|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis显示文摘Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone.Biomineralization is regulated by the ratio of inorganic phosphate(Pi) to mineral inhibitor pyrophosphate(PPi), where local Piand PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase(TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1(NPP1). The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enpp1 null mouse increased acellular cementum, with little effect on cellular cementum.Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enpp1 gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPienvironment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPihave little effect on cellular cementum formation, though matrix mineralization is affected. | Laura E Zweifler Mudita K Patel Francisco H Nociti Jr Helen F Wimer Jose L Milln Martha J Somerman Brian L Foster | 2015 | International Journal of Oral Science2015，7，1： | 5 |
| 2 | 在与心肌的梗塞介绍的就医的病人的心率的预示的意义显示文摘 AIM: To investigate the prognostic significance of resting heart rate in patients with acute coronary syndrome (ACS), independent of other known factors. METHODS: Patients 40 years of age or older who had been admitted with acute coronary syndrome (ACS) to one of the 94 hospitals participating in the Prevalence of Peripheral Arterial Disease in Patients with Acute Coronary Syndrome (PAMISCA) study were included. Patients were divided into two groups based on their resting heart rate (HR ≥ or < 70 bpm). Complications were recording during a follow-up period of 1 year. RESULTS: There were 1054 ACS patients analyzed (43.5% with ST segment elevation and 56.5% without elevation). Mean age was 66.6 ± 11.7 years, 70.6% were male and 29.4% of subjects were female. During follow-up, more patients in the HR ≥ 70 bpm group were hospitalized for heart failure and they also had a higher mortality rate. In the multivariate analysis, a heart rate of ≥ 70 bpm was independently related to overall mortality during the follow-up period (hazard ratio 2.5; 95% confidence interval, 1.26-4.97, P = 0.009). CONCLUSION: A resting heart rate ≥ 70 bpm in patients who survive an ACS is an indicator of a high risk of suffering cardiovascular events during follow-up. | Lorenzo Fácila Pedro Morillas Juan Quiles Federico Soria Alberto Cordero Pilar Mazón Manuel Anguita Cándido Martín-Luengo Jose Ramón Gonzalez-Juanatey Vicente Bertomeu | 2012 | World Journal of Cardiology2012，4，1： | 3 |
| 3 | Functional Heterogeneity of Cancer-Associated Fibroblasts from Human Colon Tumors Shows Specific Prognostic Gene Expression Signature显示文摘 | Mercedes Herrera Abul B.M.M.K. Islam Alberto Herrera Paloma Martín Vanesa García Javier Silva Jose M. Garcia Clara Salas Ignacio Casal Antonio García de Herreros Félix Bonilla Cristina Pe?a | 2013 | Clinical Cancer Research2013，，21： | 2 |
| 4 | Multi-element determination of Cu, Fe, Ni and Zn content in vegetable oils samples by high-resolution continuum source atomic absorption spectrometry and microemulsion sample preparation 显示文摘 | LUANA S N JOSE T P B ANDREA P F | 2011 | Food Chemistry2011，127，2： | 1 |
| 5 | Rejection after conversion to a proliferation signal inhibitor in chronic heart transplantation显示文摘 | Francisco González‐Vílchez José A. Vázquez de Prada María J. Paniagua Luis Almenar Sonia Mirabet Manuel Gómez‐Bueno Beatriz Díaz‐Molina Jose M. Arizón Juan Delgado Félix Pérez‐Villa María G. Crespo‐Leiro Luis Martínez‐Dolz Eulalia Roig Javier Segovia José | 2013 | Clin Transplant2013，，6： | 1 |
| 6 | Tea polyphenol epig-allocatechin- 3-gallate inhibits ergosterol synthesis by dis-turbing folic acid metabolism in Candida albicans显示文摘 | Maria D F G Jose N | | Journal of Antimicrobial Chemotherapy0，57，6： | 1 |
| 7 | Photocatalytic transformation of sixteen substituted phenylurea herbicides in aqueous semiconductor suspensions: Intermediates and degradation pathways显示文摘 | Jose F Paula S Gines N | | Journal of Hazardous Materials0，244，： | 1 |
| 8 | An efficient approach to the traveling salesman problem using self-organizing maps显示文摘 | Frederico C V Adiao D D N & Jose A F | 2003 | International Journal of Neural Systems2003，13，2： | 1 |
| 9 | Development of Cu-based oxygen carriers for chemical-looping combustion显示文摘 | Luis F de Diego Francisco Garc??a-Labiano Juan Adánez Pilar Gayán Alberto Abad Beatriz M Corbella Jose Mar??a Palacios | 2004 | Fuel2004，，13： | 1 |
| 10 | Narrow-bandshort-time frequency^domain blind signal separation ofpassive sonar signals显示文摘 | Natanael N M Eduardo F S F Jose M S | 2009 | Lecture Notes in Computer Sci-ence2009，5441，1： | 1 |
| 11 | Nearshore sedimentation as a record of landuse change and erosion: Jurujuba Sound, Niterel, SE Brazil 显示文摘 | Jose A B N Cintia F B Maria A M S | 2013 | Ocean & Coastal Management2013，，77： | 1 |
| 12 | The gene pat-2, which induces natural parthenocarpy, alters the gibberellin content in unpollinated tomato ovaries 显示文摘 | Marino F Femado N Jose L G M | 2000 | Plant Physiol2000，122，： | 1 |
| 13 | Noncausal prediction image codec 显示文摘 | Balram N Moura Jose M F | 1996 | IEEE Transactions on lmage Processing1996，5，8： | 1 |
| 14 | Multi-element de- termination of Cu, Fe, Ni and Zn content in vegetable oils sam- pies by high-resolution continuum source atomic absorption spec- trometry and microemulsion sample preparation显示文摘 | Luana S N Jose T P B Andrea P F | 2011 | Food Chem- istry2011，127，2： | 1 |
| 15 | Multi-element determination of Cu, Fe, Ni and Zn content in vegetable oils samples by high-resolution continuum source atomic absorption spectrometry and microemulsion sample preparation显示文摘 | LUANA S N JOSE T P B ANDREA P F | 2011 | Food Chemistry2011，127，2： | 1 |
| 16 | Multi-element determina-tion of Cu,Fe,Ni and Zn content in vegetable oils samples by high-resolution continuum source atomic absorption spectrometry and mi-croemulsion sample preparation显示文摘 | Luana S N Jose TPB Andrea P F | 2011 | Food Chemistry2011，127，2： | 1 |
| 17 | Multi-element determination of Cu, Fe, Ni and Zn content in vegetable oils samples by high-resolution continuum source atomic absorp- tion spectrometry and microemulsion sample preparation 显示文摘 | Luana S N Jose T P B Andrea P F | 2011 | Food Chemistry2011，127，2： | 1 |
| 18 | Precision of genetic relationship estimates based on molecular markers显示文摘 | JOSE F BARBOSA N TALBERT L E | 1997 | Euphytica1997，98，： | 1 |
| 19 | Utilization of solar energy in the photodegradation of gasoline in water and of oil-field-produced water显示文摘 | Jose(a)E F M Douglas N S Frankh Q | | 0，，13： | 1 |
| 20 | Profiling of Root Canal Bacterial Communities Associated with Chronic Apical Periodontitis from Brazilian and Norwegian Subjects 显示文摘 | Jose F Siqueira -JF Jr Isabela N | 2008 | J Endod2008，34，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员