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| 1 | NOD2: Ethnic and geographic differences显示文摘进在与危险性联系到 Crohn 的疾病的 NOD2 的三风险等位基因 R702W, G908R 和 1007fsInsC 的继承的调查例如越过种族和人口表明了异质的显著数量,与越过欧洲的地区性的变化,建议本地创始人效果。在非白种人人口, Crohn 的疾病继续在发生增加,但是这增加看起来不是在 NOD2 的变化的后果,进一步为另外的危险性部位推进积累的证据。已知的等位基因的频率处于健康和疾病越过人口被比较,为在 NOD2 的另外的等位基因的证据被考察。在染色体 16 上基于它的位置与一些另外的自体免疫的疾病危险性本地化重合,研究作为另外的自体免疫的混乱的潜在的原因指向了 NOD2 变化。当这些调查主要归还了否定调查结果,二疾病对主人疾病时,被显示了被风险等位基因在 NOD2 引起。这在复杂疾病调查是经常的,一些结果等候 NOD2 和差别的确认,而是鉴定在以内并且越过人口加薪关于在这个地点的变化的人口遗传的吸引人的问题。 | Juleen Cavanaugh | 2006 | World Journal of Gastroenterology2006，12，23： | 4 |
| 2 | Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle显示文摘 | Carles Cantó Lake Q. Jiang Atul S. Deshmukh Chikage Mataki Agnes Coste Marie Lagouge Juleen R. Zierath Johan Auwerx | 2010 | Cell Metabolism2010，，3： | 2 |
| 3 | Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitus显示文摘 | Sameer S. Kulkarni Firoozeh Salehzadeh Tomas Fritz Juleen R. Zierath Anna Krook Megan E. Osler | 2012 | Metabolism2012，，2： | 1 |
| 4 | Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression显示文摘 | Leandro Z. Agudelo Teresa Femenía Funda Orhan Margareta Porsmyr-Palmertz Michel Goiny Vicente Martinez-Redondo Jorge C. Correia Manizheh Izadi Maria Bhat Ina Schuppe-Koistinen Amanda T. Pettersson Duarte M.S. Ferreira Anna Krook Romain Barres Juleen R. Zi | 2014 | Cell2014，，1： | 1 |
| 5 | Sending the Signal: Molecular Mechanisms Regulating Glucose Uptake显示文摘 | ANNA KROOK HARRIET WALLBERG-HENRIKSSON JULEEN R. ZIERATH | 2004 | Medicine & Science in Sports & Exercise2004，，7： | 1 |
| 6 | AMP-activated protein kinase signalingin metabolic regulation显示文摘 | YUN CHAU LONG JULEEN R ZIERATH | 2006 | J Clin Invest2006，116，7： | 1 |
| 7 | Downregulation of Diacylglycerol Kinase Delta Contributes to Hyperglycemia-Induced Insulin Resistance显示文摘 | Alexander V. Chibalin Ying Leng Elaine Vieira Anna Krook Marie Bj?rnholm Yun Chau Long Olga Kotova Zhihui Zhong Fumio Sakane Tatiana Steiler Carolina Nylén Jianjun Wang Markku Laakso Matthew K. Topham Marc Gilbert Harriet Wallberg-Henriksson Juleen R. Zie | 2008 | Cell2008，，3： | 1 |
| 8 | AMP-activated protein kinase signaling in metabolic regulation显示文摘 | Yun Chau Long Juleen R Zierath | 2006 | The Journal of Clinical Investigation2006，116，7： | 1 |
| 9 | Hypoallergenic formula with Lactobacillus rhamnosus GGfor babies with colic:A pilot study of recruitment,retention,and fecal biomarkers显示文摘AIM To investigate recruitment, retention, and estimatesfor effects of formula supplementation withLactobacillus rhamnosus GG (LGG) on inflammatorybiomarkers and fecal microbial community in infants withcolic.METHODS: A prospective, double-blind, placebocontrolledtrial was conducted in otherwise healthyinfants with colic. We screened 74 infants and randomizedand analyzed results in 20 infants [9 receivingLGG (LGG+) and 11 not receiving LGG (LGG-)]. LGG wasincorporated in the formula (Nutramigen?) (minimum of3 × 10^7 CFU/d) in the LGG+ group. Fecal microbiota andinflammatory biomarkers, including fecal calprotectin(FC), plasma cytokines, circulating regulatory T cells(Tregs), and crying + fussing time were analyzed todetermine optimal time points and effect sizes for alarger trial.RESULTS: Recruitment in this population was slow, withabout 66% of eligible infants willing to enroll; subjectretention was better (75%). These rates were influencedby parents' reluctance to volunteer their infant for aclinical trial and by their tendency to change formulas.The maximal difference of crying + fussing time wasobserved at day 14, comparing the 2 groups, with amean difference of -91 (95%CI: -76, 259) min (P = NS).FC showed no significant difference, but the optimaltime to determine a potential effect was at day 90 [witha mean difference of 121 (95%CI: -48, 291) μg/g stool],observing a lower level of FC in the LGG+ group. Thefecal microbial communities were chaotic, as determinedby Shannon's diversity index and not apparently influencedby the probiotic. No significant change wasobserved in plasma inflammatory cytokines or Tregs,comparing LGG+ to LGG- groups.CONCLUSION: Designing future colic trials involving aprobiotic-supplemented formula for infants in the UnitedStates will require consideration for difficult enrollment.Infants with colic have major variations in feal microbiotaand calprotectin, both of which improve with time, withoptimal time points for measurement at days 14 and 90after treatment. | Nicole Y Fatheree Yuying Liu Michael Ferris Melissa Van Arsdall Valarie McMurtry Marcela Zozaya Chunyan Cai Mohammad H Rahbar Manouchehr Hessabi Ta Vu Christine Wong Juleen Min Dat Q Tran Fernando Navarro Wallace Gleason Sara Gonzalez J Marc Rhoads | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 1 |
| 10 | Methotrexate Promotes Glucose Uptake and Lipid Oxidation in Skeletal Muscle via AMPK Activation显示文摘 | Pirkmajer Sergej Kulkarni Sameer S Tom Robby Z Ross Fiona A Hawley Simon A Grahame-Hardie D Zierath Juleen R Chibalin Alexander V | 2015 | Diabetes2015，，： | 1 |
| 11 | 2011, Multiple reassortment between pandemic (H1N1) 2009 and endemic influenza viruses in pigs, U- nited States显示文摘 | Ducatez M F Hause B Stigger-Rosser E Darnell D Corzo C Juleen K Simonson R Brockwell-Staats C Rubrum A Wang D Webb A Crumpton J C Lowe J Gramer M Webby R J | 2011 | Emerging Infectious Diseases2011，17，9： | 1 |
| 12 | Insulin action in skeletal muscle from patients with NIDDM显示文摘 | Juleen R. Zierath Anna Krook Harriet Wallberg-Henriksson | 1998 | Molecular and Cellular Biochemistry (-)1998，，1： | 1 |
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