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| 1 | Stem cells:An eventual treatment option for heart diseases显示文摘Stem cells are of global excitement for various diseases including heart diseases. It is worth to understand the mechanism or role of stem cells in the treatment of heart failure. Bone marrow derived stem cells are commonly practiced with an aim to improve the function of the heart. The majority of studies have been conducted with acute myocardial infarction and a few has been investigated with the use of stem cells for treating chronic or dilated cardiomyopathy. Heterogeneity in the treated group using stem cells has greatly emerged. Ever increasing demand for any alternative made is of at most priority for cardiomyopathy. Stem cells are of top priority with the current impact that has generated among physicians. However,meticulous selection of proper source is required since redundancy is clearly evident with the present survey. This review focuses on the methods adopted using stem cells for heart diseases and outcomes that are generated so far with an idea to determine the best therapeutic possibility in order to fulfill the present demand. | Joseph C Bilgimol Subbareddy Ragupathi Lakshmanan Vengadassalapathy Nathan S Senthil Kali-muthu Selvakumar M Ganesan Sadananda Rao Manjunath | 2015 | World Journal of Stem Cells2015，7，8： | 6 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | Optical disassembly of cellular clusters by tunable ‘tug-of-war’ tweezers显示文摘Bacterial biofilms underlie many persistent infections,posing major hurdles in antibiotic treatment.Here we design and demonstrate‘tug-of-war’optical tweezers that can facilitate the assessment of cell–cell adhesion—a key contributing factor to biofilm development,thanks to the combined actions of optical scattering and gradient forces.With a customized optical landscape distinct from that of conventional tweezers,not only can such‘tug-of-war’tweezers stably trap and stretch a rod-shaped bacterium in the observing plane,but,more importantly,they can also impose a tunable lateral force that pulls apart cellular clusters without any tethering or mechanical movement.As a proof of principle,we examined a Sinorhizobium meliloti strain that forms robust biofilms and found that the strength of intercellular adhesion depends on the growth medium.This technique may herald new photonic tools for optical manipulation and biofilm study,as well as other biological applications. | Anna S Bezryadina Daryl C Preece Joseph C Chen Zhigang Chen | 2016 | Light(Science & Applications)2016，5，1： | 4 |
| 4 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 5 | Brake squeal a literature review 显示文摘 | Papinniemi Antti Lai Joseph C S Zhao Jiye | 2002 | Applied Acoustics2002，63，4： | 1 |
| 6 | Synthesis in inverse emulsion and properties of water-soluble associating polymers显示文摘 | Martial P Jean-Marc C Joseph S | 2002 | Applied Polymer Science2002，84，： | 1 |
| 7 | Wavelet entropy for subband segmentation of EEG during in- jury and recover显示文摘 | Hasan A A Joseph S P Wendy C Z | 2003 | Annals of Biomedical Engineer- ing2003，31，6： | 1 |
| 8 | Effectively Utilizing Group Reading Strategies to Enhance Comprehension 显示文摘 | Joseph S C | 2003 | Reading Improvement2003，40，3： | 1 |
| 9 | Expression profile of eukaryotie translation factors in human cancer tissues and cell lines 显示文摘 | Joseph P O' Kemiek C M Othumpangat S | 2004 | Mol Carcinog2004，40，3： | 1 |
| 10 | Systemic nitroglycerin induces Fos immunoreactivity in brainstem and fore- brain structures of the rat显示文摘 | TASSORELLI C JOSEPH S A | 1995 | Brain Res1995，682，12： | 1 |
| 11 | Sonographic diagnosis of Mirizzi's syndrome显示文摘 | Carvajal S Odwin C | 1985 | J Clin Ultrasound1985，13，： | 1 |
| 12 | Gatifloxacin-associated corrected QT interval prolongation, torsades de points and ventricular fibrillation in patients with hnown risk factors显示文摘 | JOSEPH S BERTINO JR ROBERT C | 2002 | ID2002，34，15： | 1 |
| 13 | Generalized system for relaxed cocoercive variational inequalities in Hibert spaces 显示文摘 | CHANG S S JOSEPH LEE H W CHAHN C K | 2007 | Appl Math Lett2007，20，： | 1 |
| 14 | Self-eare and qual- ity of life of heart failure patients at a multidisciplinary heart function clinic显示文摘 | Emily S Kevin J L Joseph A C | 2011 | J Cardiovase Nuts2011，26，5： | 1 |
| 15 | Sonographic diagnosis of Mirizzi's syndrome显示文摘 | Joseph S Carvajal S Odwin C | 1985 | J Clin Ultrasound1985，13，3： | 1 |
| 16 | Expression profile of eukaryotic translation factors in human cancer tissues and cell lines 显示文摘 | Joseph P O'Kernick C M Othumpangat S | 2004 | Mol Carcinog2004，40，3： | 1 |
| 17 | Replenishment of hard clam stocks using hatchery seed:combined importance of bottom type, seed size, planting season, and density显示文摘 | Charles H P Henry C S Joseph H | 1995 | J Shellfish Res1995，14，2： | 1 |
| 18 | Tacrolimus for the treatment of fistulas in patients with crohn’s disease: a randomized, placebo-controlled trial显示文摘 | William J Sandborn Daniel H Present Kim L Isaacs Douglas C Wolf Eugene Greenberg Stephen B Hanauer Brian G Feagan Lloyd Mayer Therese Johnson Joseph Galanko Christopher Martin Robert S Sandler | 2003 | Gastroenterology2003，，2： | 1 |
| 19 | Generalized System for Relaxed Cocoercive Variational Lnequalities in Hilbert Spaces 显示文摘 | Chang S S Joseph Lee H W Chan C K | 2007 | Appl Math Lett2007，20，： | 1 |
| 20 | Systemic nitroglycerin induces Fos immunoreactivity in brainstem and forebrain structures of the rat显示文摘 | rassorelli C Joseph S A | 1995 | Brain Res1995，682，12： | 1 |
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