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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | Thompson CB: The B7 and CD28 receptor families显示文摘 | June C H Bluestone J A Nadler L M | 1994 | Immunol Today1994，15，7： | 1 |
| 3 | Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology显示文摘 | Kalos M June C H | 2013 | Immunity2013，39，1： | 1 |
| 4 | Antibiotic resistance in triclosan tolerant fecal coliforms isolated from surface waters near wastewater treatment plant outflows显示文摘 | June H M James D S | 2013 | Ecotoxicology En?vironment Safafety2013，88，1： | 1 |
| 5 | Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology 显示文摘 | Kalos M June C H | 2013 | Immunity2013，39，1： | 1 |
| 6 | Structure of the ferrous form of (4-Hydroxyphenyl)pyruvate dioxygenase from Streptomyces avermitilis in complex with the therapeutic herbicide,NTBC显示文摘 | JUNE M B KAYUNTA J W DAVID H T | 2004 | Biochem2004，43，： | 1 |
| 7 | Examina tion of the inhibitory and stimulatory effects of IFN-alpha, beta, and -gamma on human B-cell proliferation induced by various B-cell mitogens 显示文摘 | FRANCOIS D T KATONA I M JUNE C H | 1988 | Clin Immunol Immunopathol1988，48，3： | 1 |
| 8 | The B7 and CD28 receptor families显示文摘 | JUNE C H BLUESTONE L M NADLER L M | 1994 | Immunol Today1994，15，7： | 1 |
| 9 | A systematic approach to determine the fouling index for a RO/NF membrane process显示文摘 | June S C Tae M H | 2009 | Desalination2009，238，10： | 1 |
| 10 | The B7 and CD28 Receptor Families显示文摘 | JUNE C H BLUESTONE J A NADLER L M | 1994 | Immunol Today1994，15，： | 1 |
| 11 | The B7 and CD28 receptor families显示文摘 | June G H Bluestone J A Nadler L M | 1994 | Immunol Today1994，15，7： | 1 |
| 12 | Adoptive t cell transfer for cancer immunotherapy in the era of synthetic biology显示文摘 | Kalos M June C H | 2013 | Immunity2013，39，1： | 1 |
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