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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Thermochemistry of gasphase 1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane(b-HMX)显示文摘 | Fan X W Ju X H Xiao H M | 2005 | J Mol Struct(THEOCHEM)2005，714，14： | 1 |
| 3 | Behind organizational slack and firm performance in China: the moderating roles of owner- ship and competitive intensity显示文摘 | Ju M Zhao H | 1996 | Asia Pacific Journal of Management Journal1996，39，： | 1 |
| 4 | Structure-property relationship of cast Ti-Nb alloys 显示文摘 | LEE C M JU C P CHERN-LIN J H | 2002 | J Oral Rehabil2002，29，： | 1 |
| 5 | Knowledge sharing be- havior in virtual communities: the relationship between trust, self-efficacy, and outcome expectations显示文摘 | HSU M H JU T L YEN C H | 2007 | Human-Computer Studies2007，65，2： | 1 |
| 6 | Knowledge Sharing Behavior in Virtual Communities:The Relationship Between Trust Self- efficacy and Outcome Expectation 显示文摘 | Hsu M H Ju T L Yeh C H | 2007 | Human - Computer Studies2007，65，： | 1 |
| 7 | A rehabilitation robot with force-po- sition hybrid fuzzy controller: hybrid fuzzy control of rehabilitation robot 显示文摘 | Ju M S Lin C C K Lin D H | 2005 | IEEE Transactionjs on Neural Systems and Rehabilitation Engi- neering2005，13，3： | 1 |
| 8 | Behind organizational slack and firm per- formance in China:The moderating roles of ownership and competitive intensity 显示文摘 | JU M ZHAO H | 2009 | Asia Pacific Journal of Manage- ment2009，26，4： | 1 |
| 9 | pH/temperature-responsive behaviors of semi-IPN and comb-type graft hydrogels composed of alginate and poly(Nqsopropylacrylamide)显示文摘 | Ju H K Kim S Y Lee Y M | 2001 | Polymer2001，42，16： | 1 |
| 10 | Mitral valve replacement with or without a concomitant Maze procedure in patients with atrial fibril- lation显示文摘 | Kim J B Ju M H Yun S C | 2010 | Heart2010，96，14： | 1 |
| 11 | Investigation of the effects of bottom anti- reflective coating on nanoscale patterns by laser interfer- ence lithography显示文摘 | Park E M Choi J Kang B H Dong K Y Park Y Song I S Ju B K | 2011 | Thin Solid Films2011，519，13： | 1 |
| 12 | Stability and stabilization for discrete-time systems with time-varying delays via augmented Lyapunov-Krasovskii functional显示文摘 | KWON O M PARK M J JU H | 2013 | Jour of the Frank Instit2013，350，5： | 1 |
| 13 | Knowledge sharing behavor in virtual communities:The relationship between trust,self-efficacy,and outcore expectations显示文摘 | Hsu M H Ju T L Yen C H et a1 | | 0，，2： | 1 |
| 14 | Analysis on robust H∞math Container Loading Mathjax performance and stability for linear systems with interval time-varying state delays via some new augmented Lyapunov-Krasovskii functional显示文摘 | KWON O M PARK M J JU H P | 2013 | Applied Mathematics and Computation2013，224，： | 1 |
| 15 | Knowledge sharing behav- ior in virtual communities: the relationship between trust, self- efficacy, and outcome expectations 显示文摘 | Hsu M H Ju T L Yen C H etc | 2007 | International Journal of Human-Computer Studies2007，65，： | 1 |
| 16 | Ews-based management application interface and integration mechanisms for webbased element management 显示文摘 | JU H T CHOI M J HONG J W | 2001 | Journal of Net- work and Systems Management2001，9，1： | 1 |
| 17 | Polymer-based devices for optical communications显示文摘 | Lee M H Ju J J Park S | 2002 | ETRI Journal2002，24，4： | 1 |
| 18 | Improved approaches to stability criteria for neural networks with time-varying delays显示文摘 | KWON O M PARK M J JU H P | 2013 | Journal of the Franklin Institute2013，350，9： | 1 |
| 19 | Drying characteristics and modeling of yam slices under different relative humidity conditions显示文摘 | Ju Haoyu El-Mashad H M Fang Xiaoming | 2016 | Drying Technology2016，34，3： | 1 |
| 20 | A rehabilitation robot with force-position hybrid fuzzy controller: hybrid fuzzy control of rehabilitation robot 显示文摘 | M S Ju C C K Lin D H Lin | 2005 | IEEE Transactions on Neural Systems and Rehabilitation Engineering (S1534-4320)2005，13，3： | 1 |
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