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| 1 | Integrative lipidomic and transcriptomic study unravels the therapeutic effects of saikosaponins A and D on non-alcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD)has become one of the most prominent causes of chronic liver diseases and malignancies.However,few therapy has been approved.Radix Bupleuri(RB)is the most frequently used herbal medicine for the treatment of liver diseases.In the current study,we aim to systemically evaluate the therapeutic effects of saikosaponin A(SSa)and saikosaponin D(SSd),the major bioactive monomers in RB,against NAFLD and to investigate the underlying mechanisms.Our results demonstrated that both SSa and SSd improved diet-induced NAFLD.Integrative lipidomic and transcriptomic analysis revealed that SSa and SSd modulated glycerolipid metabolism by regulating related genes,like Lipe and Lipg.SSd profoundly suppressed the fatty acid biosynthesis by downregulating Fasn and Acaca expression and promoted fatty acid degradation by inducing Acox1 and Cpt1 a expression.Bioinformatic analysis further predicted the implication of master transcription factors,including peroxisome proliferator-activated receptor alpha(PPARα),in the protective effects of SSa and SSd.These results were further confirmed in vitro in mouse primary hepatocytes.In summary,our study uncoded the complicated mechanisms underlying the promising anti-steatosis activities of saikosaponins(SSs),and provided critical evidence inspiring the discovery of innovative therapies based on SSa and SSd for the treatment of NAFLD and related complications. | Xiaojiaoyang Li Junde Ge Yajing Li Yajie Cai Qi Zheng Nana Huang Yiqing Gu Qi Han Yunqian Li Rong Sun Runping Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 15 |
| 2 | Electron-Deficient Zn-N_(6) Configuration Enabling Polymeric Carbon Nitride for Visible-Light Photocatalytic Overall Water Splitting显示文摘Despite of suitable band structures for harvesting solar light and driving water redox reactions,polymeric carbon nitride(PCN)has suffered from poor charge transfer ability and sluggish surface reaction kinetics,which limit its photocatalytic activity for water splitting.Herein,atomically dispersed Zn-coordinated three-dimensional(3D)sponge-like PCN(Zn-PCN)is synthesized through a novel intermediate coordination strategy.Advanced characterizations and theoretical calculations well evidence that Zn single atoms are coordinated and stabilized on PCN in the form of Zn-N_(6) configura-tion featured with an electron-deficient state.Such an electronic configuration has been demonstrated contributive to promoted electron excitation,accelerated charge separation and transfer as well as reduced water redox barriers.Further benefited from the abundant surface active sites derived from the 3D porous structure,Zn-PCN realizes visible-light photocatalysis for overall water splitting with H_(2) and O_(2) simultaneously evolved at a stoichiometric ratio of 2:1.This work brings new insights into the design of novel single-atom photocatalysts by deepening the understanding of electronic configurations and reactive sites favorable to excellent photocatalysis for water splitting and related solar energy conversion reactions. | Daming Zhao Yiqing Wang Chung-Li Dong Fanqi Meng Yu-Cheng Huang Qinghua Zhang Lin Gu Lan Liu Shaohua Shen | 2022 | Nano-Micro Letters2022，14，12： | 2 |
| 3 | Degree Distribution Based HARQ for Irregular LDPC 显示文摘 | Yiqing Cao Jian Gu Lin Qi | 2006 | Electronic letters2006，42，6： | 1 |
| 4 | Anchoring Single Nickel Atoms on Carbon-vacant Carbon Nitride Nanosheets for Efficient Photocatalytic Hydrogen Evolution显示文摘Polymeric carbon nitride(PCN)has emerged as a promising candidate for photocatalytic hydrogen evolution,but its dependence on scarce and high-cost noble metal co-catalysts severely limits its extensive application.It will be of great promise to develop non-noble metal single-atom co-catalysts with low-cost and high atom utilization to improve the photocatalytic performance over PCN.Herein,single Ni atoms are successfully anchored onto carbon-vacant PCN nanosheets(CCN-SANi)via a two-step ammonia thermal treatment and photo-deposition process.Theoretical calculations and experimental results demonstrate that the optical absorption property and the charge transfer ability of CCN-SANi have been significantly improved with the introduction of single Ni atoms to form Ni-N3 sites.In comparison to carbon-vacant PCN(CCN)loaded with Ni clusters,the obtained CCN-SANi exhibits 11.4 times increased photocatalytic performance,with the highest hydrogen evolution rate reaching 511μmol/(g·h),which is even 1.7 times higher than that of CCN loaded with Pt clusters.This research proposes an inspiring and reliable strategy to design novel single-atom semiconducting polymers with electronic structures manipulated for efficient photocatalysis. | LIN Zhi ZHANG Zhengqi WANG Yiqing PENG Zhiming WANG Xinxin WANG Ruizhe HUANG Yu-Cheng MENG Fanqi LI Mingtao DONG Chung-Li ZHANG Qinghua GU Lin SHEN Shaohua | 2022 | Chemical Research in Chinese Universities2022，38，5： | 1 |
| 5 | Degree distri- bution based HARQ for Irregular LDPC 显示文摘 | Cao Yiqing Gu Jian Qi Lin | 2006 | Elec- tronic Letters2006，42，6： | 1 |
| 6 | Preparation and properties of transparent PMMA/ZrO2 nanocomposites using 2-hydroxyethyl methacrylate as a coupling agent显示文摘 | Hu Yiqing Gu Guangxin Zhou Shuxue | 2011 | Polymer2011，52，1： | 1 |
| 7 | Resistin and insulin resistance in hepatocytes: Resistin disturbs glycogen metabolism at the protein level显示文摘 | Yang Yang Meifang Xiao Yiqing Mao Hui Li Shuyong Zhao Yi Gu Rong Wang Jianqiang Yu Xuemei Zhang David M. Irwin Gang Niu Huanran Tan | 2008 | Biomedicine & Pharmacotherapy2008，，5： | 1 |
| 8 | Synergistic effect of F and triggered oxygen vacancies over F-TiO_(2) on enhancing NO ozonation显示文摘Oxidation-absorption technology is a key step for NOxremoval from low-temperature gas.Under the condition of low O_(3)concentration(O_(3)/NO molar ratio = 0.6), F-TiO_(2)(F-TiO_(2)), which is cheap and environmentally friendly, has been prepared as ozonation catalysts for NO oxidation. Catalytic activity tests performed at 120℃showed that the NO oxidation efficiency of F-TiO_(2)samples was higher than that of TiO_(2)(about 43.7%), and the NO oxidation efficiency of F-TiO_(2)-0.15 was the highest, which was 65.3%. Combined with physicochemical characteristics of catalysts and the analysis of active species, it was found that there was a synergistic effect between F sites and oxygen vacancies on F-TiO_(2), which could accelerate the transformation of monomolecular O_(3)into multi-molecule singlet oxygen(1O_(2)), thus promoting the selective oxidation of NO to NO_(2). The oxidation reaction of NO on F-TiO_(2)-0.15 follows the Eley-Rideal mechanism, that is, gaseous NO reacts with adsorbed O_(3)and finally form NO_(2). | Lina Guo Xu Zhang Fanyu Meng Jing Yuan Yiqing Zeng Chenyang Han Yong Jia Mingyan Gu Shule Zhang Qin Zhong | 2023 | Journal of Environmental Sciences2023，，3： | 0 |
| 9 | Cassiae Semen improves non-alcoholic fatty liver disease through autophagy-related pathway显示文摘Objective:Cassiae Semen(CS,Juemingzi in Chinese)has been used for thousands of years in ancient Chinese history for relieving constipation,improving liver function as well as preventing myopia.Here we aimed to elucidate the anti-steatosis effect and underlying mechanism of CS against non-alcoholic fatty liver disease(NAFLD).Methods:High-performance liquid chromatography(HPLC)was used to identify the major components of CS water extract.Mice were fed with a high-fat and sugar-water(HFSW)diet to induce hepatic steatosis and then treated with CS.The anti-NAFLD effect was determined by measuring serum biomarkers and histopathology staining.Additionally,the effects of CS on cell viability and lipid metabolism in oleic acid and palmitic acid(OAPA)-treated HepG2 cells were measured.The expression of essential genes and proteins involved in lipid metabolism and autophagy signalings were measured to uncover the underlying mechanism.Results:Five compounds,including aurantio-obtusin,rubrofusarin gentiobioside,cassiaside C,emodin and rhein were simultaneously identified in CS extract.CS not only improved the diet-induced hepatic steatosis in vivo,as indicated by decreased number and size of lipid droplets,hepatic and serum triglycerides(TG)levels,but also markedly attenuated the OAPA-induced lipid accumulation in hepatocytes.These lipid-lowering effects induced by CS were largely dependent on the inhibition of fatty acid synthase(FASN)and the activation of autophagy-related signaling,including AMP-activated protein kinase(AMPK),light chain 3-II(LC3-II)/LC3-1 and autophagy-related gene5(ATG5).Conclusion:Our study suggested that CS effectively protected liver steatosis via decreasing FASN-related fatty acid synthesis and activating AMPK-mediated autophagy,which might become a promising therapeutic strategy for relieving NAFLD. | Mingning Ding Fei Zhou Yijie Li Chuanyang Liu Yiqing Gu Jianzhi Wu Guifang Fan Yajing Li Xiaojiaoyang Li | 2023 | Chinese Herbal Medicines2023，15，3： | 0 |
| 10 | Field-tuned magnetic structure and phase diagram of the honeycomb magnet YbCl_(3)显示文摘We report thermodynamic and neutron diffraction measurements on the magnetic ordering properties of the honeycomb lattice magnet YbCl_(3). We find YbCl_(3) exhibits a Ne′el type long-range magnetic order at the wavevector(0, 0, 0) below TN= 600 mK.This magnetic order is associated with a small sharp peak in heat capacity and most magnetic entropy release occurs above the magnetic ordering temperature. The magnetic moment lies in-plane, parallel to the monoclinic a-axis, whose magnitude mYb= 0.86(3) μBis considerably smaller than the expected fully ordered moment of 2.24 μBfor the doublet crystal-field ground state. The magnetic ordering moment gradually increases with increasing magnetic field perpendicular to the ab-plane, reaching a maximum value of 1.6(2) μBat 4 T, before it is completely suppressed above ~ 9 T. These results indicate the presence of strong quantum fluctuations in YbCl_(3). | YiQing Hao HongLiang Wo YiMeng Gu XiaoWen Zhang YiQing Gu ShiYi Zheng Yang Zhao GuangYong Xu Jeffrey WLynn Kenji Nakajima Naoki Murai WenBin Wang Jun Zhao | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，3： | 0 |
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