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| 1 | Integrative lipidomic and transcriptomic study unravels the therapeutic effects of saikosaponins A and D on non-alcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD)has become one of the most prominent causes of chronic liver diseases and malignancies.However,few therapy has been approved.Radix Bupleuri(RB)is the most frequently used herbal medicine for the treatment of liver diseases.In the current study,we aim to systemically evaluate the therapeutic effects of saikosaponin A(SSa)and saikosaponin D(SSd),the major bioactive monomers in RB,against NAFLD and to investigate the underlying mechanisms.Our results demonstrated that both SSa and SSd improved diet-induced NAFLD.Integrative lipidomic and transcriptomic analysis revealed that SSa and SSd modulated glycerolipid metabolism by regulating related genes,like Lipe and Lipg.SSd profoundly suppressed the fatty acid biosynthesis by downregulating Fasn and Acaca expression and promoted fatty acid degradation by inducing Acox1 and Cpt1 a expression.Bioinformatic analysis further predicted the implication of master transcription factors,including peroxisome proliferator-activated receptor alpha(PPARα),in the protective effects of SSa and SSd.These results were further confirmed in vitro in mouse primary hepatocytes.In summary,our study uncoded the complicated mechanisms underlying the promising anti-steatosis activities of saikosaponins(SSs),and provided critical evidence inspiring the discovery of innovative therapies based on SSa and SSd for the treatment of NAFLD and related complications. | Xiaojiaoyang Li Junde Ge Yajing Li Yajie Cai Qi Zheng Nana Huang Yiqing Gu Qi Han Yunqian Li Rong Sun Runping Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 15 |
| 2 | Spatial and temporal dynamics of phytoplankton and bacterioplankton biomass in Sanya Bay, northern South China Sea显示文摘The composition of phytoplankton and the dynamics of phytoplankton and bacterioplankton biomass (PB and BB, respectively) of Sanya Bay, South China Sea, were determined. A total of 168 species (67 genera) phytoplankton were identified, including Bacillariophyta (diatom, 128 species), Pyrrophyta (35 species), Cyanophyta (3 species), and Chrysophyta (2 species). Annual average abundance of phytoplankton was 1.2 × 107 cells/m3, with the highest abundance in autumn, and the lowest in summer. Annual average diversity index (H ) and evenness (J) values were 3.96 and 0.70, respectively. Average chlorophyll-a was 2.5 mg/m3, and the average PB was 124 mg C/m3, with the highest value in autumn. Surface PB was higher than the bottom, except for summer. Annual mean bacterioplankton abundance and BB were 6.9 × 1011 cells/m3 and 13.8 mg C/m3, respectively. The highest BB was found in summer, followed by winter, spring, and autumn. Surface BB was higher than bottom all year round. The spatial distribution patterns of PB and BB were very similar with the highest biomass in the estuary, and decreased seaward, primarily due to the terrestrial input from the Sanya River and influx of oceanic water. The main factor influencing PB and BB was dissolved inorganic nitrogen (DIN). Other factors such as temperature, which is above 22°C throughout the year, had a negligible impact. The correlation between BB and PB was significant (P < 0.01). The annual average ratio of BB/PB was 0.12 (0.06-0.15). Phytoplankton primary production was one of the most important factors in controlling the distribution of bacterioplankton. | ZHOU Weihua | 2009 | Journal of Environmental Sciences2009，21，5： | 11 |
| 3 | The bacterial diversity in surface sediment from the South China Sea显示文摘16S rDNA sequencing results from this study and literatures demonstrate that sediment bacteria in the South China Sea (SCS) were very diverse,which contained 22 of the 24 phyla of bacteria investigated from marine sediment,however,it was very imbalance among stations.So bacterial diversity from 15 samples which covered a wide range of sediment types from 20 to 3 888 m in depth was studied in DGGE (denature gradient gel electrophoresis) in this paper.The DGGE results indicate that both sediment bacterial diversity and diversity difference among stations were significant.Thirty representative and differential fingerprints among samples were recovered and sequenced,phylogenetic analysis indicates that they may belong to Proteobacteria (α-,β-,γ-,δ-,ε-),Planctomycetes,Firmicutes,Chloroflexi,Acidobacteria,Actinobacteria,Nitrospirae,Gemmatimonadetes,candidate division WS3 and so on,of which,Gemmatimonadetes and candidate division WS3 bacteria were first detected in SCS sediment.This study also shows that bacterial diversity analysis based on DGGE was more potential than traditional 16S rDNA clone library in multiple sample analysis. | WANG Guanghua DONG Junde LI Xiang SUN Huimin | 2010 | Acta Oceanologica Sinica2010，29，4： | 5 |
| 4 | Recent development on COX-2 inhibitors as promising anti-inflammatory agents:The past 10 years显示文摘Cyclooxygenases play a vital role in inflammation and are responsible for the production of prostaglandins.Two cyclooxygenases are described,the constitutive cyclooxygenase-1 and the inducible cyclooxygenase-2,for which the target inhibitors are the non-steroidal anti-inflammatory drugs(NSAIDs).Prostaglandins are a class of lipid compounds that mediate acute and chronic inflammation.NSAIDs are the most frequent choices for treatment of inflammation.Nevertheless,currently used anti-inflammatory drugs have become associated with a variety of adverse effects which lead to diminished output even market withdrawal.Recently,more studies have been carried out on searching novel selective COX-2 inhibitors with safety profiles.In this review,we highlight the various structural classes of organic and natural scaffolds with efficient COX-2 inhibitory activity reported during 2011-2021.It will be valuable for pharmaceutical scientists to read up on the current chemicals to pave the way for subsequent research. | Zhiran Ju Menglan Li Junde Xu Daniel C.Howell Zhiyun Li Fen-Er Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 4 |
| 5 | Synthesis of diamond using nano-graphite and Fe powder under high pressure and high temperature显示文摘 | Chao Wen Zhihao Jin Xiaoxin Liu Deyu Sun Xun Li Gang Zhou Junde Lin Zhaoyin Hao | 2006 | Materials Letters2006，，29： | 1 |
| 6 | Continuity and boundedness for operator-valued matrix mappings显示文摘 | WU Junde LI Ronglu Swartz C | 1998 | Taiwan Journal of Math1998，4，： | 1 |
| 7 | The study on the arc plasma temperature measurement by optical emission spectroscopy with fiber optical transmission显示文摘 | Wang Junde Li Baoming Cu Binghe | 1998 | Spectroscopy Letters1998，31，1： | 1 |
| 8 | Predicting the in-fluence of oPerating conditions on DCMD flux and thermalefficiency for incomPressible and comPressible membranesystems显示文摘 | Zhang Jianhua Gray StePhen Li Junde | 2013 | Desalination2013，323，： | 1 |
| 9 | Spatial distribution characteristics of organic matter and total sulfur of different marsh soils in the Yellow River Estuary显示文摘 | JUNDE LI ZHIJUN SUN FANG SUN | 2014 | Environmental Engineering2014，864，： | 1 |
| 10 | Characterizations of a class of matrix transformations显示文摘 | Wu Junde Cheng Wei Li Ronglu | 1998 | Prope Revi De Math1998，17，1： | 1 |
| 11 | A continuous process for the synthesis of homopiperazine catalyzed by Cu-based catalysts显示文摘 | Hefang Wang Ligong Chen Dezhi Luan Yang Li Xilong Yan Yuecheng Zhang Junde Xing | | 0，，： | 1 |
| 12 | A secure fast handover scheme based on AAA protocol in mobile IPv6 networks显示文摘 | Song Mei Wang Li Song Junde | 2008 | The Journal of China Universities of Posts and Telecommunications2008，15，： | 1 |
| 13 | Modelling heat and mass transfers in DCMD using compressible mem- branes 显示文摘 | Jianhua Zhang Stephen Gray Junde Li | 2012 | Journal of Membrane Science2012，，387388： | 1 |
| 14 | Advances in membrane distillation for water desalination and purification applications 显示文摘 | Camacho L M Dumée L Zhang Jianhua Li Junde | 2013 | Water2013，5，1： | 1 |
| 15 | Numerical study of the seasonal salinity budget of the upper ocean in the Bay of Bengal in 2014显示文摘Impact factors on the salinity budget, especially the eddy salt fluxes and smaller-scale diffusive salt fluxes for the upper 50 m of the Bay of Bengal(BoB) in 2014 are investigated using a box model based on the Regional Ocean Modeling System(ROMS) daily outputs. The model results reproduce that the precipitation and river runoff s are the dominant factors modulating the sharp salinity decrease during the summer monsoon season. The analysis shows that the salinity increase after the summer monsoon is mostly due to the meridional advective and diffusive salt fluxes. The vertical advective salt flux, which is sensitive to the different signals of the wind stress curl, plays an important role in balancing the salinity change induced by the meridional advective salt flux during both the summer and winter monsoon seasons. Distinctive spatial mesoscale structures are presented in the eddy salt flux throughout the year, and their contributions are sizeable(over 30% in the meridional direction and about 10%–30% in the vertical direction). The meridional eddy salt flux is larger in the monsoon seasons than that in the inter-monsoon seasons, and in a positive pattern near the western boundary during the winter monsoon and autumn inter-monsoon. The vertical eddy salt flux makes an important contribution to the salinity budget, especially along the coastal area and around the Andaman and Nicobar Islands. The vertical eddy salt flux becomes large when a tropical cyclone passes the area. | Qingyue WANG Changming DONG Junde LI Jingsong YANG Qing TIAN | 2021 | Journal of Oceanology and Limnology2021，39，4： | 0 |
| 16 | Multiple-scale temporal variations and fluxes near a hydrothermal vent over the Southwest Indian Ridge显示文摘一个深海洋的绳索系统被部署 100 m 离开一活跃热水在西南印度理兹(SWIR ) 上发泄,在水深度是大约 2,800 m 的地方。一年离开海洋地板的海洋温度 50 m 上并且在在四个层次(离开海洋地板的 44 m, 40 m, 36 m,和 32 m ) 的速度上的数据被系在的系统收集。Multiplescale 变化从这些数据被提取:季节,潮汐,超级潮汐,并且旋涡规模。半天的潮是在在水流和温度的所有潮汐的成分之中的最强壮的潮汐的信号。与在数据介绍的多重规模的变化,一个新方法被开发以时间的规模把数据分解成五部分:时间平均数,季节,潮汐,超级潮汐,并且回旋。回旋,这被显示出,潮汐的热(动量) 流动被变化在底部地形学描绘:在沿着深线方向的热和动量的潮汐的流动是比在跨深线的方向的那些强壮得多的。为热流动,旋涡热流动是比在跨深线的方向的潮汐的热流动强壮的,当旋涡热流动在沿着深线方向是更弱的时。为动量流动,旋涡动量流动是比在两个方向的潮汐的动量流动弱的。在四个层次的旋涡动量流动与吝啬的水流的大小有一种好关系:它在一种指数的关系中与吝啬的水流增加了。 | Xiaodan CHEN Chujin LIANG Changming DONG Beifeng ZHOU Guanghong LIAO Junde LI | 2015 | Frontiers of Earth Science2015，9，4： | 0 |
| 17 | Benzaldehyde lyase-catalyzed enantioselective C-C bond formation and cleavage:A review显示文摘Benzaldehyde lyase(BAL)is an enzyme which was originally found from Pseudomonas fluorescens biovar I.It has long been used in the formation of a C-C bond.BAL can exclusively yield(R)-enantioselective products from the synthesis ofα-hydroxy ketones and has so far been explored as an important enzyme to prepare the corresponding intermediate of pharmaceuticals.Due to its substrate spectrum and stereospecificity,this enzyme extends the synthetic potential for carboligations appreciably.In this review,we highlight the biotransformation applications of BAL in recent years,some of which have achieved intriguing results and provided the theoretical basis for drug development and industrial purpose in the future. | Zhiran Ju Junde Xu Zhiyun Li Jingjie Fang Menglan Li Daniel C.Howell FenEr Chen | 2022 | Green Synthesis and Catalysis2022，3，4： | 0 |
| 18 | BEVGGC:Biogeography-Based Optimization Expert-VGG for Diagnosis COVID-19 via Chest X-ray Images显示文摘Purpose:As to January 11,2021,coronavirus disease(COVID-19)has caused more than 2 million deaths worldwide.Mainly diagnostic methods of COVID-19 are:(i)nucleic acid testing.This method requires high requirements on the sample testing environment.When collecting samples,staff are in a susceptible environment,which increases the risk of infection.(ii)chest computed tomography.The cost of it is high and some radiation in the scan process.(iii)chest X-ray images.It has the advantages of fast imaging,higher spatial recognition than chest computed tomography.Therefore,our team chose the chest X-ray images as the experimental dataset in this paper.Methods:We proposed a novel framework—BEVGG and three methods(BEVGGC-I,BEVGGC-II,and BEVGGC-III)to diagnose COVID-19 via chest X-ray images.Besides,we used biogeography-based optimization to optimize the values of hyperparameters of the convolutional neural network.Results:The experimental results show that the OA of our proposed three methods are 97.65%±0.65%,94.49%±0.22%and 94.81%±0.52%.BEVGGC-I has the best performance of all methods.Conclusions:The OA of BEVGGC-I is 9.59%±1.04%higher than that of state-of-the-art methods. | Junding Sun Xiang Li Chaosheng Tang Shixin Chen | 2021 | Computer Modeling in Engineering & Sciences2021，，11： | 0 |
| 19 | Microbiome Engineering:A Promising Approach to Improve Coral Health显示文摘The world’s coral reefs are threatened by the cumulative impacts of global climate change and local stressors.Driven largely by a desire to understand the interactions between corals and their symbiotic microorganisms,and to use this knowledge to eventually improve coral health,interest in coral microbiology and the coral microbiome has increased in recent years.In this review,we summarize the role of the coral microbiome in maintaining a healthy metaorganism by providing nutrients,support for growth and development,protection against pathogens,and mitigation of environmental stressors.We explore the concept of coral microbiome engineering,that is,precise and controlled manipulation of the coral microbiome to aid and enhance coral resilience and tolerance in the changing oceans.Although coral microbiome engineering is clearly in its infancy,several recent breakthroughs indicate that such engineering is an effective tool for restoration and preservation of these valuable ecosystems.To assist with identifying future research targets,we have reviewed the common principles of microbiome engineering and its applications in improving human health and agricultural productivity,drawing parallels to where coral microbiome engineering can advance in the not-too-distant future.Finally,we end by discussing the challenges faced by researchers and practitioners in the application of microbiome engineering in coral reefs and provide recommendations for future work. | Jie Li Qingsong Yang Junde Dong Michael Sweet Ying Zhang Cong Liu Yanying Zhang Xiaoyu Tang Wenqian Zhang Si Zhang | 2023 | Engineering2023，，9： | 0 |
| 20 | PREPARATION AND PROPERTIES OF HYDROGEN STORAGE MATERIAL TiFe WITH AMORPHOUS Si COATING显示文摘An evident improvement on activation properties of hydrogen storage was made by sput-tering an amorphous coating of commercial Si on TiFe alloy.SEM observation revealedan obvious difference between the morphologies before and after hydrogen storage forTiFe alloy with or without amorphous Si coating.It is believed that this may be quitea developable hydrogen storage material. | XU Wenyang LI Jinping DONG Jinxiang PAN Junde Taiyuan Polytechnical University,Taiyuan,China | 1992 | Acta Metallurgica Sinica(English Letters)1992，5，10： | 0 |
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