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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | The impact of household consumption patterns on emissions in Spain显示文摘 | Rosa D Alfredo M Julio S | 2010 | Energy Economics2010，32，1： | 1 |
| 3 | Mechanisms of karyotype differentiation in Cassidinae sensu lato (Coleoptera, Polyphaga, Chrysomelidae) based on seven species of the Brazilian fauna and an overview of the cytogenetic data显示文摘 | JULIO M D FEMANDES F R COSTA C | 2010 | Micron2010，41，1： | 1 |
| 4 | DNAadenine methylase is essential for viability and plays a role in the pathognesis of Yersinia Pseudotuberculosis and Vibrio Cholerae显示文摘 | Julio S M Heithoff D M Provenzano D | 2001 | Infect Immun2001，69，12： | 1 |
| 5 | A luminal epithelial stem cell that is a cell of origin for prostatecancer显示文摘 | WANG X KRUITHOF-DE JULIO M ECONOMIDES K D | 2009 | Nature2009，461，7263： | 1 |
| 6 | A state-of-the-art review on shear-friction 显示文摘 | SANTOS P M D JULIO E N B S | 2012 | Engineering Structures2012，45，： | 1 |
| 7 | DNA adenine methylase is essential for viability and plays role in the pathogenesis of Yersinia Pseudotuberculosis and Vibrio cholerae显示文摘 | Heithoff D M Provenzano D Klose K E Sinsheimer R L Low D A Mahan M J | 2001 | Infect Immun2001，69，12： | 1 |
| 8 | Static shear correction factor for laminated rectangular beams显示文摘 | Prabhu M R Julio F D | 1996 | Composites: Part B1996，27，： | 1 |
| 9 | MERRA: NASA’s Modern-Era Retrospective Analysis for Research and Applications显示文摘 | Rienecker Michele M Suarez Max J Gelaro Ronald Todling Ricardo Bacmeister Julio Liu Emily Bosilovich Michael G Schubert Siegfried D Takacs Lawrence Kim Gi-Kong Bloom Stephen Chen Junye Collins Douglas Conaty Austin Da Silva Arlindo Gu Wei | 2011 | Journal of Climate2011，，14： | 1 |
| 10 | Sulfur fertilization improves nitrogen use efficiency in wheat by increasing nitrogen uptake 显示文摘 | Salvagiotti F Julio M Miralles D J Pedrol H M | 2009 | Field Crops Research2009，113，2： | 1 |
| 11 | 显示文摘 | Henry D Tran Ian Norris Julio M D'Arcy | 2008 | Macromolecules2008，41，： | 1 |
| 12 | Feeding strategies for the rearing of creole kid goats显示文摘 | Raul Meneses R Patricio Perez M Julio Pittet D | 2001 | Chilean journal of agricultural research2001，6，2： | 1 |
| 13 | A subnanogram assay for phospholipase activity based on a long-chain radioiodinatable phosphatidylcholine显示文摘 | JULIO J C JOSM D | 2004 | Analytical Biochemistry2004，333，2： | 1 |
| 14 | The use of continuous insulin delivery systems in severely insulin-resistant patients 显示文摘 | Julio W Muriel M Isaiah D | 2001 | Diabetes Care2001，24，7： | 1 |
| 15 | Comparison of three different methods for trehalose determination in yeast extracts显示文摘 | Julio C Ferreira V M F P Anita D Panek | 1996 | Food Chemistry1996，60，2： | 1 |
| 16 | Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison显示文摘 | Julio A Chalela Chelsea S Kidwell Lauren M Nentwich Marie Luby John A Butman Andrew M Demchuk Michael D Hill Nicholas Patronas Lawrence Latour Steven Warach | 2007 | The Lancet2007，，9558： | 1 |
| 17 | Factors affecting bond between new and old concrete 显示文摘 | Santos P M D Julio E N B S | 2011 | ACI Material Journal2011，108，4： | 1 |
| 18 | Image processing techniques in a preliminary morphometric characterization of corneal epithelium by scanning electron microscopy显示文摘 | Julio G Merindano D Canals M | 2010 | Microsc Res Tech2010，73，11： | 1 |
| 19 | Expression of renal aquapofins 1,2and3 in a rat model of cisplatin-induced polyuria 显示文摘 | ishore B K Krane C M Di Julio D | 2000 | Kidney Int2000，58，： | 1 |
| 20 | Substituted polyaniline nanofibers produced via rapid initiated polymerization显示文摘 | HENRY D T IAN N JULIO M D | | 0，，20： | 1 |
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