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| 1 | Perspectives on the Application of Genome-Editing Technologies in Crop Breeding显示文摘Most conventional and modern crop-improvement methods exploit natural or artificially induced genetic variations and require laborious characterization of the progenies of multiple generations derived from time-consuming genetic crosses.Genome-editing systems,in contrast,provide the means to rapidly modify genomes in a precise and predictable way,making it possible to introduce improvements directly into elite varieties.Here,we describe the range of applications available to agricultural researchers using existing genome-editing tools.In addition to providing examples of genome-editing applications in crop breeding,we discuss the technical and social challenges faced by breeders using genome-editing tools for crop improvement. | Kai Hua Jinshan Zhang Jose Ramon Botella Changle Ma Fanjiang Kong Baohui Liu Jian-Kang Zhu | 2019 | Molecular Plant2019，12，8： | 19 |
| 2 | Extragastric manifestations of Helicobacter pylori infection: Possible role of bacterium in liver and pancreas diseases显示文摘Helicobacter pylori(H. pylori) is an ancient microorganism that has co-evolved with humans for over 60000 years. This bacterium typically colonizes the human stomach and it is currently recognized as the most common infectious pathogen of the gastroduodenal tract. Although its chronic infection is associated with gastritis, peptic ulcer, dysplasia, neoplasia, MALT lymphoma and gastric adenocarcinoma, it has been suggested the possible association of H. pylori infection with several extragastric effects including hepatobiliary and pancreatic diseases. Since a microorganism resembling H. pylori was detected in samples from patients with hepatobiliary disorders, several reports have been discussed the possible role of bacteria in hepatic diseases as hepatocellular carcinoma, cirrhosis and hepatic encephalopathy, nonalcoholic fatty liver disease and fibrosis. Additionally, studies have reported the possible association between H. pylori infection and pancreatic diseases, especially because it has been suggested that this infection could change the pancreatic physiology. Some of them have related a possible association between the microorganism and pancreatic cancer. H. pylori infection has also been suggested to play a role in the acute and chronic pancreatitis pathogenesis, autoimmune pancreatitis, diabetes mellitus and metabolic syndrome. Considering that association of H. pylori to liver and pancreas diseases needs further clarification, our work offers a review about the results of some investigations related to the potential pathogenicity of H. pylori in these extragastric diseases. | Elizabeth MA Rabelo-Goncalves Bruna M Roesler Jose MR Zeitune | 2015 | World Journal of Hepatology2015，7，30： | 16 |
| 3 | Connexin 43 hemichannels protect bone loss during estrogen deficiency显示文摘Estrogen deficiency in postmenopausal women is a major cause of bone loss,resulting in osteopenia,osteoporosis,and a high risk for bone fracture.Connexin 43 (Cx43) hemichannels (HCs) in osteocytes play an important role in osteocyte viability,bone formation,and remodeling.We showed here that estrogen deficiency reduced Cx43 expression and HC function.To determine if functional HCs protect osteocytes and bone loss during estrogen deficiency,we adopted an ovariectomy model in wild-type (WT) and two transgenic Cx43 mice:R76W (dominant-negative mutant inhibiting only gap junction channels) and Cx43 Δ130–136 (dominant-negative mutant compromising both gap junction channels and HCs).The bone mineral density (BMD),bone structure,and histomorphometric changes of cortical and trabecular bones after ovariectomy were investigated.Our results showed that the Δ130–136 transgenic cohort had greatly decreased vertebral trabecular bone mass compared to WT and R76W mice,associated with a significant increase in the number of apoptotic osteocyte and empty lacunae.Moreover,osteoclast surfaces in trabecular and cortical bones were increased after ovariectomy in the R76W and WT mice,respectively,but not in Δ130–136 mice.These data demonstrate that impairment of Cx43 HCs in osteocytes accelerates vertebral trabecular bone loss and increase in osteocyte apoptosis,and further suggest that Cx43 HCs in osteocytes protect trabecular bone against catabolic effects due to estrogen deficiency. | Liang Ma Rui Hua Yi Tian Hongyun Cheng Roberto Jose Fajardo Joseph J. Pearson Teja Guda Daniel Brian Shropshire Sumin Gu Jean X. Jiang | 2019 | Bone Research2019，7，2： | 11 |
| 4 | Cytomegalovirus frequency in neonatal intrahepatic cholestasis determined by serology, histology, immunohistochemistry and PCR显示文摘AIM: To determine cytomegalovirus (CMV) frequency in neonatal intrahepatic cholestasis by serology, histological revision (searching for cytomegalic cells), immunohistochemistry, and polymerase chain reaction (PCR), and to verify the relationships among these methods.METHODS: The study comprised 101 non-consecutive infants submitted for hepatic biopsy between March 1982 and December 2005. Serological results were obtained from the patient's f iles and the other methods were performed on paraffin-embedded liver samples from hepatic biopsies. The following statistical measures were calculated: frequency, sensibility, specif ic positive predictive value, negative predictive value, and accuracy.RESULTS: The frequencies of positive results were as follows: serology, 7/64 (11%); histological revision, 0/84; immunohistochemistry, 1/44 (2%), and PCR, 6/77 (8%). Only one patient had positive immunohistochemical fi ndings and a positive PCR. The following statistical measures were calculated between PCR and serology: sensitivity, 33.3%; specificity, 88.89%; positive predictive value, 28.57%; negative predictive value, 90.91%; and accuracy, 82.35%. CONCLUSION: The frequency of positive CMV varied among the tests. Serology presented the highest positive frequency. When compared to PCR, the sensitivity and positive predictive value of serology were low. | Maria Angela Bellomo-Brandao Paula D Andrade Sandra CB Costa Cecilia AF Escanhoela Jose Vassallo Gilda Porta Adriana MA De Tommaso Gabriel Hessel | 2009 | World Journal of Gastroenterology2009，15，27： | 8 |
| 5 | Weighted variation inequalities for differential operators and singular integrals in higher dimensions显示文摘We prove weighted q-variation inequalities with 2 | MA Tao TORREA Jose L. XU QuanHua | 2017 | Science China Mathematics2017，60，8： | 5 |
| 6 | Phylotranscriptomic insights into Asteraceae diversity,polyploidy,and morphological innovation显示文摘Biodiversity is not evenly distributed among relatedgroups,raising questions about the factors con-tributing to such disparities.The sunflower family(Asteraceae,>26,000 species)is among the largestand most diverse plant families,but its species di-versity is concentrated in a few subfamilies,pro-viding an opportunity to study the factors affectingbiodiversity.Phylotranscriptomic analyses here of244 transcriptomes and genomes produced a phy-logeny with strong support for the monophyly ofAsteraceae and the monophyly of most subfamiliesand tribes.This phylogeny provides a reference fordetecting changes in diversification rates and pos-sible factors affecting Asteraceae diversity,whichinclude global climate shifts,whole‐genome dupli-cations(WGDs),and morphological evolution.Theorigin of Asteraceae was estimated at~83 Mya,with most subfamilies having diverged before theCretaceous–Paleocene boundary.Phylotran-scriptomic analyses supported the existence of 41WGDs in Asteraceae.Changes to herbaceousnessand capitulescence with multipleflower‐like capitula,often with distinctflorets and scaly pappus/re-ceptacular bracts,are associated with multiple up-shifts in diversification rate.WGDs might have con-tributed to the survival of early Asteraceae byproviding new genetic materials to support mor-phological transitions.The resulting competitive ad-vantage for adapting to different niches would haveincreased biodiversity in Asteraceae. | Caifei Zhang Chien‐Hsun Huang Mian Liu YiHu Jose L.Panero Federico Luebert Tiangang Gao Hong Ma | 2021 | Journal of Integrative Plant Biology2021，63，7： | 4 |
| 7 | High Elevation Energy and Water Balance:the Roles of Surface Albedo and Temperature显示文摘Observation and modeling of the coupled energy and water balance is the key to understand hydrospheric and cryospheric processes at high elevation.The paper summarizes the progress to address this aspect in relation with different earth system elements,from glaciers to wetlands.The energy budget of two glaciers,i.e.Xiao Dongkemadi and Parlung No.4,was studied by means of extended field measurements and a distributed model of the coupled energy and mass balance was developed and evaluated.The need for accurate characterization of surface albedo was further documented for the entire Qinghai Tibet Plateau by numerical experiments with Weather Research and Forecast(WRF)on the sensitivity of the atmospheric boundary layer to the parameterization of land surface processes.A new approach to the calibration of a coupled distributed watershed model of the energy and water balance was demonstrated by a case study on the Heihe River Basin in northwestern China.The assimilation of land surface temperature did lead to the retrieval of critical soil and vegetation properties as the soil permeability and the canopy resistance to the exchange of vapour and carbon dioxide.The retrievals of actual Evapo-Transpiration(ET)were generated by the ETMonitor system and evaluated against eddy covariance measurements at sites spread throughout Asia.As regards glacier response to climate variability,the combined findings based on satellite data and model experiments showed that the spatial variability of surface albedo and temperature is significant and controls both glacier mass balance and flow.Experiments with both atmospheric and hydrosphere-cryosphere models documented the need and advantages of using accurate retrievals of land surface albedo to capture lan-atmosphere interactions at high elevation. | Massimo MENENTI Li JIA Marco MANCINI Xin LI Francesca PELLICCIOTTI Kun YANG Jiancheng SHI Maria Jose ESCORIHUELA Chiara CORBARI Shaoting REN Chunfeng MA Chaolei ZHENG Lian LIU Thomas SHAW Baohong DING Wei YANG | 2020 | Journal of Geodesy and Geoinformation Science2020，3，4： | 3 |
| 8 | HCl-induced and ATP-dependent upregulation of TRPV1 receptor expression and cytokine production by human esophageal epithelial cells显示文摘 | Jie Ma Annamaria Altomare Michele Guarino Michele Cicala Florian Rieder Claudio Fiocchi Dan Li Weibiao Cao Jose Behar Piero Biancani Karen M. Harnett | 2012 | AJP: Gastrointestinal and Liver Physiology2012，，5： | 2 |
| 9 | A robust soc-MOF platform exhibiting high gravimetric uptake and volumetric deliverable capacity for on-board methane storage显示文摘Emerging as an outperformed class of metal-organic frameworks(MOFs),square-octahedron(soc)topology MOFs(soc-MOFs)feature superior properties of high porosity,large gas storage capacity,and excellent thermal/chemical stability.We report here an iron based soc-MOF,denoted as Fe-pbpta(H4pbpta=4,4',4'',4'''-(1,4-phenylenbis(pyridine-4,2-6-triyl))-tetrabenzoic acid)possessing a very high Brunauer,Emmett and Teller(BET)surface area of 4,937 m2/g and a large pore volume of 2.15 cm3/g.The MOF demonstrates by far the highest gravimetric uptake of 369 cm3(STP)/g under the DOE operational storage conditions(35 bar and 298 K)and a high volumetric deliverable capacity of 192 cc/cc at 298 K and 65 bar.Furthermore,Fe-pbpta exhibits high thermal and aqueous stability making it a promising candidate for on-board methane storage. | Gaurav Verma Sanjay Kumar Harsh Vardhan Junyu Ren Zheng Niu Tony Pham Lukasz Wojtas Sydney Butikofer Jose C Echeverria Garcia Yu-Sheng Chen Brian Space and Shengqian Ma | 2021 | Nano Research2021，14，2： | 2 |
| 10 | Modelling potential evapotranspiration of potential vegetation显示文摘 | Jose Ma Rey | 1999 | Ecological Modelling1999，132，： | 1 |
| 11 | Mucins CA125, CA19 - 9, CA153 and TAG -723 as tumor markers in patients with lung cancer: comparison with Cyfra21 - 1, CEA, SCC and NSE 显示文摘 | Rafael M Jose MA Jose ME | 2008 | Tumor Biol2008，29，7： | 1 |
| 12 | Vascular oxidant stress:molecular mechanisms and pathophysiological implications显示文摘 | Zalba G Beaumont J San Jose G Fortuno A Fortuno MA Diez J | 2000 | J Physiol Biochem2000，56，： | 1 |
| 13 | Role of SLAM in NKT cell development revealed by transgenic complementation in NOD mice 显示文摘 | Jordan MA Fletcher JM Jose R | 2011 | J Immunol2011，186，7： | 1 |
| 14 | Mucins CA125,CA199,CA153 and TAG-723 as tumor markers in patients with lung cancer:comparison with Cyfra211,CEA,SCC and NSE显示文摘 | Rafael M Jose MA Jose ME | 2008 | Tumor Bio2008，29，7： | 1 |
| 15 | CBF2-DBEB1C is a negative regulator of CBF1-DREB1B and CBF3-DREB1A expression and plays a central role in stress tolerance in Arabidopsis显示文摘 | Fernando N Jose MA Joseph R | 2004 | Proc Natl Acad Sci USA2004，101，11： | 1 |
| 16 | Combustion characteristics and emissions of 2-methylfuran compared to 2,5-dimethylfuran, gasoline and ethanol in a DISI engine显示文摘 | Chongming Wang Hongming Xu Ritchie Daniel Akbar Ghafourian Jose Martin Herreros Shijin Shuai Xiao Ma | 2013 | Fuel2013，，： | 1 |
| 17 | The real-time polymerase chain reaction显示文摘 | Mikael KA Jose MA Martin B | | 0，，： | 1 |
| 18 | Roles of homocysteine in cell metabolism: old and new functions 显示文摘 | Medina MA Jose LU Maria IAS | 2001 | Eur J Biochem2001，268，14： | 1 |
| 19 | Dopamine neurons derived from embryonic stem cells function in an animal model of parkinson's disease显示文摘 | Jong HK Jonathan MA Jose A | 2002 | Nature2002，418，4： | 1 |
| 20 | The real-time polymerase chain reaction 显示文摘 | Mikael K Jose MA Martin B | 2006 | Molecular Aspects of Medicine2006，27，23： | 1 |
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