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| 1 | Liver cancer stem cells as a hierarchical society:yes or no?显示文摘Cancer stem cells(CSCs)are cells possessing abilities of self-renewal,differentiation,and tumori-genicity in NOD/SCID mice.Based on this definition,multiple cell surface markers(such as CD24,CD133,CD90,and EpCAM)as well as chemical methods are discovered to enrich liver CSCs in the recent decade.Accumulated studies have revealed molecular signatures and signaling pathways involved in regulating different liver CSCs.Among liver CSCs positive for different markers,some molecular features and regulatory pathways are commonly shared,while some are only unique in certain CSC populations.These studies imply that liver CSCs exhibit diverse heterogeneity,while a functional relationship also exists.The aim of this review is to revisit the society of liver CSCs and summarize the common or unique molecular features of known liver CSCs.We hope to call for attention of researchers on the relationship of the liver CSC subgroups and to provide clues on the hierarchical structure of the liver CSC society. | Yuanzhuo Gu Xin Zheng Junfang Ji | 2020 | Acta Biochimica et Biophysica Sinica2020，52，7： | 3 |
| 2 | Clinical Implications of Cancer Stem Cell Biology in Hepatocellular Carcinoma显示文摘 | Junfang Ji Xin Wei Wang | 2012 | Seminars in Oncology2012，，4： | 2 |
| 3 | A Noncovalently Fused-Ring Asymmetric Electron Acceptor Enables Efficient Organic Solar Cells显示文摘Main observation and conclusion Recently,the asymmetric nonfullerene acceptors(NFAs)with acceptor-donor-acceptor(A-D-A)structure have been developed rapidly,especially for the modification of asymmetric core,asymmetric side chains and asymmetric end groups.In this work,a novel asymmetric A-D-π-A type NFA with a noncovalently fused-ring core named PIST-4F is synthesized,containing an indacenodithieno[3,2-b]dithiophene(IDT),two strong electron-withdrawing end groups and an alkylthio-substituted thiopheneπ-bridge.Benefiting from the S···S noncovalent interaction between the sulfur atom onπ-bridge and the adjacent thiophene in IDT,the PIST-4F presents nearly planar geometry and extended conjugated area,resulting in the optimized electronic properties,charge transport,and film morphology compared to the symmetric NFA PI-4F.As a result,PM6:PIST-4F-based devices achieve a higher power conversion efficiency(PCE)of 13.8%,while the PM6:PI-4F-based devices only show a PCE of 7.1%.Notably,the PM6:PIST-4F-based devices processed with nonhalogen solvent toluene exhibit an excellent PCE as high as 13.1%.These results indicate that PIST-4F is an effective acceptor for high-efficiency organic solar cells. | Ji Lin Qing Guo Qi Liu Junfang Lv Haiyan Liang Yang Wang Lei Zhu Feng Liu Xia Guo Maojie Zhang | 2021 | Chinese Journal of Chemistry2021，39，10： | 1 |
| 4 | A race to uncover a panoramic view of primary liver cancer显示文摘Introduction Primary liver cancer,the second most common cause of cancer related death worldwide1,presents ethnic,etiological,sex,and geographical diversity2(Figure 1A).At the histological level,liver cancer includes two major types:hepatocellular carcinoma(HCC,about 80%)and cholangiocarcinoma(CCA,about 15%).Many etiological factors contribute to HCC development,such as hepatitis | Ruidong Xue Jing Li Fan Bai Xinwei Wang Junfang Ji Yinying Lu | 2017 | Cancer Biology & Medicine2017，14，4： | 1 |
| 5 | Integrated Metabolite and Gene Expression Profiles Identify Lipid Biomarkers Associated With Progression of Hepatocellular Carcinoma and Patient Outcomes显示文摘 | Anuradha Budhu Stephanie Roessler Xuelian Zhao Zhipeng Yu Marshonna Forgues Junfang Ji Edward Karoly Lun–Xiu Qin Qing–Hai Ye Hu–Liang Jia Jia Fan Hui–Chuan Sun Zhao–You Tang Xin Wei Wang | 2013 | Gastroenterology2013，，5： | 1 |
| 6 | Identification ofMicroRNA-181 by Genome-Wide Screen?ing as a Critical Player in EpCAM-Positive Hepatic Cancer Stem Cells显示文摘 | Junfang Ji | 2009 | Hepatology2009，50，2： | 1 |
| 7 | Wnt/beta catenin signaling activates microRNA 181 expression in hepatocellular carcinoma显示文摘 | Junfang Ji Taro Yamashita Xin W Wang | 2011 | Cell& Bioseience2011，1，1： | 1 |
| 8 | Alternative splicing of the cell fate determinant Numb in hepatocellular carcinoma显示文摘 | Yinying Lu Wanping Xu Junfang Ji Dechun Feng Carole Sourbier Youfeng Yang Jianhui Qu Zhen Zeng Chunping Wang Xiujuan Chang Yan Chen Alok Mishra Max Xu Min‐Jung Lee Sunmin Lee Jane Trepel W. Marston Linehan Xinwei Wang Yongping Yang Len Neckers | 2015 | Hepatology2015，，： | 1 |
| 9 | Identification of micro RNA - 181 by genome - wide screening as a critical player in EpCAM - positive hepatic cancer stem cells 显示文摘 | Junfang Ji Taro Yamashita Anuradha Budhu | 2009 | Hepatology2009，，50： | 1 |
| 10 | The role of per- oxisome proliferator-activated receptor and effects of its agonist, pioglitazone, on a rat model of optic nerve crush: PPARc in retinal neuroprotection 显示文摘 | Juming Zhu Junfang Zhang Min Ji | 2013 | PLoS One2013，8，68： | 1 |
| 11 | MicroRNA expression, sur- vival, and response to interferon in liver cancer显示文摘 | Junfang Ji Jiong Shi Anuradha Budhu et M | 2009 | N Engl J Med2009，361，15： | 1 |
| 12 | EpCAM- positive hepatocellular carcinoma ceils are tumor-initiating cells with stem/progenitor cell features 显示文摘 | YAMASHITA T JI Junfang BUDHU A | 2009 | Gastroenterolo- gy2009，136，3： | 1 |
| 13 | p53 functional activation is independent of its genotype infive esophageal squamous cell carcinoma cell lines显示文摘p53 mutations have been found in many esophageal squamous cell carcinoma(ESCC)clinical specimens and cell lines.We reasoned that functional inactivation of wild-type p53 or the functional activation of mutant-type p53 might exist in these specimens and cell lines.In this study,we identified the correlation between p53 functional activation and its genotype infive different ESCC cell lines.To examine the potential p53 activation in a certain ESCC cell line,DNA damage methods including X-ray exposure and cisplatin treatment were employed to treat cells.Further,the expression of p53 protein and four transcripts of well-known p53 target genes were investi-gated using Western blot and reverse transcription-polymerase chain reaction(RT-PCR)after cell exposure to DNA damage.The results showed that in KYSE 30 cell line with mutant p53 and KYSE 150 with wild-type p53,p53 could be activated by DNA damages.However,p53 could not be activated following the DNA damages in YES 2 with wild-type p53,KYSE 70 with mutant p53,and EC9706 with unknown p53 genotype.All our data indicated that p53 function in certain cells is not closely correlated with its genotype.To judge p53 function in a particular cell line,it is important to examine the p53 functional activation,but not to simply rely on the p53 genotype. | Junfang JI Kun WU Min WU Qimin ZHAN | 2010 | Frontiers of Medicine2010，4，4： | 0 |
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