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| 1 | A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer显示文摘The immune checkpoint blockade therapy has profoundly revolutionized the field of cancer immunotherapy. However, despite great promise for a variety of cancers, the efficacy of immune checkpoint inhibitors is still low in colorectal cancer(CRC). This is mainly due to the immunosuppressive feature of the tumor microenvironment(TME). Emerging evidence reveals that certain chemotherapeutic drugs induce immunogenic cell death(ICD), demonstrating great potential for remodeling the immunosuppressive TME. In this study, the potential of ginsenoside Rg3(Rg3) as an ICD inducer against CRC cells was confirmed using in vitro and in vivo experimental approaches. The ICD efficacy of Rg3 could be significantly enhanced by quercetin(QTN) that elicited reactive oxygen species(ROS). To amelioratein vivo delivery barriers associated with chemotherapeutic drugs, a folate(FA)-targeted polyethylene glycol(PEG)-modified amphiphilic cyclodextrin nanoparticle(NP) was developed for co-encapsulation of Rg3 and QTN. The resultant nanoformulation(CD-PEG-FA.Rg3.QTN) significantly prolonged blood circulation and enhanced tumor targeting in an orthotopic CRC mouse model, resulting in the conversion of immunosuppressive TME. Furthermore, the CD-PEG-FA.Rg3.QTN achieved significantly longer survival of animals in combination with Anti-PD-L1. The study provides a promising strategy for the treatment of CRC. | Dandan Sun Yifang Zou Liu Song Shulan Han Hao Yang Di Chu Yun Dai Jie Ma Caitriona M.O’Driscoll Zhuo Yu Jianfeng Guo | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 8 |
| 2 | A two-stage blade-packing rotating packed bed for intensification of continuous distillation显示文摘A two-stage blade-packing rotating packed bed(TSBP-RPB) was designed and developed for the intensification of continuous distillation. The mass transfer parameters of the TSBP-RPB were investigated using a chemisorption system. Continuous distillation experiments were conducted in the TSBP-RPB by the methanol–water binary system. Experimental results showed that values of the effective interfacial area and liquid-side mass transfer coefficient of the TSBP-RPB were 93–337 m^2·m^(-3) and 0.05–0.19 cm·s^(-1), respectively. The height of equivalent theoretical plate(HETP) of the TSBP-RPB ranged from 1.9 to 10 cm. Moreover, the TSBP-RPB is easy to be manufactured, which shows great potential for the application of continuous distillation. | Yong Luo Guangwen Chu Le Sang Haikui Zou Yang Xiang Jianfeng Chen | 2016 | Chinese Journal of Chemical Engineering2016，24，1： | 6 |
| 3 | Preparation of polypyrrole/TiO2 nanocomposites with enhanced photocatalytic performance显示文摘 | Fei Gao, Xianhui Hou Aolan Wang Guangwen Chu Wei Wu Jianfeng Chen Haikui Zou | 2016 | Particuology2016，14，3： | 4 |
| 4 | Safety of endovascular therapy for symptomatic intracranial artery stenosis:a national prospective registry显示文摘Introduction The safety outcomes of endovascular therapy for intracranial artery stenosis in a real-world stetting are largely unknown.The Clinical Registration Trial of Intracranial Stenting for Patients with Symptomatic Intracranial Artery Stenosis(CRTICAS)was a prospective,multicentre,real-world registry designed to assess these outcomes and the impact of centre experience.Methods 1140 severe,symptomatic intracranial arterial stenosis(ICAS)patients treated with endovascular therapy were included from 26 centres,further divided into three groups according to the annual centre volume of intracranial angioplasty and stent placement procedures over 2 years:(1)high volume for≥25 cases/year;(2)moderate volume for 10–25 cases/year and(3)low volume for<10 cases/year.Results The rate of 30-day stroke,transient ischaemic attack or death was 9.7%(111),with 5.4%,21.1%and 9.7%in high-volume,moderate-volume and low-volume centres,respectively(p<0.05).Multivariable logistic regression confirmed high-volume centres had a significantly lower primary endpoint compared with moderate-volume centres(OR=0.187,95%CI:0.056 to 0.627;p≤0.0001),while moderate-volume and low-volume centres showed no significant difference(p=0.8456).Conclusion Compared with the preceding randomised controlled trials,this real-world,prospective,multicentre registry shows a lower complication rate of endovascular treatment for symptomatic ICAS.Non-uniform utilisation in endovascular technology,institutional experience and patient selection in different volumes of centres may have an impact on overall safety of this treatment. | Yabing Wang Tao Wang Adam Andrew Dmytriw Kun Yang Liqun Jiao Huaizhang Shi Jie Lu Tianxiao Li Yujie Huang Zhenwei Zhao Wei Wu Jieqing Wan Qinjian Sun Bo Hong Yongli Li Liyong Zhang Jianfeng Chu Qiong Cheng Yiling Cai Pengfei Wang Qi Luo Hua Yang Baijing Dong Yang Zhang Jun Zhao Zuoquan Chen Wei Li Xiaoxin Bai Weiwen He Xueli Cai Maimai Ti Osama O Zaidat | 2022 | Stroke & Vascular Neurology2022，7，2： | 3 |
| 5 | Prevalence and Presentation of Lactose Intolerance and Effects on Dairy Product Intake in Healthy Subjects and Patients With Irritable Bowel Syndrome显示文摘 | Jianfeng Yang Yanyong Deng Hua Chu Yanqun Cong Jianmin Zhao Daniel Pohl Benjamin Misselwitz Michael Fried Ning Dai Mark Fox | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 2 |
| 6 | A Novel Route to Prepare Nanocomposites in Larger Scale显示文摘准备 nanocomposites 的一条新奇线路通过润滑油的 preparingoverbased 钙石油 sulfonate 被说明净化在旋转 packedbed ( RPB )代替常规反应 vessel.The 被用作反应堆的地方,结果证明 thecarbonation 效率被改进,原料消费被减少,并且 thedispersibilities ,在 overbased 的 缩放nano 的 CaCO3 粒子的尺寸和形态学净化的 areenhanced.It 相当被推出这条线路能是广泛地 | Wei WU Lailong LUO Guangwen CHU Shengjun BAI Haikui ZOU Jianfeng CHEN | 2007 | Journal of Materials Science & Technology2007，23，3： | 2 |
| 7 | An efficient three-party authentication key exchange protocol for wireless sensor networks显示文摘 | Li Hongtu Hu Liang Chu Jianfeng | 2013 | Sensor Letters2013，11，5： | 1 |
| 8 | Degradation of phenol by ozone in the presence of Fenton reagent in a rotating packed bed 显示文摘 | Zeng Zequan Zou Haikui Li Xin Arowo M Sun Baochang Chen Jianfeng Chu Guangwen Shao Lei | 2013 | Chemical Engineering Journal2013，229，： | 1 |
| 9 | Experimental investigation of nanoparticles precipitation in a rotating packed bed显示文摘Precipitation of BaSO4 nanoparticles was studied for the first time in a specially designed rotating packed bed(RPB),which allowed sampling at different radial positions to provide better insight of the mechanism of precipitation in RPB.Particle size and morphology were characterized by TEM,while the quality of synthesized BaSO4 powders was analyzed by XRD and BET,and compared with those prepared in a stirred-tank reactor.The important role of the inlet region of the RPB in the whole precipitation process was experimentally confirmed,as a significant essence for the design of industrial RPB for the precipitation of sparingly soluble materials.The effects of different operating conditions on particle size were also investigated,showing that particle size decreases with increasing rotational speed and liquid flow rate,due to the enhancement of micromixing in the RPB. | Yang Xiang Guangwen Chu Lixiong Wen Kuang Yang Guangting Xiao Jianfeng Chen | 2010 | Particuology2010，8，4： | 1 |
| 10 | Determination of the effectiveinterfacial area in rotating packed bed 显示文摘 | Yang Kuang Chu Guangwen Zou Haikui Sun Baochang Shao Lei Chen Jianfeng | 2011 | ChemicalEngineering2011，168，： | 1 |
| 11 | Liquid-solid mass transfer in a rotating packed bed reactor with structured foam packing显示文摘A rotating packed bed(RPB) reactor has substantially potential for the process intensification of heterogeneous catalytic reactions. However, the scarce knowledge of the liquid–solid mass transfer in the RPB reactor is a barrier for its design and scale-up. In this work, the liquid–solid mass transfer in a RPB reactor installed with structured foam packing was experimentally studied using copper dissolution by potassium dichromate. Effects of rotational speed, liquid and gas volumetric flow rate on the liquid–solid mass transfer coefficient(kLS) have been investigated. The correlation for predicting kLSwas proposed, and the deviation between the experimental and predicted values was within±12%. The liquid–solid volumetric mass transfer coefficient(kLSaLS) ranged from 0.04–0.14 1^-1, which was approximately 5 times larger than that in the packed bed reactor. This work lays the foundation for modeling of the RPB reactor packed with structured foam packing for heterogeneous catalytic reaction. | Yazhao Liu Zhi hao Li Guangwen Chu Lei Shao Yong Luo Jianfeng Chen | 2020 | Chinese Journal of Chemical Engineering2020，28，10： | 1 |
| 12 | High Selectivity Cascaded Quadruplet Bandpass Filter with Three Pairs of Transmission Zeros显示文摘A novel microstrip Cascaded quadruplet(CQ) bandpass filter using quarter wavelength resonators and three-quarter wavelength resonators is proposed.Based on cross coupling and source-load coupling,three pairs of finite transmission zeros are generated at the stopband.As a result,the out-of-band rejection can be enhanced and high selectivity is achieved.Based on the proposed structure,a cascaded quadruplet filter centering at 3.0GHz is designed and fabricated.Good agreement between the measured and simulated data is obtained. | CHEN Jianfeng CHEN Fuchang LI Runshuo XIE Zeming CHU Qingxin | 2017 | Chinese Journal of Electronics2017，26，5： | 0 |
| 13 | Multi-Pattern Matching Algorithm with Wildcards Based on Bit-Parallelism显示文摘Multi-pattern matching with wildcards is a problem of finding the occurrence of all patterns in a pattern set{p^1,---,p^k}in a given text t. If the percentage of wildcards in pattern set is not high,this problem can be solved using finite automata. We introduce a multi-pattern matching algorithm with a fixed number of wildcards to overcome the high percentage of the occurrence of wildcards in patterns. In our proposed method,patterns are matched as bit patterns using a sliding window approach. The window is a bit window that slides along the given text,matching against stored bit patterns. Matching process is executed using bit wise operations. The experimental results demonstrate that the percentage of wildcard occurrence does not affect the proposed algorithm's performance and the proposed algorithm is more efficient than the algorithms based on the fast Fourier transform. The proposed algorithm is simple to implement and runs efficiently in O(n+d(n/σ)(m/w))time,where n is text length,d is symbol distribution over k patterns,m is pattern length,and σ is alphabet size. | Ahmed A. F. Saif HU Liang CHU Jianfeng | 2017 | Wuhan University Journal of Natural Sciences2017，22，2： | 0 |
| 14 | Intrinsic kinetics of catalytic hydrogenation of 2-nitro-4-acetylamino anisole to 2-amino-4-acetylamino anisole over Raney nickel catalyst显示文摘The catalytic hydrogenation of 2-nitro-4-acetylamino anisole(NMA)is a less-polluting and efficient method to produce 2-amino-4-acetamino anisole(AMA).However,the kinetics of catalytic hydrogenation of NMA to AMA remains obscure.In this work,the kinetic models including power-law model and Langmuir-Hinshelwood-Hougen-Watson(LHHW)model of NMA hydrogenation to AMA catalyzed by Raney nickel catalyst were investigated.All experiments were carried out under the elimination of mass transfer resistance within the temperature range of 70–100°C and the hydrogen pressure of 0.8–1.5 MPa.The reaction was found to follow 0.52-order kinetics with respect to the NMA concentration and 1.10-order kinetics in terms of hydrogen pressure.Based on the LHHW model,the dual-site dissociation adsorption of hydrogen was analyzed to be the rate determining step.The research of intrinsic kinetics of NMA to AMA provides the guidance for the reactor design and inspires the catalyst modification. | Xiangyang Cui Xin Zhang Baoju Wang Yuqi Sun Haikui Zou Guangwen Chu Yong Luo Jianfeng Chen | 2023 | Chinese Journal of Chemical Engineering2023，64，12： | 0 |
| 15 | Synthesis of Petroleum Sulfonate Surfactant with Ultra-Low Interfacial Tension in Rotating Packed Bed Reactor显示文摘Petroleum sulfonate is one of the most important surfactants used in surfactant flooding for enhanced oil recovery, which is mainly obtained by treating high-boiling petroleum fractions in a stirred tank reactor(STR) or in a fallingfilm reactor(FFR). The synthesis of petroleum sulfonate with ultra-low interfacial tension from viscous petroleum fractions was carried out in a rotating packed bed(RPB) reactor using dilute liquid sulfur trioxide as the sulfonating agent in this study. The effects of various experimental conditions on components content and oil-water interfacial tension(IFT) were investigated. Under the optimum conditions, the active matter content could reach up to 50.3% and the IFT could be equal to 4.7×10-3 m N/m. Compared with the traditional reactor, the active matter content is by 14.12% higher in the RPB as compared to that obtained in the STR. The uneven change of the test oil droplets during the IFT measurement was also discussed. The increase of heavy components content not only can eliminate the contraction phenomenon, but also can reduce the IFT to a minimum. This can be conducive to explaining the reason for producing IFT and the preparation of proper formulations for practical application. | Weng Zhan Zhang Pengyuan Chu Guangwen Zou Haikui Jimmy Yun Chen Jianfeng | 2015 | China Petroleum Processing & Petrochemical Technology2015，17，1： | 0 |
| 16 | Shanghai Autism Early Development:An Integrative Chinese ASD Cohort显示文摘Why Was the Cohort Set Up?Autism spectrum disorder(ASD)is a child neurodevelopmental disorder,the onset of which is generally within 3 years of age,and often leads to lifelong impaired social and cognitive functions,which impose significant mental pressure and economic burdens on the family and society. | Yuan Dai Yuqi Liu Lingli Zhang Tai Ren Hui Wang Juehua Yu Xin Liu Zilin Chen Lin Deng Minyi Tao Hangyu Tan Chu‑Chung Huang Jiaying Zhang Qiang Luo Jianfeng Feng Miao Cao Fei Li | 2022 | Neuroscience Bulletin2022，38，12： | 0 |
| 17 | SiRAP2-12,a Positive Regulatory Factor,Effectively Improves the Waterlogging Tolerance of Foxtail Millet(Setaria italica)显示文摘Foxtail millet(Setaria italica)growth was inhibited because of waterlogging stress,which has caused yield reduc-tion.ERF family plays an important role to plant adversity tolerance.In our study,we obtained 19,819 differential expressed genes(DEGs)between the two treatments based on the RNA-seq sequencing of foxtail millet of water-logging stress.Furthermore,a total of 28 ERF family members were obtained,which have a complete open read-ing frame.We studied the evolution and function of SiERF family and how they affected the waterlogging tolerance.It was found that SiERF1A/B/C(GenBank ID:OR775217,OR775219,OR775218)and SiRAP2-12(GenBank ID:OR775216)have similar functions to the known waterlogging tolerance genes of other plants.Among them,the SiRAP2-12 expression was obviously significantly up-regulated in foxtail millet after 5d water-logging stress.After SiRAP2-12 was silenced,the activity of defense enzymes in millet decreased significantly.In details,superoxide dismutase(SOD),catalase(CAT)and peroxidase(POD),the osmotic regulator proline(Pro),and the activity of the anaerobic respiratory enzyme alcohol dehydrogenase(ADH)content were decreased by 78.61%,29.52%,79.95%,19.41%and 54.77%,respectively.In contrast,the relative electrical conductivity contents(REC),malondialdehyde(MDA),and hydrogen peroxide(H_(2)O_(2))of the foxtail millet subjected to virus-induced gene silencing clearly increased by 1.03-fold,36.09%,and 15.21%,respectively.The content of sodium(Na^(+))in the SiRAP2-12-silenced foxtail millet also increased,but that of potassium(K^(+))decreased.Interestingly,we found that ethylene content was significantly reduced.Further,the SiAOC1 expression,an essential gene for ethylene synthesis,was inhibited in SiRAP2-12-silenced foxtail millet after waterlogging stress.Taken together,we hypothesized that SiRAP2-12 might be a positive regulator of millet tolerance to waterlogging stress. | Xueyan Xia Xiaohong Fu Yu Zhao Jihan Cui Nuoya Xiao Jingxin Wang Yiwei Lu Meihong Huang Cheng Chu Jia Zhang Mengxin Yang Shunguo Li Jianfeng Liu | 2024 | Phyton-International Journal of Experimental Botany2024，93，3： | 0 |
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