| 11 | Latent dirchlet alloca- tion 显示文摘 | Blei D M Ng A Jordan M | 2003 | Journal of Machine Learning Research2003，2，3： | 1 |
| 12 | Latent Dirichlet Allo- cation显示文摘 | Blei D M Ng A Y Jordan M I | 2003 | The Journal of Machine Learning Research2003，3，： | 1 |
| 13 | Measuring In- dividual differences in implicit cognition: the implicit asso- ciation test显示文摘 | Greenwald A G Jordan E M Schwartz L K | 1998 | Journal of Personality and Social psycholo- gy1998，74，： | 1 |
| 14 | The effect of diets supplemented with thyme essential oils and rosemary extract on the deterioration of farmed gilthead seabrcam(Sparus aurata) during storage on ice显示文摘 | Olvarez A Gareia G B Jordan M J | 2012 | Food Chemistry2012，132，： | 1 |
| 15 | On spectral clustering: Analy- sis and an algorithm显示文摘 | NG A Y JORDAN M I WEISS Y | 2002 | Advances in Neural Information Processing Systems2002，14，： | 1 |
| 16 | Latent dirichlet allocation显示文摘 | Blei D M Ng A Y Jordan M I | 2003 | Joumal of Machine Learning Research2003，3，45： | 1 |
| 17 | The Medicinal Chemist's Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates显示文摘 | Roughley S D Jordan A M | 2011 | J Med Chem2011，54，10： | 1 |
| 18 | Latent dirichlet allocation显示文摘 | Blei D M Ng A Y Jordan M I | 2003 | Journal of Machine Learning Research2003，，3： | 1 |
| 19 | Latent dirichlet allocation 显示文摘 | Blei D M Ng A Y Jordan M I | 2003 | Journal of Machine Learning Research2003，3，45： | 1 |
| 20 | Estradiol protects a- gainst hippocampal damage and impairments in fear conditioning re- suiting from transient global ischemia in mice 显示文摘 | Durham J L Jordan K A DeVos M J | 2012 | Brain research2012，，1443： | 1 |
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