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| 1 | Connexin 43 hemichannels protect bone loss during estrogen deficiency显示文摘Estrogen deficiency in postmenopausal women is a major cause of bone loss,resulting in osteopenia,osteoporosis,and a high risk for bone fracture.Connexin 43 (Cx43) hemichannels (HCs) in osteocytes play an important role in osteocyte viability,bone formation,and remodeling.We showed here that estrogen deficiency reduced Cx43 expression and HC function.To determine if functional HCs protect osteocytes and bone loss during estrogen deficiency,we adopted an ovariectomy model in wild-type (WT) and two transgenic Cx43 mice:R76W (dominant-negative mutant inhibiting only gap junction channels) and Cx43 Δ130–136 (dominant-negative mutant compromising both gap junction channels and HCs).The bone mineral density (BMD),bone structure,and histomorphometric changes of cortical and trabecular bones after ovariectomy were investigated.Our results showed that the Δ130–136 transgenic cohort had greatly decreased vertebral trabecular bone mass compared to WT and R76W mice,associated with a significant increase in the number of apoptotic osteocyte and empty lacunae.Moreover,osteoclast surfaces in trabecular and cortical bones were increased after ovariectomy in the R76W and WT mice,respectively,but not in Δ130–136 mice.These data demonstrate that impairment of Cx43 HCs in osteocytes accelerates vertebral trabecular bone loss and increase in osteocyte apoptosis,and further suggest that Cx43 HCs in osteocytes protect trabecular bone against catabolic effects due to estrogen deficiency. | Liang Ma Rui Hua Yi Tian Hongyun Cheng Roberto Jose Fajardo Joseph J. Pearson Teja Guda Daniel Brian Shropshire Sumin Gu Jean X. Jiang | 2019 | Bone Research2019，7，2： | 11 |
| 2 | Screening for gastric cancer in Asia: current evidence and practice显示文摘 | Wai K Leung Ming-shiang Wu Yasuo Kakugawa Jae J Kim Khay-guan Yeoh Khean Lee Goh Kai-chun Wu Deng-chyang Wu Jose Sollano Udom Kachintorn Takuji Gotoda Jaw-town Lin Wei-cheng You Enders KW Ng Joseph JY Sung | 2008 | Lancet Oncology2008，，3： | 7 |
| 3 | International NeuroAIDS: prospects of HIV-1 associated neurological com-plications显示文摘Neurological complications associated with HIV-1/AIDS are being recognized with a high frequency that parallels the increased number of AIDS cases. The early infiltration by HIV-1 into the nervous system can cause primary and/or secondary neurological complications. The most common neurocognitive disorder is AIDS Dementia Complex (ADC). In developing countries of Asia the three most opportunistic infections are tuberculosis (TB), cryptococcosis, and Pneumocystis carinii pneumonia. Therefore, it is expected that secondary neurological complications due to TB and cryptococcosis will be the most common cause of morbility and mortality in HIV-1/AIDS cases in China. Research of NeuroAIDS in China is necessary to understand the impact and the biology of HIV-1 in the nervous system. Future studies would include, the molecular epidemiology and the description of opportunistic infections associated to HIV-1; the neuropathological description of primary and secondary HIV-1 complications in different groups; the HIV-1 neurot- ropism and immune response studies for China’s unique HIV-1 strains and recombinant forms derived from the nervous system, including experimental models such as the use of transgenic rats; and the study of potential resistant virus, primarily when the anti-retroviral therapy (ART) has not full access in the brain. | J Roberto TRUJILLO Gilberto JARAMILLO-RANGEL Marta ORTEGA-MARTINEZ Augusto C PENALVA de OLIVEIRA Jose E VIDAL Joseph BRYANT Robert C GALLO | 2005 | Cell Research2005，15，11： | 4 |
| 4 | Screening for gastric cancer in Asia: current evidence and practice显示文摘 | Wai K Leung Ming-shiang Wu Yasuo Kakugawa Jae J Kim Khay-guan Yeoh Khean Lee Goh Kai-chun Wu Deng-chyang Wu Jose Sollano Udom Kachintorn Takuji Gotoda Jaw-town Lin Wei-cheng You Enders KW Ng Joseph JY Sung | 2008 | Lancet Oncology2008，，3： | 3 |
| 5 | Colorectal neoplasm in asymptomatic Asians: a prospective multinational multicenter colonoscopy survey显示文摘 | Jeong-Sik Byeon Suk-Kyun Yang Tae Il Kim Won Ho Kim James Y.W. Lau Wai-Keung Leung Rikiya Fujita Govind K. Makharia Murdan Abdullah Ida Hilmi Jose Sollano Khay-Guan Yeoh Deng-Chyang Wu Min Hu Chen Pradermchai Kongkam Joseph J.Y. Sung | 2007 | Gastrointestinal Endoscopy2007，，： | 2 |
| 6 | Recommendations for Radioembolization of Hepatic Malignancies Using Yttrium-90 Microsphere Brachytherapy: A Consensus Panel Report from the Radioembolization Brachytherapy Oncology Consortium显示文摘 | Andrew Kennedy Subir Nag Riad Salem Ravi Murthy Alexander J. McEwan Charles Nutting Al Benson Joseph Espat Jose Ignacio Bilbao Ricky A. Sharma James P. Thomas Douglas Coldwell | 2007 | International Journal of Radiation Oncology, Biology, Physics2007，，： | 2 |
| 7 | The antimicrobial activity of microencapsulated thymol and carvacrol显示文摘 | Abel Guarda Javiera F. Rubilar Joseph Miltz Maria Jose Galotto | 2011 | International Journal of Food Microbiology2011，，2： | 2 |
| 8 | Dynamic Mechani-cal Properties of Oil Palm Microfibril-reinforced Natural Rub-ber Composites显示文摘 | Joseph S Sreekumar P A Jose M K | 2010 | Journal of Applied Polymer Science2010，117，3： | 1 |
| 9 | Biallelic knockout of the α-1,3 galactosyltransferase gene in porcine liver-derived cells using zinc finger nucleases显示文摘 | Ping Li Jose L. Estrada Christopher Burlak A. Joseph Tector | 2012 | Journal of Surgical Research2012，，： | 1 |
| 10 | Squamous-Cell Carcinoma of the Rectum: A Rare but Curable Tumor显示文摘 | Caio S. R. Nahas M.D. Jinru Shia M.D. Romane Joseph M.D. Deborah Schrag M.D. Bruce D. Minsky M.D. Martin R. Weiser M.D. Jose G. Guillem M.D. Phillip B. Paty M.D. David S. Klimstra M.D. Laura H. Tang M.D. W. Douglas Wong M.D. Larissa K. Temple M.D | 2007 | Diseases of the Colon & Rectum2007，，9： | 1 |
| 11 | NPH4/ARF7 and ARF19 promote leaf expansion and auxin‐induced lateral root formation显示文摘 | Jill C.Wilmoth ShucaiWang Shiv B.Tiwari Atul D.Joshi GretchenHagen Thomas J.Guilfoyle Jose M.Alonso Joseph R.Ecker Jason W.Reed | 2005 | The Plant Journal2005，，1： | 1 |
| 12 | Computed tomography-based anatomic characterization of proximal aortic dissection with consideration for endovascular candidacy显示文摘 | Michael C. Moon Roy K. Greenberg Jose P. Morales Zenia Martin Qingsheng Lu Joseph F. Dowdall Adrian V. Hernandez | 2011 | Journal of Vascular Surgery2011，，4： | 1 |
| 13 | Cloning, expression, and characterization ofavian reovirus guanylytransferase显示文摘 | Joseph H Jose M C Javier B | 2002 | Virology2002，296，2： | 1 |
| 14 | Double knockout pigs deficient in N ‐glycolylneuraminic acid and G alactose α‐1,3‐ G alactose reduce the humoral barrier to xenotransplantation显示文摘 | Andrew J. Lutz Ping Li Jose L. Estrada Richard A. Sidner Ray K. Chihara Susan M. Downey Christopher Burlak Zheng‐Yu Wang Luz M. Reyes Bess Ivary Fuqin Yin Ross L. Blankenship Leela L. Paris A. Joseph Tector | 2013 | Xenotransplantation2013，，1： | 1 |
| 15 | CBF2-DBEB1C is a negative regulator of CBF1-DREB1B and CBF3-DREB1A expression and plays a central role in stress tolerance in Arabidopsis显示文摘 | Fernando N Jose MA Joseph R | 2004 | Proc Natl Acad Sci USA2004，101，11： | 1 |
| 16 | Current status quo on COVID-19 including chest imaging显示文摘With each day the number coronavirus disease 2019(COVID-19)cases continue to rise rapidly and our imaging knowledge of this disease is expeditiously evolving.The role of chest computed tomography(CT)in the screening or diagnosis of COVID-19 remains the subject of much debate.Despite several months having passed since identifying the disease,and numerous studies related to it,controversy and concern still exists regarding the widespread use of chest CT in the evaluation and management of COVID-19 suspect patients.Several institutes and organizations around the world have released guidelines,recommendations and statements against the use of CT for diagnosing or screening COVID-19 infection and advocating its use only for those cases with a strong clinical suspicion of complication or an alternate diagnosis.However,these guidelines and recommendations are in disagreement with majority of the widely available literature,which strongly favour CT as a pivotal tool in the early diagnosis,management and even follow-up of COVID-19 infection.This article besides comprehensively reviewing the current status quo on COVID-19 disease in general,also writes upon the current consensus statements/recommendations on the use of diagnostic imaging in COVID-19 as well as highlighting the precautions and various disinfection procedures being employed world-wide at the workplace to prevent the spread of infection. | Rishi Philip Mathew Merin Jose Vinayak Jayaram Paul Joy Danny George Maria Joseph TeenaSleeba Ajith Toms | 2020 | World Journal of Radiology2020，12，12： | 1 |
| 17 | Interleukin-17–Dependent Autoimmunity to Collagen Type V in Atherosclerosis显示文摘 | Melanie L. Dart Ewa Jankowska-Gan Guorui Huang Drew A. Roenneburg Melissa R. Keller Jose R. Torrealba Aaron Rhoads Byoungjae Kim Joseph L. Bobadilla Lynn D. Haynes David S. Wilkes William J. Burlingham Daniel S. Greenspan | 2010 | Circulation Research2010，，9： | 1 |
| 18 | The Cox maze procedure in mitral valve disease: Predictors of recurrent atrial fibrillation显示文摘 | A. Marc Gillinov Jon Sirak Eugene H. Blackstone Patrick M. McCarthy Jeevanantham Rajeswaran Gosta Pettersson F. Joseph Sabik Lars G. Svensson Jose L. Navia Delos M. Cosgrove Nassir Marrouche Andrea Natale | 2005 | The Journal of Thoracic and Cardiovascular Surgery2005，，6： | 1 |
| 19 | Prevalence of coronary artery disease in patients with rheumatic heart disease in the current era显示文摘 | Jose VJ Gupta SN Joseph G | 2004 | Indian Heart Journal2004，56，2： | 1 |
| 20 | Prevalence of coronary artery disease in patients with rheumatic heart disease in the current era显示文摘 | Jose VJ Gupta SN Joseph G | 2004 | Indian Heart J2004，56，2： | 1 |
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