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| 1 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping Zhu Zhi-Nan Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 2 | Sonochemical effect of a bifrequency irradiation显示文摘The sonochemical effect of a bifrequency orthogonal ultrasonic irradiation has been studied by using two different detecting methods. It has been shown that the sonochemical yield produced by the bifrequency irradiation appears to be much more than the sum of the yields produced separately by the two irradiations. The bifrequency irradiation, therefore, can be expected to exert a great influence on the development of sonohemical | ZHU Changping, FENG Ruo & ZHAO Yiyun Department of Physics. Jingzhou Normal College, Jingzhou 434100, China State Key Laboratory of Modern Acoustics, Nanjing University, Nanjing 210093, China Chemistry Department of Yunnan University, Kunming 650091, Ch | 2000 | Chinese Science Bulletin2000，45，2： | 7 |
| 3 | Albuterol in the treatment of acute respiratory distress syndrome: A meta-analysis of randomized controlled trials显示文摘BACKGROUND: This meta-analysis of randomized controlled trials aimed to systematically evaluate the value of albuterol in the treatment of patients with acute respiratory distress syndrome(ARDS).DATA SOURCES: Randomized controlled trials on albuterol treatment of ARDS from its inception to October 2014 were searched systematically. The databases searched included: Pub Med, Ovid EMBASE, Ovid Cochrane, CNKI, WANFANG and VIP. The trials were screened according to the pre-designed inclusion and exclusion criteria. We performed a systematic review and meta-analysis of the randomized controlled trials(RCTs) on albuterol treatment, attempting to improve outcomes, i.e. lowering the 28-day mortality and ventilator-free days.RESULTS: Three RCTs involving 646 patients met the inclusion criteria. There was no significant decrease in the 28-day mortality(risk difference=0.09; P=0.07, P for heterogeneity=0.22, I2=33%). The ventilator-free days and organ failure-free days were significantly lower in the patients who received albuterol(mean difference=–2.20; P<0.001, P for heterogeneity=0.49, I2=0% and mean difference=–1.71, P<0.001, P for heterogeneity=0.60, I2=0%).CONCLUSIONS: Current evidences indicate that treatment with albuterol in the early course of ARDS was not effective in increasing the survival, but significantly decreasing the ventilator-free days and organ failure-free days. Owing to the limited number of included trails, strong recommendations cannot be made. | Ruo Wu Shi-yun Lin Hui-min Zhao | 2015 | World Journal of Emergency Medicine2015，6，3： | 6 |
| 4 | Diverse coagulopathies in a rabbit model with different abdominal injuries显示文摘BACKGROUND: Although coagulopathy can be very common in severe traumatic shock patients, the exact incidence and mechanism remain unclear. In this study, a traumatic shock rabbit model with special abdomen injuries was developed and evaluated by examining indicators of clotting and fi brinolysis.METHODS: Forty New Zealand white rabbits were randomly divided into four groups: group 1(sham), group 2(hemorrhage), group 3(hemorrhage-liver injury), and group 4(hemorrhage-liver injury/intestinal injury-peritonitis). Coagulation was detected by thromboelastography before trauma(T0), at 1 hour(T1) and 4 hours(T2) after trauma.RESULTS: Rabbits that suffered from hemorrhage alone did not differ in coagulation capacity compared with the sham group. The clot initiations(R times) of group 3 at T1 and T2 were both shorter than those of groups 1, 2, and 4(P<0.05). In group 4, clot strength was decreased at T1 and T2 compared with those in groups 1, 2, and 3(P<0.05), whereas the R time and clot polymerization were increased at T2(P<0.05). The clotting angle signifi cantly decreased in group 4 compared with groups 2 and 3 at T2(P<0.05).CONCLUSION: This study suggests that different abdominal traumatic shock show diverse coagulopathy in the early phase. Isolated hemorrhagic shock shows no obvious effect on coagulation. In contrast, blunt hepatic injury with hemorrhage shows hypercoagulability, whereas blunt hepatic injury with hemorrhage coupled with peritonitis caused by a ruptured intestine shows a tendency toward hypocoagulability. | Ruo Wu Luo-gen Peng Hui-min Zhao | 2017 | World Journal of Emergency Medicine2017，8，2： | 3 |
| 5 | The structure of the nucleosome core particle of chromatin in chicken erythrocytes visualized by using atomicforce microscopy显示文摘INTRODUCTIONAlleukaryoticchromosomesconsistsofaregularlyrepeatingprotein--DNAcomplexcalledthenucleosome(Kornberg,1977)[if.Itistraditionallyconsideredtobethefundamentalunitofchromatinstructure.Thephysicalpropertiesofnucleosomedependonsolutioncondition... | ZHAO HUI YI ZHANG SHU BING ZHANG CHUJIANG QI YE HE MIN QIAN LI RUO LANQIAN( Shanghai Institute of Cell Biology, Chinese Academyof Sciences, Shanghai 200031, China)( Shanghai Institute of Nuclear Research, ChineseAcademy of Sciences, Shanghai 201800, | 1999 | Cell Research1999，9，4： | 2 |
| 6 | A Multigrid Block LU-SGS Algorithm for Euler Equations on Unstructured Grids显示文摘We propose an efficient and robust algorithm to solve the steady Euler equa- tions on unstructured grids.The new algorithm is a Newton-iteration method in which each iteration step is a linear multigrid method using block lower-upper symmetric Gauss-Seidel(LU-SGS)iteration as its smoother To regularize the Jacobian matrix of Newton-iteration,we adopted a local residual dependent regularization as the replace- ment of the standard time-stepping relaxation technique based on the local CFL number The proposed method can be extended to high order approximations and three spatial dimensions in a nature way.The solver was tested on a sequence of benchmark prob- lems on both quasi-uniform and local adaptive meshes.The numerical results illustrated the efficiency and robustness of our algorithm. | Ruo Li Xin Wang Weibo Zhao | 2008 | Numerical Mathematics(Theory,Methods and Applications)2008，1，1： | 2 |
| 7 | Mechanism of Learning and Memory Impairment in Rats Exposed to Arsenic and/or Fluoride Based on Microbiome and Metabolome显示文摘Objective Arsenic(As) and fluoride(F) are two of the most common elements contaminating groundwater resources. A growing number of studies have found that As and F can cause neurotoxicity in infants and children, leading to cognitive, learning, and memory impairments. However, early biomarkers of learning and memory impairment induced by As and/or F remain unclear. In the present study, the mechanisms by which As and/or F cause learning memory impairment are explored at the multi-omics level(microbiome and metabolome).Methods We stablished an SD rats model exposed to arsenic and/or fluoride from intrauterine to adult period.Results Arsenic and/fluoride exposed groups showed reduced neurobehavioral performance and lesions in the hippocampal CA1 region. 16S rRNA gene sequencing revealed that As and/or F exposure significantly altered the composition and diversity of the gut microbiome, featuring the Lachnospiraceae_NK4A136_group, Ruminococcus_1, Prevotellaceae_NK3B31_group, [Eubacterium]_xylanophilum_group. Metabolome analysis showed that As and/or F-induced learning and memory impairment may be related to tryptophan, lipoic acid, glutamate, gamma-aminobutyric acidergic(GABAergic) synapse, and arachidonic acid(AA) metabolism. The gut microbiota, metabolites, and learning memory indicators were significantly correlated.Conclusion Learning memory impairment triggered by As and/or F exposure may be mediated by different gut microbes and their associated metabolites. | ZHANG Xiao Li YU Sheng Nan QU Ruo Di ZHAO Qiu Yi PAN Wei Zhe CHEN Xu Shen ZHANG Qian LIU Yan LI Jia GAO Yi LYU Yi YAN Xiao Yan LI Ben REN Xue Feng QIU Yu Lan | 2023 | Biomedical and Environmental Sciences2023，36，3： | 2 |
| 8 | The Advance of Application of Ultrasound to Biotechnology 显示文摘 | FENG Ruo ZHAO Yi-yun LI Hua-mao | 1994 | Prog Bioehem Siophps1994，21，6： | 1 |
| 9 | Enhancement of ultrasound cavitation yield by multi-frequency sonication显示文摘 | Feng Ruo Zhao Yiyun Zhu Changping | 2002 | Ultrasonics Sonochemistry2002，9，5： | 1 |
| 10 | Electroless coating ofcopper on ceramic in an ultrasonic field显示文摘 | ZHAO Yiyun BAO Ciguang FENG Ruo | 1995 | Ultrasonics Sonochemisty1995，2，2： | 1 |
| 11 | An amperometric immunosensor with a DNA polyion complex membrane/gold nanoparticles-backbone for antibody immobilisation显示文摘 | Na Li Hongwen Zhao Ruo Yuan Kanfu Peng Yaqin Chai | 2008 | Electrochimica Acta2008，，2： | 1 |
| 12 | Electroless coating of copper on ceramic in an ultrasonic field显示文摘 | YIYUN Zhao CIGUANG Bao RUO Feng | 1995 | Ultrasonics Sonochemisty1995，2，2： | 1 |
| 13 | The genetic diversity of mtDNA D - loop and the origin of Chinese goats 显示文摘 | Liu Ruo - yu Yang Gong - she Lei Chu - zhao | 2006 | Acta Genetiea Sinica2006，33，5： | 1 |
| 14 | Enhancement of ultrasonic cavitation yield by multi-frequency sonication显示文摘 | FENG Ruo ZHAO Yiyun ZHU Changping Mason T J | 2002 | Ultrasonics Sonochemisty2002，9，： | 1 |
| 15 | Enhancement of ultrasonic cavimfional yield by multi-frequency sonication显示文摘 | FENG Ruo ZHAO Yiyun ZHU Changping | 2002 | Ultrason Sonochem2002，9，5： | 1 |
| 16 | Sonochemistry in China显示文摘 | FENG Ruo ZHAO Yiyun BAO Ciguang | 1997 | Ultrason Sonochem1997，4，2： | 1 |
| 17 | Direct electrochemistry and enzymatic activity of hemoglobin in positively charged colloid Au nanoparticles and hemoglobin layer-by-layer self-assembly films显示文摘Alternate adsorption of positively charged colloid-Au nanoparticles (nano-Au⊕) and negatively charged hemoglobin (Hb) on L-cysteine (L-cys) modified gold electrode resulted in the assembly of {Hb/nano-Au⊕}n layer-by-layer films/L-cys modified gold electrode. The nano-Au⊕ was characterized by transmission electron micrograph (TEM) and microelectrophoresis. The modified electrode interface morphology was characterized by electrochemical impedance spectroscopy (EIS), atomic force mi- croscopy (AFM), cyclic voltammograms (CV) and chronoamperometry. Direct electron transfer between hemoglobin and gold electrodes was studied, and the apparent Michaelis-Menten constant ( km app) of the modified electrode was evaluated to be 0.10 mmol·L?1. Moreover, the higher activity of proteins in the nano-Au⊕ films could be retained compared with the electropolymerization membrane, since the pro- teins in nano-Au⊕ films retained their near-native structure. Direct electron transfer between hemoglo- bin and electrode and electrochemically catalyzed reduction of hydrogen peroxide on a modified elec- trode was studied, and the linear range was from 2.1×10-8 to 1.2 ×10?3 mol·L-1 (r = 0.994) with a detection limit of 1.1×10-8 mol·L-1 H2O2. | YUAN Ruo CAO ShuRui CHAI YaQin GAO FengXian ZHAO Qing TANG MingYu TONG ZhongQiang XIE Yi | 2007 | Science China Chemistry2007，50，5： | 1 |
| 18 | Sonochemistry in China between 1997 and 2002显示文摘 | ZHAO Yiyun FENG Ruo SHI Yongshou | 2005 | Ultrason Sonochem2005，12，3： | 1 |
| 19 | Enhancement of ultrasound cavitation yield by multi - frequency sonication 显示文摘 | Ruo Feng Yiyun Zhao Changping Zhu | 2002 | Ultrasonics Sonochemistry2002，9，5： | 1 |
| 20 | A combination dimensionality reduction approach to codon position patterns of eubacteria based on their complete genomes显示文摘 | QI Zhao Hui WEI Ruo Yan | 2011 | Journal of theoretical biology2011，272，1： | 1 |
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