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| 1 | Puerarin affects bone biomarkers in the serum of rats with intrauterine growth restriction显示文摘OBJECTIVE:To investigate serum bone biomarkers in rats with intrauterine growth restriction(IUGR)in order to determine the effects of puerarin on bone metabolism.METHODS:A rat model of IUGR was induced using a low protein diet during pregnancy.The offspring were given puerarin or an identical volume of saline via subcutaneous abdominal injection.All rats were studied at 1,3,and 8 weeks of age.Serum biomarkers of bone formation,including insulin-like growth factor-1(IGF-1),bone-specific alkaline phosphatase(BALP),osteocalcin(OC),osteoprotegerin(OPG),receptor-activator of nuclear factor-κB ligand(RANKL),as well as blood levels of calcium and phosphorus were measured.RESULTS:Serum BALP,OPG,IGF-1,and OC levels,as well as the OPG/RANKL ratio,were lower in the IUGR group compared with the control group at 1week of age(P=0.024,0.011,0.014,0.004,and0.002,respectively).At 3 weeks of age,the serum BALP and OC levels were higher in the protein-re-stricted group compared with the control group(P=0.003 and 0.001,respectively).A comparison between the IUGR plus puerarin intervention group and the IUGR group revealed differences in the levels of BALP and IGF-1 at 3 weeks of age(P=0.008 and 0.003,respectively).In addition,serum OPG and OC levels and the OPG/RANKL ratio were higher at 8 weeks of age(P=0.044,0.007,and0.016,respectively).No differences in serum calcium and phosphorus levels were observed among the three groups.CONCLUSION:Our study demonstrates that the bone microenvironment of the fetus can be altered by a low protein maternal diet and that puerarin can reverse these effects.These results indicate that the nutritional environment plays an important role in early skeletal development and that the bone turnover of IUGR rats can be altered by puerarin treatment. | Chen Juncao Chen Pingyang Qi Huaxue Huang Danhong | 2016 | Journal of Traditional Chinese Medicine2016，36，2： | 9 |
| 2 | Electrolyte solvation chemistry for lithium-sulfur batteries with electrolyte-lean conditions显示文摘Lithium-sulfur(Li-S)batteries possess overwhelming energy density of 2654 Wh kg-1,and are considered as the next-generation battery technology for energy demanding applications.Flooded electrolytes are ubiquitously employed in cells to ensure sufficient redox kinetics and preclude the interference of the electrolyte depletion due to side reactions with the lithium metal anode.This strategy is capable of enabling long-lasting,high-capacity and excellent-rate battery performances,but it mask the requirements of practical Li-S batteries,where high-sulfur-loading/content and lean electrolyte are prerequisite to realize the energy-dense Li-S batteries.Sparingly and highly solvating electrolytes have emerged as effective yet simple approaches to decrease the electrolyte/sulfur ratio through altering sulfur species and exerting new reaction pathways.Sparingly solvating electrolytes are characterized by few free solvents to solvate lithium polysulfides,rendering a quasi-solid sulfur conversion and decoupling the reaction mechanisms from electrolyte quantity used in cells;while highly solvating electrolytes adopt highdonicity or high-permittivity solvents and take their advantages of strong solvation ability toward polysulfide intermediates,thereby favoring the polysulfide formation and stabilizing unique radicals,which subsequently accelerate redox kinetics.Both solvation chemistry approaches have their respective features to allow the operation of cells under electrolyte-starved conditions.This Review discusses their unique features and basic physicochemical properties in the working Li-S batteries,presents remaining technical and scientific issues and provides future directions for the electrolyte chemistry to attain highenergy Li-S batteries. | Long Kong Lihong Yin Fei Xu Juncao Bian Huimin Yuan Zhouguang Lu Yusheng Zhao | 2021 | Journal of Energy Chemistry2021，30，4： | 5 |
| 3 | Estrogen influences the differentiation, maturation and function of dendritic cells in rats with experimental autoimmune encephalomyelitis显示文摘AIM: To examine if estrogen can affect the immune response at the dendritic cells (DCs) level in rats with experi- mental autoimmune encephalomyelitis (EAE). METHODS: Lewis rats were immunized with inoculum containing MBP68-86. DCs were derived from spleen monocytes of EAE rats with IL-4 and GM-CSF in presence of 17β- estradiol (E2). Nitric oxide (NO) was detected by Griess reagent. The surface markers and cytokines production of DCs were shown by flow cytometry. DCs were cocultured with MBP-specific T cells, [3H]-TdR incoportation was used to reveal the antigen presentability, the supernatant of the coculture were collected to examine the cytokines secretion by ELISA. RESULTS: E2 activated DCs by accelerating the maturation process characterized by upregulation of MHC II and costimulating molecule B7-1, B7-2, drastic high expression of CD40. IFN-γ–produc- ing DCs were also elevated without any alteration of IL-10. Estradiol-treated DCs (E2-DCs) secreted more NO in the culture supernatant. By contrast, E2-DCs showed decreased antigen presentation ability with reduced secretion of IFN-γ but no alteration of IL-10 in the coculture with T cells. CONCLUSION: Estrogen can affect the differentiation, maturation and function of DCs from EAE rats, which may be attributed to its protection against EAE and the remission of multiple sclerosis patients in pregnancy. | Qing-hongZHANG Yu-zhenHU JunCAO Yan-qingZHONG Yu-fengZHAO Qi-bingMEI | 2004 | Acta Pharmacologica Sinica2004，25，4： | 3 |
| 4 | Effect of complex amino acid imbalance on growth of tumor in tumor-bearing rats显示文摘AIM: To investigate the effect of complex amino acid imbalance on the growth of tumor in tumor-bearing (TB) rats.METHODS: Sprague-Dawlley (SD) rats underwent jejunostomy for nutritional support. A suspension of Walker256 carcinosarcoma cells was subcutaneously inoculated.TB rats were randomly divided into groups A, B, C and D according to the formula of amino acids in enteral nutritional solutions, respectively. TB rats received jejunal feedings supplemented with balanced amino acids (group A),methionine-depleted amino acids (group B), valine-depleted amino acids (group C) and methionine- and valine-depleted complex amino acid imbalance (group D) for 10 days. Tumor volume, inhibitory rates of tumor, cell cycle and life span of TB rats were investigated.RESULTS: The G0/G1 ratio of tumor cells in group D (80.5±9.0) % was higher than that in groups A, B and C which was 67.0±5.1 %, 78.9±8.5 %, 69.2±6.2 %, respectively (P<0.05). The ratio of S/G2M and PI in group D were lower than those in groups A, B and C. The inhibitory rate of tumor in groups B, C and D was 37.2 %, 33.3 % and 43.9 %,respectively (P<0.05). The life span of TB rats in group D was significantly longer than that in groups B, C, and A.CONCLUSION: Methionine/valine-depleted amino acid imbalance can inhibit tumor growth. Complex amino acids of methionine and valine depleted imbalance have stronger inhibitory effects on tumor growth. | Yin-ChengHe Yuan-HongWang JunCao Ji-WeiChen Ding-YuPan Ya-KuiZhou | 2003 | World Journal of Gastroenterology2003，9，12： | 3 |
| 5 | DFT study on adduct reaction paths of GaN MOCVD growth显示文摘The adduct reaction paths for GaN growth by metal organic chemical vapor deposition (MOCVD) were studied by quantum chemical calculations employing density functional theory (DFT). Five possible adduct reaction paths with or without the ex-cess NH3were proposed and the corresponding potential energy surfaces were calculated. From the calculation results, it is concluded that after the formation of DMGNH2from TMG:NH3, the further decomposition paths have very slim probability because of the high energy barriers; whereas the oligomerization pathway to form oligomers [DMGNH2]x(x=2, 3) is probable,because of zero energy barrier. Since the oligomers tend to further polymerize, the nanoparticles are easily formed through this path. When NH3is in excess, TMG:NH3 tends to combine with the second NH3to form two new complexes: the coordination-bonded compound H3N:TMG:NH3and the hydrogen-bonded compound TMG:NH3 NH3. The formation of hydrogen-bonded compound TMG:NH3 NH3 will be more probable because of the lower energy than H3N:TMG:NH3. By comparing the potential energy surfaces in five adduct reaction paths, we postulate that, under the growth conditions of GaN MOCVD, the formation of hydrogen-bonded compound TMG:NH3 NH3 followed by the reversible decomposition may be the main reaction path for GaN thin film growth; while the adduct oligomerization path to generate oligomers [DMGNH2]2 and [DMGNH2]3might be the main reaction path for nanoparticles formation. | SHI JunCao ZUO Ran MENG SuCi | 2013 | Science China(Technological Sciences)2013，56，7： | 3 |
| 6 | Relationship between nuclear morphometry,DNA content and resectability of pancreatic cancer显示文摘AIM: To investigate the association of nuclear morphometry and DNA content with resectability of pancreatic cancer.METHODS: A total of 36 patients with pancreatic adenocarcinoma were divided into resectable group and unresectable group. The nuclear morphometry and DNA contents of tumor cells were analyzed by IBAS autoimagine analyzer from paraffin-embedded materials. Localization size,histological type and grade, and clinical stage of the tumor were evaluated. Factors influencing resectability of pancreatic cancer were investigated using stepwise regression analysis.RESULTS: Statistical significance was found in nuclear DNA content (integrated optical density, IOD) of tumor cells (1.64±0.41 vs 2.96±0.55), DNA ploidy, ages (46.5±5.3 years vs 58.6±0.7 years) and tumor volumes (298.1±101.5 cm3 vs 634.7±512.5 cm3) in both groups (P<0.05), and no difference was found in the nuclear morphometry (P>0.05). The rates of diploid/tetraploid and aneuploid were 66.7 % and 33.3% in resectable group respectively, and 38.9 % and 62.1%in unresectable group, respectively (P<0.05). IOD (X12), ploidy status (X13) and clinical stage (X3) were radical resectable indicators with statistical significance. The regression equation for resectability was Y=-9.2053+3.5428X12+2.5390X13-2.3001X3(RR=0.8780, P<0.01).CONCLUSION: There is a high correlation between resectability of pancreatic cancers and their DNA contents,DNA ploidy status and clinical stage. | Yin-ChengHe WeiPeng Jian-GuoQiao JunCao Ji-WeiChen | 2003 | World Journal of Gastroenterology2003，9，8： | 1 |
| 7 | Effects of sodium butyrate on the differentiation of pancreatic and hepatic progenitor cells from mouse embryonic stem cells显示文摘 | MengRen LiYan Chang‐ZhenShang JunCao Li‐HongLu JunMin HuaCheng | 2009 | J Cell Biochem2009，，1： | 1 |
| 8 | Elucidating the suppression of lithium dendrite growth with a void-reduced anti-perovskite solid-state electrolyte pellet for stable lithium metal anodes显示文摘Solid-state lithium-metal batteries,with their high theoretical energy density and safety,are highly promising as a next-generation battery contender.Among the alternatives proposed as solid-state electrolyte,lithium-rich anti-perovskite(Li RAP)materials have drawn the most interest because of high theoretical Li^(+)conductivity,low cost and easy processing.Although solid-state electrolytes are believed to have the potential to physically inhibit the lithium dendrite growth,lithium-metal batteries still suffer from the lithium dendrite growth and thereafter the short circuiting.The voids in practical Li RAP pellets are considered as the root cause.Herein,we show that reducing the voids can effectively suppress the lithium dendrite growth.The voids in the pellet resulted in an irregular Li^(+)flux distribution and a poor interfacial contact with lithium metal anode;and hence the ununiform lithium dendrites.Consequently,the lithium-metal symmetric cell with void-reduced Li_(2)OHCl-HT pellet was able to display excellent cycling performance(750 h at 0.4 m A cm^(-2))and stability at high current density(0.8 m A cm^(-2)for 120 h).This study provides not only experimental evidence for the impact of the voids in Li RAP pellets on the lithium dendrite growth,but also a rational pellet fabrication approach to suppress the lithium dendrite growth. | Yu YeXinyan Ye Haoxian Zhu Juncao Bian Haibin Lin Jinlong Zhu Yusheng Zhao | 2023 | Journal of Energy Chemistry2023，，2： | 0 |
| 9 | Effects of fluorination on crystal structure and electrochemical performance of antiperovskite solid electrolytes显示文摘The development of all-solid-state lithium batteries(ASSLBs)depends on exploiting solid-state electrolytes(SSEs)with high ionic conductivity and electrochemical stability.Fluorination is generally considered to be an effective strategy to improve the ionic conductivity and electrochemical stability of inorganic SSEs.Here,we report the partial fluorination of the chlo rine sites in an antiperovskite,by which the orthorhombic Li_(2)OHCl was transformed into cubic Li_(2)OHCl_(0.9)F_(0.1),resulting in a fourfold increase in ionic conductivity at 30℃.The ab initio molecular dynamics simulations suggest that both the crystal symmetry and the anions electronegativity influence the diffusion of Li+in the antiperovskite structure.Besides,from the perspective of experiments and calculations,it is confirmed that fluorination is a feasible method to improve the electrochemical stability of antiperovskite SSEs.The LiFePO_(4)|Li cell based on Li_(2)OHCl_(0.9)F_(0.1) is also assembled and exhibits stable cycle performance,which indicates that fluorination of antiperovskite SSEs is an effective way to produce high-performance SSEs for practical application of ASSLBs. | Lei Gao Manrong Song Ruo Zhao Songbai Han Jinlong Zhu Wei Xia Juncao Bian Liping Wang Song Gao Yonggang Wang Ruqiang Zou Yusheng Zhao | 2023 | Journal of Energy Chemistry2023，，2： | 0 |
| 10 | Finite Element Analysis of Modeling Residual Stress Distribution in All-position Duplex Stainless Steel Welded Pipe显示文摘On the basis of the thermal-elastic-plastic theory, a three-dimensional finite element numerical simulation is performed on the girth welded residual stresses of the duplex stainless steel pipe with ANSYS nonlinear finite element program for the first time. Three-dimensional FEM using mobile heat source for analysis transient temperature field and welding stress field in circumferential joint of pipes is founded. Distributions of axial and hoop residual stresses of the joint are investigated. The axial and the hoop residual stresses at the weld and weld vicinity on inner surface of pipes are tensile, and they are gradually transferred into compressive with the increase of the departure from the weld. The axial residual stresses at the weld and weld vicinity on outer surface of pipes is compressive while the hoop one is tensile. The distributions of residual stresses compared positive-circle with negative-circle show distinct symmetry. These results provide theoretical knowledge for the optimization of process and the control of welding residual stresses. | XiaojunJIN LixingHUO YufengZHANG BingrenBAI XiaoweiLI JunCAO | 2004 | Journal of Materials Science & Technology2004，20，4： | 0 |
| 11 | A fiber-reinforced solid polymer electrolyte by in situ polymerization for stable lithium metal batteries显示文摘Solid polymer electrolytes(SPEs)by in situ polymerization are attractive due to their good interfacial contact with electrodes.Previously reported in situ polymerized SPEs,however,suffer from the low polymerization degree that causes poor mechanical strength,Li dendrite penetration,and performance decay in Li-metal batteries.Although highly polymerized SPEs are more stable than lowly polymerized ones,they are restricted by their sluggish long-chain mobility and poor ionic conductivity.In this work,a three-dimensional fibrous membrane with ion selectivity was prepared and used as a functional filler for the in situ formed SPE.The obtained SPE has high stability due to its high polymerization degree after the long-term heating process.The fibrous membrane plays a vital role in improving the SPE’s properties.The rich anion-adsorption sites on the fibrous membrane can alleviate the polarization effect and benefit a uniform current distribution at the interface.The fibrous nanostructure can efficiently interact with the polymeric matrix,providing rich hopping sites for fast Li+migration.Consequently,the obtained SPE enables a uniform Li deposition and long-term cycling performance in Li-metal batteries.This work reported an in situ formed SPE with both high polymerization degree and ionic conductivity,paving the way for designing high-performance SPEs with good comprehensive properties. | Yifan Xu Ruo Zhao Lei Gao Tingsong Gao Wenjuan Wang Juncao Bian Songbai Han Jinlong Zhu Qiang Xu Yusheng Zhao | 2023 | Nano Research2023，16，7： | 0 |
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