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| 1 | The effects and regulatory mechanism of RIP3 on RGC-5 necroptosis following elevated hydrostatic pressure显示文摘Necroptosis 是在各种各样的疾病被含有的调整房间死亡的一种类型。交往受体的蛋白质 3 (RIP3 ) , RIP 家庭的一个成员,是 necroptotic 小径的一个重要调停人。在由 caspase-8 的 Asp328 的 RIP3 的劈开废除 RIP3 的 kinase 活动,它为 necroptosis 是批评的。而且, RIP3 是显著地 upregulated 在尖锐高 intra 眼睛的压力和氧葡萄糖剥夺的早阶段期间。在这研究, RIP3 的效果在提高的静水力学的压力(EHP ) 期间被调查, caspase-8 通过调整了 RIP3 劈开的可能的机制被探索。流动 cytometry 分析表明导致 EHP 的坏死的网膜的中心房间 5 的数字(RGC-5 ) 房间被减少在以后 RIP3 击倒。而且,在正常 RGC-5 房间的 malondialdehyde (MDA ) 层次和肝糖 phosphorylase (PYGL ) 活动比在在 EHP 以后的 RIP3 击倒的房间的那些高得多。导致 EHP 的 RGC-5 坏死显著地与 butylated hydroxyanisole (BHA ) 在处理以后被减少,反应的氧种类(ROS ) scavenger。MDA 层次和 PYGL 活动比在有在 EHP 以后的 caspase-8 抑制的房间的那些在正常 RGC-5 房间是更低的。西方的污点分析证明 RIP3 劈开产品是在有 caspase-8 抑制的房间的 upregulated。另外,流动 cytometry 分析表明导致 EHP 的坏死的 RGC-5 房间的数字在 caspase-8 抑制以后被增加。我们的结果建议 RGC-5 necroptosis 追随者 EHP 被 RIP3 通过 PYGL 活动和随后的 ROS 累积的正式就职调停。因此, caspase-8 可以经由 RIP3 劈开参予 RGC-5 necroptosis 的规定。 | Lei Shang Wei Ding Na Li Lvshuang Liao Dan Chen Jufang Huang Kun Xiong | 2017 | Acta Biochimica et Biophysica Sinica2017，49，2： | 9 |
| 2 | Medical expenditures for colorectal cancer diagnosis and treatment: A 10-year high-level-hospital-based multicenter retrospective survey in China, 2002-2011显示文摘Objective: Colorectal cancer(CRC) causes a substantial burden of disease in China and the evidence of economic burden triggered is fundamental for priority setting. The aim of this survey was to quantify medical expenditures and the time trends for CRC diagnosis and treatment in China.Methods: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 13 provinces across China. For each eligible CRC patient diagnosed from 2002 to 2011, clinical information and expenditure data were extracted using a uniform questionnaire. All expenditure data were reported in Chinese Yuan(CNY)using 2011 values.Results: Of the 14,536 CRC patients included, the average age at diagnosis was 58.2 years and 15.8% were stageI cases. The average medical expenditure per patient was estimated at 37,902 CNY [95 % confidence interval(95%CI): 37,282-38,522], and the annual average increase rate was 9.2% from 2002 to 2011(P for trend <0.001), with a cumulative increase of 2.4 times(from 23,275 CNY to 56,010 CNY). The expenditure per patient in stages Ⅰ, Ⅱ, Ⅲ and Ⅳ were 31,698 CNY, 37,067 CNY, 38,918 CNY and 42,614 CNY, respectively(P<0.001). Expenditure significantly differed within various subgroups. Expenses for drugs contributed the largest proportion(52.6%).Conclusions: These conservative estimates illustrated that medical expenditures for CRC diagnosis and treatment in tertiary hospitals in China were substantial and increased rapidly over the 10 years, with drugs continually being the main expense by 2011. Relatively, medical expenditures are lower for CRC in the earlier stages. These findings will facilitate the economic evaluation of CRC prevention and control in China. | Jufang Shi Guoxiang Liu Hong Wang Ayan Mao Chengcheng Liu Lanwei Guo Huiyao Huang Jiansong Ren Xianzhen Liao Yana Bai Xiaojie Sun Xinyu Zhu Jialin Wang Bingbing Song Jinyi Zhou Lin Zhu Haike Lei Yuqin Liu Yunyong Liu Lingbin Du Yutong He Kai Zhang Ni Li Wanqing Chen Min Dai Jie He | 2019 | Chinese Journal of Cancer Research2019，31，5： | 8 |
| 3 | No expenditure difference among patients with liver cancer at stageⅠ-ⅣV:Findings from a multicenter cross-sectional study in China显示文摘Objective:The number of liver cancer patients in China accounts for more than half of the world.However,China currently lacks national,multicenter economic burden data,and meanwhile,measuring the differences among different subgroups will be informative to formulate corresponding policies in liver cancer control.Thus,the aim of the study was to measure the economic burden of liver cancer by various subgroups.Methods:A hospital-based,multicenter and cross-sectional survey was conducted during 2012・2014,covering 39 hospitals and 21 project sites in 13 provinces across China.The questionnaire covers clinical information,sociology,expenditure,and related variables.All expenditure data were reported in Chinese Yuan(CNY)using 2014 values.Results:A total of 2,223 liver cancer patients were enrolled,of whom 59.61%were late-stage cases(III-IV),and 53.8%were hepatocellular carcinoma.The average total expenditure per liver cancer patient was estimated as 53,220 CNY,including 48,612 CNY of medical expenditures(91.3%)and 4,608 CNY of non-medical expenditures(8.7%).The average total expenditures in stage I,H,m and stage IV were 52,817 CNY,50,877 CNY,50,678 CNY and 54,089 CNY(P>0.05),respectively.Non-medical expenditures including additional meals,additional nutrition care,transportation,accommodation and hired informal nursing were 1,453 CNY,839 CNY,946 CNY,679 CNY and 200 CNY,respectively.The one-year out-of-pocket expenditure of a newly diagnosed patient was 24,953 CNY,and 77.2%of the patients suffered an unmanageable financial burden.Multivariate analysis showed that overall expenditure differed in almost all subgroups(P<0.05),except for sex,clinical stage,and pathologic type.Conclusions:There was no difference in treatment expenditure for liver cancer patients at different clinical stages,which suggests that maintaining efforts on treatment efficacy improvement is important but not enough.To fiirtherly reduce the overall economic burden from liver cancer,more effort should be given to primary and secondary prevention strategies. | Haike Lei Lin Lei Jufang Shi Yongzhong Wu Ling Liang Huiyao Huang Mei He Fangzhou Bai Maomao Cao Hui Qiu Yuting Wang Chengcheng Liu Jia Du Hong Wang Yan Zhang Mengdi Cao Ji Peng Ni Li Chunfeng Qu Min Dai Wanqing Chen Jie He | 2020 | Chinese Journal of Cancer Research2020，32，4： | 7 |
| 4 | Mixed lineage kinase domain-like protein induces RGC-5 necroptosis following elevated hydrostatic pressure显示文摘 | Lvshuang Liao Lei Shang Na Li Shuchao Wang Mi Wang Yanxia Huang Dan Chen Jufang Huang Kun Xiong | 2017 | Acta Biochimica et Biophysica Sinica2017，49，10： | 5 |
| 5 | Short-term environmental enrichment exposure induces proliferation and maturation of doublecortin-positive cells in the prefrontal cortex显示文摘Previous studies have demonstrated that doublecortin-positive immature neurons exist predominantly in the superficial layer of the cerebral cortex of adult mammals such as guinea pigs, and these neurons exhibit very weak properties of self-proliferation during adulthood under physiological conditions. To verify whether environmental enrichment has an impact on the proliferation and maturation of these immature neurons in the prefrontal cortex of adult guinea pigs, healthy adult guinea pigs were subjected to short-term environmental enrichment. Animals were allowed to play with various cognitive and physical stimulating objects over a period of 2 weeks, twice per day, for 60 minutes each. Immunofluorescence staining results indicated that the number of doublecortin-positive cells in layer II of the prefrontal cortex was significantly increased after short-term environmental enrichment exposure. In addition, these doublecortin-positive cells co-expressed 5-bromo-2-deoxyuridine(a marker of cell proliferation), c-Fos(a marker of cell viability) and NeuN(a marker of mature neurons). Experimental findings showed that short-term environmental enrichment can induce proliferation, activation and maturation of doublecortin-positive cells in layer II of the prefrontal cortex of adult guinea pigs. | Chunling Fan Mengqi Zhang Lei Shang Ngobe Akume Cynthia Zhi Li Zhenyu Yang Dan Chen Jufang Huang Kun Xiong | 2014 | Neural Regeneration Research2014，9，3： | 4 |
| 6 | Beta-amyloid precursor protein cleavage enzyme-1 expression in adult rat retinal neurons in the early period after lead exposure显示文摘Previous studies have reported that non-human primates and rodents exposed to lead during brain development may become dependent on the deposition of pre-determined β-amyloid protein (Aβ),and exhibit upregulation of β-site amyloid precursor protein expression in old age.However,further evidence is required to elucidate the precise relationship and molecular mechanisms underlying the effects of early lead exposure on excessive Aβ production in adult mammals.The present study investigated the effects of lead exposure on expression of β-amyloid precursor protein cleavage enzyme-1 (BACE-1) in the rat retina and the production of Aβ in early development,using the retina as a window for studying Alzheimer's disease.Adult rats were intraocularly injected with different doses of lead acetate (10μmol/L,100μmol/L,1 mmol/L,10 mmol/L and 100 mmol/L).The results revealed that retinal lead concentration,BACE-1 and its cleavage products β-C-terminal fragment and retina Aβ1-40 were all significantly increased in almost all of the lead exposure groups 48 hours later in a dose-dependent manner.The only exception was the 10μmol/L group.The distribution of BACE-1 in the retina did not exhibit obvious changes,and no distinctive increase in the activation of retinal microglia was apparent.Similarly,retinal synaptophysin expression did not exhibit any clear changes.These data suggest that lead exposure can result in the upregulation of retinal neuron BACE-1 expression in the early period of development and further increase the overproduction of Aβ1-40 in the retina.Our results provided novel insight into the molecular mechanisms underlying environmentally-induced Alzheimer's disease. | Jufang Huang Kai Huang Lei Shang Hui Wang Xiaoxin Yan Kun Xiong | 2011 | Neural Regeneration Research2011，6，14： | 3 |
| 7 | Spatiotemporal alterations of presynaptic elements in the retina after high intraocular pressure显示文摘A rat model of acute high intraocular pressure was established by injecting saline into the anterior chamber of the left eye.Synaptophysin expression was increased in the inner plexiform layer at 2 hours following injury,and was widely distributed in the outer plexiform layer at 3-7 days,and then decreased to the normal level at 14 days.This suggests that expression of this presynaptic functional protein experienced spatiotemporal alterations after elevation of intraocular pressure.There was no significant change in the fluorescence intensity and distribution pattern for synapse-associated protein 102 following elevated intraocular pressure.Synapse-associated protein 102 immunoreactivity was confined to the outer plexiform layer,while synaptophysin immunoreactivity spread into the outer plexiform layer and the outer nuclear layer at 3 and 7 days following injury.These alterations in presynaptic elements were not accompanied by changes in postsynaptic components. | Jufang Huang Lihong Zhou Hui Wang Jia Luo Kun Xiong Leping Zeng Dan Chen | 2012 | Neural Regeneration Research2012，7，16： | 2 |
| 8 | Regulatory effects of inhibiting the activation of glial cells on retinal synaptic plasticity显示文摘Various retinal injuries induced by ocular hypertension have been shown to induce plastic changes in retinal synapses,but the potential regulatory mechanism of synaptic plasticity after retinal injury was still unclear.A rat model of acute ocular hypertension was established by injecting saline intravitreally for an hour,and elevating the intraocular pressure to 14.63 kPa(110 mmHg).Western blot assay and immunofluorescence results showed that synaptophysin expression had a distinct spatiotemporal change that increased in the inner plexiform layer within 1 day and spread across the outer plexiform layer after 3 days.Glial fibrillary acidic protein expression in retinae was greatly increased after 3 days,and reached a peak at 7 days,which was also consistent with the peak time of synaptophysin expression in the outer plexiform layer following the increased intraocular pressure.Fluorocitrate,a glial metabolic inhibitor,was intravitreally injected to inhibit glial cell activation following high intraocular pressure.This significantly inhibited the enhanced glial fibrillary acidic protein expression induced by high intraocular pressure injury.Synaptophysin expression also decreased in the inner plexiform layer within a day and the widened distribution in the outer plexiform layer had disappeared by 3 days.The results suggested that retinal glial cell activation might play an important role in the process of retinal synaptic plasticity induced by acute high intraocular pressure through affecting the expression and distribution of synaptic functional proteins,such as synaptophysin. | Lihong Zhou Hui Wang Jia Luo Kun Xiong Leping Zeng Dan Chen Jufang Huang | 2014 | Neural Regeneration Research2014，9，4： | 2 |
| 9 | An effective method of DNA extraction for bioleaching bacteria from acid mine drainage显示文摘 | Leping Zeng Jufang Huang Yanfei Zhang Guanzhou Qiu Jianbin Tong Dan Chen Jin Zhou Xuegang Luo | 2008 | Applied Microbiology and Biotechnology2008，，5： | 1 |
| 10 | Optical characteristics of Si/SiO2 muhilayers prepared by magnetron sputtering显示文摘 | XIAO Hong HUANG Shihua ZHENG Jufang | 2009 | Mieroelectronic Engineering2009，86，11： | 1 |
| 11 | Biochemical characterization of human peroxiredoxin 2, an antioxidative protein显示文摘人的 peroxiredoxin 2 (Prx2 ) ,它充满红血球,被显示了在由清除保护红血球免于氧化应力起一个关键作用象参予房间信号 transduction 一样的反应的氧种类。这里,人的 Prx2 基因成功地为 Prx2 表示被克隆进 Escherichia coli BL21 (DE3 ) 。钠 dodecyl 硫酸盐 polyacrylamide 胶化电气泳动分析建议 recombinant 蛋白质主要在一种可溶的形式被表示。recombinant 蛋白质被一步舞 Ni-nitrilotriacetic 酸 chelating 亲密关系层析净化到多达 91.5% 的纯净。Prx2 的 peroxidase 活动 H2O2 被 ferrithiocyanate 试金决定清除。Prx2 的能力被使用一个混合功能氧化系统测试保护 plasmid DNA,并且结果证明 Prx2 能阻止 DNA 经历氧化应力。紫外(紫外) 导致的房间 apoptosis 试金证明 Prx2 也能保护 NIH/3T3 房间免受紫外导致损坏的伤害,在化妆品和另外的区域建议它的可能的应用。 | Sheng Yan Shaopei Chen Zhendong Li Haiying Wang Tuxiong Huang Xiaoning Wang Jufang Wang | 2012 | Acta Biochimica et Biophysica Sinica2012，44，9： | 1 |
| 12 | Melatonin alleviates pyroptosis of retinal neurons following acute intraocular hypertension显示文摘Glaucoma is a multifactorial optic neuropathy progressive characterized by structural loss of retinal ganglion cells(RGCs)and irreversible loss of vision.High intraocular pressure(HIOP)is a high risk factor for glaucoma.It has been reported that the manners of RGCs'loss are in-depth explored after acute HIOP injury,such as,apoptosis,autophagy and necrosis.However,pyroptosis,a novel type of pro-inflammatory cell programmed necrosis,rarely reported after HIOP injury.Researches also showed that melatonin possessing substantial anti-inflammatory properties.However,whether melatonin could alleviate retinal neurons death,especially pyroptosis,by HIOP injury is unclear.This study explored pyroptosis of retinal neurons and the effects of melatonin preventing retinal neurons form pyroptosis after acute HIOP injury.Establish acute HIOP model in rat by increasing the IOP and then reperfusion. | Zhang Yu Huang Yanxia Guo Limin Zhang Yun Zhao Mingxuan Xue Fuyao Tan Cheng Huang Jufang Chen Dan | 2021 | 解剖学杂志2021，44，S01： | 1 |
| 13 | Production of bioactive human βdefensin-3 in Escherichia coli by soluble fusion expression显示文摘 | HUANG Lei WANG Jufang ZHONG Zhixia | 2006 | Bioteehnol Lett2006，28，9： | 1 |
| 14 | Hepatocellular carcinoma derived exsomal miR-21-5p induces macrophages M2 polarization显示文摘Macrophages are an important component of innate and adaptive immunity in liver that they play important roles in maintaining homeostasis,resisting pathogen invasion and activating the immune system.However,many studies have proved that tumor associated macrophages(TAMs)promoted the malignant progression of hepatocellular carcinoma(HCC).Associated regulatory mechanisms of TAMs phenotype in tumor microenvironment(TME)are still not fully understood. | Yu Haiyang Cai Deyang Pan Jing Huang Jufang | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 15 | A chemotherapy-driven increase in Mcl-1 mediates the effect of miR-375 on cisplatin resistance in osteosarcoma cells显示文摘Osteosarcoma(OS)is one of the most difficult cancers to treat due to its resistance to chemotherapy.The essential role played by Mel-l in promoting chemoresistance has been observed in a variety of cancers,including OS,while the underlying mechanism remains unclear.We investigated the expression of Mcl-1 in 42 paired OS specimens obtained before and after adjuvant chemotherapy,and its correlation with clinicopathological characteristics.Loss and gain of function studies were performed to analyze the effects of Mcl-1 modulations on the chemosensitivity,and the mechanism involved in the deregulation of Mcl-1 in OS cells. | Liu Ansong Yu Haiyang Huang Jufang | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 16 | The inhibitory effects of STAT3 phosphorylation on mitochondrial function of osteoblasts显示文摘Osteoporosis(OP)is a metabolic bone disease characterized by decreased bone mass,reduced bone density,and destruction of bone microstructures,which resulting in an increased brittleness and susceptibility to fractures.The incidence of osteoporosis is associated with aging and some genetical and physiology abnormalities.With the accelerated growth of aged population in China,a large group of population has reduced bone density.The mid-aged and senior people are highly susceptible to osteoporosis.While some young people who have irregular dietary schedule and unhealthy life style might cause increased rate of osteoporosis.Signal transducers and activators of transcription 3(STAT3)is a transcription factor ubiquitously expressed in somatic and stem cells such as tumor cells,mesenchymal stem cells,osteoblasts,osteoclasts and osteocytes.STAT3 is involved in the regulation of cell proliferation differentiation,apoptosis,and other physiological functions.The results of relevant animal experiments and clinical trials showed that abnormal expression of STAT3 would affect normal bone development. | Mi Tuoyang Zhou Hongkang Huang Jufang | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 17 | TrkB and p-trkB expression in brain-derived neurotrophic factor-pretreated rat retina following acute high intraocular pressure显示文摘BACKGROUND: Exogenous brain-derived neurotrophic factor (BDNF) promotes retinal ganglion cell survival. However, the protective mechanisms remain unclear. OBJECTIVE: To investigate changes in retinal tyrosine kinase receptor B (trkB) expression and effects of exogenous BDNF on trkB activation in a rat model of acute high intraocular pressure (HIOP). DESIGN, TIME AND SETTING: A randomized, controlled, animal experiment was performed at the Department of Anatomy and Neurobiology, Xiangya Medical School, Central South University from January 2004 to August 2006. MATERIALS: Rabbit anti-BDNF and anti-trkB.FL(full-length) polyclonal antibodies were purchased from Santa Cruz Biotechnology, USA; rabbit anti-p-trkB polyclonal antibodies were purchased from Cellsignal, USA. METHODS: A total of 48 healthy, adult, Sprague Dawley rats were randomly assigned to acute HIOP (without BDNF pre-treatment) and BDNF pre-treated groups, with 24 animals in each group. In the BDNF pre-treated group, the left eyes were intravitreally injected with 3 μg/kg BDNF 2 days prior to HIOP. Rats in the acute HIOP group were not pre-treated with BDNF. HIOP models were established by increased intraocular pressure in the left eyes until the b-wave of flash electroretinogragh disappeared and pressure was maintained for 60 minutes. The right eyes of all rats were not treated and served as the normal controls. MAIN OUTCOME MEASURES: Retinal structure and cell numbers in the ganglion cell layer (GCL) were detected by Nissl staining; expression of trkB and phosphorylated trkB in the rat retina were determined by immunohistochemistry. RESULTS: A greater number of GCL neurons were observed in the pre-treated group compared to the acute HIOP group (P < 0.05). TrkB expression was significantly increased following HIOP at days 1 and 3 (P < 0.05), but expression varied between retinal areas. Although trkB expression decreased at 7 days, phosphorylated trkB dramatically decreased with increasing time (P < 0.05). TrkB expression in BDNF pre-treated rats was similar to the acute HIOP group at early injury time points. Nevertheless, trkB expression was significantly decreased compared to the acute HIOP group at 7 days (P < 0.05), and phosphorylated trkB expression was significantly greater compared to the acute HIOP group at each time point (P < 0.05). CONCLUSION: TrkB expression displayed temporal and spatial changes in the rat retina following acute HIOP, and trkB up-regulation suggested that more BDNF was required for treating the injured retina. Exogenous BDNF partially ameliorated decreased expression of phosphorylated trkB and provided protection to the injured retina, to a certain degree, following HIOP. | Lizhu Jiang Jufang Huang Hui Wang Dan Chen Hongnian Zhao | 2010 | Neural Regeneration Research2010，5，12： | 0 |
| 18 | Establishment of eye tumor biobank to provide resources for exploring new biomarkers of various ocular tumors显示文摘In addition to the lens,tumors can oceur in almost all tissues of the eye.Lacking of effective biomarkers makes diagnosis of ocular tumors difficult.Biobanks are important resources for biomarker discovery and assay development.To support the validation of novel biomarkers and assays,we established a biobank to collect body fluids and tissue and associate data from subjects with ocular tumor diseases.A standard operating procedure of collection,transportation,processing and preservation of human samples according to the experience of biobanks domestic and foreign have been established.Associated data had been collected and statistical analysis of the existing data had been performed.Cooperation between the eye tumor biobank and the Department of Ophthalmology,Xiangya Hospital,Central South University has been established,and various samples can be obtained.Currently,708 samples are available from 78 subjects with 11 types of benign tumors and 12 types of malignant tumors,including hemangioma,schwannoma,retinoblastoma,lymphoma,basal cell carcinoma,melanoma,sarcomas,ect. | Gao Zhaolin Zhou Ziyu Zhang Yun Zhou Mushi Yu Haiyang Tan Jia Huang Jufang | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 19 | Effects of diethyldithiocarbamate on myelin basic protein expression in the rat lateral olfactory tract显示文摘BACKGROUND:Dithiocarbamates can cause demyelination of axons in the peripheral nervous system.Its derivate,diethyldithiocarbamate,is cytotoxic,and causes olfactory mucosal damage and atrophy of the olfactory bulb.However,it is still unclear whether the myelin sheath of the lateral olfactory tract is affected by diethyldithiocarbamate. OBJECTIVE:To investigate the effects of diethyldithiocarbamate on the myelin sheath of the rat lateral olfactory tract.This was done by examining changes in myelin basic protein expression after diethyldithiocarbamate treatment. DESIGN,TIME AND SETTING:A randomized,controlled,animal study was performed at the Laboratory of the Department of Human Anatomy and Neurobiology,Xiangya School of Medicine, Central South University,China from July to November 2007. MATERIALS:A total of 72 Sprague Dawley rats were randomly assigned into a diethyldithiocarbamate group(n = 32),a solvent control group(n = 32),and a blank control group (n = 8).The diethyldithiocarbamate and solvent control groups were separately divided into 3-d, 7-d,14-d and 28-d survival subgroups,with eight rats in each.Diethyldithiocarbamate(Sigma, USA) and goat anti-myelin basic protein polyclonal antibody(Santa Cruz,USA) were used in this study. METHODS:Rats in the diethyldithiocarbamate and solvent control groups were subcutaneously injected with diethyldithiocarbamate(600 mg/kg) and 0.01 mol/L phosphate buffered saline (600 mg/kg) at the posterior neck,respectively.Rats in the blank control group received no treatment. MAIN OUTCOME MEASURES:Immunohistochemical staining and Western blot assay were used to measure myelin basic protein expression in the rat lateral olfactory tract. RESULTS:Following immunohistochemical staining,myelin basic protein was uniformly distributed in the rat lateral olfactory tract in the blank control and solvent control groups.Western blot assay showed 21.5,18,17 and 14 ku positive bands.No significant difference was found in myelin basic protein distribution and blot pattern,in the rat lateral olfactory tract,in the diethyldithiocarbamate group,following immunohistochemical staining and Western blot assay. Myelin basic protein expression gradually decreased at day 3,reached the lowest level at day 7, and gradually increased again at days 14 and 28. CONCLUSION:Demyelination is induced by diethyldithiocarbamate in the rat lateral olfactory tract in an early stage,followed by remyelination at later stages. | Kun Xiong He Huang Hui Wang Yan Cai Jing Yang Jufang Huang Xuegang Luo | 2009 | Neural Regeneration Research2009，4，4： | 0 |
| 20 | Measurements of Relative Ionizations for Ar Ion Beams显示文摘MeasurementsofRelativeIonizationsforArIonBeams￥LiQiang;WeiZengquan;DangBingrong;ZhangShumin;LiWenjian;XieHongmei;HanGuangwu;Z... | Li Qiang Wei Zengquan Dang Bingrong Zhang Shumin Li Wenjian Xie Hongmei Han Guangwu Zhou Guangming Chen Weiqiang Huang Tao and Wang Jufang | 1996 | IMP & HIRFL Annual Report1996，，1： | 0 |
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