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| 1 | The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis显示文摘上皮间充质的转变(EMT ) 把上皮的肿瘤房间变换成侵略、变形的癌症房间,导致在癌症病人的死亡。尽管扭曲为胸和另外的癌症是 EMT 和转移的一个主人管理者,为调停扭曲的基因抄写负责的机制仍然保持未知。在这研究, TWIST 蛋白质建筑群的纯化和描述表明那扭曲与改变的 Mi2/nucleosome 和 deacetylase (Mi2/NuRD ) 的几个部件交往建筑群, MTA2, RbAp46, Mi2 和 HDAC2,和成员他们到为 transcriptional 压抑的 E-cadherin 倡导者的近似区域。从取决于的房间线高效地为转移扭曲的癌症的这些扭曲建筑群部件的弄空在老鼠在文化和肺转移压制房间移植和侵略。这些调查结果不仅提供在扭曲和 Mi2/NuRD 建筑群之间的新奇机械学、功能的连接而且为在癌症复杂的 Mi2/NuRD 的部件建立新必要角色转移。 | Junjiang Fu Li Qin Tao He Jun Qin Jun Hong Jiemin Wong Lan Liao Jianming XU | 2011 | Cell Research2011，21，2： | 51 |
| 2 | Steroid receptor coactivator 3 regulates autophagy in breast cancer cells through macrophage migration inhibitory factor显示文摘SRC-3/AIB1 (在乳癌 1 的类固醇受体激活剂 3/amplified ) 是在癌症病人贡献药抵抗和差的没有疾病的幸存的发展的真 oncogene。Autophagy 也是让肿瘤 suppressor 工作的重要房间死亡机制。在这研究,我们识别了巨噬细胞移植禁止的因素(MIF ) 作为 SRC-3 的新奇目标基因并且在房间幸存表明了它的重要性。明确地,我们证明 MIF 是 autophagic 房间死亡的强壮的 suppressor。我们进一步证明接着, MIF 的抑制导致了 autophagic 房间死亡,提高了 chemosensitivity 并且禁止了在一个异种皮移植老鼠 tumorigenesis 模型的 tumorigenesis。我们的学习证明 MIF 表示的那条规定和 autophagic 房间死亡的抑制是 SRC-3 由贡献增加的 chemoresistance 和 tumorigenicity 的有势力机制。 | Mei-Yi Wu Junjiang Fu Jianming Xu Bert W O'MaUey Ray-Chang Wu | 2012 | Cell Research2012，22，6： | 12 |
| 3 | Static mechanical properties of hybrid RTM-made composite Ⅰ-and Ⅱ-beams under three-point flexure显示文摘This paper deals with three-point flexure tests on hybrid I-and P-beams,made out of multi-layer carbon fiber/epoxy resin(including twill woven fabric CF3031/5284 and unidirectional cord fabric U3160/5284)reinforced composites,processed using the RTM(resin transfer molding)technique.Static bending properties were determined and failure initiation mechanism was deduced from experimental observations.Failure mode of the tested hybrid RTM-made I-beams can be reckoned to be characteristic of the delamination from the cutout edge within the web and the debonding propagation along the interface between the inverted triangular resin-rich zone and the adjacent curved web until local buckling within the curved webs around the conjunction fillet region.In contrast,as distinct from hybrid RTM I-beams subjected to three-point bending loading,hybrid RTM-made P-beams in three-point flexure tests experienced the resin debonding in the inverted triangular resin-rich zones and the debonding propagation along the interface between the inverted triangular resin-rich zone and the adjacent curved web until complete separation of the curved web from the flange.Progressive damage models(PDMs)were presented to predict failure loads and process of hybrid RTM-made I-and P-beams under three-point flexure.Good correlation was achieved between experimental and numerical results. | Fu Yu Xiong Junjiang Luo Chuyang Yun Xinyao | 2015 | Chinese Journal of Aeronautics2015，28，3： | 5 |
| 4 | Mutant p53 promotes cell spreading and migration via ARHGAP44显示文摘The tumor suppressor p53 protein is either lost or mutated in about half of all human cancers.Loss of p53 function is well known to influence cell spreading,migration and invasion.While expression of mutant p53 is not equivalent to p53 loss,mutant p53 can acquire new functions to drive cell spreading and migration via different mechanisms.In our study,we found that mutant p53 significantly increased cell spreading and migration when comparing with p53-null cells.RNA-Seq analysis suggested that Rho GTPase activating protein 44(ARHGAP44) is a new target of mutant p53,which suppressed AKHGAP44 transcription.ARHGAP44 has GAP activity and catalyze GTP hydrolysis on Cdc42.Higher level of GTP-Cdc42 was correlated with increase expression of mutant p53 and reduced ARHGAP44.Importantly,wt-ARHGAP44 but not mutant ARHGAP44(R291A) suppressed mutant p53 mediated cell spreading and migration.Bioinformatics analysis indicated lower expression of ARHGAP44 in lung carcinoma compared with normal tissues,which was verified by RT-qPCR using specimens from patients.More interestingly,ARHGAP44 mRNA level was lower in tumors with mutant p53 than those with normal p53.Collectively,our results disclose a new mechanism by which mutant p53 stimulates cell spreading and migration. | Jinjin Xu Jian Jiao Wei Xu Lei Ji Dongjie Jiang Shaofang Xie Syeda Kubra Xiaotao Li Junjiang Fu Jianru Xiao Bianhong Zhang | 2017 | Science China(Life Sciences)2017，60，9： | 4 |
| 5 | Twist: a molecular target in cancer therapeutics显示文摘 | Md. Asaduzzaman Khan Han-chun Chen Dianzheng Zhang Junjiang Fu | 2013 | Tumor Biology2013，，5： | 1 |
| 6 | Epithelial to mesenchymal transition inducing transcription factors and metastatic cancer显示文摘 | Mousumi Tania Md. Asaduzzaman Khan Junjiang Fu | 2014 | Tumor Biology2014，，8： | 1 |
| 7 | Relationship between microdeletion on Y chromosome and patients with idiopathic azoospermia and severe oligozoospermia in the Chinese显示文摘 | Fu Junjiang Li Luyun Lu Guangxiu | 2002 | J Chn Med2002，115，： | 1 |
| 8 | No tillage outperforms conventional tillage under arid conditions and following fertilization显示文摘Reduced tillage practices present a tool that could sustainably intensify agriculture.The existing literature,however,lacks a consensus on how and when reduced tillage practices should get implemented.We reanalyzed here an extensive dataset comparing how regular tillage practices(i.e.,conventional tillage)impacted yield of eight crops compared to stopping tillage altogether(i.e.,no-tillage practice).We observed that aridity and fertilization favored no tillage over conventional tillage whereas conventional tillage performed better under high fertility settings.We further show that the responses are consistent across the crops.Our reanalysis complements the original and fills a gap in the literature questioning the conditions under which reducing tillage presents a viable alternative to common tillage practices. | Stavros D.Veresoglou Junjiang Chen Xuheng Du Qi Fu QingLiu Geng Chenyan Huang Xilin Huang Nan Hu Yiming Hun Guolin C.Li Zhiman Lin Zhiyu Ma Yuyi Ou Shuo Qi Haitian Qin Yingbo Qiu Xibin Sun Ye Tao YiLing Tian Jie Wang Lingxiao Wu Ziwei Wu Siqi Xie Ao Yang Dan Yang Chen Zeng Ying Zeng RuJie Zhang | 2023 | Soil Ecology Letters2023，5，1： | 1 |
| 9 | Twist: a molecular target in cancer therapeutics显示文摘 | Md. Asaduzzaman Khan Han-chun Chen Dianzheng Zhang Junjiang Fu | 2013 | Tumor Biology2013，，5： | 1 |
| 10 | The TWIST/Mi2/NuRD protein complex and its essentia role in cancer metastasis 显示文摘 | Junjiang Fu Li Qin Tao He | 2010 | CeU Research2010，，： | 1 |
| 11 | Double-branch fusion network with a parallel attention selection mechanism for camouflaged object detection显示文摘To meet the challenge of camouflaged object detection(COD),which has a high degree of intrinsic similarity between the object and background,this paper proposes a double-branch fusion network(DBFN)with a parallel attention selection mechanism(PASM).In detail,a schismatic receptive field block(SRF)combined with an attention mechanism for low-level information is performed to learn texture features in one branch,and an integration of the SRF,a hybrid attention mechanism(HAM),and a depth feature polymerization module(DFPM)is employed for high-level information to extract detection features in the other branch.Then,both texture features and detection features are input into the PASM to acquire selective expression matrices.Eventually,the final result is obtained after further selective matrix optimization with atrous spatial pyramid pooling(ASPP)and a residual channel attention block(RCAB)being applied serially.Experimental results on three public datasets verify that our method outperforms the state-of-the-art methods in terms of four evaluation metrics,i.e.,mean absolute error(MAE),weighted Fβmeasure(Fβω),structural measure(S_(α)),and E-measure(E_(φ)) | Junjiang XIANG Qing PAN Zhengrong ZHANG Songnian FU Yuwen QIN | 2023 | Science China(Information Sciences)2023，66，6： | 0 |
| 12 | Linear shallow neural network to accelerate transmitter dispersion eye closure quaternary(TDECQ)assessment显示文摘To support the ever-emerging capacity requirement of datacenter interconnection(DCI)applications,transmitter dispersion eye closure quaternary(TDECQ)has been proposed by IEEE802.3 standard[1],which is specifically employed for the four-level pulse amplitude modulation(PAM-4)signals.However,the traditional scheme of TDECQ assessment needs several iterative operations。 | Junjiang XIANG Zejun CHEN Yijun CHENG Hailin YANG Xuancheng HUO Meng XIANG Gai ZHOU Yuwen QIN Songnian FU | 2024 | Science China(Information Sciences)2024，67，4： | 0 |
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