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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | The grapevine guard cell-related VvMYB60 transcription factor is in- volved in the regulation of stomatal aetivity and is differ- entially expressed in response to ABA and osmotic stress 显示文摘 | Massimo G Jose T M Prisilla F | 2011 | BioMed Central Plant Biology2011，11，： | 1 |
| 3 | Does savoring in- crease happiness? A daily diary study 显示文摘 | Jose P E Lira B T Bryant F B | 2012 | 7 (3): 176-1872012，7，3： | 1 |
| 4 | Multi-element determination of Cu, Fe, Ni and Zn content in vegetable oils samples by high-resolution continuum source atomic absorption spectrometry and microemulsion sample preparation 显示文摘 | LUANA S N JOSE T P B ANDREA P F | 2011 | Food Chemistry2011，127，2： | 1 |
| 5 | Does Savoring Increase Happiness A Daily Diary Study显示文摘 | Jose P E Lim B T Bryant F B | | 0，，03： | 1 |
| 6 | High- strength steel development for pipelines: a Brazilian perspective 显示文摘 | Ivanide S B de Luis F G S Jose C G T | 2005 | Metallurgical and Materials Transactions A2005，36，44： | 1 |
| 7 | Protoplast formation and regeneration from Streptomyces clavuligerus NRRL 3585 and elavulanie acid production 显示文摘 | Maria das G C Jose L L F Galba M C T | 2002 | Brazilian Journal of Microbiology2002，33，： | 1 |
| 8 | Catalytic wet air oxidation of carbon supported platinum catalyst显示文摘 | Helder T G Jose L F Joaquim L F | 2000 | Applied Catalysis B:Environmental2000，27，： | 1 |
| 9 | Azetidinylquinolones as antibacterial agents 显示文摘 | Jordi F Antoni T Jose A C | 1994 | Journal of Medicinal Chemistry1994，37，24： | 1 |
| 10 | Cathepsin B, D, H and L activities in the proce ssing of dry-cured ham 显示文摘 | Fidel T Elias R Jose F | 1993 | J Sci Food Agric1993，62，： | 1 |
| 11 | Synthesis and biological activity of 7-(2,3-disubstituted-l-azetidinyl)-4-oxoquinolainnde-1,8-naphthyridine-3-carboxylic acids显示文摘 | Jordi F Antoni T Jose A C | 1994 | J Med Chem1994，37，： | 1 |
| 12 | Responses of lead night transpiration to drought stress in Vitis vinifera L 显示文摘 | JOSE M E F SIGFREDO T MAGDALENA M | 2013 | Agricultural Water Management2013，118，： | 1 |
| 13 | Multi-element de- termination of Cu, Fe, Ni and Zn content in vegetable oils sam- pies by high-resolution continuum source atomic absorption spec- trometry and microemulsion sample preparation显示文摘 | Luana S N Jose T P B Andrea P F | 2011 | Food Chem- istry2011，127，2： | 1 |
| 14 | Multi-element determination of Cu, Fe, Ni and Zn content in vegetable oils samples by high-resolution continuum source atomic absorption spectrometry and microemulsion sample preparation显示文摘 | LUANA S N JOSE T P B ANDREA P F | 2011 | Food Chemistry2011，127，2： | 1 |
| 15 | The autodisplay story, from discovery to biotechnical and biomedical applications显示文摘 | JOSE J MEYER T F | 2007 | Microbiol Mol Biol Rev2007，71，4： | 1 |
| 16 | Kinetics of photocatalytic degradation of reactive dyes in a TiO2 slurry reactor 显示文摘 | Sauer T Neto G C Jose H J Moreira R F P M | 2002 | Journal of Photochemistry andPhotobiologyA-Chemistry2002，149，123： | 1 |
| 17 | Multi-element determination of Cu, Fe, Ni and Zn content in vegetable oils samples by high-resolution continuum source atomic absorp- tion spectrometry and microemulsion sample preparation 显示文摘 | Luana S N Jose T P B Andrea P F | 2011 | Food Chemistry2011，127，2： | 1 |
| 18 | Catalytic wet air oxidation of low molecular weight carboxylic acids using a carbon supported platinum catalyst 显示文摘 | HELDER T G JOSE L F JOAQUIM L F | 2000 | Applied Catalysis B: Enviromental2000，27，： | 1 |
| 19 | 查看详情显示文摘 | Jose S Fangueiro J F Smitha J Cinu T A Chacko A J | | 0，，： | 1 |
| 20 | Different patterns between mechanical and electrical activities: an approach to investigate gastric motility in a model of long-term diabetic rats显示文摘 | Rozemeire G Marques Madileine F Americo Cesar T Spadella Luciana A Corá Ricardo B Oliveira Jose Ricardo A Miranda | 2014 | Physiological Measurement2014，，1： | 1 |
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