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| 1 | Reactive capillary hemangiomas: a novel dermatologic toxicity following anti-PD-1 treatment with SHR-1210显示文摘Objective: SHR-1210 is a new and promising anti-PD-1 agent for solid tumors. During the phase I study of SHR-1210, we encountered a novel but prevalent immune-related dermatologic toxicity: reactive capillary hemangiomas(RCHs). Thus we tried to summarize the features of RCHs and estimate their relationship with tumor response.Methods: This prospective observational study systematically enrolled 98 patients with advanced solid tumors from April 27th,2016 to June 8th, 2017 in the context of the phase I clinical study of SHR-1210. This report focused on the skin toxicities. Patients underwent entire skin inspection every two weeks while taking medication. The clinical course of RCHs was recorded and their association with tumor response was estimated. The data cut-off date was November 15th, 2017.Results: After a median follow-up of 242(range, 29–567) days, RCHs were observed in 85.7%(84/98) of patients on cutaneous/mucosal surfaces; 84.5%(71/84) of the RCHs were evaluated as grade 1 adverse events. No grade 3 or 4 RCHs were observed. The time of onset of RCHs was dose dependent and shortest in the 400 mg-dose cohort(P < 0.001). Spontaneous and complete regression of RCHs was observed both during and after treatment. The objective response rate of tumors for patients with RCHs was 28.9%(24/83). However, no responders were observed among the patients without RCHs.Conclusions: RCHs were prevalent but manageable during treatment with SHR-1210. It might add to the expanding literature regarding immune-related dermatologic adverse events. | Xuelian Chen Lanying Ma Xi Wang Hongnan Mo Dawei Wu Bo Lan Dong Qu Hongtu Zhang Jing Huang Binghe Xu | 2019 | Cancer Biology & Medicine2019，16，1： | 53 |
| 2 | Rapid and Efficient Gene Modification in Rice and Brachypodium Using TALENs显示文摘 | Qiwei Shan Yanpeng Wang Kunling Chen Zhen Liang Jun Li Yi Zhang Kang Zhang Jinxing Liu Daniel F. Voytas Xuelian Zheng Yong Zhang Caixia Gao | 2013 | Molecular Plant2013，6，4： | 37 |
| 3 | Distribution of high-risk human papillomavirus genotype prevalence and attribution to cervical precancerous lesions in rural North China显示文摘Objective: Precise prevention is more desired for cervical cancer due to the huge population, high prevalence of human papillomavirus(HPV) infection in China and the vision of screen-and-treat strategies in low-and middleincome countries(LMICs). Considerations of combining type-specific prevalence and attribution proportion to high-grade cervical intraepithelial neoplasia are informative to more precise and effective region-specific cervical cancer prevention and control programs. The aim of the current study was to determine the genotype distribution of HPV and attribution to cervical precancerous lesions among women from rural areas in North China.Methods: A total of 9,526 women participated in the cervical cancer screening project in rural China. The samples of women who tested positive for HPV were retested with a polymerase chain reaction(PCR)-based HPV genotyping test. The attribution proportion of specific high-risk human papillomavirus(HR-HPV) types for different grades of cervical lesions was calculated by using the type contribution weighting method.Results: A total of 22.2%(2,112/9,526) of women were HR-HPV positive and HPV52(21.7%) was the most common HR-HPV genotype, followed by HPV58(18.2%), HPV53(18.2%) and HPV16(16.2%). The top three genotypes detected in HR-HPV-positive cervical intraepithelial neoplasia(CIN)1 were HPV16(36.7%), HPV58(20.4%), HPV56(15.3%). Among CIN2+, the most frequent genotypes were HPV16(75.6%), HPV52(17.8%),HPV58(16.7%). HPV16, 56, 58, 53, 52, 59, 68, and 18 combined were attributed to 84.17% of all CIN1 lesions,and HPV16, 58, and 52 combined were attributed to 86.98% of all CIN2+ lesions.Conclusions: The prevalence of HR-HPV infection among women from rural areas in North China was high and HPV16, HPV58, HPV52 had paramount attributable fraction in CIN2+. Type-specific HPV prevalence and attribution proportion to cervical precancerous lesions should be taken into consideration in the development of vaccines and strategy for screening in this population. | Shuang Zhao Xuelian Zhao Shangying Hu Jessica Lu Xianzhi Duan Xun Zhang Feng Chen Fanghui Zhao | 2019 | Chinese Journal of Cancer Research2019，31，4： | 30 |
| 4 | Progress in reentry trajectory planning for hypersonic vehicle显示文摘The reentry trajectory planning for hypersonic vehicles is critical and challenging in the presence of numerous nonlinear equations of motion and path constraints, as well as guaranteed satisfaction of accuracy in meeting all the specified boundary conditions. In the last ten years, many researchers have investigated various strategies to generate a feasible or optimal constrained reentry trajectory for hypersonic vehicles. This paper briefly reviews the new research efforts to promote the capability of reentry trajectory planning. The progress of the onboard reentry trajectory planning, reentry trajectory optimization, and landing footprint is summarized. The main challenges of reentry trajectory planning for hypersonic vehicles are analyzed, focusing on the rapid reentry trajectory optimization, complex geographic constraints, and cooperative strategies. | Jiang Zhao Rui Zhou Xuelian Jin | 2014 | Journal of Systems Engineering and Electronics2014，25，4： | 25 |
| 5 | 海岸线与海岸景观格局对人为干扰度的动态响应--以营口市南部海岸为例显示文摘利用多期遥感数据,提取营口南部海岸五期岸线变化信息、分维值,并利用Arcgis10.2中渔网工具创建评价单元。计算景观格局指数,构建人为干扰强度指标,并进一步探讨岸线变化和景观格局变化对人类活动的动态响应。结果表明:(1)研究区围垦导致岸线长度增长、岸线分形维数的增大,1990—2015年四个时段中岸线年增长速率为0.52%、0.53%、4.98%和0.96%;(2)景观格局指数反映2005年之前景观边界、形状复杂程度与破碎程度有所增加;2005年之后景观形状趋于规则化、土地利用趋于均衡化;(3)研究期间强干扰和弱干扰区域面积均有所增加,中等干扰强度区域面积减小;(4)斑块密度、总边缘长度、边缘密度、景观形状指数和平均分维值均与平均干扰强度指数变化同步。Shannon多样性指数与人为干扰强度变化呈反相关;(5)岸线长度变化和岸线分形维数变化都与人类干扰度呈反相关,相关性分别为-0.97和-0.98。 | 刘富强 吴涛 蒋国俊 Xuelian Meng 童丽颖 张勇 索安宁 朱丽东 | 2017 | 生态学报2017，37，22： | 25 |
| 6 | Plant Prime Editors Enable Precise Gene Editing in Rice Cells显示文摘Genome editing is revolutionizing plant research and crop breeding.Sequence-specific nucleases(SSNs)such as zinc finger nuclease(ZFN)and TAL effector nuclease(TALEN)have been used to create site-specific DNA double-strand breaks and to achieve precise DNA modifications by promoting homology-directed repair(HDR)(Steinert et al.,2016;Voytas,2013).Later,RNA-guided SSNs such as CRISPR-Cas9,Cas12a,Cas12b,and their variants were applied for genome editing in plants(Li et al.,2013;Nekrasov et alM 2013;Tang et al.,2017;Zhong et al.,2019;Ming et al.,2020;Tang et al.,2019).However,HDR relies on simultaneous delivery of SSNs and DNA donors,which has been challenging in plants(Steinert et al.,2016;Zhang et aL,2019).Another challenge for realizing efficient HDR in plants is that DNA repair favors nonhomologous end joining(NHEJ)pathways over HDR in most cell types(Puchta,2005;Qi et al.,2013). | Xu Tang Simon Sretenovic Qiurong Ren Xinyu Jia Mengke Li Tingting Fan Desuo Yin Shuyue Xiang Yachong Guo Li Liu Xuelian Zheng Yiping Qi Yong Zhang | 2020 | Molecular Plant2020，13，5： | 20 |
| 7 | Effects of process parameters on pore structure of semi-coke prepared by solid heat carrier with dry distillation显示文摘The semi-coke was prepared by solid heat carrier with dry distillation in single factor method. The pore structures of raw coal and semi-coke were characterized by Brunauer-Emmett-Teller (BET) and scanning electron microscope (SEM). The results show that the adsorption and desorption isotherm of semi-coke are not coincident. There was a wide pore distribution on the semi-coke, in which mesopores and micropores account for a considerable proportion. Also there are many more secondary pores. With the increase of the final temperature of heat carrier and constant temperature, as well as the decrease of volume ratio of coal and hot carrier reactor, specific surface area and pore volume of semi-coke increased rapidly first and then decreased and finally increased, along with the rapidly reduction of average pore size. SEM photos show that the surface of semi-coke becomes increasingly rough and glossy. | Zhou, Guoli Wu, Jianjun Miao, Zhenyong Hu, Xuelian Li, Xia Shi, Xin Cai, Zhidan Shang, Yukun | 2013 | International Journal of Mining Science and Technology2013，23，3： | 20 |
| 8 | Influence of environment and substrate quality on the decomposition of wetland plant root in the Sanjiang Plain,Northeast China显示文摘The litterbag method was used to study the decomposition of wetland plant root in three wetlands along a water level gradient in the Sanjiang Plain,Northeast China.These wetlands are Calamagrostis angustifolia(C.aa),Carex meyeriana(C.ma)and Carex lasiocarpa (C.la).The objective of our study is to evaluate the influence of environment and substrate quality on decomposition rates in the three wetlands.Calico material was used as a standard substrate to evaluate environmental influences.Roots native to each wetland were used to evaluate decomposition dynamics and substrate quality influences.Calico mass loss was statistically different among the three wetlands in the upper soil profile(0–10 cm)and in the lower depth range(10–20 cm).Hydrology,temperature and pH all influence calico decomposition rates in different ways at different depths of the soil profiles.The decomposition rates of native roots declined differentially with the increase of depth in the soil profiles.The mass loss of native roots showed a statistical decrease among the three wetlands in the upper soil profile(0–10 cm)and in the lower depth range(10–20 cm)as C.ma wetland>C.aa wetland>C.la wetland. Both the C:P ratio and N:P ratio were positively interrelated with decomposition rates.Decomposition rates were negatively related to initial P concentration in all three wetlands,indicating that P concentration seems to be an important factor controlling the litter loss. | GUO, Xuelian LU, Xianguo TONG, Shouzheng DAI, Guohua | 2008 | Journal of Environmental Sciences2008，20，12： | 14 |
| 9 | Laboratory simulation on acoustic well-logging with phased array transmitter显示文摘Two small scale acoustic phased arrays with 4 elements have been designed and assembled in the laboratory. Experiments have been carried out with them. It is found that both directivity and radiation lobe width of the phased array can be regulated by changing the time delay between the input signals on neighboring elements. Results measured are in good agreement with those calculated. By using the phased array as an acoustic transmitter and hydrophone as a receiver, small scale acoustic well-logging simulations have been carried out both on an aluminum model well and on a concrete one. Experimental results show that, by increasing the time delay of the input signals on neighboring elements, the steered radiation angle of the phased array becomes larger and larger, and generation conditions of the refracted compressional wave and the refracted shear wave are reached successively, and the refracted compressional wave, the refracted shear wave and the Stoneley wave axe strengthened, respectively. Therefore, by choosing element spacing of a phased array and acoustic wave frequency appropriately, the main radiation lobe of the phased array can be widened to cover the first critical angle of all kinds of formations, which makes it possible to apply phased array acoustic well-logging in any formation continuously without regulating directivity of the phased array. | QIAO Wenxiao CHEN Xuelian DU Guangsheng FANG Jun LI Gang(Faculty of Natural Resources and Information Technology, University of Petroleum Beijing 102249) | 2003 | Chinese Journal of Acoustics2003，22，4： | 14 |
| 10 | Significance of fossilized microbes from the Cambrian stromatolites in the Tarim Basin, Northwest China显示文摘Samples of the Cambrian microbial dolomites were collected from Penglaiba section,a well-exposed stratigraphic section in the northwestern area of the Tarim Basin.This study provides an analogue for mediated dolomites that can precipitate in microbial mats and biofilms.The Cambrian stromatolitic dolomites were studied using high-resolution scanning electron microscopy.The results are as follows:(1)dolomites with 50 nm to 100 nm spherical nanostructures are aggregated into minerals of larger sphericities;(2)nanospherical dolomites of 50 nm to 170 nm diameter are densely arranged as dumbbell-shaped or chained aggregates;(3)silicified filaments,as well as dumbbell-shaped and chain arrangements,are preserved as important microstructures.On the basis of sedimentological,compositional,geochemical,and petrographic data,the microstructures were interpreted as nanoglobules that function as bacteria in the nucleation and filament mineralization stages.The microstructures function as such because they are wrapped in extracellular polymeric substance(EPS)or mucus and mineralized fossils.Silicification accounts for the exceptional preservation of microbial mat structures,including biofilms,as well as filamentous and coccoid microbes.In addition,EPS process is capable of binding different elements,with preference for Si,Mg,and Ca.Such suitable composition favors microbe mineralization and dolomite nucleation on organic substrates.These microscopic structures suggest bacterial mineralization and provide visual evidence for the origin of microbial dolomites. | YOU XueLian SUN Shu ZHU JingQuan | 2014 | Science China Earth Sciences2014，57，12： | 10 |
| 11 | Effect of preparation method on physicochemical properties and catalytic performances of LaCoO3 perovskite for CO oxidation显示文摘Perovskite oxides LaCoO3 prepared by templating,co-precipitation and sol-gel method with different complexants were systematically characterized and its catalytic performances for CO oxidation were investigated.The samples were characterized by X-ray diffraction,thermogravimetry analysis and differential scanning calorimetry,N2 physisorption,transmission electron microscopy,temperature program reduction of hydrogen,temperature program desorption of oxygen and X-ray photoelectron spectroscopy measurement,results of which show that the properties of LaCoO3,such as surface morphology,surface area,surface compositions,redox capability,oxygen vacancy,as well as the calcination temperature and formation mechanism,depend intimately on the preparation method.Catalytic tests indicate that the sample prepared by carbon templating method shows the best activity for CO oxidation,with full CO conversion obtained at 135℃.In particular,the catalyst can be activated and significant increase of activity can be obtained with the increase of reaction time.The cyclic and longterm stability of catalysts were discussed and compared. | Shan Wang Xuelian Xu Junjiang Zhu Duihai Tang Zhen Zhao | 2019 | Journal of Rare Earths2019，37，9： | 10 |
| 12 | Plant Genome Editing Using FnCpfl and LbCpf Nucleases at Redefined and Altered PAM-Sites显示文摘 | ZhaohuiZhong Yingxiao Zhang Qi You XU Tang Qiurong Ren Shishi Liu Lijia Yang Yan Wang Xiaopei Liu Binglin Liu Tao Zhang Xuelian Zheng Ysa Le Yong Zhang Yiping Qi | 2018 | Molecular Plant2018，11，7： | 10 |
| 13 | A Fundamental Inequality for Meromorphic Functions in an Angular Domain and Its Application | Zhang Xuelian Department of Applied Mathematics Beijing Institute of Technology Beijing,100081 China | 1994 | Acta Mathematica Sinica,English Series1994，10，3： | 10 |
| 14 | Interactions of OsMADS1 with Floral Homeotic Genes in Rice Flower Development显示文摘在繁殖开发期间,米饭植物开发决定最后的谷物收益的唯一的花器官。OsMADS1,象 SEPALLATA 一样疯盒子的基因之一,被解开了玩关键角色 inrice 花的机关身份说明和花的分裂组织确定性。然而,在调整花开发与另外的花的 homeotic 基因位于 OsMADS1 的相互作用下面的分子的机制 remainslargely 逃犯。在这个工作,我们在他们的蛋白质之中与物理相互作用一起与 B- , C- ,和 D 班基因学习了 OsMADS1 的基因相互作用。我们证明在 OsMADS1 和 OsMADS3 之间的物理、基因的相互作用为花的分裂组织活动维护和机关身份说明是必要的;当 OsMADS1 身体上并且遗传上在调整花的分裂组织确定性和 suppressingspikelet 分裂组织回复与 OsMADS58 交往时。我们提供了重要基因证据在花开发期间支持二米饭 C 班基因(OsMADS3 和 OsMADS58 ) 的 neofunctionalization。基因表示介绍和量的 RT-PCR 分析进一步表明 OsMADS1 影响涉及发信号的花的身份和荷尔蒙的许多基因的表达式,并且染色质 immunoprecipitation (芯片)-PCR 试金进一步证明 OsMADS17 是 OsMADS1 的直接目标基因。一起拿,这些结果表明 OsMADS1 在指定米饭有多样化的规章的功能花的机关和分裂组织身份,可能通过它和不同花的 homeotic 管理者的基因、物理的相互作用。 | Yun Hu Wanqi Liang Changsong Yin Xuelian Yang Baozhe Ping Anxue Li Ru Jia Mingjiao Chen Zhijing Luo Qiang Cai Xiangxiang Zhao Dabing Zhang Zheng Yuan | 2015 | Molecular Plant2015，8，9： | 10 |
| 15 | Susceptibility variations of multiple origins of loess from the Ily Basin(NW China)显示文摘The magnetic susceptibility of loess from the Ily Basin,northwestern China shows maximum values in S0 paleosols but minimum values in other paleosols,the mechanism of which has been well debated.In this work,systematic magnetic measurements were made on a representative section from Neleke county.The results show that the loess horizons(L1,L2 and L3) have multi-domain magnetite grains of aeolian origin,S0 is characterized by production of pedogenetic ultrafine-grained ferrimagnetic minerals,and the other paleosols(S1,S2,and S3) are characterized by the formation of nonferrimagnetic minerals associated with waterlogging.The correlation between the low concentration of ferrimagnets,high paramagnetic content,high magnetic coercivity remanence,fine ferrimagnetic grain size and intensified pedogenesis suggest two competing processes of pedogenetic enhancement and pedogenetic depletion in the lower paleosols.Pedogenetic depletion dominates and is responsible for the low susceptibility.Changes in magnetic grain size distribution occur during pedogenetic depletion.The susceptibility variations are of multiple origins in the loess of the Ily Basin.Pedogenetic enhancement,pedogenetic depletion,and allochthonous input of magnetic minerals should all be taken into account to explain the variations of magnetic parameters. | CHEN Qu LIU XiuMing HELLER F HIRT Ann M LU Bin GUO XueLian MAO XueGang ZHAO GuoYong FENG Hua GUO Hui | 2012 | Chinese Science Bulletin2012，57，15： | 9 |
| 16 | Planting density affected biomass and grain yield of maize for seed production in an arid region of Northwest China显示文摘Field experiments were conducted from 2012 to 2015 in an arid region of Northwest China to investigate the effects of planting density on plant growth, yield, and water use efficiency(WUE) of maize for seed production. Five planting densities of 6.75, 8.25, 9.75, 11.25 and 12.75 plants/m^2 were conducted in 2012, and a planting density of 14.25 plants/m^2 was added from 2013 to 2015. Through comparison with the Aqua Crop yield model, a modified model was developed to estimate the biomass accumulation and yield under different planting densities using adjustment coefficient for normalized biomass water productivity and harvest index. It was found that the modified yield model had a better performance and could generate results with higher determination coefficient and lower error. The results indicated that higher planting density increased the leaf area index and biomass accumulation, but decreased the biomass accumulation per plant. The total yield increased rapidly as planting density increased to 11.25 plants/m^2, but only a slight increase was observed when the density was greater than 11.25 plants/m^2. The WUE also reached the maximum when planting density was 11.25 plants/m^2, which was the recommended planting density of maize for seed production in Northwest China. | JIANG Xuelian TONG Ling KANG Shaozhong LI Fusheng LI Donghao QIN Yonghui SHI Rongchao LI Jianbing | 2018 | Journal of Arid Land2018，10，2： | 9 |
| 17 | A quantitative approach to monitoring new sand cay migration in Nansha Islands显示文摘Sand cay is a special kind of islet formed by coral detritus and bioclast, which is common in Nansha Islands of China. Some sand cays play an important role in ocean strategy and economy, but surprisingly we know little about them, especially those recently formed sand cays. In this research, we monitor migration of a new sand cay in Nanxun Jiao(Gaven Reef) using a series of Quick Bird and World View-2 satellite images between June 2006 and August 2013. We conduct a regression between migration distance and wind observational data to examine the migration patterns of the new sand cay. The migration distance is calculated based on the sand cay locations extracted based on Normalized Difference Water Index(NDWI). The wind observational data downloaded from NOAA are reformed into four wind direction vectors. Based on the results of regression, we concluded that the migration of the new sand cay on Nanxun Jiao was significantly associated with the east, west and north wind.East wind was the main influence factor of the migration; its impact strength was almost twice as the west and north wind. The south wind has little effect on the migration of the sand cay, which is partly blocked by the artificial structure in the south. | ZHU Haitian JIANG Xingwei MENG Xuelian FENG Qian CUI Songxue LIANG Chao | 2016 | Acta Oceanologica Sinica2016，35，3： | 9 |
| 18 | Targeted Mutagenesis of NAC Transcription Factor Gene,OsN AC041,Leading to Salt Sensitivity in Rice显示文摘Salinity is a major abiotic stress factor that seriously affects plant growth. Many genes are involved in the response to salt stress with various metabolism pathways. A number of plant transcription factor family genes have been found to be involved in the salt stress response, and NAM, ATAF and CUC(NAC) transcription factors are thought to act as active regulators during abiotic stress, especially salt stress. In this study, we detected a rice NAC transcription factor coding gene, OsNAC041, and confirmed that it influenced the germination of seeds under salt stress and salt tolerance of plants. OsNAC041 was primarily expressed in the leaves and located in the nucleus. Furthermore, the CRISPR/Cas9 method was used to obtain a targeted osnac041 mutant, of which the plant height was higher than that of the wild-type, showing increased salt sensitivity. Moreover, RNA-seq analysis revealed a number of differentially expressed genes(DEGs) involved in several important signaling pathways in the osnac041 mutant. Subsequently, Kyoto Encyclopedia of Genes and Genomes annotation also revealed differential expression of DEGs associated with mitogen-activated protein kinase signaling, peroxisome, eukaryotictype ABC transporters, photosynthesis and plant hormones, which are involved in stress-related signaling pathways. Overall, our study suggested that OsNAC041 was involved in the salt stress response in rice. These findings not only provide empirical evidence of OsNAC041 function, but also provide new insight into its potential application in rice resistance breeding. | WANG Bo ZHONG Zhaohui ZHANG Huanhuan WANG Xia LIU Binglin YANG Lijia HAN Xiangyan YU Deshui ZHENG Xuelian WANG Chunguo SONG Wenqin CHEN Chengbin ZHANG Yong | 2019 | Rice science2019，26，2： | 8 |
| 19 | A Single Transcript CRISPR-Cas9 System for Efficient Genome Editing in Plants显示文摘 | Tang, Xu Zheng, Xuelian Qi, Yiping Zhang, Dengwei Cheng, Yan Tang, Aiting Voytas, Daniel F. Zhang, Yong | 2016 | Molecular Plant2016，9，7： | 8 |
| 20 | Differentiation potential of bone marrow mesenchymal stem cells in duck显示文摘The bone marrow mesenchymal stem cells(MSCs) are multipotent stem cells which can differentiate into mesenchymal cells in vitro.In this study,MSCs in duck were isolated from bone marrow by density gradient centrifuge separation,purified and expanded in the me-dium.The primary MSCs were expanded for 11 passages.The different-passage MSCs were induced to differentiate into osteoblasts and neuron-like cells.Karyotype analysis indicated that MSCs kept diploid condition and the hereditary feature was stable.The different-passage MSCs expressed CD44,ICAM-1 and SSEA-4,but not CD34,CD45 and SSEA-1 when detected by immunofluorescence staining.There was no significant difference among the positive rates of passages 2,6 and 8(P > 0.05),but a significant difference existed among those of passages 2,6,8 and 11(P < 0.05).After the osteogenic inducement was added,the induced different-passage MSCs expressed high-level alkaline phosphatase(ALP),and are positive for tetracycline staining,Alizarin Red staining and Von Kossa staining.After the neural inducement was added,about 70% cells exhibited typical neuron-like phenotype,the induced different-passage MSCs expressed Nestin,neuron-specific enolase(NSE) and glial fibrillary acidic protein(GFAP) when detected by immunofluorescence staining.There was no significant difference among the positive rates of passages 3,4 and 6(P>0.05),but a significant difference existed among those of passages 3,4,6 and 8(P<0.05).These results suggest that MSCs in duck were capable of differentiating into osteoblasts and neuron-like cells in vitro. | Linfeng Li Xiujuan Bai Xuelian Gong Hongkun Liu Lina Chen Weijun Guan Yuehui Ma | 2009 | Journal of Genetics and Genomics2009，36，3： | 8 |
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